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Select item 114963191.

Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein

Sarah Hui, Jimmy George, Minesh Kapadia, Hien Chau, Zahn Bariring, Rebecca Earnshaw, Kashfia Shafiq, Lorraine V. Kalia, Suneil K. Kalia

Mol Neurobiol. 2024; 61(11): 9032–9042. Published online 2024 Apr 6. doi: 10.1007/s12035-024-04131-6

PMCID:: PMC11496319

Abstract Article PDF–1.3M

Select item 106794932.

The toxicities of A30P and A53T α-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine

Abid Ali, Kiryl Zhaliazka, Tianyi Dou, Aidan P. Holman, Dmitry Kurouski

J Biol Chem. 2023 Dec; 299(12): 105383. Published online 2023 Oct 26. doi: 10.1016/j.jbc.2023.105383

PMCID:: PMC10679493

Abstract Article PDF–2.0M

Select item 104038583.

VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson’s disease

Xi Chen, Elpida Tsika, Nathan Levine, Darren J. Moore

Mol Neurodegener. 2023; 18: 51. Published online 2023 Aug 4. doi: 10.1186/s13024-023-00641-4

PMCID:: PMC10403858

Abstract Article PDF–14M

Select item 102667304.

Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation

Dmitry Zenko, Jade Marsh, Andrew R. Castle, Rahel Lewin, Roman Fischer, George K. Tofaris

Sci Adv. 2023 Jun; 9(24): eadd8910. Published online 2023 Jun 14. doi: 10.1126/sciadv.add8910

PMCID:: PMC10266730

Abstract Article PDF–2.9M

Select item 101830395.

Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats

Yajie Wang, Zhikang Miao, Chang Xu, Ying Cai, Yuting Yang, Yue Hu, Mengna Zhao, Yue Shao, Zhiqiang Li, Jincao Chen, Shi Chen, Lianrong Wang

Cell Death Dis. 2023 May; 14(5): 325. Published online 2023 May 13. doi: 10.1038/s41419-023-05846-5

PMCID:: PMC10183039

Abstract Article PDF–3.8M

Select item 97943736.

Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines

Ryan D. Hallam, Brodie Buchner-Duby, Morgan G. Stykel, Carla L. Coackley, Scott D. Ryan

J Neurosci. 2022 Dec 14; 42(50): 9473–9487. doi: 10.1523/JNEUROSCI.0074-22.2022

PMCID:: PMC9794373

Abstract Article PDF–5.4M

Select item 97389387.

UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson’s Disease

Shubhangini Tiwari, Abhishek Singh, Parul Gupta, Sarika Singh

Cells. 2022 Dec; 11(23): 3770. Published online 2022 Nov 25. doi: 10.3390/cells11233770

PMCID:: PMC9738938

Abstract Article PDF–5.5M

Select item 96375838.

α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α

Helena Borland, Izabela Rasmussen, Kaare Bjerregaard-Andersen, Michel Rasmussen, Anders Olsen, Frederik Vilhardt

J Biol Chem. 2022 Nov; 298(11): 102531. Published online 2022 Sep 24. doi: 10.1016/j.jbc.2022.102531

PMCID:: PMC9637583

Abstract Article PDF–4.5M

Select item 89167629.

Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis

Arati Tripathi, Heba Alnakhala, Elizabeth Terry-Kantor, Andrew Newman, Lei Liu, Thibaut Imberdis, Saranna Fanning, Silke Nuber, Nagendran Ramalingam, Dennis Selkoe, Ulf Dettmer

J Neurosci. 2022 Mar 9; 42(10): 2116–2130. doi: 10.1523/JNEUROSCI.1881-21.2022

PMCID:: PMC8916762

Abstract Article PDF–4.1M

Select item 794906110.

Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons

Nagendran Ramalingam, Ulf Dettmer

J Biol Chem. 2021 Jan-Jun; 296: 100271. Published online 2021 Jan 9. doi: 10.1016/j.jbc.2021.100271

PMCID:: PMC7949061

Abstract Article PDF–911K

Select item 770457911.

