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Select item 110154971.

Y chromosome damage underlies testicular abnormalities in ATR-X syndrome

Nayla Y. León, Thanh Nha Uyen Le, Andrew Garvie, Lee H. Wong, Stefan Bagheri-Fam, Vincent R. Harley

iScience. 2024 May 17; 27(5): 109629. Published online 2024 Mar 28. doi: 10.1016/j.isci.2024.109629

PMCID:: PMC11015497

Abstract Article PDF–4.6M

Select item 110149142.

Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice

Mary Esmeralda Fuentes, Xiaoyin Lu, Natasha M. Flores, Simone Hausmann, Pawel K. Mazur

Sci Rep. 2024; 14: 8510. Published online 2024 Apr 12. doi: 10.1038/s41598-024-58874-2

PMCID:: PMC11014914

Abstract Article PDF–1.7M

Select item 106255413.

Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination in male mice

Megan E. Rowland, Yan Jiang, Sarfraz Shafiq, Alireza Ghahramani, Miguel A. Pena-Ortiz, Vanessa Dumeaux, Nathalie G. Bérubé

Nat Commun. 2023; 14: 7090. Published online 2023 Nov 4. doi: 10.1038/s41467-023-42752-y

PMCID:: PMC10625541

Abstract Article PDF–3.8M

Select item 103603904.

A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects

Rebekah Tillotson, Keqin Yan, Julie Ruston, Taylor DeYoung, Alex Córdova, Valérie Turcotte-Cardin, Yohan Yee, Christine Taylor, Shagana Visuvanathan, Christian Babbs, Evgueni A Ivakine, John G Sled, Brian J Nieman, David J Picketts, Monica J Justice

Hum Mol Genet. 2023 Aug 1; 32(15): 2485–2501. Published online 2023 May 12. doi: 10.1093/hmg/ddad075

PMCID:: PMC10360390

Abstract Article PDF–1.7M

Select item 103133745.

Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus

Warren Floyd, Matthew Pierpoint, Chang Su, Rutulkumar Patel, Lixia Luo, Katherine Deland, Amy J. Wisdom, Daniel Zhu, Yan Ma, Suzanne Bartholf DeWitt, Nerissa T. Williams, Alexander L. Lazarides, Jason A. Somarelli, David L. Corcoran, William C. Eward, Diana M. Cardona, David G. Kirsch

J Clin Invest. 2023 Jul 3; 133(13): e149310. Published online 2023 Jul 3. doi: 10.1172/JCI149310

PMCID:: PMC10313374

Abstract Article PDF–10M

Select item 102522566.

Generation of an Obese Diabetic Mouse Model upon Conditional Atrx Disruption

Tiago Bordeira Gaspar, Tito Teles Jesus, Maria Teresa Azevedo, Sofia Macedo, Mariana Alves Soares, Rui Sousa Martins, Rúben Leite, Lia Rodrigues, Daniela Ferreira Rodrigues, Luís Cardoso, Inês Borges, Sule Canberk, Fátima Gärtner, Leandro Miranda-Alves, José Manuel Lopes, Paula Soares, João Vinagre

Cancers (Basel) 2023 Jun; 15(11): 3018. Published online 2023 Jun 1. doi: 10.3390/cancers15113018

PMCID:: PMC10252256

Abstract Article PDF–1.7M

Select item 101534587.

A change in biophysical properties accompanies heterochromatin formation in mouse embryos

Manuel Guthmann, Chen Qian, Irene Gialdini, Tsunetoshi Nakatani, Andreas Ettinger, Tamas Schauer, Igor Kukhtevich, Robert Schneider, Don C. Lamb, Adam Burton, Maria-Elena Torres-Padilla

Genes Dev. 2023 Apr 1; 37(7-8): 336–350. doi: 10.1101/gad.350353.122

PMCID:: PMC10153458

Abstract Article PDF–4.6M

Select item 97570628.

TERRA regulates DNA G-quadruplex formation and ATRX recruitment to chromatin

Ru-Xuan Tsai, Kuo-Chen Fang, Po-Cheng Yang, Yu-Hung Hsieh, I-Tien Chiang, Yunfei Chen, Hun-Goo Lee, Jeannie T Lee, Hsueh-Ping Catherine Chu

Nucleic Acids Res. 2022 Nov 28; 50(21): 12217–12234. Published online 2022 Nov 28. doi: 10.1093/nar/gkac1114

PMCID:: PMC9757062

Abstract Article PDF–3.2M

Select item 95362809.

Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding

Suzanne Bartholf DeWitt, Sarah Hoskinson Plumlee, Hailey E. Brighton, Dharshan Sivaraj, E.J. Martz, Maryam Zand, Vardhman Kumar, Maya U. Sheth, Warren Floyd, Jacob V. Spruance, Nathan Hawkey, Shyni Varghese, Jianhua Ruan, David G. Kirsch, Jason A. Somarelli, Ben Alman, William C. Eward

JCI Insight. 2022 Sep 8; 7(17): e151583. Published online 2022 Sep 8. doi: 10.1172/jci.insight.151583

PMCID:: PMC9536280

Abstract Article PDF–3.8M

Select item 945845910.

