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Select item 109441801.

Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells

Feng Guo, Li Zhang, Yuzhen Yu, Lu Gong, Shiyue Tao, Rhiannon B. Werder, Shreya Mishra, Yihan Zhou, Wardatul Jannat Anamika, Taotao Lao, Hiroyuki Inuzuka, Yihan Zhang, Betty Pham, Tao Liu, Tiffany S. Tufenkjian, Bradley W. Richmond, Wenyi Wei, Hongmei Mou, Andrew A. Wilson, Ming Hu, Wei Chen, Xiaobo Zhou

eBioMedicine. 2024 Mar; 101: 105026. Published online 2024 Feb 27. doi: 10.1016/j.ebiom.2024.105026

PMCID:: PMC10944180

Abstract Article PDF–2.8M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 97305853.

Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein

An-Li Jin, Lin Ding, Wen-Jing Yang, Te Liu, Wei Chen, Tong Li, Chun-Yan Zhang, Bai-Shen Pan, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Wei Guo, Xin-Rong Yang, Bei-Li Wang

BMC Gastroenterol. 2022; 22: 505. Published online 2022 Dec 8. doi: 10.1186/s12876-022-02594-2

PMCID:: PMC9730585

Abstract Article PDF–7.1M

Select item 88970224.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 86608955.

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Samuel C. Griffiths, Rebekka A. Schwab, Kamel El Omari, Benjamin Bishop, Ellen J. Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F. Covey, Robert J. C. Gilbert, Rajat Rohatgi, Christian Siebold

Nat Commun. 2021; 12: 7171. Published online 2021 Dec 9. doi: 10.1038/s41467-021-27475-2

PMCID:: PMC8660895

Abstract Article PDF–2.1M

Select item 85244346.

Long non-coding RNA HHIP-AS1 inhibits lung cancer epithelial-mesenchymal transition and stemness by regulating PCDHGA9

Zhuanzhuan Zhou, Yanping Lai, Shan Cao, Qifang Zhuo, Huiqin Tang

Mol Med Rep. 2021 Dec; 24(6): 845. Published online 2021 Oct 11. doi: 10.3892/mmr.2021.12485

PMCID:: PMC8524434

Abstract Article PDF–3.2M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80797158.

Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells

Yan Li, Li Zhang, Francesca Polverino, Feng Guo, Yuan Hao, Taotao Lao, Shuang Xu, Lijia Li, Betty Pham, Caroline A. Owen, Xiaobo Zhou

Sci Rep. 2021; 11: 9074. Published online 2021 Apr 27. doi: 10.1038/s41598-021-88434-x

PMCID:: PMC8079715

Abstract Article PDF–3.6M

Select item 78775609.

Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells

Peichao Li, Xiaoru Zhang, Anthony J Murphy, Max Costa, Xiaogang Zhao, Hong Sun

Carcinogenesis. 2021 Jan; 42(1): 136–147. Published online 2020 Jul 25. doi: 10.1093/carcin/bgaa085

PMCID:: PMC7877560

Abstract Article PDF–7.9M

Select item 737793410.

Exosomes secreted by chronic hepatitis B patients with PNALT and liver inflammation grade ≥ A2 promoted the progression of liver cancer by transferring miR‐25‐3p to inhibit the co‐expression of TCF21 and HHIP

Yi Ouyang, Yujing Tang, Lei Fu, Shifang Peng, Wanfeng Wu, Deming Tan, Xiaoyu Fu

Cell Prolif. 2020 Jul; 53(7): e12833. Published online 2020 Jun 11. doi: 10.1111/cpr.12833

PMCID:: PMC7377934

Abstract Article PDF–4.7M

Select item 678160111.

Evaluation Of HHIP Polymorphisms And Their Relationship With Chronic Obstructive Pulmonary Disease Phenotypes

Thiago Prudente Bártholo, Luis Cristovão Porto, Roberto Pozzan, Adriana Nascimento, Claudia Henrique Da Costa

Int J Chron Obstruct Pulmon Dis. 2019; 14: 2267–2272. Published online 2019 Oct 3. doi: 10.2147/COPD.S213519

PMCID:: PMC6781601

Abstract Article PDF–545K

Select item 621349712.

Whole Exome Sequencing Identifies a Novel Hedgehog-Interacting Protein G516R Mutation in Locally Advanced Papillary Thyroid Cancer

Woo Kyung Lee, Seul Gi Lee, Seung Hyuk Yim, Daham Kim, Hyunji Kim, Seonhyang Jeong, Sang Geun Jung, Young Suk Jo, Jandee Lee

Int J Mol Sci. 2018 Oct; 19(10): 2867. Published online 2018 Sep 21. doi: 10.3390/ijms19102867

PMCID:: PMC6213497

Abstract Article PDF–2.0M

Select item 562209513.

