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Select item 114249781.

DDI2 protease controls embryonic development and inflammation via TCF11/NRF1

Monika Nedomova, Stefanie Haberecht-Müller, Sophie Möller, Simone Venz, Michaela Prochazkova, Jan Prochazka, Frantisek Sedlak, Kallayanee Chawengsaksophak, Elke Hammer, Petr Kasparek, Michael Adamek, Radislav Sedlacek, Jan Konvalinka, Elke Krüger, Klara Grantz Saskova

iScience. 2024 Oct 18; 27(10): 110893. Published online 2024 Sep 5. doi: 10.1016/j.isci.2024.110893

PMCID:: PMC11424978

Abstract Article PDF–6.1M

Select item 111615122.

Protein translation rate determines neocortical neuron fate

Ekaterina Borisova, Andrew G. Newman, Marta Couce Iglesias, Rike Dannenberg, Theres Schaub, Bo Qin, Alexandra Rusanova, Marisa Brockmann, Janina Koch, Marieatou Daniels, Paul Turko, Olaf Jahn, David R. Kaplan, Marta Rosário, Takao Iwawaki, Christian M. T. Spahn, Christian Rosenmund, David Meierhofer, Matthew L. Kraushar, Victor Tarabykin, Mateusz C. Ambrozkiewicz

Nat Commun. 2024; 15: 4879. Published online 2024 Jun 7. doi: 10.1038/s41467-024-49198-w

PMCID:: PMC11161512

Abstract Article PDF–17M

Select item 110250163.

Bone marrow plasma cells require P2rX4 to sense extracellular ATP

Masaki Ishikawa, Zainul S. Hasanali, Yongge Zhao, Arundhoti Das, Marieke Lavaert, Carly J. Roman, Jennifer Londregan, David Allman, Avinash Bhandoola

Nature. Author manuscript; available in PMC 2024 Apr 18.

Published in final edited form as: Nature. 2024 Feb; 626(8001): 1102–1107. Published online 2024 Feb 14. doi: 10.1038/s41586-024-07047-2

PMCID:: PMC11025016

Abstract Article PDF–5.5M

Select item 109829714.

Serena Germani, Andrew Tri Van Ho, Alessandro Cherubini, Ersilia Varone, Alexander Chernorudskiy, Giorgia Maria Renna, Stefano Fumagalli, Marco Gobbi, Jacopo Lucchetti, Marco Bolis, Luca Guarrera, Ilaria Craparotta, Giorgia Rastelli, Giorgia Piccoli, Cosimo de Napoli, Leonardo Nogara, Elena Poggio, Marisa Brini, Angela Cattaneo, Angela Bachi, Thomas Simmen, Tito Calì, Susana Quijano-Roy, Simona Boncompagni, Bert Blaauw, Ana Ferreiro, Ester Zito

Cell Rep Med. 2024 Mar 19; 5(3): 101439. Published online 2024 Feb 22. doi: 10.1016/j.xcrm.2024.101439

PMCID:: PMC10982971

Abstract Article PDF–5.8M

Select item 109361035.

C/EBPα-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription

Mengbao Du, Mowang Wang, Meng Liu, Shan Fu, Yu Lin, Yankun Huo, Jian Yu, Xiaohong Yu, Chong Wang, Haowen Xiao, Limengmeng Wang

J Exp Clin Cancer Res. 2024; 43: 79. Published online 2024 Mar 13. doi: 10.1186/s13046-024-02975-3

PMCID:: PMC10936103

Abstract Article PDF–7.2M

Select item 109176606.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108972057.

A beneficial adaptive role for CHOP in driving cell fate selection during ER stress

Kaihua Liu, Chaoxian Zhao, Reed C Adajar, Diane DeZwaan-McCabe, D Thomas Rutkowski

EMBO Rep. 2024 Jan; 25(1): 228–253. Published online 2024 Jan 2. doi: 10.1038/s44319-023-00026-0

PMCID:: PMC10897205

Abstract Article PDF–2.1M

Select item 107877918.

Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy

Weihui Yan, Shanshan Chen, Ying Wang, Yaying You, Ying Lu, Weipeng Wang, Bo Wu, Jun Du, Shicheng Peng, Wei Cai, Yongtao Xiao

Commun Biol. 2024; 7: 94. Published online 2024 Jan 13. doi: 10.1038/s42003-024-05785-7

PMCID:: PMC10787791

Abstract Article PDF–21M

Select item 107554989.

Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion

Chun-Guang Guo, Rui Sun, Xiao Wang, Ye Yuan, Yan Xu, Shihan Li, Xueting Sun, Jue Wang, Xinli Hu, Tiannan Guo, Xiao-Wei Chen, Rui-Ping Xiao, Xiuqin Zhang

Mol Metab. 2024 Jan; 79: 101847. Published online 2023 Nov 30. doi: 10.1016/j.molmet.2023.101847

PMCID:: PMC10755498

Abstract Article PDF–3.6M

Select item 1067029110.

ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment

Jiawen Xiang, Anthony J. Pompetti, Adam P. Faranda, Yan Wang, Samuel G. Novo, David Wan-Cheng Li, Melinda K. Duncan

Cells. 2023 Nov; 12(22): 2636. Published online 2023 Nov 16. doi: 10.3390/cells12222636

PMCID:: PMC10670291

Abstract Article PDF–9.2M

Select item 1056926211.

Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development

Angelica S. Martinez-Ramirez, Thomas L. Borders, Leena Paul, Matthew Schipma, Xinkun Wang, Farida Korobova, Christopher V. Wright, Beatriz Sosa-Pineda

Gastro Hep Adv. 2022; 1(5): 807–823. Published online 2022 May 26. doi: 10.1016/j.gastha.2022.05.013

PMCID:: PMC10569262

Abstract Article PDF–6.7M

Select item 1038723712.

DELE1 is protective for mitochondrial cardiomyopathy

Helen Huynh, Siting Zhu, Sharon Lee, Yutong Bao, Jing Pang, Anh Nguyen, Yusu Gu, Chao Chen, Kunfu Ouyang, Sylvia M. Evans, Xi Fang

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Jul 30.

Published in final edited form as: J Mol Cell Cardiol. 2023 Feb; 175: 44–48. Published online 2022 Dec 17. doi: 10.1016/j.yjmcc.2022.12.003

PMCID:: PMC10387237

Abstract Article PDF–661K

Select item 1029010213.

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation

Isidoro Cobo, Sumit Paliwal, Cristina Bodas, Irene Felipe, Júlia Melià-Alomà, Ariadna Torres, Jaime Martínez-Villarreal, Marina Malumbres, Fernando García, Irene Millán, Natalia del Pozo, Joo-Cheol Park, Ray J. MacDonald, Javier Muñoz, Raúl Méndez, Francisco X. Real

Nat Commun. 2023; 14: 3761. Published online 2023 Jun 23. doi: 10.1038/s41467-023-39291-x

PMCID:: PMC10290102

Abstract Article PDF–3.4M

Select item 1024431714.

Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3

Yonglin Gao, George Z. Wei, Michael D. Forston, Benjamin Rood, Emily R. Hodges, Darlene Burke, Kariena Andres, Johnny Morehouse, Christine Armstrong, Charles Glover, Lukasz P. Slomnicki, Jixiang Ding, Julia H. Chariker, Eric C. Rouchka, Sujata Saraswat Ohri, Scott R. Whittemore, Michal Hetman

Sci Rep. 2023; 13: 9193. Published online 2023 Jun 6. doi: 10.1038/s41598-023-36258-2

PMCID:: PMC10244317

Abstract Article PDF–2.2M

Select item 1015774015.

A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis

Qian Guo, Mingyang Xin, Qingchun Lu, Dechun Feng, Vicky Yang, Lee F. Peng, Kelly A. Whelan, Wenhui Hu, Sheng Wu, Xiaofeng Yang, Hong Wang, Brad S. Rothberg, Ana M. Gamero, Glenn S. Gerhard, Bin Gao, Ling Yang

Theranostics. 2023; 13(7): 2210–2225. Published online 2023 Apr 9. doi: 10.7150/thno.81192

PMCID:: PMC10157740

Abstract Article PDF–10M

Select item 996829716.

Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

Eun-Ji Park, Hyun-Soo Kim, Do-Hyoung Lee, Su-Min Kim, Joon-Sup Yoon, Ji-Min Lee, Se Jin Im, Ho Lee, Min-Woo Lee, Chang-Woo Lee

Nat Commun. 2023; 14: 1097. Published online 2023 Feb 25. doi: 10.1038/s41467-023-36836-y

PMCID:: PMC9968297

Abstract Article PDF–4.4M

Select item 993265617.

Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion

Alicia Wong, Samantha Pritchard, Mackenzie Moore, Brian Akhaphong, Nandini Avula, Megan Beetch, Yoshio Fujitani, Emilyn U. Alejandro

J Biol Chem. 2023 Feb; 299(2): 102878. Published online 2023 Jan 6. doi: 10.1016/j.jbc.2023.102878

PMCID:: PMC9932656

Abstract Article PDF–3.4M

Select item 974633418.

CCAAT/Enhancer-binding Protein Homologous Protein Promotes ROS-mediated Liver Ischemia and Reperfusion Injury by Inhibiting Mitophagy in Hepatocytes

Shun Zhou, Zhuqing Rao, Yongxiang Xia, Qi Wang, Zheng Liu, Ping Wang, Feng Cheng, Haoming Zhou

Transplantation. 2023 Jan; 107(1): 129–139. Published online 2022 Jul 13. doi: 10.1097/TP.0000000000004244

PMCID:: PMC9746334

Abstract Article PDF–2.3M

Select item 971249619.

Loss-of-rescue of Ryr1^I4895T-related pathology by the genetic inhibition of the ER stress response mediator CHOP

Serena Germani, Alessia Celeste Marchetti, Andrea Guidarelli, Orazio Cantoni, Vincenzo Sorrentino, Ester Zito

Sci Rep. 2022; 12: 20632. Published online 2022 Nov 30. doi: 10.1038/s41598-022-25198-y

PMCID:: PMC9712496

Abstract Article PDF–2.0M

Select item 968745520.

Maternal Calorie Restriction Induces a Transcriptional Cytoprotective Response in Embryonic Liver Partially Dependent on Nrf2

George I. Habeos, Fotini Filippopoulou, Evagelia E. Habeos, Electra Kalaitzopoulou, Marianna Skipitari, Polyxeni Papadea, George Lagoumintzis, Athanasios Niarchos, Christos D. Georgiou, Dionysios V. Chartoumpekis

Antioxidants (Basel) 2022 Nov; 11(11): 2274. Published online 2022 Nov 17. doi: 10.3390/antiox11112274

PMCID:: PMC9687455

Abstract Article PDF–2.0M

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