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Select item 95826221.

Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes

Jan Mikhale B. Cajulao, Eduardo Hernandez, Mark E. von Zastrow, Erica L. Sanchez

Mol Biol Cell. 2022 Sep 1; 33(10): ar90. Published online 2022 Aug 18. doi: 10.1091/mbc.E21-09-0430

PMCID:: PMC9582622

Abstract Article PDF–5.7M

Select item 92541202.

Hepatocyte cholesterol content modulates glucagon receptor signalling

Emma Rose McGlone, T. Bertie Ansell, Cecilia Dunsterville, Wanling Song, David Carling, Alejandra Tomas, Stephen R. Bloom, Mark S.P. Sansom, Tricia Tan, Ben Jones

Mol Metab. 2022 Sep; 63: 101530. Published online 2022 Jun 16. doi: 10.1016/j.molmet.2022.101530

PMCID:: PMC9254120

Abstract Article PDF–1.9M

Select item 92434253.

Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes

Yunbo Jia, Yang Liu, Linlin Feng, Siyu Sun, Guangwei Sun

Front Endocrinol (Lausanne) 2022; 13: 928016. Published online 2022 Jun 16. doi: 10.3389/fendo.2022.928016

PMCID:: PMC9243425

Abstract Article PDF–1.8M

Select item 83638414.

Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

Emma Rose McGlone, Yusman Manchanda, Ben Jones, Phil Pickford, Asuka Inoue, David Carling, Stephen R. Bloom, Tricia Tan, Alejandra Tomas

Mol Metab. 2021 Nov; 53: 101296. Published online 2021 Jul 13. doi: 10.1016/j.molmet.2021.101296

PMCID:: PMC8363841

Abstract Article PDF–2.8M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80710546.

Ligand-Receptor Interactions and Machine Learning in GCGR and GLP-1R Drug Discovery

Mikołaj Mizera, Dorota Latek

Int J Mol Sci. 2021 Apr; 22(8): 4060. Published online 2021 Apr 14. doi: 10.3390/ijms22084060

PMCID:: PMC8071054

Abstract Article PDF–43M

Select item 78640617.

Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling

Suneet Kaur, Yuqing Chen, Sudha K. Shenoy

J Biol Chem. 2020 Dec 4; 295(49): 16630–16642. Published online 2021 Jan 13. doi: 10.1074/jbc.RA120.014532

PMCID:: PMC7864061

Abstract Article PDF–3.2M

Select item 73631208.

Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide

Rulue Chang, Xin Zhang, Anna Qiao, Antao Dai, Matthew J. Belousoff, Qiuxiang Tan, Lijun Shao, Li Zhong, Guangyao Lin, Yi-Lynn Liang, Limin Ma, Shuo Han, Dehua Yang, Radostin Danev, Ming-Wei Wang, Denise Wootten, Beili Wu, Patrick M. Sexton

J Biol Chem. 2020 Jul 10; 295(28): 9313–9325. Published online 2020 May 5. doi: 10.1074/jbc.RA120.013793

PMCID:: PMC7363120

Abstract Article PDF–5.5M

Select item 73550259.

A combined activation mechanism for the glucagon receptor

Giulio Mattedi, Silvia Acosta-Gutiérrez, Timothy Clark, Francesco Luigi Gervasio

Proc Natl Acad Sci U S A. 2020 Jul 7; 117(27): 15414–15422. Published online 2020 Jun 22. doi: 10.1073/pnas.1921851117

PMCID:: PMC7355025

Abstract Article PDF–2.1M

Select item 677813710.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 555154911.

RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling

Jaimini Cegla, Ben J. Jones, James V. Gardiner, David J. Hodson, Thomas Marjot, Emma R. McGlone, Tricia M. Tan, Stephen R. Bloom

Endocrinology. 2017 Aug 1; 158(8): 2680–2693. Published online 2017 Jun 6. doi: 10.1210/en.2016-1755

PMCID:: PMC5551549

Abstract Article

Select item 549295512.

Structure of the full-length glucagon class B G protein-coupled receptor

Haonan Zhang, Anna Qiao, Dehua Yang, Linlin Yang, Antao Dai, Chris de Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, Hui Zhang, Gye Won Han, Thomas D. Grant, Raymond G. Sierra, Uwe Weierstall, Garrett Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiaoqing Cai, Guangyao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, Patrick R. Griffin, Jesper Lau, Vadim Cherezov, Huaiyu Yang, Michael A. Hanson, Raymond C. Stevens, Qiang Zhao, Hualiang Jiang, Ming-Wei Wang, Beili Wu

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 Jun 8; 546(7657): 259–264. Published online 2017 May 17. doi: 10.1038/nature22363

PMCID:: PMC5492955

Abstract Article PDF–3.7M

Select item 548775213.

