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Select item 116150391.

Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice

Marianthi Gioulbasani, Tarmo Äijö, Siyao Liu, Stephanie A. Montgomery, Nathan D. Montgomery, David Corcoran, Ageliki Tsagaratou

Commun Biol. 2024; 7: 1606. Published online 2024 Dec 3. doi: 10.1038/s42003-024-07312-0

PMCID:: PMC11615039

Abstract Article PDF–5.4M

Select item 115739872.

TET3 regulates terminal cell differentiation at the metabolic level

Isabel Mulet, Carmen Grueso-Cortina, Mireia Cortés-Cano, Daniela Gerovska, Guangming Wu, Stefania Alexandra Iakab, Daniel Jimenez-Blasco, Andrea Curtabbi, Pablo Hernansanz-Agustín, Harmony Ketchum, Israel Manjarrés-Raza, F. Thomas Wunderlich, Juan Pedro Bolaños, Meelad M. Dawlaty, Carsten Hopf, José Antonio Enríquez, Marcos J. Araúzo-Bravo, Natalia Tapia

Nat Commun. 2024; 15: 9749. Published online 2024 Nov 18. doi: 10.1038/s41467-024-54044-0

PMCID:: PMC11573987

Abstract Article PDF–4.2M

Select item 114467553.

TET proteins regulate Drosha expression and impact microRNAs in iNKT cells

Marianthi Gioulbasani, Tarmo Äijö, Jair E. Valenzuela, Julia Buquera Bettes, Ageliki Tsagaratou

Front Immunol. 2024; 15: 1440044. Published online 2024 Sep 19. doi: 10.3389/fimmu.2024.1440044

PMCID:: PMC11446755

Abstract Article PDF–1.9M

Select item 113881594.

Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development

Yuhan Yang, Logan Rivera, Shaohai Fang, Maryn Cavalier, Ashley Suris, Yubin Zhou, Yun Huang

iScience. 2024 Sep 20; 27(9): 110631. Published online 2024 Jul 31. doi: 10.1016/j.isci.2024.110631

PMCID:: PMC11388159

Abstract Article PDF–4.4M

Select item 113529215.

Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence

Ian C. MacArthur, Liyang Ma, Cheng-Yen Huang, Hrutvik Bhavsar, Masako Suzuki, Meelad M. Dawlaty

Sci Adv. 2024 Aug 30; 10(35): eado5424. Published online 2024 Aug 28. doi: 10.1126/sciadv.ado5424

PMCID:: PMC11352921

Abstract Article PDF–15M

Select item 109044936.

Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α

Beibei Liu, Di Xie, Xinmei Huang, Sungho Jin, Yangyang Dai, Xiaoli Sun, Da Li, Anton M. Bennett, Sabrina Diano, Yingqun Huang

Diabetologia. 2024; 67(4): 724–737. Published online 2024 Jan 13. doi: 10.1007/s00125-023-06073-5

PMCID:: PMC10904493

Abstract Article PDF–1.4M

Select item 108782747.

Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis

Rachel Matrenec, Claudia E. Oropeza, Eddie Dekoven, Grant Tarnow, Mark Maienschein-Cline, Cecilia S. Chau, Stefan J. Green, Alan McLachlan

J Virol. 2024 Feb; 98(2): e01721-23. Published online 2024 Jan 5. doi: 10.1128/jvi.01721-23

PMCID:: PMC10878274

Abstract Article PDF–2.2M

Select item 107909958.

TET3 is a positive regulator of mitochondrial respiration in Neuro2A cells

Valeria Leon Kropf, Caraugh J. Albany, Anna Zoccarato, Hannah L. H. Green, Youwen Yang, Alison C. Brewer

PLoS One. 2024; 19(1): e0294187. Published online 2024 Jan 16. doi: 10.1371/journal.pone.0294187

Correction in:: PLoS One. 2024; 19(2): e0300015.

PMCID:: PMC10790995

Abstract Article PDF–1.7M

Select item 107639789.

TET3 plays a critical role in white adipose development and diet-induced remodeling

Byung Chul Jung, Dongjoo You, Ikjun Lee, Daofeng Li, Rebecca L. Schill, Katherine Ma, Anna Pi, Zehan Song, Wei-Chieh Mu, Ting Wang, Ormond A. MacDougald, Alexander S. Banks, Sona Kang

Cell Rep. Author manuscript; available in PMC 2024 Jan 3.

Published in final edited form as: Cell Rep. 2023 Oct 31; 42(10): 113196. Published online 2023 Sep 30. doi: 10.1016/j.celrep.2023.113196

PMCID:: PMC10763978

Abstract Article PDF–2.7M

Select item 1053204810.

A Lipid Nanoparticle-Based Method for the Generation of Liver-Specific Knockout Mice

Sumiyo Morita, Takuro Horii, Mika Kimura, Ryosuke Kobayashi, Hiroki Tanaka, Hidetaka Akita, Izuho Hatada

Int J Mol Sci. 2023 Sep; 24(18): 14299. Published online 2023 Sep 19. doi: 10.3390/ijms241814299

PMCID:: PMC10532048

Abstract Article PDF–1.1M

Select item 1050027111.

