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Select item 114595891.

S1PR1 mediates Th17 cell migration from the thymus to the skin in health and disease

Jonas Engesser, Huiying Wang, Sonja Kapffer, Anna Kaffke, Anett Peters, Hans-Joachim Paust, Markus Geissen, Christian F. Krebs, Ulf Panzer, Nariaki Asada

Front Immunol. 2024; 15: 1473130. Published online 2024 Sep 23. doi: 10.3389/fimmu.2024.1473130

PMCID:: PMC11459589

Abstract Article PDF–6.2M

Select item 113828832.

Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis

Nathalie Burg, Ryan Malpass, Linda Alex, Miles Tran, Eric Englebrecht, Andrew Kuo, Tania Pannelini, Margaret Minett, Kalana Athukorala, Tilla Worgall, Heather J. Faust, Susan Goodman, Bella Mehta, Michael Brenner, Dietmar Vestweber, Kevin Wei, Carl Blobel, Timothy Hla, Jane E. Salmon

JCI Insight. 2024 Jun 10; 9(11): e171467. Published online 2024 Jun 10. doi: 10.1172/jci.insight.171467

PMCID:: PMC11382883

Abstract Article PDF–5.0M

Select item 110877253.

Ligand-dependent interactions between SR-B1 and S1PR1 in macrophages and atherosclerotic plaques

Christine Bassila, George E.G. Kluck, Narmadaa Thyagarajan, Kevin M. Chathely, Leticia Gonzalez, Bernardo L. Trigatti

J Lipid Res. 2024 May; 65(5): 100541. Published online 2024 Apr 5. doi: 10.1016/j.jlr.2024.100541

PMCID:: PMC11087725

Abstract Article PDF–3.1M

Select item 110669764.

FTY720 requires vitamin B₁₂-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis

Deepa Jonnalagadda, Yasuyuki Kihara, Aran Groves, Manisha Ray, Arjun Saha, Clayton Ellington, Hyeon-Cheol Lee-Okada, Tomomi Furihata, Takehiko Yokomizo, Edward V. Quadros, Richard Rivera, Jerold Chun

Cell Rep. Author manuscript; available in PMC 2024 May 3.

Published in final edited form as: Cell Rep. 2023 Dec 26; 42(12): 113545. Published online 2023 Dec 7. doi: 10.1016/j.celrep.2023.113545

PMCID:: PMC11066976

Abstract Article PDF–2.3M

Select item 108691805.

S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes

Dhaval Dixit, Victoria M. Hallisey, Ethan Y.S. Zhu, Martyna Okuniewska, Ken Cadwell, Jerry E. Chipuk, Jordan E. Axelrad, Susan R. Schwab

J Clin Invest. 2024 Feb 15; 134(4): e174984. Published online 2024 Jan 9. doi: 10.1172/JCI174984

PMCID:: PMC10869180

Abstract Article PDF–5.8M

Select item 108486986.

Augmentation of Endothelial S1PR1 Attenuates Postviral Pulmonary Fibrosis

Patricia L. Brazee, Andreane Cartier, Andrew Kuo, Alexis M. Haring, Trong Nguyen, Lida P. Hariri, Jason W. Griffith, Timothy Hla, Benjamin D. Medoff, Rachel S. Knipe

Am J Respir Cell Mol Biol. 2024 Feb 1; 70(2): 119–128. Published online 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC

PMCID:: PMC10848698

Abstract Article PDF–1.5M

Select item 107826437.

Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis

Xin Tracy Liu, Yu Huang, Da Liu, Yingxin Celia Jiang, Min Zhao, Long Hoa Chung, Xingxing Daisy Han, Yinan Zhao, Jinbiao Chen, Paul Coleman, Ka Ka Ting, Collin Tran, Yingying Su, Claude Vincent Dennis, Atul Bhatnagar, Ken Liu, Anthony Simon Don, Mathew Alexander Vadas, Mark Douglas Gorrell, Shubiao Zhang, Michael Murray, Mary Meltem Kavurma, Geoffrey William McCaughan, Jennifer Ruth Gamble, Yanfei Qi

J Transl Med. 2024; 22: 43. Published online 2024 Jan 10. doi: 10.1186/s12967-023-04830-z

PMCID:: PMC10782643

Abstract Article PDF–7.3M

Select item 105921798.

Abnormal lymphatic S1P signaling aggravates lymphatic dysfunction and tissue inflammation

Dongeon Kim, Wen Tian, Timothy Ting-Hsuan Wu, Menglan Xiang, Ryan Vinh, Jason Lon Chang, Shenbiao Gu, Seunghee Lee, Yu Zhu, Torrey Guan, Emilie Claire Schneider, Evan Bao, J. Brandon Dixon, Peter Kao, Junliang Pan, Stanley G. Rockson, Xinguo Jiang, Mark Robert Nicolls

Circulation. Author manuscript; available in PMC 2024 Oct 17.

