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Select item 111595051.

Roles of a prostaglandin E‐type receptor, EP3, in upregulation of matrix metalloproteinase‐9 and vascular endothelial growth factor during enhancement of tumor metastasis

Hideki Amano, Yoshiya Ito, Tastunori Suzuki, Shintaro Kato, Yoshio Matsui, Fumihiro Ogawa, Takahiko Murata, Yukihiko Sugimoto, Robert Senior, Hidero Kitasato, Izumi Hayashi, Yukitoshi Satoh, Shuh Narumiya, Masataka Majima

Cancer Sci. 2009 Dec; 100(12): 2318–2324. Published online 2009 Aug 25. doi: 10.1111/j.1349-7006.2009.01322.x

PMCID:: PMC11159505

Abstract Article PDF–572K

Select item 106698092.

Prostaglandin E₂ Induces Long-Lasting Inhibition of Noradrenergic Neurons in the Locus Coeruleus and Moderates the Behavioral Response to Stressors

Yasutaka Mukai, Tatsuo S. Okubo, Michael Lazarus, Daisuke Ono, Kenji F. Tanaka, Akihiro Yamanaka

J Neurosci. 2023 Nov 22; 43(47): 7982–7999. doi: 10.1523/JNEUROSCI.0353-23.2023

PMCID:: PMC10669809

Abstract Article PDF–4.6M

Select item 96683363.

Molecular and anatomical characterization of parabrachial neurons and their axonal projections

Jordan L Pauli, Jane Y Chen, Marcus L Basiri, Sekun Park, Matthew E Carter, Elisenda Sanz, G Stanley McKnight, Garret D Stuber, Richard D Palmiter

eLife. 2022; 11: e81868. Published online 2022 Nov 1. doi: 10.7554/eLife.81868

PMCID:: PMC9668336

Abstract Article PDF–6.0M

Select item 93795454.

PGE₂‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase

Xixi Tao, Ronglu Du, Shumin Guo, Xiangling Feng, Tingting Yu, Qian OuYang, Qiaoli Chen, Xutong Fan, Xueqi Wang, Chen Guo, Xiaozhou Li, Fengxia Xue, Shuai Chen, Minghan Tong, Michael Lazarus, Shengkai Zuo, Ying Yu, Yujun Shen

EMBO J. 2022 Aug; 41(16): e110439. Published online 2022 Jul 4. doi: 10.15252/embj.2021110439

PMCID:: PMC9379545

Abstract Article PDF–20M

Select item 90147945.

EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model

Xixi Tao, Rui Zhang, Ronglu Du, Tingting Yu, Hui Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, Michael Lazarus, Lu Zhou, Bangmao Wang, Ying Yu, Yujun Shen

J Exp Med. 2022 May 2; 219(5): e20212414. Published online 2022 Apr 14. doi: 10.1084/jem.20212414

PMCID:: PMC9014794

Abstract Article PDF–8.1M

Select item 88701116.

Synergistic Cytokine Production by ATP and PGE₂ via P2X4 and EP₃ Receptors in Mouse Bone-Marrow-Derived Mast Cells

Kosuke Obayashi, Kazuki Yoshida, Masa-aki Ito, Tetsuya Mori, Kimiko Yamamoto, Toshiyashu Imai, Isao Matsuoka

Cells. 2022 Feb; 11(4): 616. Published online 2022 Feb 10. doi: 10.3390/cells11040616

PMCID:: PMC8870111

Abstract Article PDF–3.6M

Select item 85603797.

Prostaglandin EP3 receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance

Jaclyn A. Wisinski, Austin Reuter, Darby C. Peter, Michael D. Schaid, Rachel J. Fenske, Michelle E. Kimple

Am J Physiol Endocrinol Metab. 2021 Oct 1; 321(4): E479–E489. Published online 2021 Jul 6. doi: 10.1152/ajpendo.00051.2021

PMCID:: PMC8560379

Abstract Article

Select item 85295528.

Pharmacological blockade of the EP3 prostaglandin E₂ receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage

Karin J. Bosma, Spencer R. Andrei, Liora S. Katz, Ashley A. Smith, Jennifer C. Dunn, Valerie F. Ricciardi, Marisol A. Ramirez, Sharon Baumel-Alterzon, William A. Pace, Darian T. Carroll, Emily M. Overway, Elysa M. Wolf, Michelle E. Kimple, Quanhu Sheng, Donald K. Scott, Richard M. Breyer, Maureen Gannon

Mol Metab. 2021 Dec; 54: 101347. Published online 2021 Oct 6. doi: 10.1016/j.molmet.2021.101347

PMCID:: PMC8529552

Abstract Article PDF–2.5M

Select item 82115409.

Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EP₃ Receptors

Anna Eskilsson, Kiseko Shionoya, David Engblom, Anders Blomqvist

J Neurosci. 2021 Jun 16; 41(24): 5206–5218. doi: 10.1523/JNEUROSCI.0313-21.2021

PMCID:: PMC8211540

Abstract Article PDF–5.4M

Select item 751988710.

