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Items: 1 to 20 of 33

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Reversal of an existing hearing loss by gene activation in Spns2 mutant mice
Elisa Martelletti, Neil J. Ingham, Karen P. Steel
Proc Natl Acad Sci U S A. 2023 Aug 22; 120(34): e2307355120. Published online 2023 Aug 8. doi: 10.1073/pnas.2307355120
PMCID:
PMC10450448
AbstractArticlePDF–11M
3.
Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine‐1‐Phosphate
Ilaria Del Gaudio, Luisa Rubinelli, Linda Sasset, Christian Wadsack, Timothy Hla, Annarita Di Lorenzo
J Am Heart Assoc. 2021 Jul 20; 10(14): e021261. Published online 2021 Jul 9. doi: 10.1161/JAHA.121.021261
PMCID:
PMC8483458
AbstractArticlePDF–1.4M
4.
SPNS2 enables T cell egress from lymph nodes during an immune response
Martyna Okuniewska, Victoria Fang, Audrey Baeyens, Varsha Raghavan, June-Yong Lee, Dan R. Littman, Susan R. Schwab
Cell Rep. Author manuscript; available in PMC 2021 Aug 9.
Published in final edited form as: Cell Rep. 2021 Jul 13; 36(2): 109368. doi: 10.1016/j.celrep.2021.109368
PMCID:
PMC8351797
AbstractArticlePDF–1.2M
5.
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease
Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, Claudio M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P. Corr, James T. Smith, Sindhu T. Mohanty, John A. Morris, Michelle M. McDonald, Julian M. W. Quinn, Amelia R. McGlade, Nenad Bartonicek, Matt Jansson, Konstantinos Hatzikotoulas, Melita D. Irving, Ana Beleza-Meireles, Fernando Rivadeneira, Emma Duncan, J. Brent Richards, David J. Adams, Christopher J. Lelliott, Robert Brink, Tri Giang Phan, John A. Eisman, David M. Evans, Eleftheria Zeggini, Paul A. Baldock, J. H. Duncan Bassett, Graham R. Williams, Peter I. Croucher
Nat Commun. 2021; 12: 2444. Published online 2021 May 5. doi: 10.1038/s41467-021-22517-1
PMCID:
PMC8100170
AbstractArticlePDF–11M
6.
Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases
Hirotaka Goto, Masatoshi Miyamoto, Akio Kihara
J Biol Chem. 2021 Jan-Jun; 296: 100605. Published online 2021 Mar 27. doi: 10.1016/j.jbc.2021.100605
PMCID:
PMC8093947
AbstractArticlePDF–1.7M
7.
Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b
Toan Q. Nguyen, Thiet Minh Vu, Farhana Tukijan, Sneha Muralidharan, Juat Chin Foo, Jasmine Fei Li Chin, Zafrul Hasan, Federico Torta, Long N. Nguyen
J Biol Chem. 2021 Jan-Jun; 296: 100201. Published online 2021 Jan 23. doi: 10.1074/jbc.RA120.012941
PMCID:
PMC7948482
AbstractArticlePDF–3.3M
8.
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation
Louise van der Weyden, Agnieszka Swiatkowska, Vivek Iyer, Anneliese O. Speak, David J. Adams
G3 (Bethesda) 2020 Jun; 10(6): 1869–1877. Published online 2020 Apr 3. doi: 10.1534/g3.120.401128
PMCID:
PMC7263671
AbstractArticlePDF–1.0M
9.
High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node
Szandor Simmons, Naoko Sasaki, Eiji Umemoto, Yutaka Uchida, Shigetomo Fukuhara, Yusuke Kitazawa, Michiyo Okudaira, Asuka Inoue, Kazuo Tohya, Keita Aoi, Junken Aoki, Naoki Mochizuki, Kenjiro Matsuno, Kiyoshi Takeda, Masayuki Miyasaka, Masaru Ishii
eLife. 2019; 8: e41239. Published online 2019 Oct 1. doi: 10.7554/eLife.41239
PMCID:
PMC6773441
AbstractArticlePDF–8.6M
10.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
11.
Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide
Liansheng Zhong, Xue Jiang, Zhihui Zhu, Haiyan Qin, Michael B. Dinkins, Ji-Na Kong, Silvia Leanhart, Rebecca Wang, Ahmed Elsherbini, Erhard Bieberich, Yujie Zhao, Guanghu Wang
Glia. Author manuscript; available in PMC 2020 Mar 1.
Published in final edited form as: Glia. 2019 Mar; 67(3): 498–511. Published online 2018 Nov 28. doi: 10.1002/glia.23558
PMCID:
PMC6355341
AbstractArticlePDF–1013K
12.
Lymphatic endothelial S1P promotes naïve T cell mitochondrial function and survival
Alejandra Mendoza, Victoria Fang, Cynthia Chen, Madhavika Serasinghe, Akanksha Verma, James Muller, V. Sai Chaluvadi, Michael L. Dustin, Timothy Hla, Olivier Elemento, Jerry E. Chipuk, Susan R. Schwab
Nature. Author manuscript; available in PMC 2017 Nov 24.
