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Select item 111948601.

Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice

Rafael C. Gaspar, Kun Lyu, Brandon T. Hubbard, Brooks P. Leitner, Panu K. Luukkonen, Sandro M. Hirabara, Ikki Sakuma, Ali Nasiri, Dongyan Zhang, Mario Kahn, Gary W. Cline, José Rodrigo Pauli, Rachel J. Perry, Kitt F. Petersen, Gerald I. Shulman

Diabetologia. Author manuscript; available in PMC 2024 Jun 24.

Published in final edited form as: Diabetologia. 2023 Mar; 66(3): 567–578. Published online 2022 Dec 1. doi: 10.1007/s00125-022-05838-8

PMCID:: PMC11194860

Abstract Article PDF–1.2M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 96658853.

Mapping Brain Gene Coexpression in Daytime Transcriptomes Unveils Diurnal Molecular Networks and Deciphers Perturbation Gene Signatures

Nan Wang, Peter Langfelder, Matthew Stricos, Lalini Ramanathan, Jeffrey B. Richman, Raymond Vaca, Mary Plascencia, Xiaofeng Gu, Shasha Zhang, T. Katherine Tamai, Liguo Zhang, Fuying Gao, Koliane Ouk, Xiang Lu, Leonya Ivanov, Tom Vogt, Qing Richard Lu, A. Jennifer Morton, Christopher Colwell, Jeffrey S. Aaronson, Jim Rosinski, Steve Horvath, X. William Yang

Neuron. Author manuscript; available in PMC 2023 Oct 19.

Published in final edited form as: Neuron. 2022 Oct 19; 110(20): 3318–3338.e9. doi: 10.1016/j.neuron.2022.09.028

PMCID:: PMC9665885

Abstract Article PDF–4.5M

Select item 82253854.

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

Yujiao He, Zhiguo Yang, Chen-si Zhao, Zhihui Xiao, Yu Gong, Yun-Yi Li, Yiqi Chen, Yunting Du, Dianying Feng, Amnon Altman, Yingqiu Li

eLife. 2021; 10: e67123. Published online 2021 Jun 10. doi: 10.7554/eLife.67123

PMCID:: PMC8225385

Abstract Article PDF–6.0M

Select item 80184355.

Protein kinase C-θ knockout decreases serum IL-10 levels and inhibits insulin secretion from islet β cells

Feng Hong, Yang Yang, Baiyi Chen, Peng Li, Guoguang Wang, Yuxin Jiang

Islets. 2021; 13(1-2): 24–31. Published online 2021 Mar 9. doi: 10.1080/19382014.2021.1890963

PMCID:: PMC8018435

Abstract Article PDF–1.3M

Select item 75490256.

Annexin A5 is essential for PKCθ translocation during T-cell activation

Zhaoqing Hu, Lin Li, Banghui Zhu, Yi Huang, Xinran Wang, Xiaolei Lin, Maoxia Li, Peipei Xu, Xuerui Zhang, Jing Zhang, Zichun Hua

J Biol Chem. 2020 Oct 9; 295(41): 14214–14221. Published online 2020 Aug 12. doi: 10.1074/jbc.RA120.015143

PMCID:: PMC7549025

Abstract Article PDF–3.4M

Select item 72270287.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 71958498.

Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling

Jiji Xie, Xuemei Han, Chensi Zhao, Ann J. Canonigo-Balancio, John R. Yates, III, Yingqiu Li, Björn F. Lillemeier, Amnon Altman

Sci Signal. Author manuscript; available in PMC 2020 May 2.

Published in final edited form as: Sci Signal. 2019 Apr 16; 12(577): eaar3349. Published online 2019 Apr 16. doi: 10.1126/scisignal.aar3349

PMCID:: PMC7195849

Abstract Article PDF–2.0M

Select item 71778089.

Targeting PKCθ Promotes Satellite Cell Self-Renewal

Anna Benedetti, Piera Filomena Fiore, Luca Madaro, Biliana Lozanoska-Ochser, Marina Bouché

Int J Mol Sci. 2020 Apr; 21(7): 2419. Published online 2020 Mar 31. doi: 10.3390/ijms21072419

PMCID:: PMC7177808

Abstract Article PDF–3.1M

Select item 703704110.

