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Items: 1 to 20 of 87

1.
HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis
Michael F. Emmons, Richard L. Bennett, Alberto Riva, Kanchan Gupta, Larissa Anastasio Da Costa Carvalho, Chao Zhang, Robert Macaulay, Daphne Dupéré-Richér, Bin Fang, Edward Seto, John M. Koomen, Jiannong Li, Y. Ann Chen, Peter A. Forsyth, Jonathan D. Licht, Keiran S. M. Smalley
Nat Commun. 2023; 14: 7759. Published online 2023 Nov 29. doi: 10.1038/s41467-023-43519-1
PMCID:
PMC10686983
AbstractArticlePDF–4.2M
2.
The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia
Sadek Amhaz, Batiste Boëda, Mouna Chouchène, Sabrina Colasse, Florent Dingli, Damarys Loew, Julien Henri, Céline Prunier, Laurence Levy
BMC Biol. 2023; 21: 73. Published online 2023 Apr 7. doi: 10.1186/s12915-023-01576-4
PMCID:
PMC10080908
AbstractArticlePDF–3.2M
3.
Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization
Xun Zhou, Hui Chen, Yingfeng Shi, Jinqing Li, Xiaoyan Ma, Lin Du, Yan Hu, Min Tao, Qin Zhong, Danying Yan, Shougang Zhuang, Na Liu
Front Immunol. 2023; 14: 1137332. Published online 2023 Feb 23. doi: 10.3389/fimmu.2023.1137332
PMCID:
PMC9995794
AbstractArticlePDF–17M
4.
Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase
Jingxia Gao, Benjamin Siddoway, Qing Huang, Houhui Xia
Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Oct 12.
Published in final edited form as: Biochem Biophys Res Commun. 2009 Jan 30; 379(1): 1–5. Published online 2008 Dec 12. doi: 10.1016/j.bbrc.2008.11.135
PMCID:
PMC9555005
AbstractArticlePDF–660K
5.
SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation
Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang
Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5
PMCID:
PMC8314547
AbstractArticlePDF–3.7M
6.
NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition
Cheng-Yu Tsai, Huey-Jiun Ko, Shean-Jaw Chiou, Yu-Ling Lai, Chia-Chung Hou, Tehseen Javaria, Zi-Yi Huang, Tai-Shan Cheng, Tsung-I Hsu, Jian-Ying Chuang, Aij-Lie Kwan, Tsung-Hsien Chuang, Chi-Ying F. Huang, Joon-Khim Loh, Yi-Ren Hong
Int J Mol Sci. 2021 Jun; 22(11): 5907. Published online 2021 May 31. doi: 10.3390/ijms22115907
PMCID:
PMC8199487
AbstractArticlePDF–5.3M
7.
Alternative genomic diagnoses for individuals with a clinical diagnosis of Dubowitz syndrome
David A. Dyment, Anne O’Donnell-Luria, Pankaj B. Agrawal, Zeynep Coban Akdemir, Kyrieckos A. Aleck, Danny Antaki, Hind Al Sharhan, Ping-Yee B. Au, Hatip Aydin, Alan H. Beggs, Kaya Bilguvar, Eric Boerwinkle, Harrison Brand, Catherine A. Brownstein, Steve Buyske, Bernard Chodirker, Jungmin Choi, Albert E. Chudley, Carol L. Clericuzio, Gerald F. Cox, Cynthia Curry, Elke de Boer, Bert B.A. de Vries, Kathryn Dunn, Cullen M. Dutmer, Eleina M. England, Jill A. Fahrner, Bilgen B. Geckinli, Casie A. Genetti, Alper Gezdirici, William T. Gibson, Joseph G. Gleeson, Cheryl R. Greenberg, April Hall, Ada Hamosh, Taila Hartley, Shalini Jhangiani, Ender Karaca, Kristin Kernohan, Julie L. Lauzon, M.E. Suzanne Lewis, R. Brian Lowry, Francesc López-Giráldez, Tara C. Matise, Jennifer McEvoy-Venneri, Brenda McInnes, Aziz Mhanni, Sixto Garcia Minaur, Jukka Moilanen, An Nguyen, Malgorzata J.M. Nowaczyk, Jennifer Posey, Katrin Õunap, Davut Pehlivan, Sander Pajusalu, Lynette S. Penney, Timothy Poterba, Paolo Prontera, Maria Juliana Rodovalho Doriqui, Sarah L. Sawyer S, Nara Sobreira, Valentina Stanley, Deniz Torun, David Wargowski, P. Dane Witmer, Isaac Wong, Jinchuan Xing, Maha S. Zaki, Yeting Zhang, Care4Rare Consortium, Centers for Mendelian Genomics, Kym M. Boycott, Michael J. Bamshad, Deborah A. Nickerson, Elizabeth E. Blue, A. Micheil Innes
Am J Med Genet A. Author manuscript; available in PMC 2021 Jul 1.
Published in final edited form as: Am J Med Genet A. 2021 Jan; 185(1): 119–133. Published online 2020 Oct 24. doi: 10.1002/ajmg.a.61926
PMCID:
PMC8197629
AbstractArticlePDF–1.4M
8.
HDAC8 Activates AKT through Upregulating PLCB1 and Suppressing DESC1 Expression in MEK1/2 Inhibition-Resistant Cells
Soon-Duck Ha, Naomi Lewin, Shawn S. C. Li, Sung-Ouk Kim
Cells. 2021 May; 10(5): 1101. Published online 2021 May 4. doi: 10.3390/cells10051101
PMCID:
PMC8147860
AbstractArticlePDF–3.6M
9.
