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Select item 69599961.

Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

Chantell S Evans, Erika LF Holzbaur

eLife. 2020; 9: e50260. Published online 2020 Jan 14. doi: 10.7554/eLife.50260

PMCID:: PMC6959996

Abstract Article PDF–4.1M

Select item 61337492.

Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line

Myoung Sup Shim, Keun-Young Kim, Mark Noh, Ji Yoon Ko, Sangphil Ahn, Michelle A. An, Takeshi Iwata, Guy A. Perkins, Robert N. Weinreb, Won-Kyu Ju

Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Sep 18.

Published in final edited form as: Biochem Biophys Res Commun. 2018 Sep 18; 503(4): 2690–2697. Published online 2018 Aug 9. doi: 10.1016/j.bbrc.2018.08.025

PMCID:: PMC6133749

Abstract Article PDF–1.0M

Select item 55242693.

Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity

Xinxin Hu, Yi Dai, Xinghuai Sun

Mol Vis. 2017; 23: 447–456. Published online 2017 Jul 19.

PMCID:: PMC5524269

Abstract Article PDF–1.7M

Select item 50366204.

From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson’s Disease Models

John Pierce Wise, Jr., Jason Cannon

Toxicol Sci. 2016 Oct; 153(2): 372–381. Published online 2016 Jul 29. doi: 10.1093/toxsci/kfw133

PMCID:: PMC5036620

Abstract Article PDF–1.0M

Select item 48821905.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

Select item 44412156.

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

Nidhi Sahni, Song Yi, Mikko Taipale, Juan I. Fuxman Bass, Jasmin Coulombe-Huntington, Fan Yang, Jian Peng, Jochen Weile, Georgios I. Karras, Yang Wang, István A. Kovács, Atanas Kamburov, Irina Krykbaeva, Mandy H. Lam, George Tucker, Vikram Khurana, Amitabh Sharma, Yang-Yu Liu, Nozomu Yachie, Quan Zhong, Yun Shen, Alexandre Palagi, Adriana San-Miguel, Changyu Fan, Dawit Balcha, Amelie Dricot, Daniel M. Jordan, Jennifer M. Walsh, Akash A. Shah, Xinping Yang, Ani Stoyanova, Alex Leighton, Michael A. Calderwood, Yves Jacob, Michael E. Cusick, Kourosh Salehi-Ashtiani, Luke J. Whitesell, Shamil Sunyaev, Bonnie Berger, Albert-László Barabási, Benoit Charloteaux, David E. Hill, Tong Hao, Frederick P. Roth, Yu Xia, Albertha J.M. Walhout, Susan Lindquist, Marc Vidal

Cell. Author manuscript; available in PMC 2016 Apr 23.

Published in final edited form as: Cell. 2015 Apr 23; 161(3): 647–660. doi: 10.1016/j.cell.2015.04.013

PMCID:: PMC4441215

Abstract Article PDF–1.2M

Select item 44410567.

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

Thomas M. Durcan, Edward A. Fon

Genes Dev. 2015 May 15; 29(10): 989–999. doi: 10.1101/gad.262758.115

PMCID:: PMC4441056

Abstract Article PDF–341K

Select item 42665888.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 42102839.

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

Yvette C. Wong, Erika L. F. Holzbaur

Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42): E4439–E4448. Published online 2014 Oct 7. doi: 10.1073/pnas.1405752111

PMCID:: PMC4210283

Abstract Article PDF–3.0M

Select item 407777310.

Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology

Jie Gao, Masafumi Ohtsubo, Yoshihiro Hotta, Shinsei Minoshima

PLoS One. 2014; 9(7): e101206. Published online 2014 Jul 1. doi: 10.1371/journal.pone.0101206

PMCID:: PMC4077773

Abstract Article PDF–954K

Select item 386878111.

Gel-based Protease Proteomics for Identifying the Novel Calpain Substrates in Dopaminergic Neuronal Cell

Chiho Kim, Nuri Yun, Young Mook Lee, Jae Y. Jeong, Jeong Y. Baek, Hwa Young Song, Chung Ju, Moussa B. H. Youdim, Byung K. Jin, Won-Ki Kim, Young J. Oh

J Biol Chem. 2013 Dec 20; 288(51): 36717–36732. Published online 2013 Nov 14. doi: 10.1074/jbc.M113.492876

PMCID:: PMC3868781

Abstract Article PDF–4.2M

Select item 371453812.