Lack of PKCθ Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury

Piera Filomena Fiore, Anna Benedetti, Martina Sandonà, Luca Madaro, Marco De Bardi, Valentina Saccone, Pier Lorenzo Puri, Cesare Gargioli, Biliana Lozanoska-Ochser, Marina Bouché

Int J Mol Sci. 2020 Feb; 21(3): 932. Published online 2020 Jan 31. doi: 10.3390/ijms21030932

PMCID:: PMC7037041

Abstract Article PDF–1.6M

Select item 698873211.

Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ)

Ghazi M. Rahman, Sreejesh Shanker, Nancy E. Lewin, Noemi Kedei, Colin S. Hill, B. V. Venkataram Prasad, Peter M. Blumberg, Joydip Das

Biochem J. Author manuscript; available in PMC 2020 Jan 29.

Published in final edited form as: Biochem J. 2013 Apr 1; 451(1): 33–44. doi: 10.1042/BJ20121307

PMCID:: PMC6988732

Abstract Article PDF–2.1M

Select item 672933912.

The Role of the Theta Isoform of Protein Kinase C (PKC) in Activity-Dependent Synapse Elimination: Evidence from the PKC Theta Knock-Out Mouse In Vivo and In Vitro

Min-Xu Li, Min Jia, Li-Xia Yang, Hao Jiang, Maria A. Lanuza, Carmen M. Gonzalez, Phillip G. Nelson

J Neurosci. 2004 Apr 14; 24(15): 3762–3769. doi: 10.1523/JNEUROSCI.3930-03.2004

PMCID:: PMC6729339

Abstract Article PDF–465K

Select item 640895513.

Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis

Chintan K. Kikani, Erik V. Verona, Jiyoon Ryu, Yanying Shen, Qingqing Ye, Li Zheng, Ziliang Qian, Hiroshi Sakaue, Kyoko Nakamura, Jie Du, Qunsheng Ji, Wataru Ogawa, Lu-Zhe Sun, Lily Q. Dong, Feng Liu

Sci Signal. Author manuscript; available in PMC 2019 Mar 9.

Published in final edited form as: Sci Signal. 2012 Nov 6; 5(249): ra80. Published online 2012 Nov 6. doi: 10.1126/scisignal.2003065

PMCID:: PMC6408955

Abstract Article PDF–1.1M

Select item 630926814.

PKCθ via Activating Transcription Factor 2-mediated CD36 Expression and Foam Cell Formation of Ly6C^hi Cells Contributes to Atherosclerosis

Somasundaram Raghavan, Nikhlesh K. Singh, Sivaiah Gali, Arul M. Mani, Gadiparthi N. Rao

Circulation. Author manuscript; available in PMC 2019 Nov 20.

Published in final edited form as: Circulation. 2018 Nov 20; 138(21): 2395–2412. doi: 10.1161/CIRCULATIONAHA.118.034083

PMCID:: PMC6309268

Abstract Article PDF–4.3M

Select item 613554915.

GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease

Huai-Chia Chuang, Ching-Yi Tsai, Chia-Hsin Hsueh, Tse-Hua Tan

Sci Adv. 2018 Sep; 4(9): eaat5401. Published online 2018 Sep 12. doi: 10.1126/sciadv.aat5401

PMCID:: PMC6135549

Abstract Article PDF–6.9M

Select item 577699816.

SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ–dependent manner

Subha Sen, Fei Wang, Jing Zhang, Zhiheng He, Jian Ma, Yousang Gwack, Jianming Xu, Zuoming Sun

Proc Natl Acad Sci U S A. 2018 Jan 16; 115(3): E458–E467. Published online 2017 Dec 27. doi: 10.1073/pnas.1717789115

PMCID:: PMC5776998

Abstract Article PDF–2.1M

Select item 552942517.

PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells

Khaled Alharshawi, Alejandra Marinelarena, Prabhakaran Kumar, Osama El-Sayed, Palash Bhattacharya, Zuoming Sun, Alan L. Epstein, Ajay V. Maker, Bellur S. Prabhakar

Sci Rep. 2017; 7: 6594. Published online 2017 Jul 26. doi: 10.1038/s41598-017-05254-8