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Select item 108300861.

Sirtuin3 promotes the degradation of hepatic Z alpha-1 antitrypsin through lipophagy

Brittney Poole, Regina Oshins, Zhiguang Huo, Alek Aranyos, Jesse West, Sergio Duarte, Virginia C. Clark, Thiago Beduschi, Ali Zarrinpar, Mark Brantly, Nazli Khodayari

Hepatol Commun. 2024 Feb; 8(2): e0370. Published online 2024 Jan 29. doi: 10.1097/HC9.0000000000000370

Correction in:: Hepatol Commun. 2024 Jun; 8(6): e0439.

PMCID:: PMC10830086

Abstract Article PDF–1.4M

Select item 94991712.

Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways

Sri Harsha Meghadri, Beatriz Martinez-Delgado, Lena Ostermann, Gema Gomez-Mariano, Sara Perez-Luz, Srinu Tumpara, Sabine Wrenger, David S. DeLuca, Ulrich A. Maus, Tobias Welte, Sabina Janciauskiene

Int J Mol Sci. 2022 Sep; 23(18): 10425. Published online 2022 Sep 9. doi: 10.3390/ijms231810425

PMCID:: PMC9499171

Abstract Article PDF–1.8M

Select item 90694733.

Placental HTRA1 cleaves α₁-antitrypsin to generate a NET-inhibitory peptide

Robert A. Campbell, Heather D. Campbell, J. Samuel Bircher, Claudia Valeria de Araujo, Frederik Denorme, Jacob L. Crandell, John L. Rustad, Josh Monts, Mark J. Cody, Yasuhiro Kosaka, Christian C. Yost

Blood. 2021 Sep 16; 138(11): 977–988. Prepublished online 2021 Jun 30. doi: 10.1182/blood.2020009021

PMCID:: PMC9069473

Abstract Article

Select item 78613544.

Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury

Kyle Stearns, Monica Goldklang, Rui Xiao, Tina Zelonina, Keith Blomenkamp, Jeffery Teckman, Jeanine M. D’Armiento

PLoS One. 2021; 16(2): e0246040. Published online 2021 Feb 4. doi: 10.1371/journal.pone.0246040

PMCID:: PMC7861354

Abstract Article PDF–1.0M

Select item 75049275.

CHOP and c-JUN up-regulate the mutant Z α₁-antitrypsin, exacerbating its aggregation and liver proteotoxicity

Sergio Attanasio, Rosa Ferriero, Gwladys Gernoux, Rossella De Cegli, Annamaria Carissimo, Edoardo Nusco, Severo Campione, Jeffrey Teckman, Christian Mueller, Pasquale Piccolo, Nicola Brunetti-Pierri

J Biol Chem. 2020 Sep 18; 295(38): 13213–13223. Published online 2020 Jul 28. doi: 10.1074/jbc.RA120.014307

PMCID:: PMC7504927

Abstract Article PDF–3.0M

Select item 69124536.

Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in HFE Knockout Mice

Nurdan Guldiken, Karim Hamesch, Shari Malan Schuller, Mahmoud Aly, Cecilia Lindhauer, Carolin V. Schneider, Malin Fromme, Christian Trautwein, Pavel Strnad

Cells. 2019 Nov; 8(11): 1415. Published online 2019 Nov 9. doi: 10.3390/cells8111415

PMCID:: PMC6912453

Abstract Article PDF–2.6M

Select item 65224767.

A combined in silico and in vitro study on mouse Serpina1a antitrypsin-deficiency mutants

Reto Eggenschwiler, Atanas Patronov, Jan Hegermann, Mariane Fráguas-Eggenschwiler, Guangming Wu, Leon Cortnumme, Matthias Ochs, Iris Antes, Tobias Cantz

Sci Rep. 2019; 9: 7486. Published online 2019 May 16. doi: 10.1038/s41598-019-44043-3

PMCID:: PMC6522476

Abstract Article PDF–1.9M

Select item 64841128.

Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α₁-antitrypsin disposal

Nazli Khodayari, Regina Oshins, Abdel A. Alli, Kubra M. Tuna, L. Shannon Holliday, Karina Krotova, Mark Brantly

J Biol Chem. 2019 Apr 19; 294(16): 6240–6252. Published online 2019 Mar 4. doi: 10.1074/jbc.RA118.006142

PMCID:: PMC6484112

Abstract Article PDF–3.7M

Select item 53882189.

Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy

Lijie Feng, Jin Zhang, Na Zhu, Qian Ding, Xiaojie Zhang, Jishuang Yu, Weimin Qiang, Zhetao Zhang, Yuyang Ma, Dake Huang, Yujun Shen, Shengyun Fang, Yifan Yu, Haiping Wang, Yuxian Shen

Autophagy. 2017; 13(4): 686–702. Published online 2017 Jan 25. doi: 10.1080/15548627.2017.1280207

PMCID:: PMC5388218

Abstract Article PDF–1.7M

Select item 538122610.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 522315911.

