PMC Links for GEO Profiles (Select 23112709) - PMC

Liyan Fan, David R. Sweet, Erica K. Fan, Domenick A. Prosdocimo, Annmarie Madera, Zhen Jiang, Roshan Padmanabhan, Saptarsi M. Haldar, Vinesh Vinayachandran, Mukesh K. Jain

J Biol Chem. 2022 Jun; 298(6): 101926. Published online 2022 Apr 9. doi: 10.1016/j.jbc.2022.101926

PMCID:: PMC9190004

Abstract Article PDF–1.9M

Select item 91067165.

Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ

Yi Liu, Yasunori Deguchi, Daoyan Wei, Fuyao Liu, Micheline J. Moussalli, Eriko Deguchi, Donghui Li, Huamin Wang, Lovie Ann Valentin, Jennifer K. Colby, Jing Wang, Xiaofeng Zheng, Haoqiang Ying, Mihai Gagea, Baoan Ji, Jiaqi Shi, James C. Yao, Xiangsheng Zuo, Imad Shureiqi

Nat Commun. 2022; 13: 2665. Published online 2022 May 13. doi: 10.1038/s41467-022-30392-7

PMCID:: PMC9106716

Abstract Article PDF–6.5M

Select item 88256016.

Endothelial PPARδ facilitates the post-ischemic vascular repair through interaction with HIF1α

Yalan Wu, Xiaolong Tang, Sharen Lee, Huiling Hong, Xiaoyun Cao, Chi Wai Lau, Baohua Liu, Ajay Chawla, Ronald Ching Wan Ma, Yu Huang, Kathy O Lui, Xiao Yu Tian

Theranostics. 2022; 12(4): 1855–1869. Published online 2022 Jan 24. doi: 10.7150/thno.69017

PMCID:: PMC8825601

Abstract Article PDF–3.5M

Select item 82586307.

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

Miyeko D. Mana, Amanda M. Hussey, Constantine N. Tzouanas, Shinya Imada, Yesenia Barrera Millan, Dorukhan Bahceci, Dominic R. Saiz, Anna T. Webb, Caroline A. Lewis, Peter Carmeliet, Maria M. Mihaylova, Alex K. Shalek, Ömer H. Yilmaz

Cell Rep. Author manuscript; available in PMC 2021 Jul 6.

Published in final edited form as: Cell Rep. 2021 Jun 8; 35(10): 109212. doi: 10.1016/j.celrep.2021.109212

PMCID:: PMC8258630

Abstract Article PDF–1.1M

Select item 77439808.

The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model

Linfu Liu, Chuang Liu, Manyu Zhao, Qianru Zhang, Ying Lu, Ping Liu, Hua Yang, Jinliang Yang, Xiaoxin Chen, Yuqin Yao

PLoS One. 2020; 15(12): e0243911. Published online 2020 Dec 16. doi: 10.1371/journal.pone.0243911

PMCID:: PMC7743980

Abstract Article PDF–4.9M

Select item 75198879.

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis

Nicholas S Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah I Mazi, Matthew L Edin, Mark Geoffrey Chambers, Marina Korotkova, Xiaomeng Wang, Walter Wahli, Darryl C Zeldin, Rolf Nüsing, Yingbi Zhou, Per-Johan Jakobsson, Jane A Mitchell

Cardiovasc Res. 2020 Oct 1; 116(12): 1972–1980. Published online 2019 Nov 5. doi: 10.1093/cvr/cvz290

PMCID:: PMC7519887

Abstract Article PDF–928K

Select item 750907410.

Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism

Xin Nie, Weiqi Tang, Zihui Zhang, Chunmiao Yang, Lei Qian, Xinya Xie, Erjiao Qiang, Jingyang Zhao, Wenfei Zhao, Lei Xiao, Nanping Wang

Redox Biol. 2020 Oct; 37: 101728. Published online 2020 Sep 15. doi: 10.1016/j.redox.2020.101728

PMCID:: PMC7509074

Abstract Article PDF–8.8M

Select item 748436711.

Differential effects of myeloid cell PPARδ and IL10 in regulating macrophage recruitment, phenotype and regeneration following acute muscle injury.

Steven S. Welc, Michelle Wehling-Henricks, Jacqueline Antoun, Tracey T. Ha, Isabella Tous, James G. Tidball

J Immunol. Author manuscript; available in PMC 2021 Sep 15.

Published in final edited form as: J Immunol. 2020 Sep 15; 205(6): 1664–1677. Published online 2020 Aug 19. doi: 10.4049/jimmunol.2000247

PMCID:: PMC7484367

Abstract Article PDF–2.0M

Select item 746062812.

PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation

Hung-Che Chien, Paul L. Greenhaff, Dumitru Constantin-Teodosiu

Int J Mol Sci. 2020 Aug; 21(16): 5942. Published online 2020 Aug 18. doi: 10.3390/ijms21165942

PMCID:: PMC7460628

Abstract Article PDF–2.3M

Select item 742986913.

