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Select item 108687891.

Distinct roles for type I and type III interferons in virulent human metapneumovirus pathogenesis

Yu Zhang, Jiuyang Xu, Margot Miranda-Katz, Jorna Sojati, Sharon J. Tollefson, Michelle L. Manni, John F. Alcorn, Saumendra N. Sarkar, John V. Williams

PLoS Pathog. 2024 Feb; 20(2): e1011840. Published online 2024 Feb 5. doi: 10.1371/journal.ppat.1011840

PMCID:: PMC10868789

Abstract Article PDF–2.8M

Select item 108208802.

Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains

Ines Ambite, Thi Hien Tran, Daniel S. C. Butler, Michele Cavalera, Murphy Lam Yim Wan, Shahram Ahmadi, Catharina Svanborg

Pathogens. 2024 Jan; 13(1): 42. Published online 2023 Dec 31. doi: 10.3390/pathogens13010042

PMCID:: PMC10820880

Abstract Article PDF–4.1M

Select item 107493323.

NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner

Mégane Nascimento, Sarah Huot-Marchand, Manoussa Fanny, Marjolène Straube, Marc Le Bert, Florence Savigny, Lionel Apetoh, Jacques Van Snick, Fabrice Trovero, Mathias Chamaillard, Valérie F. J. Quesniaux, Bernhard Ryffel, Philippe Gosset, Aurélie Gombault, Nicolas Riteau, Harry Sokol, Isabelle Couillin

Front Immunol. 2023; 14: 1224383. Published online 2023 Dec 11. doi: 10.3389/fimmu.2023.1224383

PMCID:: PMC10749332

Abstract Article PDF–8.1M

Select item 103260104.

ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler’s murine encephalomyelitis virus

Dandan Li, Melanie Bühler, Sandra Runft, Gisa Gerold, Katarzyna Marek, Wolfgang Baumgärtner, Till Strowig, Ingo Gerhauser

Sci Rep. 2023; 13: 10960. Published online 2023 Jul 6. doi: 10.1038/s41598-023-38152-3

PMCID:: PMC10326010

Abstract Article PDF–4.1M

Select item 102446725.

IL11 activates the placental inflammasome to drive preeclampsia

Ellen Menkhorst, Leilani L. Santos, Wei Zhou, Guannan Yang, Amy L. Winship, Katarzyna E. Rainczuk, Philana Nguyen, Jian-Guo Zhang, Paddy Moore, Michelle Williams, Kim-Anh Lê Cao, Ashley Mansell, Evdokia Dimitriadis

Front Immunol. 2023; 14: 1175926. Published online 2023 May 24. doi: 10.3389/fimmu.2023.1175926

PMCID:: PMC10244672

Abstract Article PDF–15M

Select item 101950326.

Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity

Ravi Bharadwaj, Christina F. Lusi, Siavash Mashayekh, Abhinit Nagar, Okuda, Amanda Monahan, Donggi Paik, Anubhab Nandy, Madison V. Anonick, William E. Goldman, Thirumala-Devi Kanneganti, Megan H. Orzalli, Catherine Leimkuhler Grimes, Prabhani U. Atukorale, Neal Silverman

Immunity. Author manuscript; available in PMC 2024 May 9.

Published in final edited form as: Immunity. 2023 May 9; 56(5): 998–1012.e8. Published online 2023 Apr 27. doi: 10.1016/j.immuni.2023.04.001

PMCID:: PMC10195032

Abstract Article PDF–2.5M

Select item 101599197.

The adjuvant combination of dmLT and MPL-A activates the canonical, non-pyroptotic NLRP3 inflammasome in dendritic cells and significantly interact to expand antigen-specific CD4 T cells

David L. Bauer, Louay Bachnak, Vanessa M. Limbert, Rebecca M. Horowitz, Robin L. Baudier, Shaina J D’Souza, Victoria E. Immethun, Jonathan R Kurtz, Samuel B. Grant, James B. McLachlan

J Immunol. Author manuscript; available in PMC 2024 May 15.

Published in final edited form as: J Immunol. 2023 May 15; 210(10): 1519–1530. doi: 10.4049/jimmunol.2200221

PMCID:: PMC10159919

Abstract Article PDF–1.7M

Select item 100665768.

ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery

Manuel O. Jakob, Daniel Spari, Daniel Sànchez Taltavull, Lilian Salm, Bahtiyar Yilmaz, Rémi Doucet Ladevèze, Catherine Mooser, David Pereyra, Ye Ouyang, Theresa Schmidt, Irene Mattiola, Patrick Starlinger, Deborah Stroka, Franziska Tschan, Daniel Candinas, Georg Gasteiger, Christoph S.N. Klose, Andreas Diefenbach, Mercedes Gomez de Agüero, Guido Beldi

Cell Rep. 2023 Mar 28; 42(3): 112269. Published online 2023 Mar 17. doi: 10.1016/j.celrep.2023.112269

PMCID:: PMC10066576

Abstract Article

Select item 100269849.

Cigarette smoke depletes alveolar macrophages and delays clearance of Legionella pneumophila

Markus Fleischmann, Andrew G. Jarnicki, Andrew S. Brown, Chao Yang, Gary P. Anderson, Natalio Garbi, Elizabeth L. Hartland, Ian R. van Driel, Garrett Z. Ng

Am J Physiol Lung Cell Mol Physiol. 2023 Mar 1; 324(3): L373–L384. Published online 2023 Jan 31. doi: 10.1152/ajplung.00268.2022

PMCID:: PMC10026984

Abstract Article

Select item 988706910.

Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3

Jae-Sung Kim, Hyo Keun Kim, Joongho Lee, Sein Jang, Euni Cho, Seok-Jun Mun, Seokhyun Yoon, Chul-Su Yang

Cell Mol Immunol. 2023 Feb; 20(2): 189–200. Published online 2023 Jan 5. doi: 10.1038/s41423-022-00971-1

PMCID:: PMC9887069

Abstract Article PDF–5.0M

Select item 984421311.

DPP9 deficiency: an Inflammasomopathy which can be rescued by lowering NLRP1/IL-1 signaling

Cassandra R. Harapas, Kim S. Robinson, Kenneth Lay, Jasmine Wong, Ricardo Moreno Traspas, Nasrin Nabavizadeh, Annick Rass-Rothschild, Bertrand Boisson, Scott B. Drutman, Pawat Laohamonthonkul, Devon Bonner, Jingwei Rachel Xiong, Mark D. Gorrell, Sophia Davidson, Chien-Hsiung Yu, Mark D. Fleming, Jonas Gudera, Jerry Stein, Miriam Ben-Harosh, Emily Groopman, Akiko Shimamura, Hannah Tamary, Hülya Kayserili, Nevin Hatipoğlu, Jean-Laurent Casanova, Jonathan A. Bernstein, Franklin L. Zhong, Seth L. Masters, Bruno Reversade

Sci Immunol. Author manuscript; available in PMC 2023 Mar 16.

Published in final edited form as: Sci Immunol. 2022 Sep 16; 7(75): eabi4611. Published online 2022 Sep 16. doi: 10.1126/sciimmunol.abi4611

PMCID:: PMC9844213

Abstract Article PDF–1.7M

Select item 950485112.

Role of Caspases and Gasdermin A during HSV-1 Infection in Mice

Lupeng Li, Stephen B. Kovacs, Ine Jørgensen, Heather N. Larson, Helen M. Lazear, Edward A. Miao

Viruses. 2022 Sep; 14(9): 2034. Published online 2022 Sep 13. doi: 10.3390/v14092034

PMCID:: PMC9504851

Abstract Article PDF–2.2M

Select item 934597813.

Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation

Ting Xu, Weiwei Yu, Hui Fang, Zhen Wang, Zhexu Chi, Xingchen Guo, Danlu Jiang, Kailian Zhang, Sheng Chen, Mobai Li, Yuxian Guo, Jian Zhang, Dehang Yang, Qianzhou Yu, Di Wang, Xue Zhang

Cell Death Differ. 2022 Aug; 29(8): 1582–1595. Published online 2022 Feb 2. doi: 10.1038/s41418-022-00947-8

PMCID:: PMC9345978

Abstract Article PDF–3.6M

Select item 925473514.

Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1β Production

Andrea Borrego, Francesca Colombo, Jean Gabriel de Souza, José Ricardo Jensen, Alice Dassano, Rocco Piazza, Barbara Anaís Rodrigues dos Santos, Orlando Garcia Ribeiro, Marcelo De Franco, Wafa Hanna Koury Cabrera, Marcelo Yudi Icimoto, Nancy Starobinas, Geraldo Magalhães, Leticia Figueiredo Monteleone, Silas Fernandes Eto, Carlos DeOcesano-Pereira, Mauricio Barbugiani Goldfeder, Kerly Fernanda Mesquita Pasqualoto, Tommaso A. Dragani, Olga Célia Martinez Ibañez

Front Immunol. 2022; 13: 899569. Published online 2022 Jun 21. doi: 10.3389/fimmu.2022.899569

PMCID:: PMC9254735

Abstract Article PDF–17M

Select item 919665215.

USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3

Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu, Chengjiang Gao

Autophagy. 2022; 18(5): 990–1004. Published online 2021 Sep 5. doi: 10.1080/15548627.2021.1965426

PMCID:: PMC9196652

Abstract Article PDF–5.0M

Select item 889682716.

Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon

Alejandro Peñin-Franch, José Antonio García-Vidal, Carlos Manuel Martínez, Pilar Escolar-Reina, Rosa M Martínez-Ojeda, Ana I Gómez, Juan M Bueno, Francisco Minaya-Muñoz, Fermín Valera-Garrido, Francesc Medina-Mirapeix, Pablo Pelegrín

eLife. 2022; 11: e73675. Published online 2022 Feb 24. doi: 10.7554/eLife.73675

PMCID:: PMC8896827

Abstract Article PDF–1.4M

Select item 885363417.

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

Rajendra Karki, Balamurugan Sundaram, Bhesh Raj Sharma, SangJoon Lee, R.K. Subbarao Malireddi, Lam Nhat Nguyen, Shelbi Christgen, Min Zheng, Yaqiu Wang, Parimal Samir, Geoffrey Neale, Peter Vogel, Thirumala-Devi Kanneganti

Cell Rep. Author manuscript; available in PMC 2022 Feb 17.

Published in final edited form as: Cell Rep. 2021 Oct 19; 37(3): 109858. doi: 10.1016/j.celrep.2021.109858

PMCID:: PMC8853634

Abstract Article PDF–2.8M

Select item 882849418.

Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage

Lingui Gu, Mingjiang Sun, Ruihao Li, Xingyu Zhang, Yihao Tao, Ye Yuan, Xu Luo, Zongyi Xie

Front Immunol. 2022; 13: 810582. Published online 2022 Jan 27. doi: 10.3389/fimmu.2022.810582

PMCID:: PMC8828494

Abstract Article PDF–16M

Select item 876731419.

DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs

Shao-bin Wang, Siddharth Narendran, Shuichiro Hirahara, Akhil Varshney, Felipe Pereira, Ivana Apicella, Meenakshi Ambati, Vidya L. Ambati, Praveen Yerramothu, Kameshwari Ambati, Yosuke Nagasaka, Dionne Argyle, Peirong Huang, Kirstie L. Baker, Kenneth M. Marion, Kartik Gupta, Bo Liu, David R. Hinton, Scott W. Canna, Tamer Sallam, Srinivas R. Sadda, Nagaraj Kerur, Bradley D. Gelfand, Jayakrishna Ambati

Sci Immunol. Author manuscript; available in PMC 2022 Jun 3.

Published in final edited form as: Sci Immunol. 2021 Dec 3; 6(66): eabi4493. Published online 2021 Dec 3. doi: 10.1126/sciimmunol.abi4493

PMCID:: PMC8767314

Abstract Article PDF–1.0M

Select item 875318220.

Extracellular cathepsin Z signals through the α₅ integrin and augments NLRP3 inflammasome activation

Rhiannon I. Campden, Amy L. Warren, Catherine J. Greene, Jose A. Chiriboga, Corey R. Arnold, Devin Aggarwal, Neil McKenna, Christina F. Sandall, Justin A. MacDonald, Robin M. Yates

J Biol Chem. 2022 Jan; 298(1): 101459. Published online 2021 Dec 2. doi: 10.1016/j.jbc.2021.101459

PMCID:: PMC8753182

Abstract Article PDF–1.9M

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