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Select item 112090811.

Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription

Sheng Shen, Ran Yan, Zhanglian Xie, Xiaoyang Yu, Hongyan Liang, Qiuhong You, Hu Zhang, Jinlin Hou, Xiaoyong Zhang, Yuanjie Liu, Jian Sun, Haitao Guo

Viruses. 2024 Jun; 16(6): 890. Published online 2024 May 31. doi: 10.3390/v16060890

PMCID:: PMC11209081

Abstract Article PDF–3.7M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 94023073.

TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein

Yongbin Lu, Yi Xiao, Jingru Yang, Hongxin Su, Xiaobin Zhang, Fei Su, Baohong Tian, Da Zhao, Xiaoling Ling, Tao Zhang

Oxid Med Cell Longev. 2022; 2022: 4374978. Published online 2022 Aug 17. doi: 10.1155/2022/4374978

PMCID:: PMC9402307

Abstract Article PDF–3.2M

Select item 93406364.

TRIM65 determines the fate of a novel subtype of pituitary neuroendocrine tumors via ubiquitination and degradation of TPIT

Hong Yao, Wanqun Xie, Yuting Dai, Yanting Liu, Weiting Gu, Jianfeng Li, Liang Wu, Jing Xie, Weiwei Rui, Bohan Ren, Li Xue, Yijun Cheng, Shaojian Lin, Changsheng Li, Hao Tang, Yu Wang, Meiqing Lou, Xiaobiao Zhang, Ronggui Hu, Hanbing Shang, Jinyan Huang, Zhe Bao Wu

Neuro Oncol. 2022 Aug; 24(8): 1286–1297. Published online 2022 Feb 26. doi: 10.1093/neuonc/noac053

PMCID:: PMC9340636

Abstract Article PDF–21M

Select item 91052355.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 84362056.

LncRNA LINC00963 promotes colorectal cancer cell proliferation and metastasis by regulating miR-1281 and TRIM65

Haidong Lv, Dixia Zhou, Guoqing Liu

Mol Med Rep. 2021 Nov; 24(5): 781. Published online 2021 Sep 7. doi: 10.3892/mmr.2021.12421

PMCID:: PMC8436205

Abstract Article PDF–11M

Select item 84274307.

The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

Tiantian Tang, Ping Li, Xinhui Zhou, Rui Wang, Xiuqin Fan, Mengyi Yang, Kemin Qi

Front Immunol. 2021; 12: 741839. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.741839

PMCID:: PMC8427430

Abstract Article PDF–2.1M

Select item 81836768.

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

Kazuki Kato, Sadeem Ahmad, Zixiang Zhu, Janet M. Young, Xin Mu, Sehoon Park, Harmit S. Malik, Sun Hur

Mol Cell. Author manuscript; available in PMC 2021 Jun 7.

Published in final edited form as: Mol Cell. 2021 Feb 4; 81(3): 599–613.e8. Published online 2020 Dec 28. doi: 10.1016/j.molcel.2020.11.047

PMCID:: PMC8183676

Abstract Article PDF–3.6M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812022710.

KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1

Wenxue Liu, Zhiyan Zhan, Meiying Zhang, Bowen Sun, Qiqi Shi, Fei Luo, Mingda Zhang, Weiwei Zhang, Yanli Hou, Xiuying Xiao, Yanxin Li, Haizhong Feng

Theranostics. 2021; 11(13): 6278–6292. Published online 2021 Apr 15. doi: 10.7150/thno.57455

PMCID:: PMC8120227

Abstract Article PDF–2.7M

Select item 718172211.

TRIM65 E3 ligase targets VCAM-1 degradation to limit LPS-induced lung inflammation

Yong Li, Xuan Huang, Fang Guo, Tianhua Lei, Shitao Li, Paula Monaghan-Nichols, Zhisheng Jiang, Hong-Bo Xin, Mingui Fu

J Mol Cell Biol. 2020 Mar; 12(3): 190–201. Published online 2019 Jul 16. doi: 10.1093/jmcb/mjz077

PMCID:: PMC7181722

Abstract Article PDF–1.6M

Select item 677813712.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 675623613.

Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation

Daici Chen, Yichen Li, Xiaowen Zhang, Haiyong Wu, Qian Wang, Jian Cai, Yanmei Cui, Huanliang Liu, Ping Lan, Jianping Wang, Zihuan Yang, Lei Wang

Oncogene. 2019; 38(37): 6429–6444. Published online 2019 Jul 22. doi: 10.1038/s41388-019-0891-6

PMCID:: PMC6756236

Abstract Article PDF–5.6M

Select item 659455114.

PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling

Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin

Cell Rep. Author manuscript; available in PMC 2019 Jun 26.

Published in final edited form as: Cell Rep. 2019 May 14; 27(7): 2157–2170.e8. doi: 10.1016/j.celrep.2019.04.060

PMCID:: PMC6594551

Abstract Article PDF–1.4M

Select item 654668315.

Knockdown of TRIM65 inhibits autophagy and cisplatin resistance in A549/DDP cells by regulating miR-138-5p/ATG7

Xufeng Pan, Yong Chen, Yuzhou Shen, Jicheng Tantai

Cell Death Dis. 2019 Jun; 10(6): 429. Published online 2019 Jun 3. doi: 10.1038/s41419-019-1660-8

PMCID:: PMC6546683

Abstract Article PDF–3.8M

Select item 554841316.

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling

Parveen Kumar, Prathyusha Munnangi, KVS Rammohan Chowdary, Varun J. Shah, Swapnil R. Shinde, Nanci R. Kolli, Rachita R. Halehalli, Hampapathalu A. Nagarajaram, Subbareddy Maddika

J Proteome Res. 2017 Aug 4; 16(8): 2789–2801. Published online 2017 Jul 4. doi: 10.1021/acs.jproteome.7b00065

PMCID:: PMC5548413

Abstract Article PDF–5.2M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 552091318.

ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65

Jun Meng, Zhenyu Yao, Yaqing He, Renli Zhang, Yanwei Zhang, Xiangjie Yao, Hong Yang, Long Chen, Zhen Zhang, Hailong Zhang, Xueqin Bao, Gang Hu, Tangchun Wu, Jinquan Cheng

Cell Death Dis. 2017 Jun; 8(6): e2866. Published online 2017 Jun 8. doi: 10.1038/cddis.2017.257

PMCID:: PMC5520913

Abstract Article PDF–1.4M

Select item 534841019.

Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer

Xiao-Lin Wang, Wei-Ping Shi, Hong-Can Shi, Shi-Chun Lu, Kang Wang, Chao Sun, Jian-Sheng He, Wei-Guo Jin, Xiao-Xia Lv, Hui Zou, Yu-Sheng Shu

Oncotarget. 2016 Dec 6; 7(49): 81527–81540. Published online 2016 Nov 5. doi: 10.18632/oncotarget.13131

Retraction in:: Oncotarget. 2024; 15: 312.

PMCID:: PMC5348410

Abstract Article

Select item 529485020.

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

Xueting Lang, Tiantian Tang, Tengchuan Jin, Chen Ding, Rongbin Zhou, Wei Jiang

J Exp Med. 2017 Feb; 214(2): 459–473. doi: 10.1084/jem.20160592

PMCID:: PMC5294850

Abstract Article PDF–2.8M

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