Deficiency in fibroblast PPARβ/δ reduces nonmelanoma skin cancers in mice

Mark Wei Yi Tan, Ming Keat Sng, Hong Sheng Cheng, Zun Siong Low, Benjamin Jia Juin Leong, Damien Chua, Eddie Han Pin Tan, Jeremy Soon Kiat Chan, Yun Sheng Yip, Yin Hao Lee, Mintu Pal, Xiaomeng Wang, Walter Wahli, Nguan Soon Tan

Cell Death Differ. 2020 Sep; 27(9): 2668–2680. Published online 2020 Apr 20. doi: 10.1038/s41418-020-0535-y

PMCID:: PMC7429869

Abstract Article PDF–7.9M

Select item 735305814.

Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice

Sze Yuan Ho, Yuet Ping Kwan, Beiying Qiu, Alison Tan, Hannah Louise Murray, Veluchamy Amutha Barathi, Nguan Soon Tan, Chui Ming Gemmy Cheung, Tien Yin Wong, Walter Wahli, Xiaomeng Wang

Int J Mol Sci. 2020 Jun; 21(12): 4403. Published online 2020 Jun 20. doi: 10.3390/ijms21124403

PMCID:: PMC7353058

Abstract Article PDF–2.7M

Select item 735175415.

PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties

R. A. Contreras-Lopez, R. Elizondo-Vega, M. J. Torres, A. M. Vega-Letter, N. Luque-Campos, M. J. Paredes-Martinez, C. Pradenas, G. Tejedor, K. Oyarce, M. Salgado, C. Jorgensen, M. Khoury, G. Kronke, M. A. Garcia-Robles, C. Altamirano, P. Luz-Crawford, F. Djouad

Sci Rep. 2020; 10: 11423. Published online 2020 Jul 10. doi: 10.1038/s41598-020-68347-x

PMCID:: PMC7351754

Abstract Article PDF–1.1M

Select item 727489516.

A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation

Tomoya Sakamoto, Timothy R. Matsuura, Shibiao Wan, David M. Ryba, Junil Kim, Kyoung Jae Won, Ling Lai, Christopher Petucci, Nataliya Petrenko, Kiran Musunuru, Rick B. Vega, Daniel P. Kelly

Circ Res. Author manuscript; available in PMC 2021 Jun 5.

Published in final edited form as: Circ Res. 2020 Jun 5; 126(12): 1685–1702. Published online 2020 Mar 26. doi: 10.1161/CIRCRESAHA.119.316100

PMCID:: PMC7274895

Abstract Article PDF–2.7M

Select item 725953817.

Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα

Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J. Gonzalez, Kalipada Pahan

JCI Insight. 2020 May 21; 5(10): e136654. Published online 2020 May 21. doi: 10.1172/jci.insight.136654

PMCID:: PMC7259538

Abstract Article PDF–18M

Select item 724247918.

PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Dorothea I. H. Müller, Cornelia Stoll, Katrin Palumbo-Zerr, Christina Böhm, Brenda Krishnacoumar, Natacha Ipseiz, Jule Taubmann, Max Zimmermann, Martin Böttcher, Dimitrios Mougiakakos, Jan Tuckermann, Farida Djouad, Georg Schett, Carina Scholtysek, Gerhard Krönke

Sci Rep. 2020; 10: 8428. Published online 2020 May 21. doi: 10.1038/s41598-020-65305-5

PMCID:: PMC7242479

Abstract Article PDF–2.9M

Select item 719100019.

Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα–mediated lipid metabolism

Xin Zhou, Chenxi He, Jiangong Ren, Congxin Dai, Sharon R. Stevens, Qianghu Wang, Daniel Zamler, Takashi Shingu, Liang Yuan, Chythra R. Chandregowda, Yunfei Wang, Visweswaran Ravikumar, Arvind U.K. Rao, Feng Zhou, Hongwu Zheng, Matthew N. Rasband, Yiwen Chen, Fei Lan, Amy B. Heimberger, Benjamin M. Segal, Jian Hu

J Clin Invest. 2020 May 1; 130(5): 2220–2236. Published online 2020 Mar 23. doi: 10.1172/JCI131800

PMCID:: PMC7191000

Abstract Article PDF–16M

Select item 708439220.

PPARβ/δ Agonism Upregulates Forkhead Box A2 to Reduce Inflammation in C2C12 Myoblasts and in Skeletal Muscle

Wendy Wen Ting Phua, Wei Ren Tan, Yun Sheng Yip, Ivan Dongzheng Hew, Jonathan Wei Kiat Wee, Hong Sheng Cheng, Melvin Khee Shing Leow, Walter Wahli, Nguan Soon Tan

Int J Mol Sci. 2020 Mar; 21(5): 1747. Published online 2020 Mar 4. doi: 10.3390/ijms21051747