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Select item 105057321.

Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure

Penny A. F. Whiley, Michael C. M. Luu, Liza O’Donnell, David J. Handelsman, Kate L. Loveland

Front Endocrinol (Lausanne) 2023; 14: 1234712. Published online 2023 Sep 1. doi: 10.3389/fendo.2023.1234712

PMCID:: PMC10505732

Abstract Article PDF–9.9M

Select item 97094572.

A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization

Isaac W. Shaw, Phoebe M. Kirkwood, Diane Rebourcet, Fiona L. Cousins, Rebecca J. Ainslie, Dawn E. W. Livingstone, Lee B. Smith, Philippa T.K. Saunders, Douglas A. Gibson

Front Endocrinol (Lausanne) 2022; 13: 1027164. Published online 2022 Nov 16. doi: 10.3389/fendo.2022.1027164

PMCID:: PMC9709457

Abstract Article PDF–16M

Select item 96717723.

Possible testosterone redundancy for 5α-dihydrotestosterone in the masculinization of mouse external genitalia

Yuko Ueda, Kentaro Suzuki, Mizuki Kajimoto, Kota Fujimoto, Mala Mahendroo, Masatsugu Ema, Gen Yamada, Isao Hara

Exp Anim. 2022; 71(4): 451–459. Published online 2022 May 24. doi: 10.1538/expanim.22-0038

PMCID:: PMC9671772

Abstract Article PDF–5.7M

Select item 93380404.

TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway

Moïra Rossitto, Stephanie Déjardin, Chris M. Rands, Stephanie Le Gras, Roberta Migale, Mahmoud-Reza Rafiee, Yasmine Neirijnck, Alain Pruvost, Anvi Laetitia Nguyen, Guillaume Bossis, Florence Cammas, Lionel Le Gallic, Dagmar Wilhelm, Robin Lovell-Badge, Brigitte Boizet-Bonhoure, Serge Nef, Francis Poulat

Nat Commun. 2022; 13: 4412. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32061-1

PMCID:: PMC9338040

Abstract Article PDF–11M

Select item 82118545.

Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker

Georgina E. T. Blake, Xiaohui Zhao, Hong wa Yung, Graham J. Burton, Anne C. Ferguson-Smith, Russell S. Hamilton, Erica D. Watson

Nat Commun. 2021; 12: 3714. Published online 2021 Jun 17. doi: 10.1038/s41467-021-24036-5

PMCID:: PMC8211854

Abstract Article PDF–1.9M

Select item 79048556.

Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma

Renjie Dou, Jinjun Qian, Wei Wu, Yanxin Zhang, Yuxia Yuan, Mengjie Guo, Rongfang Wei, Shu Yang, Artur Jurczyszyn, Siegfried Janz, Meral Beksac, Chunyan Gu, Ye Yang

Cell Death Dis. 2021 Feb; 12(2): 206. Published online 2021 Feb 24. doi: 10.1038/s41419-021-03510-4

PMCID:: PMC7904855

Abstract Article PDF–4.5M

Select item 72130617.

Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis

Anna Heinrich, Sarah J. Potter, Li Guo, Nancy Ratner, Tony DeFalco

Cell Rep. Author manuscript; available in PMC 2020 May 11.

Published in final edited form as: Cell Rep. 2020 Apr 14; 31(2): 107513. doi: 10.1016/j.celrep.2020.03.077

PMCID:: PMC7213061

Abstract Article PDF–4.4M

Select item 67357378.

Role of Hepatic Glucocorticoid Receptor in Metabolism in Models of 5αR1 Deficiency in Male Mice

Tracy C S Mak, Dawn E W Livingstone, Mark Nixon, Brian R Walker, Ruth Andrew

Endocrinology. 2019 Sep; 160(9): 2061–2073. Published online 2019 Jun 14. doi: 10.1210/en.2019-00236

PMCID:: PMC6735737

Abstract Article

Select item 56562599.

Subcellular localization of the five members of the human steroid 5α-reductase family

Antonella Scaglione, Linda Celeste Montemiglio, Giacomo Parisi, Italia Anna Asteriti, Renato Bruni, Gabriele Cerutti, Claudia Testi, Carmelinda Savino, Filippo Mancia, Patrizia Lavia, Beatrice Vallone

Biochim Open. 2017 Jun; 4: 99–106. Published online 2017 Mar 21. doi: 10.1016/j.biopen.2017.03.003

PMCID:: PMC5656259

Abstract Article PDF–1.7M

Select item 542660010.

