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Select item 113028761.

Helicobacter pylori promotes gastric cancer through CagA-mediated mitochondrial cholesterol accumulation by targeting CYP11A1 redistribution

Zhijun Zhang, Hongxin Huang, Zetian Chen, Mengpei Yan, Chen Lu, Zekuan Xu, Zheng Li

Int J Biol Sci. 2024; 20(10): 4007–4028. Published online 2024 Jul 15. doi: 10.7150/ijbs.96425

PMCID:: PMC11302876

Abstract Article PDF–9.9M

Select item 107167802.

The multistep oxidation of cholesterol to pregnenolone by human cytochrome P450 11A1 is highly processive

Kevin D. McCarty, Lu Liu, Yasuhiro Tateishi, Hannah L. Wapshott-Stehli, F. Peter Guengerich

J Biol Chem. 2024 Jan; 300(1): 105495. Published online 2023 Nov 24. doi: 10.1016/j.jbc.2023.105495

PMCID:: PMC10716780

Abstract Article PDF–1.3M

Select item 93175583.

In-Silico Investigation of Effects of Single-Nucleotide Polymorphisms in PCOS-Associated CYP11A1 Gene on Mutated Proteins

Fatima Muccee, Osama Bijou, Steve Harakeh, Rabi’atul Adawiyah, R. Z. Sayyed, Leila Haghshenas, Dikhnah Alshehri, Mohammad Javed Ansari, Shakira Ghazanfar

Genes (Basel) 2022 Jul; 13(7): 1231. Published online 2022 Jul 12. doi: 10.3390/genes13071231

PMCID:: PMC9317558

Abstract Article PDF–7.2M

Select item 82052654.

The significance of CYP11A1 expression in skin physiology and pathology

RM Slominski, C Raman, C Elmets, AM Jetten, AT Slominski, RC Tuckey

Mol Cell Endocrinol. Author manuscript; available in PMC 2022 Jun 15.

Published in final edited form as: Mol Cell Endocrinol. 2021 Jun 15; 530: 111238. Published online 2021 Mar 12. doi: 10.1016/j.mce.2021.111238

PMCID:: PMC8205265

Abstract Article PDF–1.6M

Select item 79804995.

Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students

Jing Zhang, Mengyi Yang, Pengfei Luan, Wei Jia, Qiujun Liu, Zhanbing Ma, Jie Dang, Hong Lu, Qian Ma, Yanfeng Wang, Chunlan Mu, Zhenghao Huo

Med Sci Monit. 2021; 27: e930591-1–e930591-13. Prepublished online 2021 Mar 3. Published online 2021 Mar 16. doi: 10.12659/MSM.930591

PMCID:: PMC7980499

Abstract Article PDF–1.8M

Select item 72720766.

Expression and activation of the steroidogenic enzyme CYP11A1 is associated with IL-13 production in T cells from peanut allergic children

Meiqin Wang, Matthew J. Strand, Bruce J. Lanser, Carah Santos, Kreso Bendelja, Jennifer Fish, Elizabeth A. Esterl, Shigeru Ashino, Jordan K. Abbott, Vijaya Knight, Erwin W. Gelfand

PLoS One. 2020; 15(6): e0233563. Published online 2020 Jun 4. doi: 10.1371/journal.pone.0233563

PMCID:: PMC7272076

Abstract Article PDF–1.3M

Select item 70550277.

CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study

Ning Gao, Hong Tang, Ling Gao, Guolong Tu, Han Luo, Ying Xia

BMC Neurol. 2020; 20: 77. Published online 2020 Mar 4. doi: 10.1186/s12883-020-1628-4

PMCID:: PMC7055027

Abstract Article PDF–631K

Select item 66079628.

Characterization of the CYP11A1 Nonsynonymous Variant p.E314K in Children Presenting With Adrenal Insufficiency

Vipula Kolli, Hannah Kim, Ahmed Torky, Qizong Lao, Christina Tatsi, Ashwini Mallappa, Deborah P Merke

J Clin Endocrinol Metab. 2019 Feb; 104(2): 269–276. Published online 2018 Oct 8. doi: 10.1210/jc.2018-01661

PMCID:: PMC6607962

Abstract Article

Select item 65419269.

Active site structures of CYP11A1 in the presence of its physiological substrates and alterations upon binding of Adrenodoxin

Qianhong Zhu, Piotr J. Mak, Robert C. Tuckey, James R. Kincaid

Biochemistry. Author manuscript; available in PMC 2019 May 30.

Published in final edited form as: Biochemistry. 2017 Oct 31; 56(43): 5786–5797. Published online 2017 Oct 20. doi: 10.1021/acs.biochem.7b00766

PMCID:: PMC6541926

Abstract Article PDF–864K

Select item 488219010.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

Select item 473251711.

Evidence that Compound I is the active species in both the hydroxylase and lyase steps by which P450scc converts cholesterol to pregnenolone: EPR/ENDOR/cryoreduction/annealing studies

Roman Davydov, Natallia Strushkevich, David Smil, Aliaksei Yantsevich, Andrey Gilep, Sergey Usanov, Brian M. Hoffman

Biochemistry. Author manuscript; available in PMC 2016 Dec 8.