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis

Nicholas S Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah I Mazi, Matthew L Edin, Mark Geoffrey Chambers, Marina Korotkova, Xiaomeng Wang, Walter Wahli, Darryl C Zeldin, Rolf Nüsing, Yingbi Zhou, Per-Johan Jakobsson, Jane A Mitchell

Cardiovasc Res. 2020 Oct 1; 116(12): 1972–1980. Published online 2019 Nov 5. doi: 10.1093/cvr/cvz290

PMCID:: PMC7519887

Abstract Article PDF–928K

Select item 719149711.

The deleterious role of the prostaglandin E₂ EP₃ receptor in angiotensin II hypertension

Timothy D. Bryson, Teja S. Pandrangi, Safa Z. Khan, Jiang Xu, Tengis S. Pavlov, Pablo A. Ortiz, Edward Peterson, Pamela Harding

Am J Physiol Heart Circ Physiol. 2020 Apr 1; 318(4): H867–H882. Published online 2020 Mar 6. doi: 10.1152/ajpheart.00538.2019

PMCID:: PMC7191497

Abstract Article

Select item 708353912.

EP3R-Expressing Glutamatergic Preoptic Neurons Mediate Inflammatory Fever

Natalia L.S. Machado, Sathyajit S. Bandaru, Stephen B.G. Abbott, Clifford B. Saper

J Neurosci. 2020 Mar 18; 40(12): 2573–2588. doi: 10.1523/JNEUROSCI.2887-19.2020

PMCID:: PMC7083539

Abstract Article PDF–6.5M

Select item 605648113.

Contribution of prostanoid FP receptor and prostaglandins in transient inflammatory ocular hypertension

Reiko Yamagishi-Kimura, Megumi Honjo, Makoto Aihara

Sci Rep. 2018; 8: 11098. Published online 2018 Jul 23. doi: 10.1038/s41598-018-29273-1

PMCID:: PMC6056481

Abstract Article PDF–1.3M

Select item 590133914.

Prostaglandin Receptor Signaling in Disease

Toshiyuki Matsuoka, Shuh Narumiya

ScientificWorldJournal. 2007; 7: 1329–1347. Published online 2007 Sep 1. doi: 10.1100/tsw.2007.182

PMCID:: PMC5901339

Abstract PDF–391K

Select item 583909715.

Leukotriene D₄ and prostaglandin E₂ signals synergize and potentiate vascular inflammation in a mast cell–dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3

Vinay Kondeti, Nosayba Al-Azzam, Ernest Duah, Charles K. Thodeti, Joshua A. Boyce, Sailaja Paruchuri

J Allergy Clin Immunol. Author manuscript; available in PMC 2018 Mar 6.

Published in final edited form as: J Allergy Clin Immunol. 2016 Jan; 137(1): 289–298. Published online 2015 Aug 5. doi: 10.1016/j.jaci.2015.06.030

PMCID:: PMC5839097

Abstract Article PDF–964K

Select item 558534816.

Decidualisation and placentation defects are a major cause of age-related reproductive decline

Laura Woods, Vicente Perez-Garcia, Jens Kieckbusch, Xiaoqiu Wang, Francesco DeMayo, Francesco Colucci, Myriam Hemberger

Nat Commun. 2017; 8: 352. Published online 2017 Sep 5. doi: 10.1038/s41467-017-00308-x

PMCID:: PMC5585348

Abstract Article PDF–4.3M

Select item 556654217.

Increased role of E prostanoid receptor-3 in prostacyclin-evoked contractile activity of spontaneously hypertensive rat mesenteric resistance arteries

Bin Liu, Mengyi Zhan, Yingzhan Zhang, Hui Li, Xiangzhong Wu, Fengfeng Zhuang, Wenhong Luo, Yingbi Zhou

Sci Rep. 2017; 7: 8927. Published online 2017 Aug 21. doi: 10.1038/s41598-017-09288-w

PMCID:: PMC5566542

Abstract Article PDF–2.3M

Select item 544174018.

Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development

Meade Haller, Qianxing Mo, Akira Imamoto, Dolores J. Lamb

Proc Natl Acad Sci U S A. 2017 May 9; 114(19): 4981–4986. Published online 2017 Apr 24. doi: 10.1073/pnas.1619523114

PMCID:: PMC5441740

Abstract Article PDF–3.0M

Select item 533803519.

Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction

Juan Tang, Yujun Shen, Guilin Chen, Qiangyou Wan, Kai Wang, Jian Zhang, Jing Qin, Guizhu Liu, Shengkai Zuo, Bo Tao, Yu Yu, Junwen Wang, Michael Lazarus, Ying Yu

Nat Commun. 2017; 8: 14656. Published online 2017 Mar 3. doi: 10.1038/ncomms14656

PMCID:: PMC5338035

Abstract Article PDF–3.8M

Select item 529270020.

Role of E-type prostaglandin receptor EP3 in the vasoconstrictor activity evoked by prostacyclin in thromboxane-prostanoid receptor deficient mice

Zhenhua Li, Yingzhan Zhang, Bin Liu, Wenhong Luo, Hui Li, Yingbi Zhou

Sci Rep. 2017; 7: 42167. Published online 2017 Feb 6. doi: 10.1038/srep42167

PMCID:: PMC5292700

Abstract Article PDF–1.4M

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