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

Philipp Wild, Hesso Farhan, David G. McEwan, Sebastian Wagner, Vladimir V. Rogov, Nathan R. Brady, Benjamin Richter, Jelena Korac, Oliver Waidmann, Chunaram Choudhary, Volker Dötsch, Dirk Bumann, Ivan Dikic

Science. Author manuscript; available in PMC 2013 Jul 18.

Published in final edited form as: Science. 2011 Jul 8; 333(6039): 228–233. Published online 2011 May 26. doi: 10.1126/science.1205405

PMCID:: PMC3714538

Abstract Article PDF–2.5M

Select item 361021413.

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome

Gaëlle Blandin, Sylvie Marchand, Karine Charton, Nathalie Danièle, Evelyne Gicquel, Jean-Baptiste Boucheteil, Azéddine Bentaib, Laetitia Barrault, Daniel Stockholm, Marc Bartoli, Isabelle Richard

Skelet Muscle. 2013; 3: 3. Published online 2013 Feb 15. doi: 10.1186/2044-5040-3-3

PMCID:: PMC3610214

Abstract Article PDF–1.7M

Select item 344340914.

Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis

Chan-Hyun Na, Drew R. Jones, Yanling Yang, Xusheng Wang, Yanji Xu, Junmin Peng

J Proteome Res. Author manuscript; available in PMC 2013 Sep 7.

Published in final edited form as: J Proteome Res. 2012 Sep 7; 11(9): 4722–4732. Published online 2012 Aug 15. doi: 10.1021/pr300536k

PMCID:: PMC3443409

Abstract Article PDF–4.2M

Select item 335795215.

Differential Involvement of Optineurin in Amyotrophic Lateral Sclerosis With or Without SOD1 Mutations

Dr Han-Xiang Deng, Dr Eileen H. Bigio, Dr Hong Zhai, Dr Faisal Fecto, Dr Kaouther Ajroud, Dr Yong Shi, Dr Jianhua Yan, Dr Manjari Mishra, Dr Senda Ajroud-Driss, Dr Scott Heller, Dr Robert Sufit, Mss Nailah Siddique, Dr Enrico Mugnaini, Dr Teepu Siddique

Arch Neurol. Author manuscript; available in PMC 2012 May 22.

Published in final edited form as: Arch Neurol. 2011 Aug; 68(8): 1057–1061. doi: 10.1001/archneurol.2011.178

PMCID:: PMC3357952

Abstract Article PDF–1.6M

Select item 324448916.

Effects of optineurin siRNA on apoptotic genes and apoptosis in RGC-5 cells

Hongyang Li, Xiuqin Ao, Juan Jia, Qingzhong Wang, Zhongzhi Zhang

Mol Vis. 2011; 17: 3314–3325. Published online 2011 Dec 17.

PMCID:: PMC3244489

Abstract Article PDF–881K

Select item 321719217.

Genome wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget’s disease of bone

Omar ME Albagha, Micaela R Visconti, Nerea Alonso, Anne L Langston, Tim Cundy, Rosemary Dargie, Malcolm G Dunlop, William D Fraser, Michael J Hooper, Gianluca Isaia, Geoff C Nicholson, Javier del Pino Montes, Rogelio Gonzalez-Sarmiento, Marco di Stefano, Albert Tenesa, John P Walsh, Stuart H Ralston

Nat Genet. Author manuscript; available in PMC 2011 Nov 16.

Published in final edited form as: Nat Genet. 2010 Jun; 42(6): 520–524. Published online 2010 May 2. doi: 10.1038/ng.562

PMCID:: PMC3217192

Abstract Article PDF–629K

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 303036619.

Processing of Optineurin in Neuronal Cells

Xiang Shen, Hongyu Ying, Ye Qiu, Jeong-Seok Park, Rajalekshmy Shyam, Zai-Long Chi, Takeshi Iwata, Beatrice Y. J. T. Yue

J Biol Chem. 2011 Feb 4; 286(5): 3618–3629. Published online 2010 Nov 8. doi: 10.1074/jbc.M110.175810

PMCID:: PMC3030366

Abstract Article PDF–5.4M

Select item 288585220.

Disease Gene Candidates Revealed by Expression Profiling of Retinal Ganglion Cell Development

Jack T. Wang, Noelia J. Kunzevitzky, Jason C. Dugas, Meghan Cameron, Ben A. Barres, Jeffrey L. Goldberg

J Neurosci. 2007 Aug 8; 27(32): 8593–8603. doi: 10.1523/JNEUROSCI.4488-06.2007

PMCID:: PMC2885852

Abstract Article PDF–504K

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