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression

Alexandra Naba, Karl R. Clauser, D. R. Mani, Steven A. Carr, Richard O. Hynes

Sci Rep. 2017; 7: 40495. Published online 2017 Jan 10. doi: 10.1038/srep40495

PMCID:: PMC5223159

Abstract Article PDF–2.3M

Select item 510711812.

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation

Andrea Di Francesco, Clara Di Germanio, Amaresh C. Panda, Phu Huynh, Robert Peaden, Ignacio Navas-Enamorado, Paul Bastian, Elin Lehrmann, Alberto Diaz-Ruiz, David Ross, David Siegel, Jennifer L. Martindale, Michel Bernier, Myriam Gorospe, Kotb Abdelmohsen, Rafael de Cabo

Free Radic Biol Med. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Free Radic Biol Med. 2016 Oct; 99: 225–233. Published online 2016 Aug 8. doi: 10.1016/j.freeradbiomed.2016.08.005

PMCID:: PMC5107118

Abstract Article PDF–787K

Select item 488375813.

Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus

Ahmed S. Elshikha, Yuanqing Lu, Mong-Jen Chen, Mohammad Akbar, Leilani Zeumer, Andrea Ritter, Hanaa Elghamry, Mahmoud A. Mahdi, Laurence Morel, Sihong Song

PLoS One. 2016; 11(5): e0156583. Published online 2016 May 27. doi: 10.1371/journal.pone.0156583

PMCID:: PMC4883758

Abstract Article PDF–3.8M

Select item 454881414.

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α₁-antitrypsin while allowing its antiproteinase activity

Adriana Ordóñez, Juan Pérez, Lu Tan, Jennifer A. Dickens, Neda Motamedi-Shad, James A. Irving, Imran Haq, Ugo Ekeowa, Stefan J. Marciniak, Elena Miranda, David A. Lomas

FASEB J. 2015 Jun; 29(6): 2667–2678. Published online 2015 Mar 10. doi: 10.1096/fj.14-267351

PMCID:: PMC4548814

Abstract Article

Select item 454666715.

FBG1 Is the Final Arbitrator of A1AT-Z Degradation

John H. Wen, Hsiang Wen, Katherine N. Gibson-Corley, Kevin A. Glenn

PLoS One. 2015; 10(8): e0135591. Published online 2015 Aug 21. doi: 10.1371/journal.pone.0135591

PMCID:: PMC4546667

Abstract Article PDF–1.9M

Select item 402997816.

Rapid Renal Alpha-1 Antitrypsin Gene Induction in Experimental and Clinical Acute Kidney Injury

Richard A. Zager, Ali C. M. Johnson, Kirsten B. Frostad

PLoS One. 2014; 9(5): e98380. Published online 2014 May 21. doi: 10.1371/journal.pone.0098380

PMCID:: PMC4029978

Abstract Article PDF–1.9M

Select item 399057217.

Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium

Angelia D. Lockett, Mary Beth Brown, Nieves Santos-Falcon, Natalia I. Rush, Houssam Oueini, Amber J. Oberle, Esther Bolanis, Miryam A. Fragoso, Daniela N. Petrusca, Karina A. Serban, Kelly S. Schweitzer, Robert G. Presson Jr., Michael Campos, Irina Petrache

PLoS One. 2014; 9(4): e93979. Published online 2014 Apr 17. doi: 10.1371/journal.pone.0093979

PMCID:: PMC3990572

Abstract Article PDF–1.1M

Select item 388007718.

Update of the human and mouse SERPIN gene superfamily

Claire Heit, Brian C Jackson, Monica McAndrews, Mathew W Wright, David C Thompson, Gary A Silverman, Daniel W Nebert, Vasilis Vasiliou

Hum Genomics. 2013; 7(1): 22. Published online 2013 Oct 30. doi: 10.1186/1479-7364-7-22

PMCID:: PMC3880077

Abstract Article PDF–595K

Select item 351098019.

Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency

Nancy Y Marcus, Keith Blomenkamp, Muneeb Ahmad, Jeffrey H Teckman

Exp Biol Med (Maywood) Author manuscript; available in PMC 2013 Oct 26.

Published in final edited form as: Exp Biol Med (Maywood). 2012 Oct 1; 237(10): 1163–1172. Published online 2012 Oct 26. doi: 10.1258/ebm.2012.012106

PMCID:: PMC3510980

Abstract Article PDF–1.6M

Select item 345838620.

Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival

Maria Koulmanda, Manoj Bhasin, Zhigang Fan, Dusan Hanidziar, Nipun Goel, Prabhakar Putheti, Babak Movahedi, Towia A. Libermann, Terry B. Strom

Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38): 15443–15448. Published online 2012 Sep 4. doi: 10.1073/pnas.1018366109

PMCID:: PMC3458386

Abstract Article PDF–863K

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