Published in final edited form as: Circulation. 2023 Oct 17; 148(16): 1231–1249. Published online 2023 Aug 23. doi: 10.1161/CIRCULATIONAHA.123.064181

PMCID:: PMC10592179

Abstract Article PDF–3.3M

Select item 101914419.

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities

Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji

Sci Adv. 2023 May; 9(20): eade3888. Published online 2023 May 17. doi: 10.1126/sciadv.ade3888

PMCID:: PMC10191441

Abstract Article PDF–2.4M

Select item 1013321810.

Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction

Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Carolin Helten, Philipp Mourikis, Samantha Ahlbrecht, Laura Wildeis, Justus Ziese, Dorothee Zikeli, Daniel Metzen, Hao Hu, Leonard Baensch, Nathalie H. Schröder, Petra Keul, Sarah Weske, Philipp Wollnitzke, Dragos Duse, Süreyya Saffak, Mareike Cramer, Florian Bönner, Tina Müller, Markus H. Gräler, Tobias Zeus, Malte Kelm, Bodo Levkau

Nat Commun. 2023; 14: 2404. Published online 2023 Apr 26. doi: 10.1038/s41467-023-38069-5

PMCID:: PMC10133218

Abstract Article PDF–1.3M

Select item 990662111.

Opposing Roles of Sphingosine 1-Phosphate Receptors 1 and 2 in Fat Deposition and Glucose Tolerance in Obese Male Mice

Motochika Asano, Kazuo Kajita, Masayuki Fuwa, Toshiko Kajita, Ichiro Mori, Noriyuki Akahoshi, Isao Ishii, Hiroyuki Morita

Endocrinology. 2023 Mar; 164(3): bqad019. Published online 2023 Jan 24. doi: 10.1210/endocr/bqad019

PMCID:: PMC9906621

Abstract Article

Select item 987347612.

Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney

Shinji Tanaka, Shuqiu Zheng, Yugesh Kharel, Russell G. Fritzemeier, Tao Huang, Daniel Foster, Nabin Poudel, Eibhlin Goggins, Yusuke Yamaoka, Kinga P. Rudnicka, Jonathan E. Lipsey, Hope V. Radel, Sophia M. Ryuh, Tsuyoshi Inoue, Junlan Yao, Diane L. Rosin, Susan R. Schwab, Webster L. Santos, Kevin R. Lynch, Mark D. Okusa

Sci Transl Med. Author manuscript; available in PMC 2023 Jan 24.

Published in final edited form as: Sci Transl Med. 2022 Aug 17; 14(658): eabj2681. Published online 2022 Aug 17. doi: 10.1126/scitranslmed.abj2681

PMCID:: PMC9873476

Abstract Article PDF–2.6M

Select item 970010313.

Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma

Devaraj Basavarajappa, Vivek Gupta, Nitin Chitranshi, Roshana Vander Wall, Rashi Rajput, Kanishka Pushpitha, Samridhi Sharma, Mehdi Mirzaei, Alexander Klistorner, Stuart L. Graham

Neural Regen Res. 2023 Apr; 18(4): 840–848. Published online 2022 Sep 16. doi: 10.4103/1673-5374.344952

PMCID:: PMC9700103

Abstract Article PDF–60M

Select item 961365614.

LncRNA ANRIL-mediated miR-181b-5p/S1PR1 axis is involved in the progression of uremic cardiomyopathy through activating T cells

Ying Xu, Luxi Cao, Shuiyu Ji, Wei Shen

Sci Rep. 2022; 12: 18027. Published online 2022 Oct 27. doi: 10.1038/s41598-022-22955-x

PMCID:: PMC9613656

Abstract Article PDF–13M

Select item 947065515.

Sphingosine 1-Phoshpate Receptors are Located in Synapses and Control Spontaneous Activity of Mouse Neurons in Culture

Cecilia Skoug, Isak Martinsson, Gunnar K. Gouras, Anja Meissner, João M. N. Duarte

Neurochem Res. 2022; 47(10): 3114–3125. Published online 2022 Jul 4. doi: 10.1007/s11064-022-03664-3

PMCID:: PMC9470655

Abstract Article PDF–3.7M

Select item 943310316.

Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment

Silvia Squillace, Michael L. Niehoff, Timothy M. Doyle, Michael Green, Emanuela Esposito, Salvatore Cuzzocrea, Christopher K. Arnatt, Sarah Spiegel, Susan A. Farr, Daniela Salvemini

J Clin Invest. 2022 Sep 1; 132(17): e157738. Published online 2022 Sep 1. doi: 10.1172/JCI157738