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Items: 1 to 20 of 150

1.
OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination
Liqun Peng, Tiangen Wu, Yingyi Liu, Dongli Zhao, Wenzhi He, Yufeng Yuan
Cell Oncol (Dordr) 2024; 47(3): 987–1004. Published online 2024 Feb 5. doi: 10.1007/s13402-023-00913-7
PMCID:
PMC11219430
AbstractArticlePDF–8.4M
2.
OTUB1 contributes to the stability and function of Influenza A virus NS2
Yu-Jyun Li, Chi-Yuan Chen, Yu-Shen Kuo, Yi-Wen Huang, Rei-Lin Kuo, Li-Kwan Chang, Jeng-How Yang, Chih-Ho Lai, Shin-Ru Shih, Ya-Fang Chiu
PLoS Pathog. 2024 May; 20(5): e1012279. Published online 2024 May 30. doi: 10.1371/journal.ppat.1012279
PMCID:
PMC11166342
AbstractArticlePDF–2.7M
3.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
4.
YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation
Xuefeng Zhao, Suli Lv, Neng Li, Qingli Zou, Lidong Sun, Tanjing Song
J Biol Chem. 2024 Apr; 300(4): 107152. Published online 2024 Mar 9. doi: 10.1016/j.jbc.2024.107152
PMCID:
PMC11002313
AbstractArticlePDF–2.8M
5.
Involvement of the OTUB1‐YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma
Shengjian Jin, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Hiroko Hagita, Motoharu Sarubo, Natsumi Fujiwara, Guangying Qi, Naozumi Ishimaru, Yasusei Kudo
Cancer Med. 2023 Dec; 12(24): 22156–22169. Published online 2023 Nov 20. doi: 10.1002/cam4.6735
PMCID:
PMC10757095
AbstractArticlePDF–3.3M
6.
OTUB1 inhibits breast cancer by non‐canonically stabilizing CCN6
Ying Zhao, Jing Ruan, Zhongding Li, Xian Su, Kangmin Chen, Yimin Lin, Yuepiao Cai, Peng Wang, Baohua Liu, Dirk Schlüter, Guang Liang, Xu Wang
Clin Transl Med. 2023 Aug; 13(8): e1385. Published online 2023 Aug 22. doi: 10.1002/ctm2.1385
PMCID:
PMC10444971
AbstractArticlePDF–6.0M
7.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
8.
Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization
Nathaniel J. Henning, Lydia Boike, Jessica N. Spradlin, Carl C. Ward, Gang Liu, Erika Zhang, Bridget P. Belcher, Scott M. Brittain, Matthew Hesse, Dustin Dovala, Lynn M. McGregor, Rachel Valdez Misiolek, Lindsey W. Plasschaert, David J. Rowlands, Feng Wang, Andreas O. Frank, Daniel Fuller, Abigail R. Estes, Katelyn L. Randal, Anoohya Panidapu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Nat Chem Biol. Author manuscript; available in PMC 2023 Apr 24.
Published in final edited form as: Nat Chem Biol. 2022 Apr; 18(4): 412–421. Published online 2022 Feb 24. doi: 10.1038/s41589-022-00971-2
PMCID:
PMC10125259
AbstractArticlePDF–2.8M
9.
OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2
Qiong Zhu, Yesheng Fu, Chun-Ping Cui, Yi Ding, Zhikang Deng, Chao Ning, Fan Hu, Chen Qiu, Biyue Yu, Xuemei Zhou, Guan Yang, Jiang Peng, Weiguo Zou, Cui Hua Liu, Lingqiang Zhang
Signal Transduct Target Ther. 2023; 8: 142. Published online 2023 Apr 7. doi: 10.1038/s41392-023-01354-2
PMCID:
PMC10079838
AbstractArticlePDF–5.3M
10.
SET7 methylates the deubiquitinase OTUB1 at Lys 122 to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis
Hongyan Deng, Shuke Jia, Jinhua Tang, Fangjing Rong, Chenxi Xu, Xiaoyun Chen, Zixuan Wang, Chunchun Zhu, Xueyi Sun, Qian Liao, Wen Liu, Wenhua Li, Wuhan Xiao, Xing Liu
J Biol Chem. 2023 Apr; 299(4): 103054. Published online 2023 Feb 22. doi: 10.1016/j.jbc.2023.103054
PMCID:
PMC10040876
AbstractArticlePDF–3.0M
11.
Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer
Li Liao, Yin-Ling Zhang, Ling Deng, Chao Chen, Xiao-Yan Ma, Lisa Andriani, Shao-Ying Yang, Shu-Yuan Hu, Fang-Lin Zhang, Zhi-Min Shao, Da-Qiang Li
Cancer Res. 2023 Feb 3; 83(3): 471–484. Published online 2022 Dec 9. doi: 10.1158/0008-5472.CAN-22-2709
PMCID:
PMC9896024
AbstractArticlePDF–17M
12.
Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor
Seung Un Seo, Seon Min Woo, Min Wook Kim, Eun-Woo Lee, Kyoung-jin Min, Taeg Kyu Kwon
Cell Death Differ. 2023 Jan; 30(1): 82–93. Published online 2022 Aug 4. doi: 10.1038/s41418-022-01047-3
PMCID:
PMC9883261
AbstractArticlePDF–4.6M
13.
CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1
Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou
Oncogene. 2023; 42(2): 83–98. Published online 2022 Nov 12. doi: 10.1038/s41388-022-02537-x
PMCID:
PMC9816059
AbstractArticlePDF–7.6M
14.
SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
Saisai Guo, Xiaobo Lei, Yan Chang, Jianyuan Zhao, Jing Wang, Xiaojing Dong, Qian Liu, Zixiong Zhang, Lidan Wang, Dongrong Yi, Ling Ma, Quanjie Li, Yongxin Zhang, Jiwei Ding, Chen Liang, Xiaoyu Li, Fei Guo, Jianwei Wang, Shan Cen
Signal Transduct Target Ther. 2022; 7: 400. Published online 2022 Dec 27. doi: 10.1038/s41392-022-01239-w
PMCID:
PMC9793359
AbstractArticlePDF–3.7M
15.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
16.
OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer
Cheng Yan, Huijie Yang, Peng Su, Xin Li, Zhongbo Li, Dehai Wang, Yifeng Zang, Tianshi Wang, Ziping Liu, Zhuocong Bao, Shuxiao Dong, Ting Zhuang, Jian Zhu, Yinlu Ding
Oncogene. 2022; 41(48): 5186–5198. Published online 2022 Oct 21. doi: 10.1038/s41388-022-02507-3
PMCID:
PMC9700521
AbstractArticlePDF–5.4M
17.
Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis
Xi Ling, Jiayi Lu, Xiaoyun Wang, Lan Liu, Lu Liu, Yadi Wang, Yujun Sun, Chune Ren, Chao Lu, Zhenhai Yu
iScience. 2022 Nov 18; 25(11): 105363. Published online 2022 Oct 14. doi: 10.1016/j.isci.2022.105363
PMCID:
PMC9626688
AbstractArticlePDF–6.0M
18.
Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function
Simon Maria Kienle, Tobias Schneider, Katrin Stuber, Christoph Globisch, Jasmin Jansen, Florian Stengel, Christine Peter, Andreas Marx, Michael Kovermann, Martin Scheffner
Nat Commun. 2022; 13: 5435. Published online 2022 Sep 16. doi: 10.1038/s41467-022-33087-1
PMCID:
PMC9481602
AbstractArticlePDF–3.7M
19.
Deubiquitination of MYC by OTUB1 contributes to HK2 mediated glycolysis and breast tumorigenesis
Xue Han, Chune Ren, Chao Lu, Pengyun Qiao, Tingting Yang, Zhenhai Yu
Cell Death Differ. 2022 Sep; 29(9): 1864–1873. Published online 2022 Mar 16. doi: 10.1038/s41418-022-00971-8
PMCID:
PMC9433372
AbstractArticlePDF–7.3M
20.
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression
Qiangqiang Liu, Qian Luo, Jianyu Feng, Yanping Zhao, Biao Ma, Hongcheng Cheng, Tian Zhao, Hong Lei, Chenglong Mu, Linbo Chen, Yuanyuan Meng, Jiaojiao Zhang, Yijia Long, Jingyi Su, Guo Chen, Yanjun Li, Gang Hu, Xudong Liao, Quan Chen, Yushan Zhu
eLife. 2022; 11: e81247. Published online 2022 Aug 1. doi: 10.7554/eLife.81247
PMCID:
PMC9377797
AbstractArticlePDF–4.9M

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