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Select item 114010341.

Proximity labeling reveals dynamic changes in the SQSTM1 protein network

Alejandro N. Rondón-Ortiz, Lushuang Zhang, Peter E.A. Ash, Avik Basu, Sambhavi Puri, Sophie J.F. van der Spek, Zihan Wang, Luke Dorrian, Andrew Emili, Benjamin Wolozin

J Biol Chem. 2024 Sep; 300(9): 107621. Published online 2024 Aug 3. doi: 10.1016/j.jbc.2024.107621

PMCID:: PMC11401034

Abstract Article PDF–5.4M

Select item 113735992.

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway

Elena Prosdocimi, Veronica Carpanese, Luca Matteo Todesca, Tatiana Varanita, Magdalena Bachmann, Margherita Festa, Daniele Bonesso, Mireia Perez-Verdaguer, Andrea Carrer, Angelo Velle, Roberta Peruzzo, Silvia Muccioli, Davide Doni, Luigi Leanza, Paola Costantini, Frank Stein, Mandy Rettel, Antonio Felipe, Michael J. Edwards, Erich Gulbins, Laura Cendron, Chiara Romualdi, Vanessa Checchetto, Ildiko Szabo

Sci Adv. 2024 Sep 6; 10(36): eadn9361. Published online 2024 Sep 4. doi: 10.1126/sciadv.adn9361

PMCID:: PMC11373599

Abstract Article PDF–11M

Select item 113604793.

Elevated expression of Aurora-A/AURKA in breast cancer associates with younger age and aggressive features

L. M. Ingebriktsen, R. O. C. Humlevik, A. A. Svanøe, A. K. M. Sæle, I. Winge, K. Toska, M. B. Kalvenes, B. Davidsen, A. Heie, G. Knutsvik, C. Askeland, I. M. Stefansson, E. A. Hoivik, L. A. Akslen, E. Wik

Breast Cancer Res. 2024; 26: 126. Published online 2024 Aug 28. doi: 10.1186/s13058-024-01882-x

PMCID:: PMC11360479

Abstract Article PDF–1.5M

Select item 113159294.

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex

Marisa Bedir, Emily Outwin, Rita Colnaghi, Lydia Bassett, Iga Abramowicz, Mark O’Driscoll

EMBO Rep. 2024 Aug; 25(8): 3432–3455. Published online 2024 Jun 28. doi: 10.1038/s44319-024-00184-9

PMCID:: PMC11315929

Abstract Article PDF–3.4M

Select item 112099355.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111729696.

Involvement of Endolysosomes and Aurora Kinase A in the Regulation of Amyloid β Protein Levels in Neurons

Zahra Afghah, Nabab Khan, Gaurav Datta, Peter W. Halcrow, Jonathan D. Geiger, Xuesong Chen

Int J Mol Sci. 2024 Jun; 25(11): 6200. Published online 2024 Jun 4. doi: 10.3390/ijms25116200

PMCID:: PMC11172969

Abstract Article PDF–2.9M

Select item 111591357.

Hypoxia‐inducible enhancer/α‐fetoprotein promoter‐driven RNA interference targeting STK15 suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells

Ping Gao, Rui Wang, Jian‐Jun Shen, Fang Lin, Xi Wang, Ke Dong, Hui‐Zhong Zhang

Cancer Sci. 2008 Nov; 99(11): 2209–2217. Published online 2008 Sep 18. doi: 10.1111/j.1349-7006.2008.00941.x

PMCID:: PMC11159135

Abstract Article PDF–375K

Select item 111048778.

Insights into the non-mitotic functions of Aurora kinase A: more than just cell division

Giulia Bertolin, Marc Tramier

Cell Mol Life Sci. 2020 Mar; 77(6): 1031–1047. Published online 2019 Sep 27. doi: 10.1007/s00018-019-03310-2

PMCID:: PMC11104877

Abstract Article PDF–1.0M

Select item 110721529.

Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length

Anne Nehlig, Cynthia Seiler, Yulia Steblyanko, Florent Dingli, Guillaume Arras, Damarys Loew, Julie Welburn, Claude Prigent, Marin Barisic, Clara Nahmias

Cell Mol Life Sci. 2021 Feb; 78(4): 1765–1779. Published online 2020 Aug 13. doi: 10.1007/s00018-020-03614-8

PMCID:: PMC11072152

Abstract Article PDF–1.8M

Select item 1103088910.

