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Select item 105892811.

Bioavailability and provitamin A activity of neurosporaxanthin in mice

Anthony P. Miller, Dámaso Hornero-Méndez, Sepalika Bandara, Obdulia Parra-Rivero, M. Carmen Limón, Johannes von Lintig, Javier Avalos, Jaume Amengual

Commun Biol. 2023; 6: 1068. Published online 2023 Oct 20. doi: 10.1038/s42003-023-05446-1

PMCID:: PMC10589281

Abstract Article PDF–1.8M

Select item 99418282.

Genetic tuning of β-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice

Jean Moon, Srinivasagan Ramkumar, Johannes von Lintig

Hum Mol Genet. 2023 Mar 1; 32(5): 798–809. Published online 2022 Sep 23. doi: 10.1093/hmg/ddac242

PMCID:: PMC9941828

Abstract Article PDF–2.0M

Select item 97070383.

The conversion of β-carotene to vitamin A in adipocytes drives the anti-obesogenic effects of β-carotene in mice

Johana Coronel, Jianshi Yu, Nageswara Pilli, Maureen A. Kane, Jaume Amengual

Mol Metab. 2022 Dec; 66: 101640. Published online 2022 Nov 15. doi: 10.1016/j.molmet.2022.101640

PMCID:: PMC9707038

Abstract Article PDF–1.9M

Select item 86883404.

Fenretinide inhibits vitamin A formation from β-carotene and regulates carotenoid levels in mice

Anthony P Miller, Molly Black, Jaume Amengual

Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Feb; 1867(2): 159070. Published online 2021 Nov 4. doi: 10.1016/j.bbalip.2021.159070

PMCID:: PMC8688340

Abstract Article PDF–1.4M

Select item 73987805.

β-Carotene Oxygenase 1 Activity Modulates Circulating Cholesterol Concentrations in Mice and Humans

Jaume Amengual, Johana Coronel, Courtney Marques, Celia Aradillas-García, Juan Manuel Vargas Morales, Flavia C D Andrade, John W Erdman, Jr, Margarita Teran-Garcia

J Nutr. 2020 Aug; 150(8): 2023–2030. Published online 2020 May 20. doi: 10.1093/jn/nxaa143

PMCID:: PMC7398780

Abstract Article PDF–415K

Select item 63684156.

Supplementation with Macular Carotenoids Improves Visual Performance of Transgenic Mice

Binxing Li, Gregory T. Rognon, Ty Mattinson, Preejith P. Vachali, Aruna Gorusupudi, Fu-Yen Chang, Arunkumar Ranganathan, Kelly Nelson, Evan W. George, Jeanne M. Frederick, Paul S. Bernstein

Arch Biochem Biophys. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Arch Biochem Biophys. 2018 Jul 1; 649: 22–28. Published online 2018 May 6. doi: 10.1016/j.abb.2018.05.003

PMCID:: PMC6368415

Abstract Article PDF–2.1M

Select item 59959317.

β-apo-10′-carotenoids support normal embryonic development during vitamin A deficiency

Elizabeth Spiegler, Youn-Kyung Kim, Beatrice Hoyos, Sureshbabu Narayanasamy, Hongfeng Jiang, Nicole Savio, Robert W. Curley, Jr., Earl H. Harrison, Ulrich Hammerling, Loredana Quadro

Sci Rep. 2018; 8: 8834. Published online 2018 Jun 11. doi: 10.1038/s41598-018-27071-3

PMCID:: PMC5995931

Abstract Article PDF–1.8M

Select item 54942578.

Retinal Accumulation of Zeaxanthin, Lutein, and β-Carotene in Mice Deficient in Carotenoid Cleavage Enzymes

Binxing Li, Preejith P. Vachali, Zhengqing Shen, Aruna Gorusupudi, Kelly Nelson, Brian M Besch, Alexis Bartschi, Simone Longo, Ty Mattinson, Saeed Shihab, Nikolay E. Polyakov, Lyubov P. Suntsova, Alexander V. Dushkin, Paul S. Bernstein

Exp Eye Res. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Exp Eye Res. 2017 Jun; 159: 123–131. Published online 2017 Mar 9. doi: 10.1016/j.exer.2017.02.016

PMCID:: PMC5494257

Abstract Article PDF–1.2M

Select item 54076269.

Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturase 1

Eugenia Poliakov, William Samuel, Todd Duncan, Danielle B. Gutierrez, Nathan L. Mata, T. Michael Redmond

PLoS One. 2017; 12(4): e0176487. Published online 2017 Apr 27. doi: 10.1371/journal.pone.0176487

PMCID:: PMC5407626

Abstract Article PDF–2.6M

Select item 525697110.

Mice lacking β-carotene-15,15’-dioxygenase exhibit reduced serum testosterone, prostatic androgen receptor signaling, and prostatic cellular proliferation

Joshua W. Smith, Nikki A. Ford, Jennifer M. Thomas-Ahner, Nancy E. Moran, Eric C. Bolton, Matthew A. Wallig, Steven K. Clinton, John W. Erdman, Jr.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1; 311(6): R1135–R1148. Published online 2016 Sep 14. doi: 10.1152/ajpregu.00261.2016

PMCID:: PMC5256971

Abstract Article

Select item 500315311.