Published in final edited form as: Nature. 2017 Jun 1; 546(7656): 158–161. Published online 2017 May 24. doi: 10.1038/nature22352
PMCID:
PMC5683179
ArticlePDF–3.0M
13.
Lymph node S1P gradients position natural killer cells and regulate their interferon-γ response
Victoria Fang, V. Sai Chaluvadi, Willy D. Ramos-Perez, Alejandra Mendoza, Audrey Baeyens, Richard Rivera, Jerold Chun, Michael Cammer, Susan R. Schwab
Nat Immunol. Author manuscript; available in PMC 2017 Nov 7.
Published in final edited form as: Nat Immunol. 2017 Jan; 18(1): 15–25. Published online 2016 Nov 14. doi: 10.1038/ni.3619
PMCID:
PMC5675020
AbstractArticlePDF–1.5M
14.
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization
Louise van der Weyden, Mark J. Arends, Andrew D. Campbell, Tobias Bald, Hannah Wardle-Jones, Nicola Griggs, Martin Del Castillo Velasco-Herrera, Thomas Tüting, Owen J. Sansom, Natasha A. Karp, Simon Clare, Diane Gleeson, Edward Ryder, Antonella Galli, Elizabeth Tuck, Emma L. Cambridge, Thierry Voet, Iain C. Macaulay, Kim Wong, Sanger Mouse Genetics Project, Sarah Spiegel, Anneliese O. Speak, David J. Adams
Nature. Author manuscript; available in PMC 2018 Jan 12.
Published in final edited form as: Nature. 2017 Jan 12; 541(7636): 233–236. Published online 2017 Jan 4. doi: 10.1038/nature20792
PMCID:
PMC5603286
AbstractArticlePDF–3.7M
15.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
16.
Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases
Michael S. Donoviel, Nitai C. Hait, Subramaniam Ramachandran, Michael Maceyka, Kazuaki Takabe, Sheldon Milstien, Tamas Oravecz, Sarah Spiegel
FASEB J. 2015 Dec; 29(12): 5018–5028. Published online 2015 Aug 31. doi: 10.1096/fj.15-274936
PMCID:
PMC4653056
AbstractArticle
17.
Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss
Jing Chen, Neil Ingham, John Kelly, Shalini Jadeja, David Goulding, Johanna Pass, Vinit B. Mahajan, Stephen H. Tsang, Anastasia Nijnik, Ian J. Jackson, Jacqueline K. White, Andrew Forge, Daniel Jagger, Karen P. Steel
PLoS Genet. 2014 Oct; 10(10): e1004688. Published online 2014 Oct 30. doi: 10.1371/journal.pgen.1004688
PMCID:
PMC4214598
AbstractArticlePDF–3.2M
18.
Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen
Hibret A. Adissu, Jeanne Estabel, David Sunter, Elizabeth Tuck, Yvette Hooks, Damian M. Carragher, Kay Clarke, Natasha A. Karp, Sanger Mouse Genetics Project, Susan Newbigging, Nora Jones, Lily Morikawa, Jacqueline K. White, Colin McKerlie
Dis Model Mech. 2014 May; 7(5): 515–524. Published online 2014 Mar 20. doi: 10.1242/dmm.015263
PMCID:
PMC4007403
AbstractArticle
19.
Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes
Jacqueline K. White, Anna-Karin Gerdin, Natasha A. Karp, Ed Ryder, Marija Buljan, James N. Bussell, Jennifer Salisbury, Simon Clare, Neil J. Ingham, Christine Podrini, Richard Houghton, Jeanne Estabel, Joanna R. Bottomley, David G. Melvin, David Sunter, Niels C. Adams, The Sanger Institute Mouse Genetics Project, David Tannahill, Darren W. Logan, Daniel G. MacArthur, Jonathan Flint, Vinit B. Mahajan, Stephen H. Tsang, Ian Smyth, Fiona M. Watt, William C. Skarnes, Gordon Dougan, David J. Adams, Ramiro Ramirez-Solis, Allan Bradley, Karen P. Steel
Cell. 2013 Jul 18; 154(2): 452–464. doi: 10.1016/j.cell.2013.06.022
PMCID:
PMC3717207
AbstractArticlePDF–3.4M
20.
The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate
Alejandra Mendoza, Béatrice Bréart, Willy D. Ramos-Perez, Lauren A. Pitt, Michael Gobert, Manjula Sunkara, Juan J. Lafaille, Andrew J. Morris, Susan R. Schwab
Cell Rep. Author manuscript; available in PMC 2013 Nov 29.
Published in final edited form as: Cell Rep. 2012 Nov 29; 2(5): 1104–1110. Published online 2012 Oct 25. doi: 10.1016/j.celrep.2012.09.021
PMCID:
PMC3616498
AbstractArticlePDF–2.2M

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