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Select item 98811361.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 88288952.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 75212503.

Association of TLX1 gene polymorphisms with the risk of acute lymphoblastic leukemia and B lineage acute lymphoblastic leukemia in Han Chinese children

Endian Mei, Xubin Wei, Jiadong Gao, Xiaolong Tian, Wei Li, Li Liu, Cheng Qian

J Clin Lab Anal. 2020 Sep; 34(9): e23414. Published online 2020 Jun 2. doi: 10.1002/jcla.23414

PMCID:: PMC7521250

Abstract Article PDF–438K

Select item 62693034.

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

Karen Verboom, Wouter Van Loocke, Pieter-Jan Volders, Bieke Decaesteker, Francisco Avila Cobos, Simon Bornschein, Charles E. de Bock, Zeynep Kalender Atak, Emmanuelle Clappier, Stein Aerts, Jan Cools, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jo Vandesompele, Frank Speleman, Kaat Durinck

Haematologica. 2018 Dec; 103(12): e585–e589. doi: 10.3324/haematol.2018.190587

PMCID:: PMC6269303

Article PDF–1.2M

Select item 60978765.

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

Marlies Vanden Bempt, Sofie Demeyer, Michaël Broux, Jolien De Bie, Simon Bornschein, Nicole Mentens, Roel Vandepoel, Ellen Geerdens, Enrico Radaelli, Beat C. Bornhauser, Andreas E. Kulozik, Jules P. Meijerink, Jean-Pierre Bourquin, Charles E. de Bock, Jan Cools

Cancer Cell. 2018 Aug 13; 34(2): 271–285.e7. doi: 10.1016/j.ccell.2018.07.007

PMCID:: PMC6097876

Abstract Article

Select item 60134226.

Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription

Lin Jia, Dinglan Wu, Yuliang Wang, Wenxing You, Zhu Wang, Lijia Xiao, Ganhui Cai, Zhenyu Xu, Chang Zou, Fei Wang, Jeremy Yuen-Chun Teoh, Chi-Fai Ng, Shan Yu, Franky L. Chan

Oncogene. 2018; 37(25): 3340–3355. Published online 2018 Mar 20. doi: 10.1038/s41388-018-0198-z

PMCID:: PMC6013422

Abstract Article PDF–4.5M

Select item 54958137.

Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation

Boris Novakovic, Thierry Fournier, Lynda K. Harris, Joanna James, Claire T. Roberts, Hannah E. J. Yong, Bill Kalionis, Danièle Evain-Brion, Peter R. Ebeling, Euan M. Wallace, Richard Saffery, Padma Murthi

Sci Rep. 2017; 7: 4523. Published online 2017 Jul 3. doi: 10.1038/s41598-017-04776-5

PMCID:: PMC5495813

Abstract Article PDF–2.7M

Select item 53712038.

Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer

Tyler McInnes, Donghui Zou, Dasari S. Rao, Francesca M. Munro, Vicky L. Phillips, John L. McCall, Michael A. Black, Anthony E. Reeve, Parry J. Guilford

BMC Cancer. 2017; 17: 228. Published online 2017 Mar 28. doi: 10.1186/s12885-017-3226-4

PMCID:: PMC5371203

Abstract Article PDF–855K

Select item 38119009.

G-Quadruplex Structures Formed at the HOX11 Breakpoint Region Contribute to Its Fragility during t(10;14) Translocation in T-Cell Leukemia

Mridula Nambiar, Mrinal Srivastava, Vidya Gopalakrishnan, Sritha K. Sankaran, Sathees C. Raghavan

Mol Cell Biol. 2013 Nov; 33(21): 4266–4281. doi: 10.1128/MCB.00540-13

PMCID:: PMC3811900

Abstract Article PDF–4.3M

Select item 329803610.

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL

Giusy Della Gatta, Teresa Palomero, Arianne Perez-Garcia, Alberto Ambesi-Impiombato, Mukesh Bansal, Zachary W. Carpenter, Kim De Keersmaecker, Xavier Sole, Luyao Xu, Elisabeth Paietta, Janis Racevskis, Peter H Wiernik, Jacob M Rowe, Jules P Meijerink, Andrea Califano, Adolfo A. Ferrando

Nat Med. Author manuscript; available in PMC 2012 Sep 1.

Published in final edited form as: Nat Med. 2012 Mar; 18(3): 436–440. Published online 2012 Feb 26. doi: 10.1038/nm.2610

PMCID:: PMC3298036

Abstract Article PDF–1.2M

Select item 317805911.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 303389812.

Transient Responses to NOTCH and TLX1/HOX11 Inhibition in T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Lesley A. Rakowski, Erica A. Lehotzky, Mark Y. Chiang

PLoS One. 2011; 6(2): e16761. Published online 2011 Feb 4. doi: 10.1371/journal.pone.0016761

PMCID:: PMC3033898

Abstract Article PDF–1.0M

Select item 297479013.

The TLX1 oncogene drives aneuploidy in T-cell transformation

Kim De Keersmaecker, Pedro Jose Real, Giusy Della Gatta, Teresa Palomero, Maria Luisa Sulis, Valeria Tosello, Pieter Van Vlierberghe, Kelly Barnes, Mireia Castillo, Xavier Sole, Michael Hadler, Jack Lenz, Peter D. Aplan, Michelle Kelliher, Barbara L. Kee, Pier Paolo Pandolfi, Dietmar Kappes, Fotini Gounari, Howard Petrie, Joni Van der Meulen, Frank Speleman, Elisabeth Paietta, Janis Racevskis, Peter H. Wiernik, Jacob M. Rowe, Jean Soulier, David Avran, Hélène Cavé, Nicole Dastugue, Susana Raimondi, Jules P.P. Meijerink, Carlos Cordon-Cardo, Andrea Califano, Adolfo A. Ferrando

Nat Med. Author manuscript; available in PMC 2011 May 1.

Published in final edited form as: Nat Med. 2010 Nov; 16(11): 1321–1327. Published online 2010 Oct 24. doi: 10.1038/nm.2246

PMCID:: PMC2974790

Abstract Article PDF–1.9M

Select item 291398314.

TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells

Irene Riz, Teresa S Hawley, Truong V Luu, Norman H Lee, Robert G Hawley

Mol Cancer. 2010; 9: 181. Published online 2010 Jul 9. doi: 10.1186/1476-4598-9-181

PMCID:: PMC2913983

Abstract Article PDF–1.6M

Select item 279504915.

Hematopoietic Immortalizing Function of the NKL-Subclass Homeobox Gene TLX1

Lynnsey A. Zweier-Renn, Teresa S. Hawley, Sandra Burkett, Ali Ramezani, Irene Riz, Rima L. Adler, Dennis D. Hickstein, Robert G. Hawley

Genes Chromosomes Cancer. Author manuscript; available in PMC 2011 Feb 1.

Published in final edited form as: Genes Chromosomes Cancer. 2010 Feb; 49(2): 119–131. doi: 10.1002/gcc.20725

PMCID:: PMC2795049

Abstract Article PDF–370K

Select item 265441316.

Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors

Irene Riz, Hyo Jung Lee, Kristin K. Baxter, Reza Behnam, Teresa S. Hawley, Robert G. Hawley

Biochem Biophys Res Commun. Author manuscript; available in PMC 2010 Mar 6.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Mar 6; 380(2): 361–365. Published online 2009 Jan 23. doi: 10.1016/j.bbrc.2009.01.099