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Select item 104474331.

Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis

Fenyong Yao, Shisheng Huang, Jiahui Liu, Chunhua Tan, Mengqi Xu, Dengkui Wang, Maoqing Huang, Yiyao Zhu, Xingxu Huang, Shuijin He

Cell Death Dis. 2023 Aug; 14(8): 543. Published online 2023 Aug 23. doi: 10.1038/s41419-023-06071-w

PMCID:: PMC10447433

Abstract Article PDF–9.2M

Select item 104258492.

LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates

Qiannan Guo, Yihui Li, Yunmei Zhang, Liping Shen, Huayue Lin, Jianing Chen, Erwei Song, Man‐Li Luo

EMBO J. 2023 Aug; 42(16): e112414. Published online 2023 Jun 29. doi: 10.15252/embj.2022112414

PMCID:: PMC10425849

Abstract Article PDF–18M

Select item 92358753.

Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis

Sabrina Shameen Alam, Shruti Kumar, Marie-Claude Beauchamp, Eric Bareke, Alexia Boucher, Nadine Nzirorera, Yanchen Dong, Reinnier Padilla, Si Jing Zhang, Jacek Majewski, Loydie A. Jerome-Majewska

Dis Model Mech. 2022 Jun 1; 15(6): dmm049544. Published online 2022 Jun 23. doi: 10.1242/dmm.049544

PMCID:: PMC9235875

Abstract Article

Select item 90912174.

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss

Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5

PMCID:: PMC9091217

Abstract Article PDF–7.2M

Select item 85756615.

MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

Koki Ueda, Rajni Kumari, Emily Schwenger, Justin C. Wheat, Oliver Bohorquez, Swathi-Rao Narayanagari, Samuel J. Taylor, Luis A. Carvajal, Kith Pradhan, Boris Bartholdy, Tihomira I. Todorova, Hiroki Goto, Daqian Sun, Jiahao Chen, Jidong Shan, Yinghui Song, Cristina Montagna, Shunbin Xiong, Guillermina Lozano, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, Ulrich Steidl

Cancer Cell. Author manuscript; available in PMC 2022 Apr 12.

Published in final edited form as: Cancer Cell. 2021 Apr 12; 39(4): 529–547.e7. Published online 2021 Mar 4. doi: 10.1016/j.ccell.2021.02.006

PMCID:: PMC8575661

Abstract Article PDF–3.7M

Select item 85610066.

The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation

Herui Wang, Bin Li, Kulsum Asha, Ryan L. Pangilinan, Asha Thuraisamy, Harman Chopra, Susumu Rokudai, Yong Yu, Carol L. Prives, Yan Zhu

J Biol Chem. 2021 Nov; 297(5): 101292. Published online 2021 Oct 8. doi: 10.1016/j.jbc.2021.101292

PMCID:: PMC8561006

Abstract Article PDF–3.4M

Select item 84594617.

MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail

Jack D. Sanford, Jing Yang, Jing Han, Laura A. Tollini, Aiwen Jin, Yanping Zhang

BMC Mol Cell Biol. 2021; 22: 46. Published online 2021 Sep 22. doi: 10.1186/s12860-021-00385-3

PMCID:: PMC8459461

Abstract Article PDF–1.1M

Select item 83191238.

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

Gerald C. Tiu, Craig H. Kerr, Craig M. Forester, Pallavi S. Krishnarao, Hannah D. Rosenblatt, Nitin Raj, Travis C. Lantz, Olena Zhulyn, Margot E. Bowen, Leila Shokat, Laura D. Attardi, Davide Ruggero, Maria Barna

Dev Cell. Author manuscript; available in PMC 2022 Jul 26.

Published in final edited form as: Dev Cell. 2021 Jul 26; 56(14): 2089–2102.e11. Published online 2021 Jul 8. doi: 10.1016/j.devcel.2021.06.013

PMCID:: PMC8319123

Abstract Article PDF–2.5M

Select item 80265499.

MDMX recruits UbcH5c to facilitate MDM2 E3 ligase activity and subsequent p53 degradation in vivo

Jing Yang, Aiwen Jin, Jing Han, Xin Chen, Junnian Zheng, Yanping Zhang

Cancer Res. Author manuscript; available in PMC 2021 Aug 15.

Published in final edited form as: Cancer Res. 2021 Feb 15; 81(4): 898–909. Published online 2020 Dec 4. doi: 10.1158/0008-5472.CAN-20-0790

PMCID:: PMC8026549

Abstract Article PDF–1.7M

Select item 795326710.

Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice

Jing Qu, Shan-Zhong Yang, Yi Zhu, Ting Guo, Victor J. Thannickal, Yong Zhou

J Exp Med. 2021 May 3; 218(5): e20202033. Published online 2021 Mar 10. doi: 10.1084/jem.20202033

PMCID:: PMC7953267

Abstract Article PDF–6.4M

Select item 774974211.

MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment

Bing Wang, Chuan-Bian Lim, Jiawei Yan, Lizhen Li, Jufang Wang, John B Little, Zhi-Min Yuan

J Mol Cell Biol. 2020 Sep; 12(9): 713–722. Published online 2020 Jul 24. doi: 10.1093/jmcb/mjaa038

PMCID:: PMC7749742

Abstract Article PDF–1.0M

Select item 752102112.

Mdm4 supports DNA replication in a p53-independent fashion

Kai Wohlberedt, Ina Klusmann, Polina K. Derevyanko, Kester Henningsen, Josephine Ann Mun Yee Choo, Valentina Manzini, Anna Magerhans, Celeste Giansanti, Christine M. Eischen, Aart G. Jochemsen, Matthias Dobbelstein

Oncogene. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Oncogene. 2020 Jun; 39(25): 4828–4843. Published online 2020 May 19. doi: 10.1038/s41388-020-1325-1

PMCID:: PMC7521021

Abstract Article PDF–2.2M

Select item 749494113.

CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells

Monika Štětková, Kateřina Growková, Petr Fojtík, Barbora Valčíková, Veronika Palušová, Amandine Verlande, Radek Jorda, Vladimír Kryštof, Václav Hejret, Panagiotis Alexiou, Vladimír Rotrekl, Stjepan Uldrijan

Cell Death Dis. 2020 Sep; 11(9): 754. Published online 2020 Sep 15. doi: 10.1038/s41419-020-02971-3

PMCID:: PMC7494941

Abstract Article PDF–2.2M

Select item 748706514.

Mdm4 controls ureteric bud branching via regulation of p53 activity

Sylvia A. Hilliard, Yuwen Li, Angelina Dixon, Samir S. El-Dahr

Mech Dev. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Mech Dev. 2020 Sep; 163: 103616. Published online 2020 May 25. doi: 10.1016/j.mod.2020.103616

PMCID:: PMC7487065

Abstract Article PDF–4.3M

Select item 736849415.

The sperm associated antigen 6 interactome and its role in spermatogenesis

Yunhao Liu, Ling Zhang, Wei Li, Yuhong Li, Junpin Liu, Shiyang Zhang, Guanglun Pin, Shizhen Song, Pierre F Ray, Christophe Arnoult, Chunghee Cho, Balbina Garcia-Reyes, Uwe Knippschild, Jerome F. Strauss, III, Zhibing Zhang

Reproduction. Author manuscript; available in PMC 2020 Jul 18.

Published in final edited form as: Reproduction. 2019 Aug; 158(2): 181–197. doi: 10.1530/REP-18-0522

PMCID:: PMC7368494

Abstract Article PDF–1.8M

Select item 736128516.

MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling

Qingling Huang, Lihong Chen, Ernst Schonbrunn, Jiandong Chen

EMBO J. 2020 Jul 15; 39(14): e104410. Published online 2020 Jun 8. doi: 10.15252/embj.2020104410

PMCID:: PMC7361285

Abstract Article PDF–3.7M

Select item 665035517.

The spatiotemporal pattern and intensity of p53 activation during embryogenesis dictates phenotypic diversity in p53-driven developmental syndromes

Margot E. Bowen, Jacob McClendon, Hannah K. Long, Aryo Sorayya, Jeanine L. Van Nostrand, Joanna Wysocka, Laura D. Attardi

Dev Cell. Author manuscript; available in PMC 2020 Jul 22.

Published in final edited form as: Dev Cell. 2019 Jul 22; 50(2): 212–228.e6. Published online 2019 Jun 6. doi: 10.1016/j.devcel.2019.05.015

PMCID:: PMC6650355

Abstract Article PDF–4.1M

Select item 639101018.

Role of smooth muscle cell p53 in pulmonary arterial hypertension

Takayuki Wakasugi, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Masaaki Nakao, Makoto Hoyano, Takeshi Kashimura, Kazufumi Nakamura, Hiroshi Ito, Takashi Nojiri, Tomoyoshi Soga, Tohru Minamino

PLoS One. 2019; 14(2): e0212889. Published online 2019 Feb 26. doi: 10.1371/journal.pone.0212889

PMCID:: PMC6391010

Abstract Article PDF–1.5M

Select item 607514819.

Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy

Meaghan Van Alstyne, Christian M. Simon, S. Pablo Sardi, Lamya S. Shihabuddin, George Z. Mentis, Livio Pellizzoni

Genes Dev. 2018 Aug 1; 32(15-16): 1045–1059. doi: 10.1101/gad.316059.118

PMCID:: PMC6075148

Abstract Article PDF–15M

Select item 589945020.

MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis

Qingling Huang, Lihong Chen, Leixiang Yang, Xiaoling Xie, Lin Gan, John L. Cleveland, Jiandong Chen

Proc Natl Acad Sci U S A. 2018 Apr 10; 115(15): E3368–E3377. Published online 2018 Mar 26. doi: 10.1073/pnas.1719090115

PMCID:: PMC5899450

Abstract Article PDF–2.0M

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