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Select item 109401541.

SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination

Da Chen, Jiangni Wu, Xinze Qiu, Shibo Luo, Shanpei Huang, Erdan Wei, Mengbin Qin, Jiean Huang, Shiquan Liu

Cancer Gene Ther. 2024; 31(3): 410–419. Published online 2023 Dec 22. doi: 10.1038/s41417-023-00711-1

PMCID:: PMC10940154

Abstract Article PDF–14M

Select item 107826432.

Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis

Xin Tracy Liu, Yu Huang, Da Liu, Yingxin Celia Jiang, Min Zhao, Long Hoa Chung, Xingxing Daisy Han, Yinan Zhao, Jinbiao Chen, Paul Coleman, Ka Ka Ting, Collin Tran, Yingying Su, Claude Vincent Dennis, Atul Bhatnagar, Ken Liu, Anthony Simon Don, Mathew Alexander Vadas, Mark Douglas Gorrell, Shubiao Zhang, Michael Murray, Mary Meltem Kavurma, Geoffrey William McCaughan, Jennifer Ruth Gamble, Yanfei Qi

J Transl Med. 2024; 22: 43. Published online 2024 Jan 10. doi: 10.1186/s12967-023-04830-z

PMCID:: PMC10782643

Abstract Article PDF–7.3M

Select item 104632603.

Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production

Chun-Xue Zhang, Yu-Ling Lin, Fei-Fei Lu, Li-Na Yu, Yang Liu, Ji-Dong Zhou, Na Kong, Dong Li, Gui-Jun Yan, Hai-Xiang Sun, Guang-Yi Cao

J Biol Chem. 2023 Sep; 299(9): 105126. Published online 2023 Aug 4. doi: 10.1016/j.jbc.2023.105126

PMCID:: PMC10463260

Abstract Article PDF–3.4M

Select item 103497754.

DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas

Noboru Tsuda, Ying Tian, Mao Fujimoto, Junko Kuramoto, Satomi Makiuchi, Hidenori Ojima, Masahiro Gotoh, Nobuyoshi Hiraoka, Teruhiko Yoshida, Yae Kanai, Eri Arai

J Cancer Res Clin Oncol. 2023; 149(8): 5109–5125. Published online 2022 Nov 8. doi: 10.1007/s00432-022-04445-9

PMCID:: PMC10349775

Abstract Article PDF–4.0M

Select item 99504775.

HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1

Xin Peng, Xiaoli Liu, Wanshan Hu, Yanling Zhou, Lianlian Ouyang, Xintong Peng, Yao Long, Jingyue Sun, Tania Tao, Ling Chen, Ying Shi, Yongguang Tao, Desheng Xiao, Shuang Liu

Cell Death Dis. 2023 Feb; 14(2): 153. Published online 2023 Feb 23. doi: 10.1038/s41419-023-05673-8

PMCID:: PMC9950477

Abstract Article PDF–6.7M

Select item 97723216.

Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM)

Fei Li, Yifan Zhang, Zhoujun Lin, Lizhong Yan, Qiao Liu, Yin Li, Xiaolin Pei, Ya Feng, Xiao Han, Juan Yang, Fangxu Zheng, Tianjiao Li, Yupeng Zhang, Zhenkun Fu, Di Shao, Jane Yu, Chenggang Li

Cell Death Dis. 2022 Dec; 13(12): 1065. Published online 2022 Dec 21. doi: 10.1038/s41419-022-05511-3

PMCID:: PMC9772321

Abstract Article PDF–6.2M

Select item 96573077.

Targeting SPHK1/PBX1 Axis Induced Cell Cycle Arrest in Non-Small Cell Lung Cancer

Zhoujun Lin, Yin Li, Xiao Han, Zhenkun Fu, Zhenhuan Tian, Chenggang Li

Int J Mol Sci. 2022 Nov; 23(21): 12741. Published online 2022 Oct 22. doi: 10.3390/ijms232112741

PMCID:: PMC9657307

Abstract Article PDF–12M

Select item 96179468.

Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance

Priyanka Bhadwal, Vinay Randhawa, Kim Vaiphei, Divya Dahiya, Navneet Agnihotri

Sci Rep. 2022; 12: 18239. Published online 2022 Oct 29. doi: 10.1038/s41598-022-20976-0

PMCID:: PMC9617946

Abstract Article PDF–4.9M

Select item 92626149.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 919458910.

Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH

David Montefusco, Maryam Jamil, Melissa A. Maczis, William Schroeder, Moshe Levi, Suman Ranjit, Jeremy Allegood, Dipankar Bandyopadhyay, Reuben Retnam, Sarah Spiegel, L. Ashley Cowart

Mol Metab. 2022 Aug; 62: 101523. Published online 2022 Jun 6. doi: 10.1016/j.molmet.2022.101523

PMCID:: PMC9194589

Abstract Article PDF–1.2M

Select item 911576911.

Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury

Alison W Ha, Tao Bai, David L Ebenezer, Tanvi Sethi, Tara Sudhadevi, Lizar Ace Mangio, Steven Garzon, Gloria S Pryhuber, Viswanathan Natarajan, Anantha Harijith

Thorax. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Thorax. 2022 Jan; 77(1): 47–57. Published online 2021 Apr 21. doi: 10.1136/thoraxjnl-2020-216469

PMCID:: PMC9115769

Abstract Article PDF–1.5M

Select item 848038312.

SPHK1 contributes to cisplatin resistance in bladder cancer cells via the NONO/STAT3 axis

Zijia Qin, Hang Tong, Tinghao Li, Honghao Cao, Junlong Zhu, Siwen Yin, Weiyang He

Int J Mol Med. 2021 Nov; 48(5): 204. Published online 2021 Sep 22. doi: 10.3892/ijmm.2021.5037

PMCID:: PMC8480383

Abstract Article PDF–6.2M

Select item 846006213.

LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR-378a-5p to enhance SPHK1 expression

Xin Wang, Hongtao Liu, Qing Zhang, Xueying Zhang, Yue Qin, Guangzhao Zhu, Jinghan Dang, Feng Wang, Xiangxiang Yang, Ruitai Fan

Int J Oncol. 2021 Nov; 59(5): 86. Published online 2021 Sep 17. doi: 10.3892/ijo.2021.5266

PMCID:: PMC8460062

Abstract Article PDF–2.5M

Select item 827262914.

Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation

Jean-Philip Truman, Christian F. Ruiz, Magali Trayssac, Cungui Mao, Yusuf A. Hannun, Lina M. Obeid

FASEB J. Author manuscript; available in PMC 2021 Jul 10.

Published in final edited form as: FASEB J. 2021 Feb; 35(2): e21284. doi: 10.1096/fj.202001814RR

PMCID:: PMC8272629

Abstract Article PDF–2.4M

Select item 816862315.

LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1

Weiyu Shen, Xunyu Hong, Chenghua Jin, Yong Xi

Cell Cycle. 2021; 20(9): 829–838. Published online 2021 Apr 14. doi: 10.1080/15384101.2021.1900499

PMCID:: PMC8168623

Abstract Article PDF–3.1M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011