5α-reductase 1 mRNA levels are positively correlated with TRAMP mouse prostate most severe lesion scores

Alexander B. Opoku-Acheampong, Jamie N. Henningson, Amanda P. Beck, Brian L. Lindshield

PLoS One. 2017; 12(5): e0175874. Published online 2017 May 11. doi: 10.1371/journal.pone.0175874

PMCID:: PMC5426600

Abstract Article PDF–7.2M

Select item 511893811.

Metabolic dysfunction in female mice with disruption of 5α-reductase 1

Dawn E W Livingstone, Emma M Di Rollo, Tracy C-S Mak, Karen Sooy, Brian R Walker, Ruth Andrew

J Endocrinol. 2016 Nov; 232(1): 29–36. Published online 2016 Nov 11. doi: 10.1530/JOE-16-0125

PMCID:: PMC5118938

Abstract Article PDF–1.0M

Select item 444697612.

Unexpected Virilization in Male Mice Lacking Steroid 5α-Reductase Enzymes

MALA S. MAHENDROO, KRISTI M. CALA, DAVID L. HESS, DAVID W. RUSSELL

Endocrinology. Author manuscript; available in PMC 2015 May 28.

Published in final edited form as: Endocrinology. 2001 Nov; 142(11): 4652–4662. doi: 10.1210/endo.142.11.8510

PMCID:: PMC4446976

Abstract Article PDF–1.2M

Select item 442563113.

Null Mutation of 5α-Reductase Type I Gene Alters Ethanol Consumption Patterns in a Sex-Dependent Manner

Matthew M. Ford, Jeffrey D. Nickel, Moriah N. Kaufman, Deborah A. Finn

Behav Genet. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Behav Genet. 2015 May; 45(3): 341–353. Published online 2014 Nov 23. doi: 10.1007/s10519-014-9694-2

PMCID:: PMC4425631

Abstract Article PDF–1.4M

Select item 441708714.

Sex Differences in Ethanol’s Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice With a Null Mutation of the 5α-Reductase Type 1 Gene

Michelle A. Tanchuck-Nipper, Matthew M. Ford, Anna Hertzberg, Amy Beadles-Bohling, Debra K. Cozzoli, Deborah A. Finn

Behav Genet. Author manuscript; available in PMC 2015 May 8.

Published in final edited form as: Behav Genet. 2015 May; 45(3): 354–367. Published online 2014 Oct 31. doi: 10.1007/s10519-014-9691-5

PMCID:: PMC4417087

Abstract Article PDF–1.7M

Select item 431955915.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 419228716.

Loss of 5α-Reductase Type 1 Accelerates the Development of Hepatic Steatosis but Protects Against Hepatocellular Carcinoma in Male Mice

Joanna K. Dowman, Laurence J. Hopkins, Gary M. Reynolds, Matthew J. Armstrong, Maryam Nasiri, Nikolaos Nikolaou, E. Leonie A. F. van Houten, Jenny A. Visser, Stuart A. Morgan, Gareth G. Lavery, Andrei Oprescu, Stefan G. Hübscher, Philip N. Newsome, Jeremy W. Tomlinson

Endocrinology. 2013 Dec; 154(12): 4536–4547. Published online 2013 Sep 30. doi: 10.1210/en.2013-1592

PMCID:: PMC4192287

Abstract Article

Select item 409893617.

Female mice with deletion of Type One 5α-reductase have reduced reproductive responding during proestrus and after hormone-priming

Carolyn J. Koonce, Cheryl A. Frye

Pharmacol Biochem Behav. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Pharmacol Biochem Behav. 2014 Jul; 122: 20–29. Published online 2014 Mar 18. doi: 10.1016/j.pbb.2014.03.010

PMCID:: PMC4098936

Abstract Article PDF–688K

Select item 376978018.

Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 5α-reductase mutant, mice enhances object recognition and placement memory and is associated with higher BDNF levels in the hippocampus and cortex

Cheryl A. Frye, Carolyn J. Koonce, Alicia A. Walf

Neurosci Lett. Author manuscript; available in PMC 2014 Sep 13.

Published in final edited form as: Neurosci Lett. 2013 Sep 13; 0: 53–57. Published online 2013 Jul 16. doi: 10.1016/j.neulet.2013.07.002

PMCID:: PMC3769780

Abstract Article PDF–629K

Select item 376136619.

Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5α-reductase Type 1 mutant, mice

Carolyn J. Koonce, Cheryl A. Frye

Behav Brain Res. Author manuscript; available in PMC 2014 Sep 15.

Published in final edited form as: Behav Brain Res. 2013 Sep 15; 253: 232–239. Published online 2013 Jul 22. doi: 10.1016/j.bbr.2013.07.025

PMCID:: PMC3761366

Abstract Article PDF–869K

Select item 357241020.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

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