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Items: 1 to 20 of 68

1.
Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis
Silvia Sozzi, Isabella Manni, Cristiana Ercolani, Maria Grazia Diodoro, Armando Bartolazzi, Francesco Spallotta, Giulia Piaggio, Laura Monteonofrio, Silvia Soddu, Cinzia Rinaldo, Davide Valente
J Exp Clin Cancer Res. 2024; 43: 265. Published online 2024 Sep 28. doi: 10.1186/s13046-024-03189-3
PMCID:
PMC11437985
AbstractArticlePDF–3.3M
2.
HIPK2 C-terminal domain inhibits NF-κB signaling and renal inflammation in kidney injury
Ye Feng, Zhengzhe Li, Heather Wang, Bi-Cheng Liu, Kyung Lee, John Cijiang He
JCI Insight. 2024 Apr 22; 9(8): e175153. Published online 2024 Mar 21. doi: 10.1172/jci.insight.175153
PMCID:
PMC11141872
AbstractArticlePDF–4.1M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High Glucose-Induced Glomerular Mesangial Cells
Wen Zhong, Chen Hong, Yejun Dong, Yuhui Li, Chenxi Xiao, Xinhua Liu
Genes (Basel) 2022 Dec; 13(12): 2244. Published online 2022 Nov 29. doi: 10.3390/genes13122244
PMCID:
PMC9816940
AbstractArticlePDF–7.5M
5.
E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury
Yu Gao, Xinyu Xiao, Jing Luo, Jianwei Wang, Qiling Peng, Jing Zhao, Ning Jiang, Yong Zhao
Int J Mol Sci. 2022 Nov; 23(21): 13648. Published online 2022 Nov 7. doi: 10.3390/ijms232113648
PMCID:
PMC9658360
AbstractArticlePDF–14M
6.
Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling
Qiulian Zhou, Danni Meng, Feng Li, Xiao Zhang, Li Liu, Yujiao Zhu, Shuqin Liu, Minjun Xu, Jiali Deng, Zhiyong Lei, Joost P.G. Sluijter, Junjie Xiao
eBioMedicine. 2022 Nov; 85: 104274. Published online 2022 Sep 28. doi: 10.1016/j.ebiom.2022.104274
PMCID:
PMC9526139
AbstractArticlePDF–4.1M
7.
HIPK2 directs cell type–specific regulation of STAT3 transcriptional activity in Th17 cell differentiation
Ka Lung Cheung, Anbalagan Jaganathan, Yuan Hu, Feihong Xu, Alannah Lejeune, Rajal Sharma, Cristina I. Caescu, Jamel Meslamani, Adam Vincek, Fan Zhang, Kyung Lee, Nilesh Zaware, Amina Abdul Qayum, Chunyan Ren, Mark H. Kaplan, John Cijiang He, Huabao Xiong, Ming-Ming Zhou
Proc Natl Acad Sci U S A. 2022 Apr 5; 119(14): e2117112119. Published online 2022 Mar 28. doi: 10.1073/pnas.2117112119
PMCID:
PMC9168845
AbstractArticlePDF–2.0M
8.
Phenotypic Effects of Homeodomain-Interacting Protein Kinase 2 Deletion in Mice
Davide De Biase, Valeria Valente, Andrea Conte, Francesca Cammarota, Nicola Boccella, Lucia D’Esposito, Ilaria d’Aquino, Orlando Paciello, Simona Paladino, Giovanna Maria Pierantoni
Int J Mol Sci. 2021 Aug; 22(15): 8294. Published online 2021 Aug 2. doi: 10.3390/ijms22158294
PMCID:
PMC8348407
AbstractArticlePDF–3.0M
9.
HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis
Fang Zhang, Linlin Qi, Qiuyun Feng, Baokai Zhang, Xiangyue Li, Chang Liu, Weiyun Li, Qiaojie Liu, Dan Yang, Yue Yin, Chao Peng, Han Wu, Zhao-Hui Tang, Xi Zhou, Zou Xiang, Zhijiang Zhang, Hongyan Wang, Bin Wei
Proc Natl Acad Sci U S A. 2021 Jul 13; 118(28): e2021798118. Published online 2021 Jul 9. doi: 10.1073/pnas.2021798118
PMCID:
PMC8285910
AbstractArticlePDF–3.5M
10.
Tubular HIPK2 is a key contributor to renal fibrosis
Wenzhen Xiao, Jing E, Li Bao, Ying Fan, Yuanmeng Jin, Andrew Wang, David Bauman, Zhengzhe Li, Ya-Li Zheng, Ruijie Liu, Kyung Lee, John Cijiang He
JCI Insight. 2020 Sep 3; 5(17): e136004. Published online 2020 Sep 3. doi: 10.1172/jci.insight.136004
PMCID:
PMC7526443
AbstractArticlePDF–20M
11.