TET3-mediated DNA oxidation is essential for intestinal epithelial cell response to stressors

Edward A. Gonzalez, Yue Liu, Dahui Wang, Maciej Jeziorek, Sheila Bandyopadhyay, Anjana Rao, Nan Gao, Jean-Pierre Etchegaray

Proc Natl Acad Sci U S A. 2023 Sep 12; 120(37): e2221405120. Published online 2023 Sep 5. doi: 10.1073/pnas.2221405120

PMCID:: PMC10500271

Abstract Article PDF–14M

Select item 1044986512.

Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons

Dalia Halawani, Yiqun Wang, Aarthi Ramakrishnan, Molly Estill, Xijing He, Li Shen, Roland H. Friedel, Hongyan Zou

Nat Commun. 2023; 14: 5165. Published online 2023 Aug 24. doi: 10.1038/s41467-023-40816-7

PMCID:: PMC10449865

Abstract Article PDF–13M

Select item 1032605413.

TET2 and TET3 loss disrupts small intestine differentiation and homeostasis

Ihab Ansari, Llorenç Solé-Boldo, Meshi Ridnik, Julian Gutekunst, Oliver Gilliam, Maria Korshko, Timur Liwinski, Birgit Jickeli, Noa Weinberg-Corem, Michal Shoshkes-Carmel, Eli Pikarsky, Eran Elinav, Frank Lyko, Yehudit Bergman

Nat Commun. 2023; 14: 4005. Published online 2023 Jul 6. doi: 10.1038/s41467-023-39512-3

PMCID:: PMC10326054

Abstract Article PDF–11M

Select item 1027019314.

Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation

Guanghui Yang, Qiliang Xin, Iris Feng, Di Wu, Jurrien Dean

Genes Dev. 2023 May 1; 37(9-10): 418–431. doi: 10.1101/gad.350400.123

PMCID:: PMC10270193

Abstract Article PDF–6.5M

Select item 1015737515.

DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation

Athmane Teghanemt, Kara Misel‐Wuchter, Jace Heath, Andrew Thurman, Priyanjali Pulipati, Garima Dixit, Ramasatya Geesala, David K Meyerholz, Thorsten Maretzky, Alejandro Pezzulo, Priya D Issuree

EMBO Rep. 2023 May; 24(5): e55543. Published online 2023 Mar 7. doi: 10.15252/embr.202255543

PMCID:: PMC10157375

Abstract Article PDF–9.7M

Select item 1011923916.

miR-488-5p mitigates hepatic stellate cell activation and hepatic fibrosis via suppressing TET3 expression

Jiannan Qiu, Shasha Wu, Peng Wang, Yan Zhou, Zhongxia Wang, Yong Sun, Chunping Jiang

Hepatol Int. 2023 Apr; 17(2): 463–475. Published online 2022 Aug 24. doi: 10.1007/s12072-022-10404-w

PMCID:: PMC10119239

Abstract Article PDF–10M

Select item 1010326217.

Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment

Xiujie Liang, Tamas Aranyi, Jianfu Zhou, Yuting Guan, Hailong Hu, Hongbo Liu, Katalin Susztak

J Am Soc Nephrol. 2023 Apr; 34(4): 572–589. Published online 2022 Dec 15. doi: 10.1681/ASN.2022040460

PMCID:: PMC10103262

Abstract Article

Select item 983945118.

Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine

Fan Wu, Xiang Li, Mario Looso, Hang Liu, Dong Ding, Stefan Günther, Carsten Kuenne, Shuya Liu, Norbert Weissmann, Thomas Boettger, Ann Atzberger, Saeed Kolahian, Harald Renz, Stefan Offermanns, Ulrich Gärtner, Michael Potente, Yonggang Zhou, Xuejun Yuan, Thomas Braun

Nat Genet. 2023; 55(1): 100–111. Published online 2022 Dec 20. doi: 10.1038/s41588-022-01252-3

PMCID:: PMC9839451

Abstract Article PDF–24M

Select item 983366719.

DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

Guo-Dong Chen, Iqra Fatima, Qin Xu, Elena Rozhkova, Michael Y. Fessing, Andrei N. Mardaryev, Andrey A. Sharov, Guo-Liang Xu, Vladimir A. Botchkarev

Sci Adv. 2023 Jan; 9(2): eabo7605. Published online 2023 Jan 11. doi: 10.1126/sciadv.abo7605

PMCID:: PMC9833667

Abstract Article PDF–3.1M

Select item 964438020.

TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment

Bertille Montibus, Jil Cercy, Tristan Bouschet, Amandine Charras, Stéphanie Maupetit-Méhouas, David Nury, Céline Gonthier-Guéret, Sabine Chauveau, Nicolas Allegre, Caroline Chariau, Charles C. Hong, Isabelle Vaillant, C. Joana Marques, Franck Court, Philippe Arnaud

Cell Mol Life Sci. 2021 Jan; 78(2): 757–768. Published online 2020 May 14. doi: 10.1007/s00018-020-03541-8