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Items: 1 to 20 of 78

1.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
2.
Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response
Erin Alvi, Ayako L. Mochizuki, Yoko Katsuki, Minori Ogawa, Fei Qi, Yusuke Okamoto, Minoru Takata, Anfeng Mu
Commun Biol. 2023; 6: 1038. Published online 2023 Oct 13. doi: 10.1038/s42003-023-05406-9
PMCID:
PMC10575959
AbstractArticlePDF–3.6M
3.
SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression
Mariafausta Fischietti, Frank Eckerdt, Ricardo E. Perez, Jamie N. Guillen Magaña, Candice Mazewski, Sang Ho, Christopher Gonzalez, Lukas D. Streich, Elspeth M. Beauchamp, Amy B. Heimberger, Aneta H. Baran, Feng Yue, C. David James, Leonidas C. Platanias
Cancer Res Commun. 2022 Sep; 2(9): 966–978. Published online 2022 Sep 13. doi: 10.1158/2767-9764.CRC-22-0192
PMCID:
PMC9648417
AbstractArticlePDF–7.7M
4.
Mechanistic understanding of human SLFN11
Felix J. Metzner, Simon J. Wenzl, Michael Kugler, Stefan Krebs, Karl-Peter Hopfner, Katja Lammens
Nat Commun. 2022; 13: 5464. Published online 2022 Sep 17. doi: 10.1038/s41467-022-33123-0
PMCID:
PMC9482658
AbstractArticlePDF–2.2M
5.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
6.
Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer
Bingnan Zhang, C. Allison Stewart, Qi Wang, Robert J. Cardnell, Pedro Rocha, Junya Fujimoto, Luisa M. Solis Soto, Runsheng Wang, Veronica Novegil, Peter Ansell, Lei He, Luisa Fernandez, Adam Jendrisak, Cole Gilbertson, Joseph D. Schonhoft, Jiyun Byun, Joshua Jones, Amanda K. L. Anderson, Ana Aparicio, Hai Tran, Marcelo V. Negrao, Jianjun Zhang, Wei-lien Wang, Ignacio I. Wistuba, Jing Wang, Rick Wenstrup, Lauren A. Byers, Carl M. Gay
Br J Cancer. 2022 Aug 1; 127(3): 569–576. Published online 2022 Apr 19. doi: 10.1038/s41416-022-01811-9
PMCID:
PMC9346119
AbstractArticlePDF–2.5M
7.
FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11
Yan-ping Yin, Li-ying Ma, Guo-zhen Cao, Jing-han Hua, Xiao-tong Lv, Wen-chu Lin
Acta Pharmacol Sin. 2022 Aug; 43(8): 2119–2127. Published online 2021 Dec 10. doi: 10.1038/s41401-021-00817-y
PMCID:
PMC9343610
AbstractArticlePDF–3.0M
8.
ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia
Linjiang Lao, Isabelle Bourdeau, Lucia Gagliardi, Xiao He, Wei Shi, Bingbing Hao, Minjia Tan, Yan Hu, Junzheng Peng, Benoit Coulombe, David J Torpy, Hamish S Scott, Andre Lacroix, Hongyu Luo, Jiangping Wu
Nucleic Acids Res. 2022 Jun 24; 50(11): 6343–6367. Published online 2022 Jun 10. doi: 10.1093/nar/gkac483
PMCID:
PMC9226510
AbstractArticlePDF–3.7M
9.
Immunohistochemical analysis of SLFN11 expression uncovers potential non-responders to DNA-damaging agents overlooked by tissue RNA-seq
Tsuyoshi Takashima, Naoya Sakamoto, Junko Murai, Daiki Taniyama, Ririno Honma, Shoichi Ukai, Ryota Maruyama, Kazuya Kuraoka, Vinodh N. Rajapakse, Yves Pommier, Wataru Yasui
Virchows Arch. Author manuscript; available in PMC 2022 Jun 8.
Published in final edited form as: Virchows Arch. 2021 Mar; 478(3): 569–579. Published online 2020 May 30. doi: 10.1007/s00428-020-02840-6
PMCID:
PMC9175511
AbstractArticlePDF–2.8M
10.
Physical and functional interactome atlas of human receptor tyrosine kinases
Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo
EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041
PMCID:
PMC9171411
AbstractArticlePDF–1.9M
11.
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling
Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser
Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151
PMCID:
PMC9105235
AbstractArticlePDF–5.8M
12.
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang
J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009
PMCID:
PMC9058836
AbstractArticlePDF–2.9M
13.
