PMC Links for GEO Profiles (Select 13728178) - PMC

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Items: 15

Select item 112096731.

C9ORF72 Deficiency Results in Neurodegeneration in the Zebrafish Retina

Natalia Jaroszynska, Andrea Salzinger, Themistoklis M. Tsarouchas, Catherina G. Becker, Thomas Becker, David A. Lyons, Ryan B. MacDonald, Marcus Keatinge

J Neurosci. 2024 Jun 19; 44(25): e2128232024. Prepublished online 2024 Apr 24. doi: 10.1523/JNEUROSCI.2128-23.2024

PMCID:: PMC11209673

Abstract Article PDF–9.9M

Select item 94829292.

Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis

Helena Chaytow, Emily Carroll, David Gordon, Yu-Ting Huang, Dinja van der Hoorn, Hannah Louise Smith, Thomas Becker, Catherina Gwynne Becker, Kiterie Maud Edwige Faller, Kevin Talbot, Thomas Henry Gillingwater

eBioMedicine. 2022 Sep; 83: 104202. Published online 2022 Aug 11. doi: 10.1016/j.ebiom.2022.104202

PMCID:: PMC9482929

Abstract Article PDF–2.4M

Select item 94049723.

A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype

Ana Quelle-Regaldie, Mónica Folgueira, Julián Yáñez, Daniel Sobrido-Cameán, Anabel Alba-González, Antón Barreiro-Iglesias, María-Jesús Sobrido, Laura Sánchez

Biomedicines. 2022 Aug; 10(8): 1814. Published online 2022 Jul 28. doi: 10.3390/biomedicines10081814

PMCID:: PMC9404972

Abstract Article PDF–11M

Select item 90107714.

Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis

Sarah Boddy, Mahjabin Islam, Tobias Moll, Julian Kurz, David Burrows, Alexander McGown, Anushka Bhargava, Thomas H Julian, Calum Harvey, Jack NG Marshall, Benjamin PC Hall, Scott P Allen, Kevin P Kenna, Eleanor Sanderson, Sai Zhang, Tennore Ramesh, Michael P Snyder, Pamela J Shaw, Christopher McDermott, Johnathan Cooper-Knock

Brain Commun. 2022; 4(2): fcac069. Published online 2022 Mar 17. doi: 10.1093/braincomms/fcac069

PMCID:: PMC9010771

Abstract Article PDF–1.0M

Select item 82333445.

Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish

Zoé Butti, Yingzhou Edward Pan, Jean Giacomotto, Shunmoogum A. Patten

Commun Biol. 2021; 4: 792. Published online 2021 Jun 25. doi: 10.1038/s42003-021-02302-y

PMCID:: PMC8233344

Abstract Article PDF–3.3M

Select item 81069596.

Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy

Ana-Maria Opris¸oreanu, Hannah L. Smith, Sophia Krix, Helena Chaytow, Neil O. Carragher, Thomas H. Gillingwater, Catherina G. Becker, Thomas Becker

Dis Model Mech. 2021 Apr 1; 14(4): dmm047761. Published online 2021 Apr 26. doi: 10.1242/dmm.047761

PMCID:: PMC8106959

Abstract Article

Select item 80841967.

CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury

Marcus Keatinge, Themistoklis M. Tsarouchas, Tahimina Munir, Nicola J. Porter, Juan Larraz, Davide Gianni, Hui-Hsin Tsai, Catherina G. Becker, David A. Lyons, Thomas Becker

PLoS Genet. 2021 Apr; 17(4): e1009515. Published online 2021 Apr 29. doi: 10.1371/journal.pgen.1009515

PMCID:: PMC8084196

Abstract Article PDF–2.4M

Select item 62409578.

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

Matthew P. Shaw, Adrian Higginbottom, Alexander McGown, Lydia M. Castelli, Evlyn James, Guillaume M. Hautbergue, Pamela J. Shaw, Tennore M. Ramesh

Acta Neuropathol Commun. 2018; 6: 125. Published online 2018 Nov 19. doi: 10.1186/s40478-018-0629-7

PMCID:: PMC6240957

Abstract Article PDF–4.3M

Select item 59325629.

Expression of C9orf72-related dipeptides impairs motor function in a vertebrate model

Amrutha Swaminathan, Marilou Bouffard, Meijiang Liao, Sarah Ryan, Janis Bennion Callister, Stuart M Pickering-Brown, Gary Alan Barclay Armstrong, Pierre Drapeau

Hum Mol Genet. 2018 May 15; 27(10): 1754–1762. Published online 2018 Mar 8. doi: 10.1093/hmg/ddy083

PMCID:: PMC5932562

Abstract Article PDF–523K

Select item 523753310.

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration

Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer, Bettina Schmid

Mol Neurodegener. 2017; 12: 6. Published online 2017 Jan 14. doi: 10.1186/s13024-016-0146-8

PMCID:: PMC5237533

Abstract Article PDF–1.4M

Select item 496822111.

The most prevalent genetic cause of ALS-FTD, C9orf72 synergizes the toxicity of ATXN2 intermediate polyglutamine repeats through the autophagy pathway

Sorana Ciura, Chantal Sellier, Maria-Letizia Campanari, Nicolas Charlet-Berguerand, Edor Kabashi

Autophagy. 2016 Aug; 12(8): 1406–1408. Published online 2016 May 31. doi: 10.1080/15548627.2016.1189070

PMCID:: PMC4968221

Abstract Article PDF–376K

Select item 463413712.

RFX transcription factors are essential for hearing in mice

Ran Elkon, Beatrice Milon, Laura Morrison, Manan Shah, Sarath Vijayakumar, Manoj Racherla, Carmen C. Leitch, Lorna Silipino, Shadan Hadi, Michèle Weiss-Gayet, Emmanuèle Barras, Christoph D. Schmid, Aouatef Ait-Lounis, Ashley Barnes, Yang Song, David J. Eisenman, Efrat Eliyahu, Gregory I. Frolenkov, Scott E. Strome, Bénédicte Durand, Norann A. Zaghloul, Sherri M. Jones, Walter Reith, Ronna Hertzano

Nat Commun. 2015; 6: 8549. Published online 2015 Oct 15. doi: 10.1038/ncomms9549

PMCID:: PMC4634137

Abstract Article PDF–5.5M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 52895914.

Hematopoietic gene expression profile in zebrafish kidney marrow

Huai-Dong Song, Xiao-Jian Sun, Min Deng, Guo-Wei Zhang, Yi Zhou, Xin-Yan Wu, Yan Sheng, Yi Chen, Zheng Ruan, Chun-Lei Jiang, Hui-Yong Fan, Leonard I. Zon, John P. Kanki, Ting Xi Liu, A. Thomas Look, Zhu Chen

Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46): 16240–16245. Published online 2004 Nov 1. doi: 10.1073/pnas.0407241101