Published in final edited form as: Biochemistry. 2015 Dec 8; 54(48): 7089–7097. Published online 2015 Nov 25. doi: 10.1021/acs.biochem.5b00903

PMCID:: PMC4732517

Abstract Article PDF–1.6M

Select item 471714612.

The anti-Müllerian hormone (AMH) acts as a gatekeeper of ovarian steroidogenesis inhibiting the granulosa cell response to both FSH and LH

Sandro Sacchi, Giovanni D’Ippolito, Paola Sena, Tiziana Marsella, Daniela Tagliasacchi, Elena Maggi, Cindy Argento, Alessandra Tirelli, Simone Giulini, Antonio La Marca

J Assist Reprod Genet. 2016 Jan; 33(1): 95–100. Published online 2015 Dec 2. doi: 10.1007/s10815-015-0615-y

PMCID:: PMC4717146

Abstract Article PDF–459K

Select item 471270313.

1,25D3 prevents CD8⁺Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter

Michaela Schedel, Yi Jia, Sven Michel, Katsuyuki Takeda, Joanne Domenico, Anthony Joetham, Fangkun Ning, Matthew Strand, Junyan Han, Meiqin Wang, Joseph J. Lucas, Christian Vogelberg, Michael Kabesch, Brian P. O'Connor, Erwin W. Gelfand

Nat Commun. 2016; 7: 10213. Published online 2016 Jan 11. doi: 10.1038/ncomms10213

PMCID:: PMC4712703

Abstract Article PDF–1.3M

Select item 425261314.

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

Robert C. Tuckey, Andrzej T. Slominski, Chloe Y. S. Cheng, Jianjun Chen, Tae-Kang Kim, Min Xiao, Wei Li

Int J Biochem Cell Biol. Author manuscript; available in PMC 2015 Oct 1.

Published in final edited form as: Int J Biochem Cell Biol. 2014 Oct; 55: 24–34. Published online 2014 Aug 13. doi: 10.1016/j.biocel.2014.08.004

PMCID:: PMC4252613

Abstract Article PDF–2.4M

Select item 409688515.

CYP11A1 microsatellite (tttta)_n polymorphism in PCOS women from South India

K. Ranjith Reddy, M. L. N. Deepika, K. Supriya, K. Prasanna Latha, S. S. Lakshmana Rao, V. Usha Rani, P. Jahan

J Assist Reprod Genet. 2014 Jul; 31(7): 857–863. Published online 2014 May 4. doi: 10.1007/s10815-014-0236-x

PMCID:: PMC4096885

Abstract Article PDF–540K

Select item 382069116.

Characterization of Prostate Cancer Bone Metastases According to Expression Levels of Steroidogenic Enzymes and Androgen Receptor Splice Variants

Emma Jernberg, Elin Thysell, Erik Bovinder Ylitalo, Stina Rudolfsson, Sead Crnalic, Anders Widmark, Anders Bergh, Pernilla Wikström

PLoS One. 2013; 8(11): e77407. Published online 2013 Nov 7. doi: 10.1371/journal.pone.0077407

PMCID:: PMC3820691

Abstract Article PDF–1.1M

Select item 369018217.

Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas

Misu Lee, Ilaria Marinoni, Martin Irmler, Tsambika Psaras, Jürgen B. Honegger, Rudi Beschorner, Natasa Anastasov, Johannes Beckers, Marily Theodoropoulou, Federico Roncaroli, Natalia S. Pellegata

Acta Neuropathol. 2013; 126(1): 137–150. Published online 2013 Jun 12. doi: 10.1007/s00401-013-1132-7

PMCID:: PMC3690182

Abstract Article PDF–1.3M

Select item 361208618.

Abnormal Apoptosis of Trophoblastic Cells Is Related to the Up-Regulation of CYP11A Gene in Placenta of Preeclampsia Patients

Guolin He, Wenming Xu, Yan Chen, Xinghui Liu, Mingrong Xi

PLoS One. 2013; 8(3): e59609. Published online 2013 Mar 29. doi: 10.1371/journal.pone.0059609

PMCID:: PMC3612086

Abstract Article PDF–4.2M

Select item 356511519.

Varied Clinical Presentations of Seven Patients With Mutations in CYP11A1 Encoding the Cholesterol Side-Chain Cleavage Enzyme, P450scc

Meng Kian Tee, Michal Abramsohn, Neta Loewenthal, Mark Harris, Sudeep Siwach, Ana Kaplinsky, Barak Markus, Ohad Birk, Val C. Sheffield, Ruti Pavari, Eli Hershkovitz, Walter L. Miller

J Clin Endocrinol Metab. 2013 Feb; 98(2): 713–720. Published online 2013 Jan 21. doi: 10.1210/jc.2012-2828

Correction in:: J Clin Endocrinol Metab. 2013 Oct; 98(10): 4213.

PMCID:: PMC3565115

Abstract Article

Select item 352009920.

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes

Andrzej T. Slominski, Tae-Kang Kim, Jianjun Chen, Minh N. Nguyen, Wei Li, Charles R. Yates, Trevor Sweatman, Zorica Janjetovic, Robert C. Tuckey

Int J Biochem Cell Biol. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: Int J Biochem Cell Biol. 2012 Nov; 44(11): 2003–2018. Published online 2012 Aug 2. doi: 10.1016/j.biocel.2012.07.027

PMCID:: PMC3520099

Abstract Article PDF–3.7M

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