Tumor suppressor BAP1 nuclear import is governed by transportin-1
Tzu-Jing Yang, Tian-Neng Li, Rih-Sheng Huang, Max Yu-Chen Pan, Shu-Yu Lin, Steven Lin, Kuen-Phon Wu, Lily Hui-Ching Wang, Shang-Te Danny Hsu
J Cell Biol. 2022 Jun 6; 221(6): e202201094. Published online 2022 Apr 21. doi: 10.1083/jcb.202201094
PMCID:
PMC9036092
AbstractArticlePDF–4.0M
14.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
15.
A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing
Alexandra Bergfort, Marco Preußner, Benno Kuropka, İbrahim Avşar Ilik, Tarek Hilal, Gert Weber, Christian Freund, Tuğçe Aktaş, Florian Heyd, Markus C. Wahl
Nat Commun. 2022; 13: 1132. Published online 2022 Mar 3. doi: 10.1038/s41467-022-28754-2
PMCID:
PMC8894380
AbstractArticlePDF–5.6M
16.
Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network
Rebecca Elizabeth Kattan, Han Han, Gayoung Seo, Bing Yang, Yongqi Lin, Max Dotson, Stephanie Pham, Yahya Menely, Wenqi Wang
Mol Cell Proteomics. 2022 Feb; 21(2): 100195. Published online 2022 Jan 8. doi: 10.1016/j.mcpro.2022.100195
PMCID:
PMC8864472
AbstractArticlePDF–3.6M
17.
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex
Katie Nightingale, Martin Potts, Leah M. Hunter, Ceri A. Fielding, Cassie M. Zerbe, Alice Fletcher-Etherington, Luis Nobre, Eddie C. Y. Wang, Blair L. Strang, Jack W. Houghton, Robin Antrobus, Nicolas M. Suarez, Jenna Nichols, Andrew J. Davison, Richard J. Stanton, Michael P. Weekes
Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2108173119. Published online 2022 Feb 1. doi: 10.1073/pnas.2108173119
PMCID:
PMC8832970
AbstractArticlePDF–1.2M
18.
BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers
Florence Coussy, Rania El-Botty, Sophie Château-Joubert, Ahmed Dahmani, Elodie Montaudon, Sophie Leboucher, Ludivine Morisset, Pierre Painsec, Laura Sourd, Léa Huguet, Fariba Nemati, Jean-Luc Servely, Thibaut Larcher, Sophie Vacher, Adrien Briaux, Cécile Reyes, Philippe La Rosa, Georges Lucotte, Tatiana Popova, Pierre Foidart, Nor Eddine Sounni, Agnès Noel, Didier Decaudin, Laetitia Fuhrmann, Anne Salomon, Fabien Reyal, Christopher Mueller, Petra Ter Brugge, Jos Jonkers, Marie-France Poupon, Marc-Henri Stern, Ivan Bièche, Yves Pommier, Elisabetta Marangoni
Sci Transl Med. Author manuscript; available in PMC 2021 Dec 10.
Published in final edited form as: Sci Transl Med. 2020 Feb 19; 12(531): eaax2625. doi: 10.1126/scitranslmed.aax2625
PMCID:
PMC8662740
AbstractArticlePDF–1.7M
19.
Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response
Sophie E. Willis, Claudia Winkler, Martine P. Roudier, Tarrion Baird, Paola Marco-Casanova, Emma V. Jones, Philip Rowe, Jaime Rodriguez-Canales, Helen K. Angell, Felicia S. L. Ng, Paul M. Waring, Darren Hodgson, Jonathan A. Ledermann, Johanne I. Weberpals, Emma Dean, Elizabeth A. Harrington, J. Carl Barrett, Andrew J. Pierce, Elisabetta Leo, Gemma N. Jones
Br J Cancer. 2021 Dec 7; 125(12): 1666–1676. Published online 2021 Oct 18. doi: 10.1038/s41416-021-01560-1
PMCID:
PMC8651811
AbstractArticlePDF–10M
20.
SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
Syed Nabeel-Shah, Hyunmin Lee, Nujhat Ahmed, Giovanni L. Burke, Shaghayegh Farhangmehr, Kanwal Ashraf, Shuye Pu, Ulrich Braunschweig, Guoqing Zhong, Hong Wei, Hua Tang, Jianyi Yang, Edyta Marcon, Benjamin J. Blencowe, Zhaolei Zhang, Jack F. Greenblatt
iScience. 2022 Jan 21; 25(1): 103562. Published online 2021 Dec 4. doi: 10.1016/j.isci.2021.103562
PMCID:
PMC8642831
AbstractArticlePDF–5.2M

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