ATRX histone binding and helicase activities have distinct roles in neuronal differentiation

Anna Bieluszewska, Phillip Wulfridge, John Doherty, Wenqing Ren, Kavitha Sarma

Nucleic Acids Res. 2022 Sep 9; 50(16): 9162–9174. Published online 2022 Aug 24. doi: 10.1093/nar/gkac683

PMCID:: PMC9458459

Abstract Article PDF–3.8M

Select item 943892911.

Context matters – Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas

Chang Sun, Jeannelyn S. Estrella, Elizabeth M. Whitley, Gilda P. Chau, Guillermina Lozano, Amanda R. Wasylishen

Dis Model Mech. 2022 Aug 1; 15(8): dmm049552. Published online 2022 Aug 26. doi: 10.1242/dmm.049552

PMCID:: PMC9438929

Abstract Article

Select item 940616712.

Characterisation of an Atrx Conditional Knockout Mouse Model: Atrx Loss Causes Endocrine Dysfunction Rather Than Pancreatic Neuroendocrine Tumour

Tiago Bordeira Gaspar, Sofia Macedo, Ana Sá, Mariana Alves Soares, Daniela Ferreira Rodrigues, Mafalda Sousa, Nuno Mendes, Rui Sousa Martins, Luís Cardoso, Inês Borges, Sule Canberk, Fátima Gärtner, Leandro Miranda-Alves, Manuel Sobrinho-Simões, José Manuel Lopes, Paula Soares, João Vinagre

Cancers (Basel) 2022 Aug; 14(16): 3865. Published online 2022 Aug 10. doi: 10.3390/cancers14163865

PMCID:: PMC9406167

Abstract Article PDF–6.4M

Select item 858861613.

ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma

Husam Babikir, Lin Wang, Karin Shamardani, Francisca Catalan, Sweta Sudhir, Manish K. Aghi, David R. Raleigh, Joanna J. Phillips, Aaron A. Diaz

Genome Biol. 2021; 22: 311. Published online 2021 Nov 11. doi: 10.1186/s13059-021-02535-4

PMCID:: PMC8588616

Abstract Article PDF–7.7M

Select item 855181014.

Ectopic Splicing Disturbs the Function of Xist RNA to Establish the Stable Heterochromatin State

Ruka Matsuura, Tatsuro Nakajima, Saya Ichihara, Takashi Sado

Front Cell Dev Biol. 2021; 9: 751154. Published online 2021 Oct 14. doi: 10.3389/fcell.2021.751154

PMCID:: PMC8551810

Abstract Article PDF–1.8M

Select item 844633815.

ACAA2 is a Ligand-dependent Coactivator for Thyroid Hormone Receptor β1

Wesley Wang, Dolena Ledee

Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Oct 22.

Published in final edited form as: Biochem Biophys Res Commun. 2021 Oct 22; 576: 15–21. Published online 2021 Aug 28. doi: 10.1016/j.bbrc.2021.08.073

PMCID:: PMC8446338

Abstract Article PDF–830K

Select item 822225616.

ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress

Yu-Ching Teng, Aishwarya Sundaresan, Ryan O’Hara, Vincent U. Gant, Minhua Li, Sara Martire, Jane N. Warshaw, Amrita Basu, Laura A. Banaszynski

Nat Commun. 2021; 12: 3887. Published online 2021 Jun 23. doi: 10.1038/s41467-021-24206-5

PMCID:: PMC8222256

Abstract Article PDF–2.5M

Select item 740636717.

Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo

Amanda R. Wasylishen, Chang Sun, Sydney M. Moyer, Yuan Qi, Gilda P. Chau, Neeraj K. Aryal, Florencia McAllister, Michael P. Kim, Michelle C. Barton, Jeannelyn S. Estrella, Xiaoping Su, Guillermina Lozano

Sci Adv. 2020 Aug; 6(32): eaba8415. Published online 2020 Aug 5. doi: 10.1126/sciadv.aba8415

PMCID:: PMC7406367

Abstract Article PDF–5.0M

Select item 732646518.

Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits

Renee J. Tamming, Vanessa Dumeaux, Yan Jiang, Sarfraz Shafiq, Luana Langlois, Jacob Ellegood, Lily R. Qiu, Jason P. Lerch, Nathalie G. Bérubé

Cell Rep. 2020 Jun 30; 31(13): 107838. Published online 2020 Jun 30. doi: 10.1016/j.celrep.2020.107838

PMCID:: PMC7326465

Abstract Article PDF–5.1M

Select item 720310919.

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

Wenqing Ren, Nicole Medeiros, Robert Warneford-Thomson, Phillip Wulfridge, Qingqing Yan, Joyce Bian, Simone Sidoli, Benjamin A. Garcia, Emmanuel Skordalakes, Eric Joyce, Roberto Bonasio, Kavitha Sarma

Nat Commun. 2020; 11: 2219. Published online 2020 May 6. doi: 10.1038/s41467-020-15902-9