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Select item 110191401.

Dual treatment with kynurenine pathway inhibitors and NAD⁺ precursors synergistically extends life span in Drosophila

Mariann M. Gabrawy, Reyhan Westbrook, Austin King, Nick Khosravian, Neeraj Ochaney, Tagide DeCarvalho, Qinchuan Wang, Yuqiong Yu, Qiao Huang, Adam Said, Michael Abadir, Cissy Zhang, Pratik Khare, Jennifer E. Fairman, Anne Le, Ginger L. Milne, Fernando J. Vonhoff, Jeremy D. Walston, Peter M. Abadir

Aging Cell. 2024 Apr; 23(4): e14102. Published online 2024 Mar 13. doi: 10.1111/acel.14102

PMCID:: PMC11019140

Abstract Article PDF–6.5M

Select item 108821372.

Mating-induced increase of kynurenine in Drosophila ovary enhances starvation resistance of progeny

Naoto Hikawa, Soshiro Kashio, Masayuki Miura

J Biol Chem. 2024 Mar; 300(3): 105663. Published online 2024 Jan 20. doi: 10.1016/j.jbc.2024.105663

PMCID:: PMC10882137

Abstract Article PDF–1.3M

Select item 104575763.

Involvement of neuronal tachykinin-like receptor at 86C in Drosophila disc repair via regulation of kynurenine metabolism

Soshiro Kashio, Shu Masuda, Masayuki Miura

iScience. 2023 Sep 15; 26(9): 107553. Published online 2023 Aug 7. doi: 10.1016/j.isci.2023.107553

PMCID:: PMC10457576

Abstract Article PDF–3.5M

Select item 103508024.

Extension of life span by down-regulation of enzymes catalyzing tryptophan conversion into kynurenine: Possible implications for mechanisms of aging

Gregory Oxenkrug, Valeriya Navrotska

Exp Biol Med (Maywood) 2023 Apr; 248(7): 573–577. Published online 2023 Jun 10. doi: 10.1177/15353702231179411

PMCID:: PMC10350802

Abstract Article PDF–799K

Select item 101057365.

Next-generation large-scale binary protein interaction network for Drosophila melanogaster

Hong-Wen Tang, Kerstin Spirohn, Yanhui Hu, Tong Hao, István A. Kovács, Yue Gao, Richard Binari, Donghui Yang-Zhou, Kenneth H. Wan, Joel S. Bader, Dawit Balcha, Wenting Bian, Benjamin W. Booth, Atina G. Coté, Steffi de Rouck, Alice Desbuleux, Kah Yong Goh, Dae-Kyum Kim, Jennifer J. Knapp, Wen Xing Lee, Irma Lemmens, Cathleen Li, Mian Li, Roujia Li, Hyobin Julianne Lim, Yifang Liu, Katja Luck, Dylan Markey, Carl Pollis, Sudharshan Rangarajan, Jonathan Rodiger, Sadie Schlabach, Yun Shen, Dayag Sheykhkarimli, Bridget TeeKing, Frederick P. Roth, Jan Tavernier, Michael A. Calderwood, David E. Hill, Susan E. Celniker, Marc Vidal, Norbert Perrimon, Stephanie E. Mohr

Nat Commun. 2023; 14: 2162. Published online 2023 Apr 15. doi: 10.1038/s41467-023-37876-0

PMCID:: PMC10105736

Abstract Article PDF–3.2M

Select item 100117326.

Coordinated efforts of different actin filament populations are needed for optimal cell wound repair

Justin Hui, Mitsutoshi Nakamura, Julien Dubrulle, Susan M. Parkhurst

Mol Biol Cell. 2023 Mar 1; 34(3): ar15. Published online 2023 Feb 21. doi: 10.1091/mbc.E22-05-0155

PMCID:: PMC10011732

Abstract Article PDF–5.9M

Select item 96356447.