Genetic dissection in a mouse model reveals interactions between carotenoids and lipid metabolism

Grzegorz Palczewski, M. Airanthi K. Widjaja-Adhi, Jaume Amengual, Marcin Golczak, Johannes von Lintig

J Lipid Res. 2016 Sep; 57(9): 1684–1695. doi: 10.1194/jlr.M069021

PMCID:: PMC5003153

Abstract Article PDF–1.3M

Select item 442495612.

A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption

M. Airanthi K. Widjaja-Adhi, Glenn P. Lobo, Marcin Golczak, Johannes Von Lintig

Hum Mol Genet. 2015 Jun 1; 24(11): 3206–3219. Published online 2015 Feb 20. doi: 10.1093/hmg/ddv072

PMCID:: PMC4424956

Abstract Article PDF–1004K

Select item 440212213.

Tissue- and sex-specific effects of β-carotene 15,15′ oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice

Youn-Kyung Kim, Michael V. Zuccaro, Brianna K. Costabile, Rebeka Rodas, Loredana Quadro

Arch Biochem Biophys. Author manuscript; available in PMC 2016 Apr 15.

Published in final edited form as: Arch Biochem Biophys. 2015 Apr 15; 572: 11–18. Published online 2015 Jan 17. doi: 10.1016/j.abb.2015.01.002

PMCID:: PMC4402122

Abstract Article PDF–1.1M

Select item 425500814.

Cardiac dysfunction in β-carotene-15,15′-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism

Seung-Ah Lee, Hongfeng Jiang, Chad M. Trent, Jason J. Yuen, Sureshbabu Narayanasamy, Robert W. Curley, Jr., Earl H. Harrison, Ira J. Goldberg, Mathew S. Maurer, William S. Blaner

Am J Physiol Heart Circ Physiol. 2014 Dec 1; 307(11): H1675–H1684. Published online 2014 Sep 26. doi: 10.1152/ajpheart.00548.2014

PMCID:: PMC4255008

Abstract Article

Select item 420209815.

Evidence for compartmentalization of mammalian carotenoid metabolism

Grzegorz Palczewski, Jaume Amengual, Charles L. Hoppel, Johannes von Lintig

FASEB J. 2014 Oct; 28(10): 4457–4469. doi: 10.1096/fj.14-252411

PMCID:: PMC4202098

Abstract Article

Select item 385668716.

Loss of β-carotene 15,15′-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols

Joseph L. Dixon, Youn-Kyung Kim, Anita Brinker, Loredana Quadro

Biochim Biophys Acta. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Biochim Biophys Acta. 2014 Jan; 1841(1): 10.1016/j.bbalip.2013.08.013. Published online 2013 Aug 27. doi: 10.1016/j.bbalip.2013.08.013

PMCID:: PMC3856687

Abstract Article PDF–714K

Select item 383714917.

Two Carotenoid Oxygenases Contribute to Mammalian Provitamin A Metabolism

Jaume Amengual, M. Airanthi K. Widjaja-Adhi, Susana Rodriguez-Santiago, Susanne Hessel, Marcin Golczak, Krzysztof Palczewski, Johannes von Lintig

J Biol Chem. 2013 Nov 22; 288(47): 34081–34096. Published online 2013 Oct 8. doi: 10.1074/jbc.M113.501049

PMCID:: PMC3837149

Abstract Article PDF–2.8M

Select item 383478818.

The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development

Sara E. Billings, Keely Pierzchalski, Naomi E. Butler Tjaden, Xiao-Yan Pang, Paul A. Trainor, Maureen A. Kane, Alexander R. Moise

FASEB J. 2013 Dec; 27(12): 4877–4889. doi: 10.1096/fj.13-227967

PMCID:: PMC3834788

Abstract Article

Select item 380489319.

Genetic ablation of carotene oxygenases and consumption of lycopene or tomato powder diets modulates carotenoid and lipid metabolism in mice

Nikki A. Ford, Amy C. Elsen, John W. Erdman, Jr.

Nutr Res. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Nutr Res. 2013 Sep; 33(9): 733–742. Published online 2013 Aug 13. doi: 10.1016/j.nutres.2013.07.007

PMCID:: PMC3804893

Abstract Article PDF–2.6M

Select item 369227420.

Hepatic stellate cells are an important cellular site for β-carotene conversion to retinoid

Igor Shmarakov, Matthew K. Fleshman, Diana N. D’Ambrosio, Roseann Piantedosi, Ken M. Riedl, Steven J. Schwartz, Robert W. Curley, Jr., Johannes von Lintig, Lewis P. Rubin, Earl H. Harrison, William S. Blaner

Arch Biochem Biophys. Author manuscript; available in PMC 2013 Jun 25.

Published in final edited form as: Arch Biochem Biophys. 2010 Dec 1; 504(1): 3–10. Published online 2010 May 12. doi: 10.1016/j.abb.2010.05.010