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition
Yahya Benslimane, María Sánchez‐Osuna, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Danielle Henry, Caroline Huard, Éric Bonneil, Pierre Thibault, Mike Tyers, Lea Harrington
Aging Cell. 2021 Apr; 20(4): e13331. Published online 2021 Mar 4. doi: 10.1111/acel.13331
PMCID:
PMC8045932
AbstractArticlePDF–1.9M
10.
Structural Analysis of Histone Deacetylase 8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders
Jeremy D. Osko, Nicholas J. Porter, Christophe Decroos, Matthew S. Lee, Paris R. Watson, Sarah E. Raible, Ian D. Krantz, Matthew A. Deardorff, David W. Christianson
J Struct Biol. Author manuscript; available in PMC 2022 Mar 1.
Published in final edited form as: J Struct Biol. 2021 Mar; 213(1): 107681. Published online 2020 Dec 11. doi: 10.1016/j.jsb.2020.107681
PMCID:
PMC7981260
AbstractArticlePDF–2.9M
11.
Histone deacetylase 8 inhibition suppresses mantle cell lymphoma viability while preserving natural killer cell function
January M. Watters, Gabriela Wright, Matthew A. Smith, Bijal Shah, Kenneth L. Wright
Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Biochem Biophys Res Commun. 2021 Jan 1; 534: 773–779. Published online 2020 Nov 13. doi: 10.1016/j.bbrc.2020.11.001
PMCID:
PMC7785659
AbstractArticlePDF–1.1M
12.
HDAC8-dependent deacetylation of PKM2 directs nuclear localization and glycolysis to promote proliferation in hepatocellular carcinoma
Ruixue Zhang, Mengqin Shen, Chunhua Wu, Yumei Chen, Jiani Lu, Jiajin Li, Li Zhao, Huannan Meng, Xiang Zhou, Gang Huang, Xiaoping Zhao, Jianjun Liu
Cell Death Dis. 2020 Dec; 11(12): 1036. Published online 2020 Dec 5. doi: 10.1038/s41419-020-03212-3
PMCID:
PMC7719180
AbstractArticlePDF–9.3M
13.
A distal regulatory region of a class I human histone deacetylase
Nicolas D. Werbeck, Vaibhav Kumar Shukla, Micha B. A. Kunze, Havva Yalinca, Ruth B. Pritchard, Lucas Siemons, Somnath Mondal, Simon O. R. Greenwood, John Kirkpatrick, Charles M. Marson, D. Flemming Hansen
Nat Commun. 2020; 11: 3841. Published online 2020 Jul 31. doi: 10.1038/s41467-020-17610-w
PMCID:
PMC7395746
AbstractArticlePDF–1.4M
14.
Association of HDAC8 Expression with Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis
Mohammad-Nazir Menbari, Karim Rahimi, Abbas Ahmadi, Samira Mohammadi-Yeganeh, Anvar Elyasi, Nikoo Darvishi, Vahedeh Hosseini, Mohammad Abdi
Iran Biomed J. 2020 Sep; 24(5): 288–294. Published online 2020 May 2. doi: 10.29252/ibj.24.5.283
PMCID:
PMC7392136
AbstractArticlePDF–891K
15.
Hydroxamic acid derivatives as HDAC1, HDAC6 and HDAC8 inhibitors with antiproliferative activity in cancer cell lines
Yudibeth Sixto-López, José Antonio Gómez-Vidal, Nuria de Pedro, Martiniano Bello, Martha Cecilia Rosales-Hernández, José Correa-Basurto
Sci Rep. 2020; 10: 10462. Published online 2020 Jun 26. doi: 10.1038/s41598-020-67112-4
PMCID:
PMC7320180
AbstractArticlePDF–2.5M
16.
HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration
Xiaolong Tang, Guo Li, Fengting Su, Yanlin Cai, Lei Shi, Yuan Meng, Zuojun Liu, Jie Sun, Ming Wang, Minxian Qian, Zimei Wang, Xingzhi Xu, Yong-Xian Cheng, Wei-Guo Zhu, Baohua Liu
Nucleic Acids Res. 2020 Apr 6; 48(6): 2912–2923. Published online 2020 Jan 23. doi: 10.1093/nar/gkaa039
PMCID:
PMC7102950
AbstractArticlePDF–8.0M
17.
Preparation of a New Construct of Human Histone Deacetylase 8 for the Crystallization of Enzyme-Inhibitor Complexes
Nicholas J. Porter, David W. Christianson
Methods Enzymol. Author manuscript; available in PMC 2020 Jul 18.
Published in final edited form as: Methods Enzymol. 2019; 626: 561–585. Published online 2019 Jul 18. doi: 10.1016/bs.mie.2019.06.029
PMCID:
PMC6941479
AbstractArticlePDF–2.2M
18.
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC
Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong
eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223
PMCID:
PMC6927754
AbstractArticlePDF–5.1M
19.
Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of Phosphomimetic S39E Mutant
Katherine R. Welker Leng, Carol Ann Castañeda, Christophe Decroos, Barira Islam, Shozeb M. Haider, David W. Christianson, Carol A. Fierke
Biochemistry. Author manuscript; available in PMC 2020 Nov 12.
Published in final edited form as: Biochemistry. 2019 Nov 12; 58(45): 4480–4493. Published online 2019 Nov 4. doi: 10.1021/acs.biochem.9b00653
PMCID:
PMC6903415
AbstractArticlePDF–2.5M
20.
Discovery of novel potential selective HDAC8 inhibitors by combine ligand-based, structure-based virtual screening and in-vitro biological evaluation
Sudhan Debnath, Tanusree Debnath, Samhita Bhaumik, Swapan Majumdar, Arunasree M. Kalle, Vema Aparna
Sci Rep. 2019; 9: 17174. Published online 2019 Nov 20. doi: 10.1038/s41598-019-53376-y
PMCID:
PMC6868012
AbstractArticlePDF–2.3M

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