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Select item 105648631.

The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains

Sebastián Oyarce-Pezoa, Guilherme Gischkow Rucatti, Francisco Muñoz-Carvajal, Nicole Sanhueza, Wileidy Gomez, Sandra Espinoza, Mario Leiva, Nicolás García, Daniela P. Ponce, Carol D. SanMartín, Diego Rojas-Rivera, Natalia Salvadores, Maria I. Behrens, Ute Woehlbier, Melissa Calegaro-Nassif, Mario Sanhueza

Sci Rep. 2023; 13: 17137. Published online 2023 Oct 10. doi: 10.1038/s41598-023-44203-6

PMCID:: PMC10564863

Abstract Article PDF–2.6M

Select item 101104022.

A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer

John E. La Marca, Robert W. Ely, Sarah T. Diepstraten, Peter Burke, Gemma L. Kelly, Patrick O. Humbert, Helena E. Richardson

Dis Model Mech. 2023 Mar 1; 16(3): dmm049769. Published online 2023 Apr 3. doi: 10.1242/dmm.049769

PMCID:: PMC10110402

Abstract Article

Select item 86644863.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 86644554.

Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing

Cristina M Ostalé, Nuria Esteban, Ana López-Varea, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab348. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab348

PMCID:: PMC8664455

Abstract Article PDF–2.9M

Select item 82474135.

Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease

Young Won Kim, Ismael Al‐Ramahi, Amanda Koire, Stephen J. Wilson, Daniel M. Konecki, Samantha Mota, Shirin Soleimani, Juan Botas, Olivier Lichtarge

Alzheimers Dement. 2021 May; 17(5): 831–846. Published online 2020 Dec 7. doi: 10.1002/alz.12240

PMCID:: PMC8247413

Abstract Article PDF–1.9M

Select item 69615786.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 59313697.

A Whole Animal Platform to Advance A Clinical Kinase Inhibitor Into New Disease Space

Masahiro Sonoshita, Alex P. Scopton, Peter M-U. Ung, Matthew A. Murray, Lisa Silber, Andres Y. Maldonado, Alexander Real, Avner Schlessinger, Ross L. Cagan, Arvin C. Dar

Nat Chem Biol. Author manuscript; available in PMC 2018 Jul 22.

Published in final edited form as: Nat Chem Biol. 2018 Mar; 14(3): 291–298. Published online 2018 Jan 22. doi: 10.1038/nchembio.2556

PMCID:: PMC5931369

Abstract Article PDF–2.9M

Select item 58274348.

The protein kinase CK2 substrate Jabba modulates lipid metabolism during Drosophila oogenesis

Emily A. McMillan, Sheila M. Longo, Michael D. Smith, Sarah Broskin, Baicheng Lin, Nisha K. Singh, Todd I. Strochlic

J Biol Chem. 2018 Feb 23; 293(8): 2990–3002. Published online 2018 Jan 11. doi: 10.1074/jbc.M117.814657

PMCID:: PMC5827434

Abstract Article PDF–2.6M

Select item 57078059.

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Piero Sanfilippo, Jiayu Wen, Eric C. Lai

Genome Biol. 2017; 18: 229. Published online 2017 Nov 30. doi: 10.1186/s13059-017-1358-0

PMCID:: PMC5707805

Abstract Article PDF–3.2M

Select item 568900210.

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

Xiaochuan Liu, Jaime Freitas, Dinghai Zheng, Marta S. Oliveira, Mainul Hoque, Torcato Martins, Telmo Henriques, Bin Tian, Alexandra Moreira

RNA. 2017 Dec; 23(12): 1807–1816. doi: 10.1261/rna.062661.117

PMCID:: PMC5689002

Abstract Article PDF–4.0M

Select item 540772211.

Modeling Monogenic Human Nephrotic Syndrome in the Drosophila Garland Cell Nephrocyte

Tobias Hermle, Daniela A. Braun, Martin Helmstädter, Tobias B. Huber, Friedhelm Hildebrandt

J Am Soc Nephrol. 2017 May; 28(5): 1521–1533. Published online 2016 Dec 8. doi: 10.1681/ASN.2016050517

PMCID:: PMC5407722

Abstract Article

Select item 533337212.

Nociceptor-enriched genes required for normal thermal nociception

Ken Honjo, Stephanie E. Mauthner, Yu Wang, J.H. Pate Skene, W. Daniel Tracey, Jr.

Cell Rep. Author manuscript; available in PMC 2017 Mar 2.

Published in final edited form as: Cell Rep. 2016 Jul 12; 16(2): 295–303. Published online 2016 Jun 23. doi: 10.1016/j.celrep.2016.06.003

PMCID:: PMC5333372

Abstract Article PDF–1.6M

Select item 482931713.

Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing

Alborz Mazloomian, Irmtraud M Meyer

RNA Biol. 2015 Dec; 12(12): 1391–1401. Published online 2015 Oct 29. doi: 10.1080/15476286.2015.1107703

PMCID:: PMC4829317

Abstract Article PDF–609K

Select item 452833014.

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders

Madeline A. Crosby, L. Sian Gramates, Gilberto dos Santos, Beverley B. Matthews, Susan E. St. Pierre, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, David B. Emmert, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1737–1749. Published online 2015 Jun 24. doi: 10.1534/g3.115.018937

PMCID:: PMC4528330

Abstract Article PDF–2.2M

Select item 452832915.

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data

Beverley B. Matthews, Gilberto dos Santos, Madeline A. Crosby, David B. Emmert, Susan E. St. Pierre, L. Sian Gramates, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, Victor Strelets, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1721–1736. Published online 2015 Jun 24. doi: 10.1534/g3.115.018929

PMCID:: PMC4528329

Abstract Article PDF–4.9M

Select item 435288716.

The Release 6 reference sequence of the Drosophila melanogaster genome

Roger A. Hoskins, Joseph W. Carlson, Kenneth H. Wan, Soo Park, Ivonne Mendez, Samuel E. Galle, Benjamin W. Booth, Barret D. Pfeiffer, Reed A. George, Robert Svirskas, Martin Krzywinski, Jacqueline Schein, Maria Carmela Accardo, Elisabetta Damia, Giovanni Messina, María Méndez-Lago, Beatriz de Pablos, Olga V. Demakova, Evgeniya N. Andreyeva, Lidiya V. Boldyreva, Marco Marra, A. Bernardo Carvalho, Patrizio Dimitri, Alfredo Villasante, Igor F. Zhimulev, Gerald M. Rubin, Gary H. Karpen, Susan E. Celniker

Genome Res. 2015 Mar; 25(3): 445–458. doi: 10.1101/gr.185579.114