Differential regional responses in soluble monomeric alpha synuclein abundance following traumatic brain injury

SW Carlson, HQ Yan, Y Li, J Henchir, X Ma, MS Young, MD Ikonomovic, C.E. Dixon

Mol Neurobiol. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: Mol Neurobiol. 2021 Jan; 58(1): 362–374. Published online 2020 Sep 19. doi: 10.1007/s12035-020-02123-w

PMCID:: PMC7704579

Abstract Article PDF–2.2M

Select item 756147312.

Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome

Anila Iqbal, Marta Baldrighi, Jennifer N. Murdoch, Angeleen Fleming, Christopher J. Wilkinson

Biol Open. 2020 Oct 15; 9(10): bio054338. Published online 2020 Oct 5. doi: 10.1242/bio.054338

PMCID:: PMC7561473

Abstract Article PDF–12M

Select item 738336813.

Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies

Janin Lautenschläger, Sara Wagner-Valladolid, Amberley D. Stephens, Ana Fernández-Villegas, Colin Hockings, Ajay Mishra, James D. Manton, Marcus J. Fantham, Meng Lu, Eric J. Rees, Clemens F. Kaminski, Gabriele S. Kaminski Schierle

J Biol Chem. 2020 Jul 24; 295(30): 10138–10152. Published online 2020 May 8. doi: 10.1074/jbc.RA119.011650

PMCID:: PMC7383368

Abstract Article PDF–3.0M

Select item 702378314.

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

Chris McKinnon, Mitchell L. De Snoo, Elise Gondard, Clemens Neudorfer, Hien Chau, Sophie G. Ngana, Darren M. O’Hara, Jonathan M. Brotchie, James B. Koprich, Andres M. Lozano, Lorraine V. Kalia, Suneil K. Kalia

Acta Neuropathol Commun. 2020; 8: 17. Published online 2020 Feb 14. doi: 10.1186/s40478-020-0894-0

PMCID:: PMC7023783

Abstract Article PDF–6.5M

Select item 690716515.

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

David R. Boyer, Binsen Li, Chuanqi Sun, Weijia Fan, Michael R. Sawaya, Lin Jiang, David S. Eisenberg

Nat Struct Mol Biol. Author manuscript; available in PMC 2020 May 6.

Published in final edited form as: Nat Struct Mol Biol. 2019 Nov; 26(11): 1044–1052. Published online 2019 Nov 6. doi: 10.1038/s41594-019-0322-y

PMCID:: PMC6907165

Abstract Article PDF–7.3M

Select item 678308116.

α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins

Natalie Ostrerova, Leonard Petrucelli, Matthew Farrer, Nitinkumar Mehta, Peter Choi, John Hardy, Benjamin Wolozin

J Neurosci. 1999 Jul 15; 19(14): 5782–5791. doi: 10.1523/JNEUROSCI.19-14-05782.1999

PMCID:: PMC6783081

Abstract Article PDF–852K

Select item 677313017.

Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons

Diane D. Murphy, Susan M. Rueter, John Q. Trojanowski, Virginia M.-Y. Lee

J Neurosci. 2000 May 1; 20(9): 3214–3220. doi: 10.1523/JNEUROSCI.20-09-03214.2000

PMCID:: PMC6773130

Abstract Article PDF–1021K

Select item 677296918.

Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain

Philipp J. Kahle, Manuela Neumann, Laurence Ozmen, Veronika Müller, Helmut Jacobsen, Alice Schindzielorz, Masayasu Okochi, Uwe Leimer, Herman van der Putten, Alphonse Probst, Elisabeth Kremmer, Hans A. Kretzschmar, Christian Haass

J Neurosci. 2000 Sep 1; 20(17): 6365–6373. doi: 10.1523/JNEUROSCI.20-17-06365.2000

PMCID:: PMC6772969

Abstract Article PDF–1.2M

Select item 675767719.

Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein

Deborah E. Cabin, Kazuhiro Shimazu, Diane Murphy, Nelson B. Cole, Wolfram Gottschalk, Kellie L. McIlwain, Bonnie Orrison, Amy Chen, Christopher E. Ellis, Richard Paylor, Bai Lu, Robert L. Nussbaum

J Neurosci. 2002 Oct 15; 22(20): 8797–8807. doi: 10.1523/JNEUROSCI.22-20-08797.2002