Characterization of human CD4 helper T cell responses against Aurora kinase A

Hiroya Kobayashi, Makoto Azumi, Satoshi Hayashi, Keisuke Sato, Naoko Aoki, Shoji Kimura, Hidehiro Kakizaki, Toshihiro Nagato, Yasuaki Harabuchi, Masatoshi Tateno, Esteban Celis

Cancer Immunol Immunother. 2010 Jul; 59(7): 1029–1039. Published online 2010 Feb 25. doi: 10.1007/s00262-010-0826-0

PMCID:: PMC11030889

Abstract Article PDF–571K

Select item 1102293811.

Biotransformation Pathways and Metabolite Profiles of Oral [¹⁴C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors

Sandeepraj Pusalkar, Xiaofei Zhou, Yuexian Li, Lawrence Cohen, Jun Johnny Yang, Suresh K. Balani, Cindy Xia, Wen Chyi Shyu, Chuang Lu, Karthik Venkatakrishnan, Swapan K. Chowdhury

Drug Metab Dispos. 2020 Mar; 48(3): 217–229. Published online 2020 Mar. doi: 10.1124/dmd.119.087338

PMCID:: PMC11022938

Abstract Article PDF–802K

Select item 1096083412.

AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis

Bing Deng, Fang Liu, Nana Chen, Xinhao Li, Jie Lei, Ning Chen, Jingjing Wu, Xuan Wang, Jie Lu, Mouxiang Fang, Ailin Chen, Zijian Zhang, Bin He, Min Yan, Yuchen Zhang, Zifeng Wang, Quentin Liu

Cell Death Dis. 2024 Mar; 15(3): 233. Published online 2024 Mar 23. doi: 10.1038/s41419-024-06577-x

PMCID:: PMC10960834

Abstract Article PDF–6.4M

Select item 1086980013.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett

Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4

PMCID:: PMC10869800

Abstract Article PDF–9.3M

Select item 1082520714.

AURKA inhibition induces Ewing’s sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis

Huimou Chen, Jing Hu, Xilin Xiong, Hongling Chen, Biaojun Lin, Yusong Chen, Yang Li, Di Cheng, Zhihua Li

Cell Death Dis. 2024 Jan; 15(1): 99. Published online 2024 Jan 29. doi: 10.1038/s41419-024-06485-0

PMCID:: PMC10825207

Abstract Article PDF–6.1M

Select item 1060304815.

Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex

Pinar Altiner, Süleyman Selim Çınaroğlu, Ahmet Can Timucin, Emel Timucin

Sci Rep. 2023; 13: 18399. Published online 2023 Oct 26. doi: 10.1038/s41598-023-45272-3

PMCID:: PMC10603048

Abstract Article PDF–6.3M

Select item 1050265716.

MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis

Debao Fang, Hao Hu, Kailiang Zhao, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu, Yide Mei

Adv Sci (Weinh) 2023 Sep; 10(26): 2303336. Published online 2023 Jul 12. doi: 10.1002/advs.202303336

PMCID:: PMC10502657

Abstract Article PDF–3.4M

Select item 1047429717.

CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly

Susana Eibes, Girish Rajendraprasad, Claudia Guasch-Boldu, Mirela Kubat, Yulia Steblyanko, Marin Barisic

Nat Commun. 2023; 14: 5317. Published online 2023 Sep 1. doi: 10.1038/s41467-023-41091-2

PMCID:: PMC10474297

Abstract Article PDF–6.3M

Select item 1035798618.

Functional Significance of Aurora Kinase A Regulatory Interactions with p53–ERα Complex in Human Breast Cancer Cells

Hiroshi Katayama, Subrata Sen

Horm Cancer. 2011 Apr; 2(2): 117–124. Published online 2011 Mar 4. doi: 10.1007/s12672-011-0070-x

PMCID:: PMC10357986

Abstract Article PDF–371K

Select item 1035394019.

E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA

Hao-Ming Shen, Di Zhang, Ping Xiao, Bin Qu, Yi-Fan Sun

Cancer Gene Ther. 2023; 30(7): 1007–1017. Published online 2023 Mar 27. doi: 10.1038/s41417-023-00607-0

PMCID:: PMC10353940

Abstract Article PDF–5.9M

Select item 1032852220.

Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

Roberta Cacioppo, Hesna Begum Akman, Taner Tuncer, Ayse Elif Erson-Bensan, Catherine Lindon

eLife. 2023; 12: RP87253. Published online 2023 Jun 29. doi: 10.7554/eLife.87253

PMCID:: PMC10328522

Abstract Article PDF–5.1M

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