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Items: 1 to 20 of 29

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Targeted Disruption of Leucine-Rich Repeat Kinase 1 But Not Leucine-Rich Repeat Kinase 2 in Mice Causes Severe Osteopetrosis
Weirong Xing, Jeff Liu, Shaohong Cheng, Peter Vogel, Subburaman Mohan, Robert Brommage
J Bone Miner Res. Author manuscript; available in PMC 2022 Oct 3.
Published in final edited form as: J Bone Miner Res. 2013 Sep; 28(9): 1962–1974. doi: 10.1002/jbmr.1935
PMCID:
PMC9528686
AbstractArticlePDF–2.7M
3.
Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice
Guodong Huang, Daniel W. Bloodgood, Jongkyun Kang, Anu Shahapal, Phoenix Chen, Konstantin Kaganovsky, Jae-Ick Kim, Jun B. Ding, Jie Shen
J Neurosci. 2022 Jun 8; 42(23): 4755–4765. doi: 10.1523/JNEUROSCI.0140-22.2022
PMCID:
PMC9186805
AbstractArticlePDF–3.8M
4.
Germline saturation mutagenesis induces skeletal phenotypes in mice
Jonathan J Rios, Kristin Denton, Jamie Russell, Julia Kozlitina, Carlos R Ferreira, Amy F Lewanda, Joshua E Mayfield, Eva Moresco, Sara Ludwig, Miao Tang, Xiaohong Li, Stephen Lyon, Anas Khanshour, Nandina Paria, Aysha Khalid, Yang Li, Xudong Xie, Jian Q Feng, Qian Xu, Yongbo Lu, Robert E Hammer, Carol A Wise, Bruce Beutler
J Bone Miner Res. Author manuscript; available in PMC 2022 Aug 1.
Published in final edited form as: J Bone Miner Res. 2021 Aug; 36(8): 1548–1565. Published online 2021 May 10. doi: 10.1002/jbmr.4323
PMCID:
PMC8862308
AbstractArticlePDF–2.5M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Sebastian Mathea, Deep Chatterjee, Prosenjit Pal, Pawel Lis, Matthew Taylor, Elena Purlyte, Robert Gourlay, Mark Dorward, Simone Weidlich, Rachel Toth, Nicole K. Polinski, Stefan Knapp, Francesca Tonelli, Dario R. Alessi
Biochem J. 2021 Feb 12; 478(3): 553–578. Prepublished online 2021 Jan 18. Published online 2021 Feb 10. doi: 10.1042/BCJ20200937
PMCID:
PMC7886321
AbstractArticlePDF–12M
7.
LRRK1 regulation of actin assembly in osteoclasts involves serine 5 phosphorylation of L‐plastin
Mingjue Si, Helen Goodluck, Canjun Zeng, Songqin Pan, Elizabeth M. Todd, Sharon Celeste Morley, Xuezhong Qin, Subburaman Mohan, Weirong Xing
J Cell Biochem. 2018 Dec; 119(12): 10351–10357. Published online 2018 Aug 22. doi: 10.1002/jcb.27377
PMCID:
PMC6218268
AbstractArticlePDF–500K
8.
Age-dependent dopaminergic neurodegeneration and impairment of the autophagy-lysosomal pathway in LRRK-deficient mice
Emilie Giaime, Youren Tong, Lisa K. Wagner, Yang Yuan, Guodong Huang, Jie Shen
Neuron. Author manuscript; available in PMC 2018 Nov 15.
Published in final edited form as: Neuron. 2017 Nov 15; 96(4): 796–807.e6. Published online 2017 Oct 19. doi: 10.1016/j.neuron.2017.09.036
PMCID:
PMC5693787
AbstractArticlePDF–4.0M
9.
The Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization
Björn Titz, Tracey Low, Evangelia Komisopoulou, Sharon S Chen, Liudmilla Rubbi, Thomas G Graeber
Oncogene. Author manuscript; available in PMC 2017 Feb 14.
Published in final edited form as: Oncogene. 2010 Nov 4; 29(44): 5895–5910. Published online 2010 Aug 9. doi: 10.1038/onc.2010.331
PMCID:
PMC5308218
AbstractArticlePDF–3.8M
10.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
11.