Solvent-accessibility of discrete residue positions in the polypeptide hormone glucagon by ¹⁹F-NMR observation of 4-fluorophenylalanine

Yaguang Hou, Wanhui Hu, Xiaona Li, John J. Skinner, Dongsheng Liu, Kurt Wüthrich

J Biomol NMR. 2017; 68(1): 1–6. Published online 2017 May 15. doi: 10.1007/s10858-017-0107-8

PMCID:: PMC5487752

Abstract Article PDF–2.1M

Select item 547324014.

Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors

Yanting Yin, Parker W. de Waal, Yuanzheng He, Li-Hua Zhao, Dehua Yang, Xiaoqing Cai, Yi Jiang, Karsten Melcher, Ming-Wei Wang, H. Eric Xu

J Biol Chem. 2017 Jun 16; 292(24): 9865–9881. Published online 2017 Mar 29. doi: 10.1074/jbc.M117.782987

PMCID:: PMC5473240

Abstract Article PDF–5.5M

Select item 494692815.

Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors

Li-Hua Zhao, Yanting Yin, Dehua Yang, Bo Liu, Li Hou, Xiaoxi Wang, Kuntal Pal, Yi Jiang, Yang Feng, Xiaoqing Cai, Antao Dai, Mingyao Liu, Ming-Wei Wang, Karsten Melcher, H. Eric Xu

J Biol Chem. 2016 Jul 15; 291(29): 15119–15130. Published online 2016 May 13. doi: 10.1074/jbc.M116.726620

PMCID:: PMC4946928

Abstract Article PDF–3.2M

Select item 453285616.

Conformational states of the full-length glucagon receptor

Linlin Yang, Dehua Yang, Chris de Graaf, Arne Moeller, Graham M. West, Venkatasubramanian Dharmarajan, Chong Wang, Fai Y. Siu, Gaojie Song, Steffen Reedtz-Runge, Bruce D. Pascal, Beili Wu, Clinton S. Potter, Hu Zhou, Patrick R. Griffin, Bridget Carragher, Huaiyu Yang, Ming-Wei Wang, Raymond C. Stevens, Hualiang Jiang

Nat Commun. 2015; 6: 7859. Published online 2015 Jul 31. doi: 10.1038/ncomms8859

PMCID:: PMC4532856

Abstract Article PDF–2.6M

Select item 429448817.

Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking

Sarah Noerklit Roed, Anne Cathrine Nøhr, Pernille Wismann, Helle Iversen, Hans Bräuner-Osborne, Sanne Moeller Knudsen, Maria Waldhoer

J Biol Chem. 2015 Jan 9; 290(2): 1233–1243. Published online 2014 Dec 1. doi: 10.1074/jbc.M114.592436

PMCID:: PMC4294488

Abstract Article PDF–1.7M

Select item 398666118.

Action and therapeutic potential of oxyntomodulin

Alessandro Pocai

Mol Metab. 2014 Jun; 3(3): 241–251. Published online 2013 Dec 14. doi: 10.1016/j.molmet.2013.12.001

PMCID:: PMC3986661

Abstract Article PDF–712K

Select item 393141919.

Insights into the structure of class B GPCRs

Kaspar Hollenstein, Chris de Graaf, Andrea Bortolato, Ming-Wei Wang, Fiona H. Marshall, Raymond C. Stevens

Trends Pharmacol Sci. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Trends Pharmacol Sci. 2014 Jan; 35(1): 12–22. Published online 2013 Dec 18. doi: 10.1016/j.tips.2013.11.001

PMCID:: PMC3931419

Abstract Article PDF–5.7M

Select item 382048020.

Structure of the class B human glucagon G protein coupled receptor

Fai Yiu Siu, Min He, Chris de Graaf, Gye Won Han, Dehua Yang, Zhiyun Zhang, Caihong Zhou, Qingping Xu, Daniel Wacker, Jeremiah S. Joseph, Wei Liu, Jesper Lau, Vadim Cherezov, Vsevolod Katritch, Ming-Wei Wang, Raymond C. Stevens

Nature. Author manuscript; available in PMC 2014 Jul 25.

Published in final edited form as: Nature. 2013 Jul 25; 499(7459): 10.1038/nature12393. Published online 2013 Jul 17. doi: 10.1038/nature12393

PMCID:: PMC3820480

Abstract Article PDF–3.5M

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