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Select item 108250591.

Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function

Erica L. Braverman, Margaret A. McQuaid, Herbert Schuler, Mengtao Qin, Sophia Hani, Keli Hippen, Darlene A. Monlish, Andrea K. Dobbs, Manda J. Ramsey, Felicia Kemp, Christopher Wittmann, Archana Ramgopal, Harrison Brown, Bruce Blazar, Craig A. Byersdorfer

J Biol Chem. 2024 Jan; 300(1): 105488. Published online 2023 Nov 22. doi: 10.1016/j.jbc.2023.105488

PMCID:: PMC10825059

Abstract Article PDF–3.2M

Select item 106291912.

Abnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG

Xiao-Wei Song, Ting Su, Bo Li, Yun-Jie Huang, Wen-Xia He, Li-Li Jiang, Chang-Jin Li, Song-Qun Huang, Song-Hua Li, Zhi-Fu Guo, Hong Wu, Bi-Li Zhang

Clin Epigenetics. 2023; 15: 178. Published online 2023 Nov 7. doi: 10.1186/s13148-023-01591-w

PMCID:: PMC10629191

Abstract Article PDF–11M

Select item 100729063.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100704184.

AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy

Xiaomei Zhang, Qiwei Jiang, Yaqing Su, Lang Bu, Zicheng Sun, Xueji Wu, Bing Gao, Lei Wang, Ying Lin, Wei Xie, Jianping Guo

Br J Cancer. 2023 Apr 12; 128(8): 1452–1465. Published online 2023 Feb 17. doi: 10.1038/s41416-022-02127-4

PMCID:: PMC10070418

Abstract Article PDF–2.8M

Select item 98519735.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 95524236.

Left ventricular non-compaction cardiomyopathy associated with the PRKAG2 mutation

Jing Zhang, Xiu Han, Qun Lu, Yunfei Feng, Aiqun Ma, Tingzhong Wang

BMC Med Genomics. 2022; 15: 214. Published online 2022 Oct 11. doi: 10.1186/s12920-022-01361-2

PMCID:: PMC9552423

Abstract Article PDF–1.1M

Select item 92665967.

Controversial molecular functions of CBS versus non‐CBS domain variants of PRKAG2 in arrhythmia and cardiomyopathy: A case report and literature review

Xue Gong, Peiyu Yu, Ting Wu, Yunru He, Kaiyu Zhou, Yimin Hua, Sha Lin, Tao Wang, He Huang, Yifei Li

Mol Genet Genomic Med. 2022 Jul; 10(7): e1962. Published online 2022 May 19. doi: 10.1002/mgg3.1962

PMCID:: PMC9266596

Abstract Article PDF–8.9M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 85616349.

CARS senses cysteine deprivation to activate AMPK for cell survival

Mengqiu Yuan, Ronghui Yan, Yi Zhang, Yue Qiu, Zetan Jiang, Haiying Liu, Ying Wang, Linchong Sun, Huafeng Zhang, Ping Gao

EMBO J. 2021 Nov 2; 40(21): e108028. Published online 2021 Sep 2. doi: 10.15252/embj.2021108028

PMCID:: PMC8561634

Abstract Article PDF–4.6M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 784513711.

Novel PRKAG2 variant presenting as liver cirrhosis: report of a family with 2 cases and review of literature

Zahra Beyzaei, Fatih Ezgu, Bita Geramizadeh, Alireza Alborzi, Alireza Shojazadeh

BMC Med Genomics. 2021; 14: 33. Published online 2021 Jan 28. doi: 10.1186/s12920-021-00879-1

PMCID:: PMC7845137

Abstract Article PDF–860K

Select item 769136112.

