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Select item 102037101.

Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos

Lu Yan, Hailing Yin, Yiwei Mi, Yu Wu, Yufang Zheng

Front Cell Dev Biol. 2023; 11: 1084245. Published online 2023 May 9. doi: 10.3389/fcell.2023.1084245

PMCID:: PMC10203710

Abstract Article PDF–4.6M

Select item 101194192.

Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function

Shuang Geng, Fabian Paul, Izabela Kowalczyk, Sandra Raimundo, Anje Sporbert, Tamrat Meshka Mamo, Annette Hammes

Front Cell Dev Biol. 2023; 11: 1173688. Published online 2023 Apr 7. doi: 10.3389/fcell.2023.1173688

PMCID:: PMC10119419

Abstract Article PDF–5.2M

Select item 97774113.

In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions

Lea Gessler, Christopher Kurtek, Mira Merholz, Yongzhi Jian, Said Hashemolhosseini

Cells. 2022 Dec; 11(24): 3968. Published online 2022 Dec 8. doi: 10.3390/cells11243968

PMCID:: PMC9777411

Abstract Article PDF–3.1M

Select item 95779394.

MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway

Alok Tripathi, Aijaz A. John, Deepak Kumar, Saurabh Kumar Kaushal, Devendra Pratap Singh, Nazim Husain, Jayanta Sarkar, Divya Singh

Front Endocrinol (Lausanne) 2022; 13: 977347. Published online 2022 Sep 29. doi: 10.3389/fendo.2022.977347

PMCID:: PMC9577939

Abstract Article PDF–16M

Select item 92950615.

The Low-density Lipoprotein Receptor-related Protein 6 Pathway in the Treatment of Intestinal Barrier Dysfunction Induced by Hypoxia and Intestinal Microbiota through the Wnt/β-catenin Pathway

Zhihua Liu, Chao Li, Min Liu, Zhen Song, Mary Pat Moyer, Dan Su

Int J Biol Sci. 2022; 18(11): 4469–4481. Published online 2022 Jul 11. doi: 10.7150/ijbs.72283

PMCID:: PMC9295061

Abstract Article PDF–2.3M

Select item 91944826.

The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice

Tianyu Zhao, Moira McMahon, Kurt Reynolds, Subbroto Kumar Saha, Arjun Stokes, Chengji J. Zhou

Dis Model Mech. 2022 Jun 1; 15(6): dmm049517. Published online 2022 Jun 10. doi: 10.1242/dmm.049517

PMCID:: PMC9194482

Abstract Article

Select item 90010777.

Activation of LRP6 with HLY78 Attenuates Oxidative Stress and Neuronal Apoptosis via GSK3β/Sirt1/PGC-1α Pathway after ICH

Peng Jin, Dongqing Qi, Yuhui Cui, Cameron Lenahan, Shuixiang Deng, Xiaogen Tao

Oxid Med Cell Longev. 2022; 2022: 7542468. Published online 2022 Apr 4. doi: 10.1155/2022/7542468

PMCID:: PMC9001077

Abstract Article PDF–3.1M

Select item 87597948.

RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

Zhiying Yue, Xin Niu, Zengjin Yuan, Qin Qin, Wenhao Jiang, Liang He, Jingduo Gao, Yi Ding, Yanxi Liu, Ziwei Xu, Zhenxi Li, Zhengfeng Yang, Rong Li, Xiwen Xue, Yankun Gao, Fei Yue, Xiang H.-F. Zhang, Guohong Hu, Yi Wang, Yi Li, Geng Chen, Stefan Siwko, Alison Gartland, Ning Wang, Jianru Xiao, Mingyao Liu, Jian Luo

J Clin Invest. 2022 Jan 18; 132(2): e144579. Published online 2022 Jan 18. doi: 10.1172/JCI144579

PMCID:: PMC8759794

Abstract Article PDF–9.4M

Select item 86501549.

Wnt1 Lineage Specific Deletion of Gpr161 Results in Embryonic Midbrain Malformation and Failure of Craniofacial Skeletal Development

Sung-Eun Kim, Karla Robles-Lopez, Xuanye Cao, Kristyn Liu, Pooja J. Chothani, Nikitha Bhavani, Lauren Rahman, Saikat Mukhopadhyay, Bogdan J. Wlodarczyk, Richard H. Finnell

Front Genet. 2021; 12: 761418. Published online 2021 Nov 23. doi: 10.3389/fgene.2021.761418

PMCID:: PMC8650154

Abstract Article PDF–2.4M

Select item 864714810.

miR‐424/503 modulates Wnt/β‐catenin signaling in the mammary epithelium by targeting LRP6

Erin A Nekritz, Ruth Rodriguez‐Barrueco, Koon‐Kiu Yan, Meredith L Davis, Rachel L Werner, Laura Devis‐Jauregui, Partha Mukhopadhyay, Jiyang Yu, David Llobet‐Navas, Jose Silva

EMBO Rep. 2021 Dec 6; 22(12): e53201. Published online 2021 Oct 11. doi: 10.15252/embr.202153201

PMCID:: PMC8647148

Abstract Article PDF–1.4M

Select item 854815011.