Hedgehog-Interacting Protein (HIP) Regulates Apoptosis Evasion and Angiogenic Function of Late Endothelial Progenitor Cells

Bom Nae Rin Lee, Yeon Sung Son, Dabin Lee, Young-Jin Choi, Sang-Mo Kwon, Hyun-Kyung Chang, Pyung-Hwan Kim, Je-Yoel Cho

Sci Rep. 2017; 7: 12449. Published online 2017 Sep 29. doi: 10.1038/s41598-017-12571-5

PMCID:: PMC5622095

Abstract Article PDF–3.2M

Select item 559196514.

Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease

Zili Zhang, Jian Wang, Zeguang Zheng, Xindong Chen, Xiansheng Zeng, Yi Zhang, Defu Li, Jiaze Shu, Kai Yang, Ning Lai, Lian Dong, Wenju Lu

Biomed Res Int. 2017; 2017: 2756726. Published online 2017 Aug 27. doi: 10.1155/2017/2756726

PMCID:: PMC5591965

Abstract Article PDF–678K

Select item 548424915.

Smoking status and gene susceptibility play important roles in the development of chronic obstructive pulmonary disease and lung function decline: A population-based prospective study

Junling Zhao, Miao Li, Jinkun Chen, Xiaomei Wu, Qin Ning, Jianping Zhao, Yongjian Xu, Jungang Xie, Jun Yu

Medicine (Baltimore) 2017 Jun; 96(25): e7283. Published online 2017 Jun 23. doi: 10.1097/MD.0000000000007283

PMCID:: PMC5484249

Abstract Article PDF–460K

Select item 544221216.

Prognostic significance of the methylation of Wnt pathway antagonists—CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling—ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas

Jarosław Paluszczak, Dorota Wiśniewska, Magdalena Kostrzewska-Poczekaj, Katarzyna Kiwerska, Reidar Grénman, Daniela Mielcarek-Kuchta, Małgorzata Jarmuż-Szymczak

Clin Oral Investig. 2017; 21(5): 1777–1788. Published online 2016 Aug 23. doi: 10.1007/s00784-016-1946-5

PMCID:: PMC5442212

Abstract Article PDF–728K

Select item 502969317.

Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma

Erh-Hsuan Lin, Yu-Rung Kao, Chih-An Lin, Ting-Yu Kuo, Sheng-Ping Yang, Chiung-Fang Hsu, Teh-Ying Chou, Chao-Chi Ho, Cheng-Wen Wu

Oncotarget. 2016 Apr 26; 7(17): 24179–24193. Published online 2016 Mar 22. doi: 10.18632/oncotarget.8253

PMCID:: PMC5029693

Abstract Article PDF–7.2M

Select item 501243018.

Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples

Mehdi H. Shahi, Idoya Zazpe, Mohammad Afzal, Subrata Sinha, Robert B. Rebhun, Bárbara Meléndez, Juan A. Rey, Javier S. Castresana

Tumour Biol. Author manuscript; available in PMC 2016 Sep 6.

Published in final edited form as: Tumour Biol. 2015 Apr; 36(4): 2383–2391. Published online 2014 Nov 22. doi: 10.1007/s13277-014-2846-4

PMCID:: PMC5012430

Abstract Article PDF–1.0M

Select item 497784119.

Hedgehog signaling inhibition by the small molecule Smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b

Maria Karlou, Vassiliki Tzelepi, Sankar Maity, Nora M. Navone, Jun Yang, Anh Hoang, Jing-Fang Lu, Christopher J. Logothetis, Eleni Efstathiou

Prostate. Author manuscript; available in PMC 2016 Aug 9.

Published in final edited form as: Prostate. 2012 Nov; 72(15): 1638–1647. Published online 2012 Mar 27. doi: 10.1002/pros.22517

PMCID:: PMC4977841

Abstract Article PDF–1.2M

Select item 492871620.

HIV–host interactome revealed directly from infected cells

Yang Luo, Erica Y. Jacobs, Todd M. Greco, Kevin D. Mohammed, Tommy Tong, Sarah Keegan, James M. Binley, Ileana M. Cristea, David Fenyö, Michael P. Rout, Brian T. Chait, Mark A. Muesing

Nat Microbiol. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Nat Microbiol. 2016 Jul; 1(7): 16068. Published online 2016 May 23. doi: 10.1038/nmicrobiol.2016.68

PMCID:: PMC4928716

Abstract Article PDF–1.1M

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