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Items: 1 to 20 of 40

1.
Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence
Sarah Grossi, Elena Berno, Priscilla Chiofalo, Anna Maria Chiaravalli, Raffaella Cinquetti, Antonino Bruno, Maria Teresa Palano, Matteo Gallazzi, Stefano La Rosa, Fausto Sessa, Francesco Acquati, Paola Campomenosi
Int J Mol Sci. 2024 Jan; 25(2): 714. Published online 2024 Jan 5. doi: 10.3390/ijms25020714
PMCID:
PMC10815008
AbstractArticlePDF–1.7M
2.
Prognostic and immunomodulatory roles of schizophrenia-associated genes HTR2A, COMT, and PRODH in pan-cancer analysis and glioma survival prediction model
Jing Shen, Qiang Wang, Fengquan Lu, Hua Xu, Peng Wang, Yu Feng
Front Immunol. 2023; 14: 1201252. Published online 2023 Jul 26. doi: 10.3389/fimmu.2023.1201252
PMCID:
PMC10411190
AbstractArticlePDF–15M
3.
Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells
Thi Yen Ly Huynh, Ilona Oscilowska, Jorge Sáiz, Magdalena Nizioł, Weronika Baszanowska, Coral Barbas, Jerzy Palka
Biomolecules. 2021 Dec; 11(12): 1888. Published online 2021 Dec 15. doi: 10.3390/biom11121888
PMCID:
PMC8699520
AbstractArticlePDF–2.8M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers
Y Liu, GL Borchert, A Surazynski, JM Phang
Oncogene. Author manuscript; available in PMC 2020 Apr 27.
Published in final edited form as: Oncogene. 2008 Dec 4; 27(53): 6729–6737. Published online 2008 Sep 15. doi: 10.1038/onc.2008.322
PMCID:
PMC7185295
AbstractArticlePDF–1.3M
6.
Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy
Thi Yen Ly Huynh, Ilona Zareba, Weronika Baszanowska, Sylwia Lewoniewska, Jerzy Palka
Mol Cell Biochem. 2020; 466(1): 35–44. Published online 2020 Jan 13. doi: 10.1007/s11010-020-03685-y
PMCID:
PMC7028810
AbstractArticlePDF–794K
7.
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik
Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.
Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834
PMCID:
PMC5557292
AbstractArticlePDF–3.4M
8.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
9.
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
Orianne Olivares, Jared R. Mayers, Victoire Gouirand, Margaret E. Torrence, Tristan Gicquel, Laurence Borge, Sophie Lac, Julie Roques, Marie-Noëlle Lavaut, Patrice Berthezène, Marion Rubis, Veronique Secq, Stéphane Garcia, Vincent Moutardier, Dominique Lombardo, Juan Lucio Iovanna, Richard Tomasini, Fabienne Guillaumond, Matthew G. Vander Heiden, Sophie Vasseur
Nat Commun. 2017; 8: 16031. Published online 2017 Jul 7. doi: 10.1038/ncomms16031
PMCID:
PMC5504351
AbstractArticlePDF–2.2M
10.
Cytosolic accumulation of L-proline disrupts GABA-ergic transmission through GAD blockade
Gregg W Crabtree, Alan J Park, Joshua A Gordon, Joseph A Gogos
Cell Rep. Author manuscript; available in PMC 2016 Nov 10.
Published in final edited form as: Cell Rep. 2016 Oct 4; 17(2): 570–582. doi: 10.1016/j.celrep.2016.09.029
PMCID:
PMC5104186
AbstractArticlePDF–1.7M
11.
Panorama of ancient metazoan macromolecular complexes
Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili
Nature. Author manuscript; available in PMC 2016 Sep 26.
Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877
PMCID:
PMC5036527
AbstractArticlePDF–4.7M
12.
A Novel Role of Proline Oxidase in HIV-1 Envelope Glycoprotein-induced Neuronal Autophagy
Jui Pandhare, Sabyasachi Dash, Bobby Jones, Fernando Villalta, Chandravanu Dash
J Biol Chem. 2015 Oct 16; 290(42): 25439–25451. Published online 2015 Sep 1. doi: 10.1074/jbc.M115.652776
PMCID:
PMC4646191
AbstractArticlePDF–1.4M
13.
Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops
Sarah K. Sasse, Zheng Zuo, Vineela Kadiyala, Liyang Zhang, Miles A. Pufall, Mukesh K. Jain, Tzu L. Phang, Gary D. Stormo, Anthony N. Gerber
J Biol Chem. 2015 Aug 7; 290(32): 19756–19769. Published online 2015 Jun 18. doi: 10.1074/jbc.M115.668558
PMCID:
PMC4528137
AbstractArticlePDF–3.7M
14.
MicroRNA-23b* targets proline oxidase, a mitochondrial tumor suppressor protein in renal cancer
W Liu, O Zabirnyk, H Wang, Y-H Shiao, M L Nickerson, S Khalil, L M Anderson, A O Perantoni, J M Phang
Oncogene. Author manuscript; available in PMC 2015 Apr 16.
