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Select item 113461811.

Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells

Xuan Luo, Di Zhang, Jiaming Zheng, Hui Liu, Longjie Sun, Hongzhou Guo, Lei Wang, Sheng Cui

BMC Biol. 2024; 22: 176. Published online 2024 Aug 26. doi: 10.1186/s12915-024-01957-3

PMCID:: PMC11346181

Abstract Article PDF–2.9M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104702613.

Sex disparities in non-small cell lung cancer: mechanistic insights from a cRaf transgenic disease model

Shen Zhong, Jürgen Borlak

eBioMedicine. 2023 Sep; 95: 104763. Published online 2023 Aug 23. doi: 10.1016/j.ebiom.2023.104763

PMCID:: PMC10470261

Abstract Article PDF–8.0M

Select item 103078524.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 101776835.

SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus

Wenwen Geng, Meiling Cao, Ke Dong, Junhua An, Haidong Gao

Cancer Biol Ther. 2023; 24(1): 2206362. Published online 2023 May 11. doi: 10.1080/15384047.2023.2206362

PMCID:: PMC10177683

Abstract Article PDF–2.5M

Select item 101324476.

COMPLETE REGRESSION OF ADVANCED PANCREATIC DUCTAL ADENOCARCINOMAS UPON COMBINED INHIBITION OF EGFR AND C-RAF

María Teresa Blasco, Carolina Navas, Guillermo Martín-Serrano, Osvaldo Graña-Castro, Carmen G. Lechuga, Laura Martín-Díaz, Magdolna Djurec, Jing Li, Lucia Morales-Cacho, Laura Esteban-Burgos, Javier Perales-Patón, Emilie Bousquet-Mur, Eva Castellano, Harrys K.C. Jacob, Lavinia Cabras, Monica Musteanu, Matthias Drosten, Sagrario Ortega, Francisca Mulero, Bruno Sainz, Jr., Nelson Dusetti, Juan Iovanna, Francisco Sánchez-Bueno, Manuel Hidalgo, Hossein Khiabanian, Raul Rabadán, Fátima Al-Shahrour, Carmen Guerra, Mariano Barbacid

Cancer Cell. Author manuscript; available in PMC 2023 Apr 26.

Published in final edited form as: Cancer Cell. 2019 Apr 15; 35(4): 573–587.e6. Published online 2019 Apr 8. doi: 10.1016/j.ccell.2019.03.002

PMCID:: PMC10132447

Abstract Article PDF–1.2M

Select item 85770997.

Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells

Xin Wang, Xiaoxiao Wang, Xinbao Zhang, Yan Zhang, Zhenhua Zhu, Yuting Li, Meng Zhang, Junxiang Ji, Yang Yu, Shou-Dong Ye

J Biol Chem. 2021 Nov; 297(5): 101332. Published online 2021 Oct 22. doi: 10.1016/j.jbc.2021.101332

PMCID:: PMC8577099

Abstract Article PDF–6.0M

Select item 83132398.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 79681449.

Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó

Cell Rep. Author manuscript; available in PMC 2021 Mar 17.

Published in final edited form as: Cell Rep. 2021 Feb 9; 34(6): 108729. doi: 10.1016/j.celrep.2021.108729

PMCID:: PMC7968144

Abstract Article PDF–1.7M

Select item 777477810.

MicroRNA-7a2 Regulates Prolactin in Developing Lactotrophs and Prolactinoma Cells

Mary P LaPierre, Svenja Godbersen, Mònica Torres Esteban, Anaïs Nura Schad, Mathias Treier, Umesh Ghoshdastider, Markus Stoffel

Endocrinology. 2021 Feb; 162(2): bqaa220. Published online 2020 Nov 28. doi: 10.1210/endocr/bqaa220

PMCID:: PMC7774778

Abstract Article

Select item 753384111.

Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas

Laura Esteban-Burgos, Haiyun Wang, Patricia Nieto, Jie Zheng, Carmen Blanco-Aparicio, Carmen Varela, Gonzalo Gómez-López, Fernando Fernández-García, Manuel Sanclemente, Carmen Guerra, Matthias Drosten, Javier Galán, Eduardo Caleiras, Jorge Martínez-Torrecuadrada, Lluis Fajas, Sheng-Bin Peng, David Santamaría, Monica Musteanu, Mariano Barbacid

Proc Natl Acad Sci U S A. 2020 Sep 29; 117(39): 24415–24426. Published online 2020 Sep 10. doi: 10.1073/pnas.2002520117

PMCID:: PMC7533841

Abstract Article PDF–2.0M

Select item 743099212.

