PMC Links for GEO Profiles (Select 21791679) - PMC

Emily W. Waigi, Laena Pernomian, Alexia M. Crockett, Tiago J. Costa, Paul Townsend, Jr., R. Clinton Webb, Joseph A. McQuail, Cameron G. McCarthy, Fiona Hollis, Camilla F. Wenceslau

GeroScience. 2024 Dec; 46(6): 5517–5536. Published online 2024 Jun 11. doi: 10.1007/s11357-024-01213-0

PMCID:: PMC11493946

Abstract Article PDF–3.9M

Select item 114853024.

Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP^SAA knock‐in mouse model of Alzheimer's disease

Andrés Norambuena, Vijay Kumar Sagar, Zhuoying Wang, Prakash Raut, Ziang Feng, Horst Wallrabe, Evelyn Pardo, Taylor Kim, Shagufta Rehman Alam, Song Hu, Ammasi Periasamy, George S. Bloom

Alzheimers Dement. 2024 Oct; 20(10): 6844–6859. Published online 2024 Aug 22. doi: 10.1002/alz.14144

PMCID:: PMC11485302

Abstract Article PDF–7.9M

Select item 114762585.

The Potential Related Genes and Mechanisms Involved in Improving the Treadmill Exercise Ability of APP/PS1 Mice

Zhe Zhao, Xingqing Wu, Weijia Wu, Yingzhe Tang, Xiangyuan Meng, Mei Peng, Changfa Tang, Lan Zheng, Wenfeng Liu

Int J Mol Sci. 2024 Oct; 25(19): 10244. Published online 2024 Sep 24. doi: 10.3390/ijms251910244

PMCID:: PMC11476258

Abstract Article PDF–12M

Select item 113747056.

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

Andrew Octavian Sasmita, Constanze Depp, Taisiia Nazarenko, Ting Sun, Sophie B. Siems, Erinne Cherisse Ong, Yakum B. Nkeh, Carolin Böhler, Xuan Yu, Bastian Bues, Lisa Evangelista, Shuying Mao, Barbara Morgado, Zoe Wu, Torben Ruhwedel, Swati Subramanian, Friederike Börensen, Katharina Overhoff, Lena Spieth, Stefan A. Berghoff, Katherine Rose Sadleir, Robert Vassar, Simone Eggert, Sandra Goebbels, Takashi Saito, Takaomi Saido, Gesine Saher, Wiebke Möbius, Gonçalo Castelo-Branco, Hans-Wolfgang Klafki, Oliver Wirths, Jens Wiltfang, Sarah Jäkel, Riqiang Yan, Klaus-Armin Nave

Nat Neurosci. 2024; 27(9): 1668–1674. Published online 2024 Aug 5. doi: 10.1038/s41593-024-01730-3

PMCID:: PMC11374705

Abstract Article PDF–14M

Select item 113540097.

A Potential Role for the Amyloid Precursor Protein in the Regulation of Interferon Signaling, Cholesterol Homeostasis, and Tau Phosphorylation in Niemann–Pick Disease Type C

Kayla L. Sanchez, Samuel D. Shin, Naren P. Rajagopal, Jacob B. White, Antonio Currais, David Soriano-Castell, Pamela Maher, Salvador Soriano

Genes (Basel) 2024 Aug; 15(8): 1066. Published online 2024 Aug 13. doi: 10.3390/genes15081066

PMCID:: PMC11354009

Abstract Article PDF–17M

Select item 113388348.

Single-cell multiregion dissection of Alzheimer’s disease

Hansruedi Mathys, Carles A. Boix, Leyla Anne Akay, Ziting Xia, Jose Davila-Velderrain, Ayesha P. Ng, Xueqiao Jiang, Ghada Abdelhady, Kyriaki Galani, Julio Mantero, Neil Band, Benjamin T. James, Sudhagar Babu, Fabiola Galiana-Melendez, Kate Louderback, Dmitry Prokopenko, Rudolph E. Tanzi, David A. Bennett, Li-Huei Tsai, Manolis Kellis

Nature. 2024; 632(8026): 858–868. Published online 2024 Jul 24. doi: 10.1038/s41586-024-07606-7

PMCID:: PMC11338834

Abstract Article PDF–27M

Select item 113196509.

Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s disease

Paul Armstrong, Hüseyin Güngör, Pariya Anongjanya, Clare Tweedy, Edward Parkin, Jamie Johnston, Ian M. Carr, Neil Dawson, Steven J. Clapcote

Neuropsychopharmacology. 2024 Sep; 49(10): 1559–1568. Published online 2024 Mar 23. doi: 10.1038/s41386-024-01852-z

PMCID:: PMC11319650

Abstract Article PDF–3.1M

Select item 1131612910.

Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging

Keiko Honda, Hiroo Takahashi, Saori Hata, Ruriko Abe, Takashi Saito, Takaomi C. Saido, Hidenori Taru, Yuriko Sobu, Kanae Ando, Tohru Yamamoto, Toshiharu Suzuki

Sci Rep. 2024; 14: 18471. Published online 2024 Aug 9. doi: 10.1038/s41598-024-69400-9

PMCID:: PMC11316129

Abstract Article PDF–7.4M

Select item 1129344211.

CNTN4 modulates neural elongation through interplay with APP

Rosemary A. Bamford, Amila Zuko, Madeline Eve, Jan J. Sprengers, Harm Post, Renske L. R. E. Taggenbrock, Dominique Fäβler, Annika Mehr, Owen J. R. Jones, Aurimas Kudzinskas, Josan Gandawijaya, Ulrike C. Müller, Martien J. H. Kas, J. Peter H. Burbach, Asami Oguro-Ando

Open Biol. 2024 May; 14(5): 240018. Published online May 15, 2024. doi: 10.1098/rsob.240018

PMCID:: PMC11293442

Abstract Article PDF–6.0M

Select item 1126566912.

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease

Rikesh M. Rajani, Robert Ellingford, Mariam Hellmuth, Samuel S. Harris, Orjona S. Taso, David Graykowski, Francesca Kar Wey Lam, Charles Arber, Emre Fertan, John S. H. Danial, Matthew Swire, Marcus Lloyd, Tatiana A. Giovannucci, Mathieu Bourdenx, David Klenerman, Robert Vassar, Selina Wray, Carlo Sala Frigerio, Marc Aurel Busche

PLoS Biol. 2024 Jul; 22(7): e3002727. Published online 2024 Jul 23. doi: 10.1371/journal.pbio.3002727

PMCID:: PMC11265669

Abstract Article PDF–2.7M

Select item 1126081213.

Toward the development of a sporadic model of Alzheimer's disease: comparing pathologies between humanized APP and the familial J20 mouse models

Peggy Rentsch, Kiruthika Ganesan, Alexander Langdon, Lyndsey M. Konen, Bryce Vissel

Front Aging Neurosci. 2024; 16: 1421900. Published online 2024 Jul 8. doi: 10.3389/fnagi.2024.1421900

PMCID:: PMC11260812

Abstract Article PDF–2.7M

Select item 1123708414.

β-amyloid monomer scavenging by an anticalin protein prevents neuronal hyperactivity in mouse models of Alzheimer’s Disease

Benedikt Zott, Lea Nästle, Christine Grienberger, Felix Unger, Manuel M. Knauer, Christian Wolf, Aylin Keskin-Dargin, Anna Feuerbach, Marc Aurel Busche, Arne Skerra, Arthur Konnerth

Nat Commun. 2024; 15: 5819. Published online 2024 Jul 10. doi: 10.1038/s41467-024-50153-y

PMCID:: PMC11237084

Abstract Article PDF–2.9M

Select item 1118085115.

