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Select item 111551441.

NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m⁵C methylation

Xuran Zhang, Ke An, Xin Ge, Yuanyuan Sun, Jingyao Wei, Weihong Ren, Han Wang, Yueqin Wang, Yue Du, Lulu He, Ouwen Li, Shaoxuan Zhou, Yong Shi, Tong Ren, Yun-gui Yang, Quancheng Kan, Xin Tian

Breast Cancer Res. 2024; 26: 94. Published online 2024 Jun 6. doi: 10.1186/s13058-024-01847-0

PMCID:: PMC11155144

Abstract Article PDF–21M

Select item 111038912.

NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m⁵C methylation

Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang, Jianwen Wang

J Transl Med. 2024; 22: 476. Published online 2024 May 19. doi: 10.1186/s12967-024-05287-4

PMCID:: PMC11103891

Abstract Article PDF–11M

Select item 110657523.

5-Methylcytosine transferase NSUN2 drives NRF2-mediated ferroptosis resistance in non-small cell lung cancer

Youming Chen, Zuli Jiang, Chenxing Zhang, Lindong Zhang, Huanxiang Chen, Nan Xiao, Lu Bai, Hongyang Liu, Junhu Wan

J Biol Chem. 2024 Apr; 300(4): 106793. Published online 2024 Feb 24. doi: 10.1016/j.jbc.2024.106793

PMCID:: PMC11065752

Abstract Article PDF–6.5M

Select item 107871154.

NSUN2-mediated mRNA m⁵C Modification Regulates the Progression of Hepatocellular Carcinoma

Dan Song, Ke An, Wenlong Zhai, Luyao Feng, Yingjie Xu, Ran Sun, Yueqin Wang, Yun-Gui Yang, Quancheng Kan, Xin Tian

Genomics Proteomics Bioinformatics. 2023 Aug; 21(4): 823–833. Published online 2022 Sep 30. doi: 10.1016/j.gpb.2022.09.007

PMCID:: PMC10787115

Abstract Article PDF–5.8M

Select item 107211805.

NSUN2-mediated m⁵C modification of HBV RNA positively regulates HBV replication

Jiangpeng Feng, Tianmo Xu, Miao He, Jiali Li, Peipei Yao, Chengbao Ma, Shimin Yang, Zaichao Xu, Kun Yan, Xianying Chen, Hongyun Wang, Jiejie Liu, Cong Zeng, Yuchen Xia, Huan Yan, Li Zhou, Yu Chen

PLoS Pathog. 2023 Dec; 19(12): e1011808. Published online 2023 Dec 4. doi: 10.1371/journal.ppat.1011808

PMCID:: PMC10721180

Abstract Article PDF–3.8M

Select item 105658766.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 104805357.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102122759.

NSUN2‐mediated m⁵C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression

Sipeng Zuo, Lin Li, Xuyang Wen, Xiang Gu, Ai Zhuang, Rui Li, Fuxiang Ye, Shengfang Ge, Xianqun Fan, Jiayan Fan, Peiwei Chai, Linna Lu

Clin Transl Med. 2023 May; 13(5): e1273. Published online 2023 May 25. doi: 10.1002/ctm2.1273

PMCID:: PMC10212275

Abstract Article PDF–9.4M

Select item 1016945810.

Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-gui Yang, Quancheng Kan, Xin Tian

Mol Cancer. 2023; 22: 81. Published online 2023 May 9. doi: 10.1186/s12943-023-01780-4

PMCID:: PMC10169458

Abstract Article PDF–8.7M

Select item 1014884311.

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin

Naphat Chantaravisoot, Piriya Wongkongkathep, Nuttiya Kalpongnukul, Narawit Pacharakullanon, Pornchai Kaewsapsak, Chaiyaboot Ariyachet, Joseph A. Loo, Fuyuhiko Tamanoi, Trairak Pisitkun

Sci Rep. 2023; 13: 7037. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33872-y

PMCID:: PMC10148843

Abstract Article PDF–11M

Select item 1013893112.

Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage

Sanna Abbasi, Laila Bayat, Caroline Schild-Poulter

Int J Mol Sci. 2023 Apr; 24(8): 7041. Published online 2023 Apr 11. doi: 10.3390/ijms24087041

PMCID:: PMC10138931

Abstract Article PDF–4.0M

Select item 998681713.

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m⁶A homeostasis

Zhan‐Cheng Zeng, Qi Pan, Yu‐Meng Sun, Heng‐Jing Huang, Xiao‐Tong Chen, Tian‐Qi Chen, Bo He, Hua Ye, Shun‐Xin Zhu, Ke‐Jia Pu, Ke Fang, Wei Huang, Yue‐Qin Chen, Wen‐Tao Wang

EMBO Rep. 2023 Mar; 24(3): e55762. Published online 2023 Jan 4. doi: 10.15252/embr.202255762

PMCID:: PMC9986817

Abstract Article PDF–3.5M

Select item 998370114.

The RNA m⁵C Methylase NSUN2 Modulates Corneal Epithelial Wound Healing

Guangying Luo, Weiwei Xu, Xiaoyan Chen, Wenji Xu, Shuai Yang, Jiao Wang, Yong Lin, Peter S. Reinach, Dongsheng Yan

Invest Ophthalmol Vis Sci. 2023 Mar; 64(3): 5. Published online 2023 Mar 2. doi: 10.1167/iovs.64.3.5

PMCID:: PMC9983701

Abstract Article PDF–3.3M

Select item 995044715.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 993887116.

m⁵C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization

Ning Wang, Ri-xin Chen, Min-hua Deng, Wen-su Wei, Zhao-hui Zhou, Kang Ning, Yong-hong Li, Xiang-dong Li, Yun-lin Ye, Jun-hua Wen, Biao Dong, Xue-pei Zhang, Zhuo-wei Liu, Fang-jian Zhou

Cell Death Dis. 2023 Feb; 14(2): 139. Published online 2023 Feb 18. doi: 10.1038/s41419-023-05661-y

PMCID:: PMC9938871

Abstract Article PDF–7.2M

Select item 993208817.

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m⁵C methylation

Min Yang, Renxiong Wei, Sheng Zhang, Sang Hu, Xiaoxiao Liang, Zhiqiang Yang, Chong Zhang, Yufeng Zhang, Lin Cai, Yuanlong Xie

Cell Death Dis. 2023 Feb; 14(2): 125. Published online 2023 Feb 15. doi: 10.1038/s41419-023-05646-x

PMCID:: PMC9932088

Abstract Article PDF–6.0M

Select item 979798818.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144