A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations

Yoshiro Niitsu, Yasushi Sato, Kunihiro Takanashi, Tsuyoshi Hayashi, Naoko Kubo-Birukawa, Fumiko Shimizu, Naoki Fujitani, Rai Shimoyama, Takehiro Kukitsu, Wataru Kurata, Yasuyuki Tashiro, Irving Listowsky

Proc Natl Acad Sci U S A. 2020 Aug 11; 117(32): 19435–19445. Published online 2020 Jul 27. doi: 10.1073/pnas.2000361117

PMCID:: PMC7430992

Abstract Article PDF–1.9M

Select item 741599113.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 679335414.

p21 Ras and Phosphatidylinositol-3 Kinase Are Required for Survival of Wild-Type and NF1 Mutant Sensory Neurons

Laura J. Klesse, Luis F. Parada

J Neurosci. 1998 Dec 15; 18(24): 10420–10428. doi: 10.1523/JNEUROSCI.18-24-10420.1998

PMCID:: PMC6793354

Abstract Article PDF–677K

Select item 662238215.

Raf Kinase Inhibitory Protein is Required for Cerebellar Long-Term Synaptic Depression by Mediating PKC-Dependent MAPK Activation

Yukio Yamamoto, Dongwon Lee, Yoonhee Kim, Bokyoung Lee, Changwoo Seo, Hiroshi Kawasaki, Shinya Kuroda, Keiko Tanaka-Yamamoto

J Neurosci. 2012 Oct 10; 32(41): 14254–14264. doi: 10.1523/JNEUROSCI.2812-12.2012

PMCID:: PMC6622382

Abstract Article PDF–3.7M

Select item 650243516.

The Noonan Syndrome-linked Raf1^L613V mutation drives increased glial number in the mouse cortex and enhanced learning

Michael C. Holter, Lauren. T. Hewitt, Stephanie V. Koebele, Jessica M. Judd, Lei Xing, Heather A. Bimonte-Nelson, Cheryl D. Conrad, Toshiyuki Araki, Benjamin G. Neel, William D. Snider, Jason M. Newbern

PLoS Genet. 2019 Apr; 15(4): e1008108. Published online 2019 Apr 24. doi: 10.1371/journal.pgen.1008108

PMCID:: PMC6502435

Abstract Article PDF–8.7M

Select item 613965517.

Inhibition of Raf1 ameliorates bleomycin-induced pulmonary fibrosis through attenuation of TGF-β1 signaling

Shuang Li, Jia Liu, Jiangning Tan, Lian Li, Mary J. Kaltreider, Jing Zhao, Daniel J. Kass, Dong Shang, Yutong Zhao

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1; 315(2): L241–L247. Published online 2018 May 3. doi: 10.1152/ajplung.00093.2018

PMCID:: PMC6139655

Abstract Article

Select item 612300018.

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43

Chen Yuan Kam, Adi D. Dubash, Elisa Magistrati, Simona Polo, Karla J.F. Satchell, Farah Sheikh, Paul D. Lampe, Kathleen J. Green

J Cell Biol. 2018 Sep 3; 217(9): 3219–3235. doi: 10.1083/jcb.201710161

PMCID:: PMC6123000

Abstract Article PDF–3.0M

Select item 598414319.

PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway

Bhanu Kanth Manne, Patrick Münzer, Rachit Badolia, Britta Walker-Allgaier, Robert A Campbell, Elizabeth Middleton, Andrew S Weyrich, Satya P Kunapuli, Oliver Borst, Matthew T. Rondina

J Thromb Haemost. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: J Thromb Haemost. 2018 Jun; 16(6): 1211–1225. Published online 2018 May 8. doi: 10.1111/jth.14005

PMCID:: PMC5984143

Abstract Article PDF–1.0M

Select item 587393820.

Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF

Verena Pfeiffer, Rudolf Götz, Guadelupe Camarero, Helmut Heinsen, Robert Blum, Ulf Rüdiger Rapp

PLoS One. 2018; 13(3): e0192067. Published online 2018 Mar 28. doi: 10.1371/journal.pone.0192067

PMCID:: PMC5873938

Abstract Article PDF–34M

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