Characterizing molecular and synaptic signatures in mouse models of late‐onset Alzheimer's disease independent of amyloid and tau pathology

Kevin P. Kotredes, Ravi S. Pandey, Scott Persohn, Kierra Elderidge, Charles P Burton, Ethan W. Miner, Kathryn A. Haynes, Diogo Francisco S. Santos, Sean‐Paul Williams, Nicholas Heaton, Cynthia M. Ingraham, Christopher Lloyd, Dylan Garceau, Rita O'Rourke, Sarah Herrick, Claudia Rangel‐Barajas, Surendra Maharjan, Nian Wang, Michael Sasner, Bruce T. Lamb, Paul R. Territo, Stacey J. Sukoff Rizzo, Gregory W. Carter, Gareth R. Howell, Adrian L. Oblak

Alzheimers Dement. 2024 Jun; 20(6): 4126–4146. Published online 2024 May 12. doi: 10.1002/alz.13828

PMCID:: PMC11180851

Abstract Article PDF–7.5M

Select item 1111390316.

Neurogenic effects of β-amyloid in the choroid plexus epithelial cells in Alzheimer’s disease

Marta Bolos, Carlos Spuch, Lara Ordoñez-Gutierrez, Francisco Wandosell, Isidro Ferrer, Eva Carro

Cell Mol Life Sci. 2013 Aug; 70(15): 2787–2797. Published online 2013 Mar 3. doi: 10.1007/s00018-013-1300-x

PMCID:: PMC11113903

Abstract Article PDF–1.1M

Select item 1109523517.

Consequences of Amyloid‐β Deficiency for the Liver

Gayane Hrachia Buniatian, Ute Schwinghammer, Roman Tremmel, Holger Cynis, Thomas S. Weiss, Ralf Weiskirchen, Volker M. Lauschke, Sonia Youhanna, Isbaal Ramos, Maria Valcarcel, Torgom Seferyan, Jens‐Ulrich Rahfeld, Vera Rieckmann, Kathrin Klein, Marine Buadze, Victoria Weber, Valentina Kolak, Rolf Gebhardt, Scott L. Friedman, Ulrike C. Müller, Matthias Schwab, Lusine Danielyan

Adv Sci (Weinh) 2024 May; 11(18): 2307734. Published online 2024 Mar 2. doi: 10.1002/advs.202307734

PMCID:: PMC11095235

Abstract Article PDF–19M

Select item 1108818118.

Monocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer’s disease

Qiang Li, Bing Li, Li Liu, Kang-Ji Wang, Ming-Yue Liu, Yu Deng, Ze Li, Wei-Dong Zhao, Li-Yong Wu, Yu-Hua Chen, Ke Zhang

J Neuroinflammation. 2024; 21: 125. Published online 2024 May 10. doi: 10.1186/s12974-024-03119-2

PMCID:: PMC11088181

Abstract Article PDF–11M

Select item 1108691719.

Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model

Masatoshi Fukuda, Hiroki Okanishi, Daisuke Ino, Kazuya Ono, Satoru Kawamura, Eri Wakai, Tsuyoshi Miyoshi, Takashi Sato, Yumi Ohta, Takashi Saito, Takaomi C. Saido, Hidenori Inohara, Yoshikatsu Kanai, Hiroshi Hibino

PLoS One. 2024; 19(5): e0303375. Published online 2024 May 10. doi: 10.1371/journal.pone.0303375

PMCID:: PMC11086917

Abstract Article PDF–1.6M

Select item 1107180520.

APP mediates tau uptake and its overexpression leads to the exacerbated tau pathology

Jiang Chen, Anran Fan, Song Li, Yan Xiao, Yanlin Fu, Jun-Sheng Chen, Dan Zi, Ling-Hui Zeng, Jun Tan

Cell Mol Life Sci. 2023 May; 80(5): 123. Published online 2023 Apr 18. doi: 10.1007/s00018-023-04774-z

PMCID:: PMC11071805

Abstract Article PDF–3.2M

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