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Items: 1 to 20 of 66

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response
Zhuoyuan Alex Li, Akhilesh Kumar Bajpai, Ruixue Wang, Yaxin Liu, Richard J. Webby, Esther Wilk, Weikuan Gu, Klaus Schughart, Kui Li, Lu Lu
Virus Res. 2024 Apr; 342: 199335. Published online 2024 Feb 17. doi: 10.1016/j.virusres.2024.199335
PMCID:
PMC10882161
AbstractArticlePDF–4.7M
3.
Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators
Kostas C. Nikolaou, Svenja Godbersen, Muthiah Manoharan, Stefan Wieland, Markus H. Heim, Markus Stoffel
JCI Insight. 2023 Nov 8; 8(21): e164694. Published online 2023 Nov 8. doi: 10.1172/jci.insight.164694
PMCID:
PMC10721265
AbstractArticlePDF–2.5M
4.
The TRIM21-FOXD1-BCL-2 axis underlies hyperglycaemic cell death and diabetic tissue damage
Wenwen Cheng, Cifeng Cai, Yifan Xu, Xueqi Xiao, Tiantian Shi, Yueling Liao, Xiaoyi Wang, Shasha Chen, Meiliang Zhou, Zhiyong Liao
Cell Death Dis. 2023 Dec; 14(12): 825. Published online 2023 Dec 13. doi: 10.1038/s41419-023-06355-1
PMCID:
PMC10719266
AbstractArticlePDF–5.4M
5.
Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling
Ri-Xu Liu, Rong-He Gu, Zhi-Peng Li, Zhi-Quan Hao, Qin-Xiao Hu, Zhen-Yan Li, Xiao-Gang Wang, Wang Tang, Xiao-He Wang, Yu-Kai Zeng, Zhen-Wei Li, Qiu Dong, Xiao-Feng Zhu, Di Chen, Ke-Wei Zhao, Rong-Hua Zhang, Zhen-Gang Zha, Huan-Tian Zhang
Bone Res. 2023; 11: 56. Published online 2023 Oct 26. doi: 10.1038/s41413-023-00296-3
PMCID:
PMC10603047
AbstractArticlePDF–11M
6.
TRIM21 Promotes Rabies Virus Production by Degrading IRF7 through Ubiquitination
Boyue Zhang, Ting Cai, Hongling He, Xuezhe Huang, Guie Chen, Yanqin Lai, Yongwen Luo, Shile Huang, Jun Luo, Xiaofeng Guo
Int J Mol Sci. 2023 Jul; 24(13): 10892. Published online 2023 Jun 30. doi: 10.3390/ijms241310892
PMCID:
PMC10341556
AbstractArticlePDF–2.3M
7.
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN
Kaini Zhang, Chen Yang, Xin Zhou, Jin Liang, Jianjin Guo, Min Li, Yi Zhang, Shulin Shao, Peng Sun, Kai Li, Jingjing Huang, Fang Chen, Xiubin Liang, Dongming Su
Cell Mol Life Sci. 2023 Jun; 80(6): 168. Published online 2023 May 30. doi: 10.1007/s00018-023-04820-w
PMCID:
PMC10229743
AbstractArticlePDF–2.9M
8.
TRIM21 deficiency protects against atrial inflammation and remodeling post myocardial infarction by attenuating oxidative stress
Xiangdong Liu, Wenming Zhang, Jiachen Luo, Wentao Shi, Xingxu Zhang, Zhiqiang Li, Xiaoming Qin, Baoxin Liu, Yidong Wei
Redox Biol. 2023 Jun; 62: 102679. Published online 2023 Mar 22. doi: 10.1016/j.redox.2023.102679
PMCID:
PMC10074251
AbstractArticlePDF–14M
9.
TRIM21 aggravates cardiac injury after myocardial infarction by promoting M1 macrophage polarization
Zhiqiang Li, Xiangdong Liu, Xingxu Zhang, Wenming Zhang, Mengmeng Gong, Xiaoming Qin, Jiachen Luo, Yuan Fang, Baoxin Liu, Yidong Wei
Front Immunol. 2022; 13: 1053171. Published online 2022 Nov 10. doi: 10.3389/fimmu.2022.1053171
PMCID:
PMC9684192
AbstractArticlePDF–18M
10.
Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors
Ya-Juan Wang, Xiao-Jing Di, Ting-Wei Mu
J Biol Chem. 2022 Oct; 298(10): 102423. Published online 2022 Aug 27. doi: 10.1016/j.jbc.2022.102423
PMCID:
PMC9493394
AbstractArticlePDF–2.6M
11.