Effect and Mechanism of LRP6 on Cardiac Myocyte Ferroptosis in Myocardial Infarction

Rui-lin Li, Cheng-hui Fan, Shi-yu Gong, Sheng Kang

Oxid Med Cell Longev. 2021; 2021: 8963987. Published online 2021 Oct 19. doi: 10.1155/2021/8963987

PMCID:: PMC8548150

Abstract Article PDF–1.5M

Select item 848855612.

Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex

Fabio Da Silva, Kaiqing Zhang, Anneline Pinson, Edoardo Fatti, Michaela Wilsch‐Bräuninger, Jessica Herbst, Valerie Vidal, Andreas Schedl, Wieland B Huttner, Christof Niehrs

EMBO J. 2021 Oct 1; 40(19): e108041. Published online 2021 Aug 25. doi: 10.15252/embj.2021108041

PMCID:: PMC8488556

Abstract Article PDF–9.2M

Select item 830793213.

Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis

Jennifer Raisch, Anthony Côté-Biron, Marie-Josée Langlois, Caroline Leblanc, Nathalie Rivard

Cells. 2021 Jul; 10(7): 1792. Published online 2021 Jul 15. doi: 10.3390/cells10071792

PMCID:: PMC8307932

Abstract Article PDF–2.3M

Select item 829230514.

Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway

Bing Liu, Han Zhou, Tiening Zhang, Xixiang Gao, Bo Tao, Hao Xing, Zhenwu Zhuang, Alan Dardik, Themis R. Kyriakides, Julie E. Goodwin

Angiogenesis. 2021; 24(3): 631–645. Published online 2021 Mar 2. doi: 10.1007/s10456-021-09773-x

PMCID:: PMC8292305

Abstract Article PDF–6.5M

Select item 824504115.

Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling

Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang

Sci Adv. 2021 Jul; 7(27): eabf1068. Published online 2021 Jun 30. doi: 10.1126/sciadv.abf1068

PMCID:: PMC8245041

Abstract Article PDF–1.8M

Select item 818025716.

MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus

Karol Kaiser, Ahram Jang, Petra Kompanikova, Melody P. Lun, Jan Prochazka, Ondrej Machon, Neil Dani, Michaela Prochazkova, Benoit Laurent, Daniel Gyllborg, Renee van Amerongen, Ryann M. Fame, Suhasini Gupta, Feizhen Wu, Roger A. Barker, Ivana Bukova, Radislav Sedlacek, Zbynek Kozmik, Ernest Arenas, Maria K. Lehtinen, Vitezslav Bryja

Development. 2021 May 15; 148(10): dev192054. Published online 2021 May 25. doi: 10.1242/dev.192054

Correction in:: Development. 2022 Feb 1; 149(3): dev200517.

PMCID:: PMC8180257

Abstract Article

Select item 811492617.

LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration

Yahan Wu, Liping Zhou, Hongyu Liu, Ran Duan, Huixing Zhou, Fulei Zhang, Xiaoyu He, Dongbo Lu, Ke Xiong, Maolin Xiong, Jinzhu Zhuang, Yi Liu, Li Li, Dandan Liang, Yi-Han Chen

Cell Res. 2021 Apr; 31(4): 450–462. Published online 2020 Sep 24. doi: 10.1038/s41422-020-00411-7

PMCID:: PMC8114926

Abstract Article PDF–5.1M

Select item 800533218.

Modulation of post-translational modifications in β-catenin and LRP6 inhibits Wnt signaling pathway in pancreatic cancer

Bharti Garg, Bhuwan Giri, Kaustav Majumder, Vikas Dudeja, Sulagna Banerjee, Ashok Saluja

Cancer Lett. Author manuscript; available in PMC 2021 Mar 28.

Published in final edited form as: Cancer Lett. 2017 Mar 1; 388: 64–72. Published online 2016 Dec 3. doi: 10.1016/j.canlet.2016.11.026

PMCID:: PMC8005332

Abstract Article PDF–1.9M

Select item 793877019.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 777008420.

Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration

Kyung-Eun Lim, Whitney A. Bullock, Daniel J. Horan, Bart O. Williams, Matthew L. Warman, Alexander G. Robling

Bone. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Bone. 2021 Feb; 143: 115708. Published online 2020 Oct 24. doi: 10.1016/j.bone.2020.115708

PMCID:: PMC7770084

Abstract Article PDF–1.7M

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