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Select item 109421041.

Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals

Laurenz A. Herr, Gina J. Fiala, Sagar, Anna-Maria Schaffer, Jonas F. Hummel, Marina Zintchenko, Katrin Raute, Rubí M.-H. Velasco Cárdenas, Beate Heizmann, Karolina Ebert, Kerstin Fehrenbach, Iga Janowska, Susan Chan, Yakup Tanriver, Susana Minguet, Wolfgang W. Schamel

Sci Adv. 2024 Mar 15; 10(11): eadj2802. Published online 2024 Mar 15. doi: 10.1126/sciadv.adj2802

PMCID:: PMC10942104

Abstract Article PDF–5.4M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104697403.

Impaired tissue homing by the Ikzf3^N159S variant is mediated by interfering with Ikaros function

Jingjie Chang, Motoi Yamashita, Aditya K. Padhi, Kam Y. J. Zhang, Ichiro Taniuchi

Front Immunol. 2023; 14: 1239779. Published online 2023 Aug 17. doi: 10.3389/fimmu.2023.1239779

PMCID:: PMC10469740

Abstract Article PDF–5.1M

Select item 100390234.

Aiolos represses CD4⁺ T cell cytotoxic programming via reciprocal regulation of T_FH transcription factors and IL-2 sensitivity

Kaitlin A. Read, Devin M. Jones, Srijana Pokhrel, Emily D. S. Hales, Aditi Varkey, Jasmine A. Tuazon, Caprice D. Eisele, Omar Abdouni, Abbey Saadey, Melissa R. Leonard, Robert T. Warren, Michael D. Powell, Jeremy M. Boss, Emily A. Hemann, Jacob S. Yount, Gang Xin, Hazem E. Ghoneim, Chan-Wang J. Lio, Aharon G. Freud, Patrick L. Collins, Kenneth J. Oestreich

Nat Commun. 2023; 14: 1652. Published online 2023 Mar 24. doi: 10.1038/s41467-023-37420-0

PMCID:: PMC10039023

Abstract Article PDF–4.6M

Select item 90142635.

AIOLOS Variants Causing Immunodeficiency in Human and Mice

Motoi Yamashita, Tomohiro Morio

Front Immunol. 2022; 13: 866582. Published online 2022 Apr 4. doi: 10.3389/fimmu.2022.866582

PMCID:: PMC9014263

Abstract Article PDF–3.1M

Select item 89589606.

A Variant in Human AIOLOS Impairs Adaptive Immunity by Interfering with IKAROS

Motoi Yamashita, Hye Sun Kuehn, Kazuki Okuyama, Satoshi Okada, Yuzaburo Inoue, Noriko Mitsuiki, Kohsuke Imai, Masatoshi Takagi, Hirokazu Kanegane, Masahiro Takeuchi, Naoki Shimojo, Miyuki Tsumura, Aditya K. Padhi, Kam Y. J. Zhang, Bertrand Boisson, Jean-Laurent Casanova, Osamu Ohara, Sergio D. Rosenzweig, Ichiro Taniuchi, Tomohiro Morio

Nat Immunol. Author manuscript; available in PMC 2022 Mar 28.

Published in final edited form as: Nat Immunol. 2021 Jul; 22(7): 893–903. Published online 2021 Jun 21. doi: 10.1038/s41590-021-00951-z

PMCID:: PMC8958960

Abstract Article PDF–4.7M

Select item 85489147.

T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients

Hye Sun Kuehn, Jingjie Chang, Motoi Yamashita, Julie E. Niemela, Chengcheng Zou, Kazuki Okuyama, Junji Harada, Jennifer L. Stoddard, Cristiane J. Nunes-Santos, Brigette Boast, Ryan M. Baxter, Elena W.Y. Hsieh, Mary Garofalo, Thomas A. Fleisher, Tomohiro Morio, Ichiro Taniuchi, Cullen M. Dutmer, Sergio D. Rosenzweig

J Exp Med. 2021 Dec 6; 218(12): e20211118. Published online 2021 Oct 25. doi: 10.1084/jem.20211118

PMCID:: PMC8548914

Abstract Article PDF–7.5M

Select item 85425748.

Aiolos regulates eosinophil migration into tissues

Jennifer M. Felton, Carine Bouffi, Justin T. Schwartz, Kaila L. Schollaert, Astha Malik, Sushmitha Vallabh, Benjamin Wronowski, Adam Z. Magier, Li Merlin, Artem Barski, Matthew T. Weirauch, Patricia C. Fulkerson, Marc E. Rothenberg

Mucosal Immunol. Author manuscript; available in PMC 2022 Feb 2.

Published in final edited form as: Mucosal Immunol. 2021 Nov; 14(6): 1271–1281. Published online 2021 Aug 2. doi: 10.1038/s41385-021-00416-4

PMCID:: PMC8542574

Abstract Article PDF–1.8M

Select item 85287049.

Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity

Jinxin Qiu, Jingjing Zhang, Yan Ji, Hanxiao Sun, Zhitao Gu, Qiangling Sun, Meizhu Bai, Jue Gong, Jupei Tang, Yunpeng Zhang, Shiyang Li, Zhen Shao, Jinsong Li, Huiming Sheng, Lei Shen, Ju Qiu

Mucosal Immunol. 2021; 14(6): 1306–1322. Published online 2021 Aug 4. doi: 10.1038/s41385-021-00431-5

PMCID:: PMC8528704

Abstract Article PDF–5.8M

Select item 803454610.

A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation

Gregory Lazarian, Shanye Yin, Elisa ten Hacken, Tomasz Sewastianik, Mohamed Uduman, Alba Font-Tello, Satyen H. Gohil, Shuqiang Li, Ekaterina Kim, Heather Joyal, Leah Billington, Elizabeth Witten, Mei Zheng, Teddy Huang, Mariano Severgnini, Valerie Lefebvre, Laura Z. Rassenti, Catherine Gutierrez, Katia Georgopoulos, Christopher J. Ott, Lili Wang, Thomas J. Kipps, Jan A. Burger, Kenneth J. Livak, Donna S Neuberg, Fanny Baran-Marszak, Florence Cymbalista, Ruben D. Carrasco, Catherine J. Wu

Cancer Cell. Author manuscript; available in PMC 2022 Mar 8.

Published in final edited form as: Cancer Cell. 2021 Mar 8; 39(3): 380–393.e8. doi: 10.1016/j.ccell.2021.02.003

PMCID:: PMC8034546

Abstract Article PDF–3.0M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 633346012.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 592658913.

Genetic Mapping and Allelic Loss Analysis in Mouse Thymic Lymphomas of Helios and Aiolos Belonging to the Ikaros Gene Family

Hongbin Xu, Yuichi Wakabayashi, Hitomi Okano, Yuko Saito, Tomonori Miyazawa, Ryo Kominami

Jpn J Cancer Res. 2001 Jan; 92(1): 36–41. doi: 10.1111/j.1349-7006.2001.tb01045.x

PMCID:: PMC5926589

Summary PDF–271K

Select item 538122614.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 529582115.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 449468816.

Ikaros mutation confers integrin-dependent pre-B cell survival and progression to acute lymphoblastic leukemia

Ila Joshi, Toshimi Yoshida, Nilamani Jena, Xiaoqing Qi, Jiangwen Zhang, Richard A. Van Etten, Katia Georgopoulos

Nat Immunol. Author manuscript; available in PMC 2015 Jul 7.

Published in final edited form as: Nat Immunol. 2014 Mar; 15(3): 294–304. Published online 2014 Feb 9. doi: 10.1038/ni.2821

PMCID:: PMC4494688

Abstract Article PDF–4.3M

Select item 428257817.

Peripheral natural killer cell maturation depends on the transcription factor Aiolos

Melissa L Holmes, Nicholas D Huntington, Rebecca PL Thong, Jason Brady, Yoshihiro Hayakawa, Christopher E Andoniou, Peter Fleming, Wei Shi, Gordon K Smyth, Mariapia A Degli-Esposti, Gabrielle T Belz, Axel Kallies, Sebastian Carotta, Mark J Smyth, Stephen L Nutt

EMBO J. 2014 Nov 18; 33(22): 2721–2734. Published online 2014 Oct 15. doi: 10.15252/embj.201487900

PMCID:: PMC4282578

Abstract Article PDF–2.2M

Select item 396495518.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 391979319.

THE GENOMIC LANDSCAPE OF HYPODIPLOID ACUTE LYMPHOBLASTIC LEUKEMIA

Linda Holmfeldt, Lei Wei, Ernesto Diaz-Flores, Michael Walsh, Jinghui Zhang, Li Ding, Debbie Payne-Turner, Michelle Churchman, Anna Andersson, Shann-Ching Chen, Kelly McCastlain, Jared Becksfort, Jing Ma, Gang Wu, Samir N. Patel, Susan L. Heatley, Letha A. Phillips, Guangchun Song, John Easton, Matthew Parker, Xiang Chen, Michael Rusch, Kristy Boggs, Bhavin Vadodaria, Erin Hedlund, Christina Drenberg, Sharyn Baker, Deqing Pei, Cheng Cheng, Robert Huether, Charles Lu, Robert S. Fulton, Lucinda L. Fulton, Yashodhan Tabib, David J. Dooling, Kerri Ochoa, Mark Minden, Ian D. Lewis, L. Bik To, Paula Marlton, Andrew W. Roberts, Gordana Raca, Wendy Stock, Geoffrey Neale, Hans G. Drexler, Ross A. Dickins, David W. Ellison, Sheila A. Shurtleff, Ching-Hon Pui, Raul C. Ribeiro, Meenakshi Devidas, Andrew J. Carroll, Nyla A. Heerema, Brent Wood, Michael J. Borowitz, Julie M. Gastier-Foster, Susana C. Raimondi, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Stephen P. Hunger, Mignon L. Loh, Charles G. Mullighan

Nat Genet. Author manuscript; available in PMC 2014 Feb 10.

Published in final edited form as: Nat Genet. 2013 Mar; 45(3): 242–252. Published online 2013 Jan 20. doi: 10.1038/ng.2532