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Select item 93814921.

HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway

Zhang Yuan, Liu Xiao-wei, Wei Juan, Liu Xiu-juan, Zhang Nian-yun, Sheng Lei

J Physiol Biochem. 2022; 78(3): 641–652. Published online 2022 Mar 22. doi: 10.1007/s13105-022-00884-7

PMCID:: PMC9381492

Abstract Article PDF–4.9M

Select item 69845992.

MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint

Hongxu Yang, Yi Wen, Mian Zhang, Qian Liu, Hongyun Zhang, Jing Zhang, Lei Lu, Tao Ye, Xiaochun Bai, Guozhi Xiao, Meiqing Wang

Autophagy. 2020; 16(2): 271–288. Published online 2019 Apr 21. doi: 10.1080/15548627.2019.1606647

PMCID:: PMC6984599

Abstract Article PDF–14M

Select item 59862183.

Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK–eIF-2α–CHOP pathway in the unfolded protein response

Xiaomin Kang, Wei Yang, Ruiqi Wang, Tianping Xie, Huixia Li, Dongxu Feng, Xinxin Jin, Hongzhi Sun, Shufang Wu

J Biol Chem. 2018 Jun 1; 293(22): 8614–8625. Published online 2018 Apr 13. doi: 10.1074/jbc.M117.809822

PMCID:: PMC5986218

Abstract Article PDF–3.2M

Select item 41769984.

Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy

Zhong-Wei Liu, Hai-Tao Zhu, Kun-Lun Chen, Xin Dong, Jin Wei, Chuan Qiu, Jia-Hong Xue

Cardiovasc Diabetol. 2013; 12: 158. Published online 2013 Nov 2. doi: 10.1186/1475-2840-12-158

PMCID:: PMC4176998

Abstract Article PDF–1.7M

Select item 38371255.

Insulin Secretion and Ca²⁺ Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin

Rong Wang, Barbara C. McGrath, Richard F. Kopp, Michael W. Roe, Xin Tang, Gong Chen, Douglas R. Cavener

J Biol Chem. 2013 Nov 22; 288(47): 33824–33836. Published online 2013 Oct 10. doi: 10.1074/jbc.M113.503664

PMCID:: PMC3837125

Abstract Article PDF–2.1M

Select item 38183706.

Regulation of Autophagy Via PERK-eIF2α Effectively Relieve the Radiation Myelitis Induced by Iodine-125

Zuozhang Yang, Yongqing Xu, Lei Xu, Giulio Maccauro, Barbara Rossi, Yanjin Chen, Hongjun Li, Jing Zhang, Hongpu Sun, Yihao Yang, Da Xu, Xuefeng Liu

PLoS One. 2013; 8(11): e76819. Published online 2013 Nov 5. doi: 10.1371/journal.pone.0076819

PMCID:: PMC3818370

Abstract Article PDF–1.1M

Select item 37489197.

Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death

Wei-Ting Liu, Chih-Yuan Huang, I-Chen Lu, Po-Wu Gean

Neuro Oncol. 2013 Sep; 15(9): 1127–1141. Published online 2013 Jun 20. doi: 10.1093/neuonc/not073

PMCID:: PMC3748919

Abstract Article PDF–1.5M

Select item 37434258.

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

Yugang Wang, Goleeta N. Alam, Yu Ning, Fernanda Visioli, Zhihong Dong, Jacques E. Nör, Peter J. Polverini

Cancer Res. Author manuscript; available in PMC 2013 Oct 15.

Published in final edited form as: Cancer Res. 2012 Oct 15; 72(20): 5396–5406. Published online 2012 Aug 20. doi: 10.1158/0008-5472.CAN-12-0474

PMCID:: PMC3743425

Abstract Article PDF–6.1M

Select item 34967219.

Transcriptional Regulation of the Ufm1 Conjugation System in Response to Disturbance of the Endoplasmic Reticulum Homeostasis and Inhibition of Vesicle Trafficking

Yinghua Zhang, Mingsheng Zhang, Jianchun Wu, Guohua Lei, Honglin Li

PLoS One. 2012; 7(11): e48587. Published online 2012 Nov 13. doi: 10.1371/journal.pone.0048587

PMCID:: PMC3496721

Abstract Article PDF–963K

Select item 349428410.

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK and IRE1a-mediated unfolded protein response

Miri Jwa, Paul Chang

Nat Cell Biol. Author manuscript; available in PMC 2013 May 1.

Published in final edited form as: Nat Cell Biol. 2012 Nov; 14(11): 1223–1230. Published online 2012 Oct 28. doi: 10.1038/ncb2593

Correction in:: volume 15 on page 123

PMCID:: PMC3494284

Abstract Article PDF–1.6M

Select item 338441211.

The impact of the unfolded protein response on human disease

Shiyu Wang, Randal J. Kaufman

J Cell Biol. 2012 Jun 25; 197(7): 857–867. doi: 10.1083/jcb.201110131

PMCID:: PMC3384412

Abstract Article PDF–1.1M

Select item 335405512.

TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

D Rojas-Rivera, R Armisén, A Colombo, G Martínez, A L Eguiguren, A Díaz, S Kiviluoto, D Rodríguez, M Patron, R Rizzuto, G Bultynck, M L Concha, J Sierralta, A Stutzin, C Hetz

Cell Death Differ. 2012 Jun; 19(6): 1013–1026. Published online 2012 Jan 13. doi: 10.1038/cdd.2011.189

PMCID:: PMC3354055

Abstract Article PDF–1.0M

Select item 332841113.

H₂S-induced sulfhydration of PTP1B and its role in the endoplasmic reticulum stress response

Navasona Krishnan, Cexiong Fu, Darryl Pappin, Nicholas K. Tonks

Sci Signal. Author manuscript; available in PMC 2012 Apr 17.

Published in final edited form as: Sci Signal. 2011 Dec 13; 4(203): ra86. Published online 2011 Dec 13. doi: 10.1126/scisignal.2002329

PMCID:: PMC3328411

Abstract Article PDF–1.1M

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 312206215.

Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12

N Badiola, C Penas, A Miñano-Molina, B Barneda-Zahonero, R Fadó, G Sánchez-Opazo, J X Comella, J Sabriá, C Zhu, K Blomgren, C Casas, J Rodríguez-Alvarez

Cell Death Dis. 2011 Apr; 2(4): e149. Published online 2011 Apr 28. doi: 10.1038/cddis.2011.31

PMCID:: PMC3122062

Abstract Article PDF–531K

Select item 307021116.

PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

Claire E. Moore, Omotola Omikorede, Edith Gomez, Gary B. Willars, Terence P. Herbert

Mol Endocrinol. 2011 Feb; 25(2): 315–326. Published online 2010 Dec 30. doi: 10.1210/me.2010-0309

PMCID:: PMC3070211

Abstract Article

Select item 279928317.

ER Stress Depresses NF-κB Activation in Mesangial Cells through Preferential Induction of C/EBPβ

Kunihiro Hayakawa, Shotaro Nakajima, Nobuhiko Hiramatsu, Maro Okamura, Tao Huang, Yukinori Saito, Yasuhiro Tagawa, Minori Tamai, Shuhei Takahashi, Jian Yao, Masanori Kitamura

J Am Soc Nephrol. 2010 Jan; 21(1): 73–81. doi: 10.1681/ASN.2009040432