Phenotypic expression and clinical outcomes in a South Asian PRKAG2 cardiomyopathy cohort

Hisham Ahamed, Aniketh Vijay Balegadde, Shilpa Menon, Ramesh Menon, Aishwarya Ramachandran, Navin Mathew, K. U. Natarajan, Indu Ramachandran Nair, Rajesh Kannan, Meghna Shankar, Oommen K. Mathew, Thong T. Nguyen, Ravi Gupta, Eric W. Stawiski, V. L. Ramprasad, Somasekar Seshagiri, Sameer Phalke

Sci Rep. 2020; 10: 20610. Published online 2020 Nov 26. doi: 10.1038/s41598-020-77124-9

PMCID:: PMC7691361

Abstract Article PDF–2.3M

Select item 742732713.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 727569414.

Wolff-Parkinson-White syndrome: De novo variants and evidence for mutational burden in genes associated with atrial fibrillation

Zeynep H. Coban-Akdemir, Wu-Lin Charng, Mahshid Azamian, Ingrid Sophie Paine, Jaya Punetha, Christopher M. Grochowski, Tomasz Gambin, Santiago Valdes, Bryan Cannon, Gladys Zapata, Patricia P. Hernandez, Shalini Jhangiani, Harsha Doddapaneni, Jianhong Hu, Fatima Boricha, Donna M. Muzny, Eric Boerwinkle, Yaping Yang, Richard A. Gibbs, Jennifer E. Posey, Xander H.T. Wehrens, John W. Belmont, Jeffrey J. Kim, Christina Y. Miyake, James R. Lupski, Seema R. Lalani

Am J Med Genet A. Author manuscript; available in PMC 2020 Jun 6.

Published in final edited form as: Am J Med Genet A. 2020 Jun; 182(6): 1387–1399. Published online 2020 Mar 31. doi: 10.1002/ajmg.a.61571

PMCID:: PMC7275694

Abstract Article PDF–915K

Select item 717593215.

PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer’s Disease Brain

Prashant Bharadwaj, Ralph N. Martins

J Alzheimers Dis. 2020; 74(2): 441–448. Prepublished online 2020 Feb 6. Published online 2020 Mar 24. doi: 10.3233/JAD-190948

PMCID:: PMC7175932

Abstract Article PDF–520K

Select item 713217216.

Identification, clinical manifestation and structural mechanisms of mutations in AMPK associated cardiac glycogen storage disease

Dan Hu, Dong Hu, Liwen Liu, Daniel Barr, Yang Liu, Norma Balderrabano-Saucedo, Bo Wang, Feng Zhu, Yumei Xue, Shulin Wu, BaoLiang Song, Heather McManus, Katherine Murphy, Katherine Loes, Arnon Adler, Lorenzo Monserrat, Charles Antzelevitch, Michael H. Gollob, Perry M. Elliott, Hector Barajas-Martinez

EBioMedicine. 2020 Apr; 54: 102723. Published online 2020 Apr 4. doi: 10.1016/j.ebiom.2020.102723

Correction in:: EBioMedicine. 2021 Apr; 66: 103295.

PMCID:: PMC7132172

Abstract Article PDF–6.1M

Select item 705010317.

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair

Zhen Chen, Chao Wang, Antrix Jain, Mrinal Srivastava, Mengfan Tang, Huimin Zhang, Xu Feng, Litong Nie, Dan Su, Yun Xiong, Sung Yun Jung, Jun Qin, Junjie Chen

Mol Cell Proteomics. 2020 Mar; 19(3): 467–477. Published online 2020 Jan 3. doi: 10.1074/mcp.RA119.001794

PMCID:: PMC7050103

Abstract Article PDF–1.8M

Select item 660284318.

Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk

Xinyuan Xu, Danwen Qian, Hongliang Liu, Diana Cruz, Sheng Luo, Kyle M. Walsh, James L. Abbruzzese, Xuefeng Zhang, Qingyi Wei

Mol Carcinog. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Mol Carcinog. 2019 Aug; 58(8): 1338–1348. Published online 2019 Apr 17. doi: 10.1002/mc.23018

PMCID:: PMC6602843

Abstract Article PDF–639K

Select item 616668219.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 599210420.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni

Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444

PMCID:: PMC5992104

Abstract Article PDF–1.2M

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