Leucine-rich repeat kinase-1 regulates osteoclast function by modulating RAC1/Cdc42 Small GTPase phosphorylation and activation
Canjun Zeng, Helen Goodluck, Xuezhong Qin, Bo Liu, Subburaman Mohan, Weirong Xing
Am J Physiol Endocrinol Metab. 2016 Oct 1; 311(4): E772–E780. Published online 2016 Sep 6. doi: 10.1152/ajpendo.00189.2016
PMCID:
PMC5241559
AbstractArticle
12.
LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation
Keiko Morimoto, Yoshihiro Baba, Hisaaki Shinohara, Sujin Kang, Satoshi Nojima, Tetsuya Kimura, Daisuke Ito, Yuji Yoshida, Yohei Maeda, Hana Sarashina-Kida, Masayuki Nishide, Takashi Hosokawa, Yasuhiro Kato, Yoshitomo Hayama, Yuhei Kinehara, Tatsusada Okuno, Hyota Takamatsu, Toru Hirano, Yoshihito Shima, Masashi Narazaki, Tomohiro Kurosaki, Toshihiko Toyofuku, Atsushi Kumanogoh
Sci Rep. 2016; 6: 25738. Published online 2016 May 11. doi: 10.1038/srep25738
PMCID:
PMC4863158
AbstractArticlePDF–1.7M
13.
Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation
Toshihiko Toyofuku, Keiko Morimoto, Shigemi Sasawatari, Atsushi Kumanogoh
Mol Cell Biol. 2015 Sep; 35(17): 3044–3058. Prepublished online 2015 Jun 22. Published online 2015 Aug 4. doi: 10.1128/MCB.00085-15
Correction in:
Mol Cell Biol. 2018 Apr 15; 38(8): e00079-18.
PMCID:
PMC4525318
AbstractArticlePDF–6.6M
14.
Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders
Heather Fairfield, Anuj Srivastava, Guruprasad Ananda, Rangjiao Liu, Martin Kircher, Anuradha Lakshminarayana, Belinda S. Harris, Son Yong Karst, Louise A. Dionne, Coleen C. Kane, Michelle Curtain, Melissa L. Berry, Patricia F. Ward-Bailey, Ian Greenstein, Candice Byers, Anne Czechanski, Jocelyn Sharp, Kristina Palmer, Polyxeni Gudis, Whitney Martin, Abby Tadenev, Laurent Bogdanik, C. Herbert Pratt, Bo Chang, David G. Schroeder, Gregory A. Cox, Paul Cliften, Jeffrey Milbrandt, Stephen Murray, Robert Burgess, David E. Bergstrom, Leah Rae Donahue, Hanan Hamamy, Amira Masri, Federico A. Santoni, Periklis Makrythanasis, Stylianos E. Antonarakis, Jay Shendure, Laura G. Reinholdt
Genome Res. 2015 Jul; 25(7): 948–957. doi: 10.1101/gr.186882.114
PMCID:
PMC4484392
AbstractArticlePDF–604K
15.
FIH-1 Disrupts an LRRK1/EGFR Complex to Positively Regulate Keratinocyte Migration
Han Peng, Nihal Kaplan, Wending Yang, Spiro Getsios, Robert M. Lavker
Am J Pathol. 2014 Dec; 184(12): 3262–3271. doi: 10.1016/j.ajpath.2014.08.014
PMCID:
PMC4258497
AbstractArticlePDF–1.6M
16.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
17.
A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson’s Research
Marco A. S. Baptista, Kuldip D. Dave, Niketa P. Sheth, Shehan N. De Silva, Kirsten M. Carlson, Yasmin N. Aziz, Brian K. Fiske, Todd B. Sherer, Mark A. Frasier
Dis Model Mech. 2013 Nov; 6(6): 1316–1324. Published online 2013 Sep 12. doi: 10.1242/dmm.011940
PMCID:
PMC3820256
AbstractArticle
18.
Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice
Florian Giesert, Andreas Hofmann, Alexander Bürger, Julia Zerle, Karina Kloos, Ulrich Hafen, Luise Ernst, Jingzhong Zhang, Daniela Maria Vogt-Weisenhorn, Wolfgang Wurst
PLoS One. 2013; 8(5): e63778. Published online 2013 May 10. doi: 10.1371/journal.pone.0063778
PMCID:
PMC3651128
AbstractArticlePDF–7.0M
19.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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