Cardiomyocyte HIPK2 Maintains Basal Cardiac Function via ERK Signaling
Yuanjun Guo, Jennifer Y. Sui, Kyungsoo Kim, Zhentao Zhang, Xiaoyan A. Qu, Young-Jae Nam, Robert N. Willette, Joey V. Barnett, Bjorn C. Knollmann, Thomas Force, Hind Lal
Circulation. Author manuscript; available in PMC 2020 Nov 26.
Published in final edited form as: Circulation. 2019 Nov 26; 140(22): 1820–1833. Published online 2019 Oct 4. doi: 10.1161/CIRCULATIONAHA.119.040740
PMCID:
PMC7219521
AbstractArticlePDF–4.5M
12.
Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover
Jiasheng Zhang, Yulei Shang, Sherry Kamiya, Sarah J. Kotowski, Ken Nakamura, Eric J. Huang
J Neurosci. 2020 Jan 15; 40(3): 557–568. doi: 10.1523/JNEUROSCI.2017-19.2019
PMCID:
PMC6961984
AbstractArticlePDF–4.0M
13.
HIPK2 is necessary for type I interferon–mediated antiviral immunity
Lili Cao, Guang Yang, Shandian Gao, Chunxia Jing, Ruth R. Montgomery, Yuxin Yin, Penghua Wang, Erol Fikrig, Fuping You
Sci Signal. Author manuscript; available in PMC 2019 Dec 5.
Published in final edited form as: Sci Signal. 2019 Mar 19; 12(573): eaau4604. Published online 2019 Mar 19. doi: 10.1126/scisignal.aau4604
PMCID:
PMC6893850
AbstractArticlePDF–2.4M
14.
Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice
Raffaele Gerlini, Elena Amendola, Andrea Conte, Valeria Valente, Mara Tornincasa, Sara Carmela Credendino, Francesca Cammarota, Chiara Gentile, Luigi Di Guida, Simona Paladino, Gabriella De Vita, Alfredo Fusco, Giovanna Maria Pierantoni
Cell Death Dis. 2019 Oct; 10(10): 747. Published online 2019 Oct 3. doi: 10.1038/s41419-019-1975-5
PMCID:
PMC6776533
AbstractArticlePDF–5.8M
15.
EGFR drives the progression of AKI to CKD through HIPK2 overexpression
Luyang Xu, Xiaozhou Li, Fei Zhang, Lidong Wu, Zheng Dong, Dongshan Zhang
Theranostics. 2019; 9(9): 2712–2726. Published online 2019 Apr 13. doi: 10.7150/thno.31424
PMCID:
PMC6526000
AbstractArticlePDF–3.5M
16.
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia
Ki Sa Sung, Sun-Jick Kim, Sang Woo Cho, Ye-Jin Park, Kun Tae, Cheol Yong Choi
Am J Cancer Res. 2019; 9(1): 94–107. Published online 2019 Jan 1.
PMCID:
PMC6356924
AbstractArticlePDF–2.5M
17.
Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy
Zhengyu Jiang, Lulong Bo, Yan Meng, Chen Wang, Tianxing Chen, Changli Wang, Xiya Yu, Xiaoming Deng
Cell Death Dis. 2018 Sep; 9(9): 847. Published online 2018 Aug 28. doi: 10.1038/s41419-018-0838-9
PMCID:
PMC6113252
AbstractArticlePDF–3.2M
18.
Thymic tuft cells promote an IL4-enriched medulla and shape thymocyte development
Corey N. Miller, Irina Proekt, Jakob von Moltke, Kristen L. Wells, Aparna R. Rajpurkar, Haiguang Wang, Kristin Rattay, Imran S. Khan, Todd C. Metzger, Joshua L. Pollack, Adam C. Fries, Wint W. Lwin, Eric J. Wigton, Audrey V. Parent, Bruno Kyewski, David J. Erle, Kristin A. Hogquist, Lars M. Steinmetz, Richard M. Locksley, Mark S. Anderson
Nature. Author manuscript; available in PMC 2019 Jan 18.
Published in final edited form as: Nature. 2018 Jul; 559(7715): 627–631. Published online 2018 Jul 18. doi: 10.1038/s41586-018-0345-2
PMCID:
PMC6062473
AbstractArticlePDF–3.8M
19.
HIPK2-Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death
Yulei Shang, Jiasheng Zhang, Eric J. Huang
J Neurosci. 2018 Apr 18; 38(16): 4006–4019. doi: 10.1523/JNEUROSCI.3577-17.2018
PMCID:
PMC5907057
AbstractArticlePDF–4.8M
20.
Effects of Y361‐auto‐phosphorylation on structural plasticity of the HIPK2 kinase domain
Antonella Scaglione, Laura Monteonofrio, Giacomo Parisi, Cristina Cecchetti, Francesca Siepi, Cinzia Rinaldo, Alessandra Giorgi, Daniela Verzili, Carlotta Zamparelli, Carmelinda Savino, Silvia Soddu, Beatrice Vallone, Linda Celeste Montemiglio
Protein Sci. 2018 Mar; 27(3): 725–737. Published online 2017 Dec 28. doi: 10.1002/pro.3367
PMCID:
PMC5818748
AbstractArticlePDF–1.4M

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