Functional skewing of TRIM21‐SIRT5 interplay dictates IL‐1β production in DSS‐induced colitis
Pengbo Yao, Taiqi Chen, Peng Jiang, Li Li, Wenjing Du
EMBO Rep. 2022 Sep; 23(9): e54391. Published online 2022 Jun 30. doi: 10.15252/embr.202154391
PMCID:
PMC9442300
AbstractArticlePDF–5.2M
12.
Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors
Mehmet Sahin, Melissa M. Remy, Benedict Fallet, Rami Sommerstein, Marianna Florova, Anna Langner, Katja Klausz, Tobias Straub, Mario Kreutzfeldt, Ingrid Wagner, Cinzia T. Schmidt, Pauline Malinge, Giovanni Magistrelli, Shozo Izui, Hanspeter Pircher, J. Sjef Verbeek, Doron Merkler, Matthias Peipp, Daniel D. Pinschewer
Cell Rep. 2022 Feb 1; 38(5): 110303. Published online 2022 Feb 1. doi: 10.1016/j.celrep.2022.110303
PMCID:
PMC8822495
AbstractArticle
13.
The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins
Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo
BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y
PMCID:
PMC8744257
AbstractArticlePDF–6.0M
14.
Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABAAR‐Dependent TRIM21 Modulation of Src Expression
Qidong Liu, Zhihao Sheng, Chun Cheng, Hui Zheng, Michael Lanuti, Rong Liu, Ping Wang, Yuan Shen, Zhongcong Xie
Adv Sci (Weinh) 2021 Sep; 8(18): 2102079. Published online 2021 Jul 15. doi: 10.1002/advs.202102079
PMCID:
PMC8456212
AbstractArticlePDF–4.3M
15.
Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin
Kai Hou, Jianliang Shen, Junrong Yan, Chuannan Zhai, Jingxia Zhang, Ji-An Pan, Ye Zhang, Yaping Jiang, Yongbo Wang, Richard Z. Lin, Hongliang Cong, Shenglan Gao, Wei-Xing Zong
EBioMedicine. 2021 Jul; 69: 103456. Published online 2021 Jul 4. doi: 10.1016/j.ebiom.2021.103456
PMCID:
PMC8261003
AbstractArticlePDF–4.7M
16.
Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels
Xu Cao, Zijing Zhou, Ye Tian, Zhengzhao Liu, Kar On Cheng, Xibing Chen, Wenbao Hu, Yuk Ming Wong, Xiaofen Li, Hailin Zhang, Ronggui Hu, Pingbo Huang
J Biol Chem. 2021 Jan-Jun; 296: 100738. Published online 2021 May 3. doi: 10.1016/j.jbc.2021.100738
PMCID:
PMC8191318
AbstractArticlePDF–2.9M
17.
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway
Fang Wang, Ye Zhang, Jianliang Shen, Bin Yang, Weiwei Dai, Junrong Yan, Sara Maimouni, Heineken Q. Daguplo, Sara Coppola, Yingtang Gao, Yijun Wang, Zhi Du, Kesong Peng, Hui Liu, Qin Zhang, Fei Tang, Peng Wang, Shenglan Gao, Yongbo Wang, Wen-Xing Ding, Grace Guo, Fengmei Wang, Wei-Xing Zong
Cell Mol Gastroenterol Hepatol. 2021; 11(5): 1369–1385. Published online 2021 Jan 19. doi: 10.1016/j.jcmgh.2021.01.007
PMCID:
PMC8024979
AbstractArticlePDF–6.9M
18.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
19.
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity
Sarah L Caddy, Marina Vaysburd, Guido Papa, Mark Wing, Kevin O’Connell, Diana Stoycheva, Stian Foss, Jan Terje Andersen, Annette Oxenius, Leo C James
EMBO J. 2021 Mar 1; 40(5): e106228. Published online 2020 Dec 1. doi: 10.15252/embj.2020106228
PMCID:
PMC7917548
AbstractArticlePDF–914K
20.
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models
Aamir S Mukadam, Lauren VC Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O’Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Science. Author manuscript; available in PMC 2023 May 9.
Published in final edited form as: Science. 2023 Mar 31; 379(6639): 1336–1341. Published online 2023 Mar 30. doi: 10.1126/science.abn1366
PMCID:
PMC7614512
AbstractArticlePDF–1.5M

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