Published in final edited form as: Oncogene. 2010 Sep 2; 29(35): 4914–4924. Published online 2010 Jun 21. doi: 10.1038/onc.2010.237
PMCID:
PMC4398970
AbstractArticlePDF–1.4M
15.
Proline oxidase functions as a mitochondrial tumor suppressor in human cancers
Yongmin Liu, Gregory L. Borchert, Steve Donald, Bhalchandra Diwan, Miriam Anver, James M. Phang
Cancer Res. Author manuscript; available in PMC 2015 Jan 8.
Published in final edited form as: Cancer Res. 2009 Aug 15; 69(16): 6414–6422. Published online 2009 Aug 4. doi: 10.1158/0008-5472.CAN-09-1223
PMCID:
PMC4287397
AbstractArticlePDF–2.6M
16.
Association between Autism Spectrum Disorder (ASD) in Individuals with Velo-Cardio-Facial (22q11.2 Deletion) Syndrome and PRODH and COMT Genotypes
Petya D. Radoeva, Ioana L. Coman, Cynthia A. Salazar, Karen L. Gentile, Anne Marie Higgins, Frank A. Middleton, Kevin M. Antshel, Wanda Fremont, Robert J. Shprintzen, Bernice E. Morrow, Wendy R. Kates
Psychiatr Genet. Author manuscript; available in PMC 2015 Dec 1.
Published in final edited form as: Psychiatr Genet. 2014 Dec; 24(6): 269–272. doi: 10.1097/YPG.0000000000000062
PMCID:
PMC4284058
AbstractArticlePDF–116K
17.
An atlas of genetic influences on human blood metabolites
So-Youn Shin, Eric B. Fauman, Ann-Kristin Petersen, Jan Krumsiek, Rita Santos, Jie Huang, Matthias Arnold, Idil Erte, Vincenzo Forgetta, Tsun-Po Yang, Klaudia Walter, Cristina Menni, Lu Chen, Louella Vasquez, Ana M. Valdes, Craig L. Hyde, Vicky Wang, Daniel Ziemek, Phoebe Roberts, Li Xi, Elin Grundberg, The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Melanie Waldenberger, J. Brent Richards, Robert P. Mohney, Michael V. Milburn, Sally L. John, Jeff Trimmer, Fabian J. Theis, John P. Overington, Karsten Suhre, M. Julia Brosnan, Christian Gieger, Gabi Kastenmüller, Tim D Spector, Nicole Soranzo
Nat Genet. Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as: Nat Genet. 2014 Jun; 46(6): 543–550. Published online 2014 May 11. doi: 10.1038/ng.2982
PMCID:
PMC4064254
AbstractArticlePDF–2.4M
18.
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
Roser Corominas, Xinping Yang, Guan Ning Lin, Shuli Kang, Yun Shen, Lila Ghamsari, Martin Broly, Maria Rodriguez, Stanley Tam, Shelly A. Wanamaker, Changyu Fan, Song Yi, Murat Tasan, Irma Lemmens, Xingyan Kuang, Nan Zhao, Dheeraj Malhotra, Jacob J. Michaelson, Vladimir Vacic, Michael A. Calderwood, Frederick P. Roth, Jan Tavernier, Steve Horvath, Kourosh Salehi-Ashtiani, Dmitry Korkin, Jonathan Sebat, David E. Hill, Tong Hao, Marc Vidal, Lilia M. Iakoucheva
Nat Commun. 2014; 5: 3650. Published online 2014 Apr 11. doi: 10.1038/ncomms4650
Correction in:
Nat Commun. 2023; 14: 569.
PMCID:
PMC3996537
AbstractArticlePDF–1.9M
19.
PRODH Polymorphisms, Cortical Volumes and Thickness in Schizophrenia
Vanessa K. Ota, Fernanda T. Bellucco, Ary Gadelha, Marcos L. Santoro, Cristiano Noto, Denise M. Christofolini, Idaiane B. Assunção, Karen M. Yamada, Ândrea K. Ribeiro-dos-Santos, Sidney Santos, Jair J. Mari, Marília A. C. Smith, Maria I. Melaragno, Rodrigo A. Bressan, João R. Sato, Andrea P. Jackowski, Sintia I. Belangero
PLoS One. 2014; 9(2): e87686. Published online 2014 Feb 3. doi: 10.1371/journal.pone.0087686
PMCID:
PMC3912045
AbstractArticlePDF–165K
20.
Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH
Maria Suntsova, Elena V. Gogvadze, Sergey Salozhin, Nurshat Gaifullin, Fedor Eroshkin, Sergey E. Dmitriev, Natalia Martynova, Kirill Kulikov, Galina Malakhova, Gulnur Tukhbatova, Alexey P. Bolshakov, Dmitry Ghilarov, Andrew Garazha, Alexander Aliper, Charles R. Cantor, Yuri Solokhin, Sergey Roumiantsev, Pavel Balaban, Alex Zhavoronkov, Anton Buzdin
Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48): 19472–19477. Published online 2013 Nov 11. doi: 10.1073/pnas.1318172110
PMCID:
PMC3845128
AbstractArticlePDF–1.1M

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