Enteric bacterial infection in Drosophila induces whole-body alterations in metabolic gene expression independently of the immune deficiency signaling pathway

Rujuta Deshpande, Byoungchun Lee, Savraj S Grewal

G3 (Bethesda) 2022 Nov; 12(11): jkac163. Published online 2022 Jul 4. doi: 10.1093/g3journal/jkac163

PMCID:: PMC9635644

Abstract Article PDF–2.2M

Select item 91697898.

Tryptophan regulates Drosophila zinc stores

Erika Garay, Nils Schuth, Alessandra Barbanente, Carlos Tejeda-Guzmán, Daniele Vitone, Beatriz Osorio, Adam H. Clark, Maarten Nachtegaal, Michael Haumann, Holger Dau, Alberto Vela, Fabio Arnesano, Liliana Quintanar, Fanis Missirlis

Proc Natl Acad Sci U S A. 2022 Apr 19; 119(16): e2117807119. Published online 2022 Apr 11. doi: 10.1073/pnas.2117807119

PMCID:: PMC9169789

Abstract Article PDF–2.1M

Select item 87444529.

Base Editing of Somatic Cells Using CRISPR–Cas9 in Drosophila

Elizabeth Marr, Christopher J. Potter

CRISPR J. December 2021; 4(6): 836–845. Published online 2021 Dec 16. doi: 10.1089/crispr.2021.0062

PMCID:: PMC8744452

Abstract Article PDF–1.1M

Select item 811827010.

RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila

Jun Xie, Yongchao Han, Tao Wang

PLoS Genet. 2021 May; 17(5): e1009558. Published online 2021 May 13. doi: 10.1371/journal.pgen.1009558

PMCID:: PMC8118270

Abstract Article PDF–4.7M

Select item 806964811.

Genetic Screen in Adult Drosophila Reveals That dCBP Depletion in Glial Cells Mitigates Huntington Disease Pathology through a Foxo-Dependent Pathway

Elodie Martin, Raheleh Heidari, Véronique Monnier, Hervé Tricoire

Int J Mol Sci. 2021 Apr; 22(8): 3884. Published online 2021 Apr 9. doi: 10.3390/ijms22083884

PMCID:: PMC8069648

Abstract Article PDF–2.8M

Select item 788512012.

Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways

Amelia R. I. Lindsey, Tamanash Bhattacharya, Richard W. Hardy, Irene L. G. Newton

mBio. 2021 Jan-Feb; 12(1): e03472-20. Published online 2021 Feb 9. doi: 10.1128/mBio.03472-20

PMCID:: PMC7885120

Abstract Article PDF–3.5M

Select item 775805113.

Autocrine insulin pathway signaling regulates actin dynamics in cell wound repair

Mitsutoshi Nakamura, Jeffrey M. Verboon, Tessa E. Allen, Maria Teresa Abreu-Blanco, Raymond Liu, Andrew N. M. Dominguez, Jeffrey J. Delrow, Susan M. Parkhurst

PLoS Genet. 2020 Dec; 16(12): e1009186. Published online 2020 Dec 11. doi: 10.1371/journal.pgen.1009186

PMCID:: PMC7758051

Abstract Article PDF–9.7M

Select item 775613714.

Kynurenine Metabolism in the Fat Body Non-autonomously Regulates Imaginal Disc Repair in Drosophila

Soshiro Kashio, Masayuki Miura

iScience. 2020 Dec 18; 23(12): 101738. Published online 2020 Nov 6. doi: 10.1016/j.isci.2020.101738

PMCID:: PMC7756137

Abstract Article PDF–11M

Select item 765475515.

A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics

Daniel C. Maddison, Mónica Alfonso-Núñez, Aisha M. Swaih, Carlo Breda, Susanna Campesan, Natalie Allcock, Anna Straatman-Iwanowska, Charalambos P. Kyriacou, Flaviano Giorgini

PLoS Genet. 2020 Nov; 16(11): e1009129. Published online 2020 Nov 10. doi: 10.1371/journal.pgen.1009129