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Select item 109319371.

Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications

Danielle Naicker, Cenza Rhoda, Falone Sunda, Afolake Arowolo

Int J Mol Sci. 2024 Mar; 25(5): 2845. Published online 2024 Feb 29. doi: 10.3390/ijms25052845

PMCID:: PMC10931937

Abstract Article PDF–1.7M

Select item 109207032.

Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes

Sowmiya Palani, Yuka Machida, Julia R. Alvey, Vandana Mishra, Allison L. Welter, Gaofeng Cui, Benoît Bragantini , Maria Victoria Botuyan, Anh T. Q. Cong, Georges Mer, Matthew J. Schellenberg, Yuichi J. Machida

Nat Commun. 2024; 15: 2064. Published online 2024 Mar 7. doi: 10.1038/s41467-024-46207-w

PMCID:: PMC10920703

Abstract Article PDF–5.2M

Select item 105516393.

FAM111A regulates replication origin activation and cell fitness

Diana O Rios-Szwed, Vanesa Alvarez, Luis Sanchez-Pulido, Elisa Garcia-Wilson, Hao Jiang, Susanne Bandau, Angus Lamond, Constance Alabert

Life Sci Alliance. 2023 Dec; 6(12): e202302111. Published online 2023 Oct 4. doi: 10.26508/lsa.202302111

PMCID:: PMC10551639

Abstract Article PDF–6.7M

Select item 104757794.

N⁶‐methyladenosine‐modified FAM111A‐DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A

Jian Pu, Zuoming Xu, Youguan Huang, Jiahui Nian, Meng Yang, Quan Fang, Qing Wei, Zihua Huang, Guoman Liu, Jianchu Wang, Xianjian Wu, Huamei Wei

Cancer Sci. 2023 Sep; 114(9): 3649–3665. Published online 2023 Jul 3. doi: 10.1111/cas.15886

PMCID:: PMC10475779

Abstract Article PDF–8.5M

Select item 104690345.

Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1

Junda Zhu, Xintao Gao, Yijing Li, Zihui Zhang, Shijie Xie, Shuning Ren, Yarui Li, Hua Li, Kang Niu, Shufang Fu, Yining Deng, Yinü Li, Bernard Moss, Wenxue Wu, Chen Peng

Proc Natl Acad Sci U S A. 2023 Aug 29; 120(35): e2304242120. Published online 2023 Aug 22. doi: 10.1073/pnas.2304242120

PMCID:: PMC10469034

Abstract Article PDF–3.7M

Select item 97725586.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 90588367.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 86910908.

IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3

Kai Ren, Ya Zhu, Honggang Sun, Shilin Li, Xiaoqiong Duan, Shuang Li, Yujia Li, Bin Li, Limin Chen

Virol J. 2021; 18: 256. Published online 2021 Dec 20. doi: 10.1186/s12985-021-01724-8

PMCID:: PMC8691090

Abstract Article PDF–1.2M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810809310.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 785742411.

FAM111A induces nuclear dysfunction in disease and viral restriction

Minghua Nie, Martina Oravcová, Yasaman Jami‐Alahmadi, James A Wohlschlegel, Eros Lazzerini‐Denchi, Michael N Boddy

EMBO Rep. 2021 Feb 3; 22(2): e50803. Published online 2020 Dec 28. doi: 10.15252/embr.202050803

PMCID:: PMC7857424

Abstract Article PDF–2.9M

Select item 753464012.

FAM111 protease activity undermines cellular fitness and is amplified by gain‐of‐function mutations in human disease

Saskia Hoffmann, Satyakrishna Pentakota, Andreas Mund, Peter Haahr, Fabian Coscia, Marta Gallo, Matthias Mann, Nicholas MI Taylor, Niels Mailand

EMBO Rep. 2020 Oct 5; 21(10): e50662. Published online 2020 Aug 9. doi: 10.15252/embr.202050662

PMCID:: PMC7534640

Abstract Article PDF–15M

Select item 706782813.

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida

Nat Commun. 2020; 11: 1318. Published online 2020 Mar 12. doi: 10.1038/s41467-020-15170-7

PMCID:: PMC7067828

Abstract Article PDF–2.7M

Select item 631010214.

Interactome and proteome dynamics uncover immune modulatory associations of the pathogen sensing factor cGAS

Krystal K. Lum, Bokai Song, Joel D. Federspiel, Benjamin A. Diner, Timothy Howard, Ileana M. Cristea

Cell Syst. Author manuscript; available in PMC 2019 Dec 26.

Published in final edited form as: Cell Syst. 2018 Dec 26; 7(6): 627–642.e6. Published online 2018 Nov 21. doi: 10.1016/j.cels.2018.10.010

PMCID:: PMC6310102

Abstract Article PDF–3.5M

Select item 629516515.

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression

Lei Yu, Natee Jearawiriyapaisarn, Mary P. Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B. Vojtek, Jean-François Rual, James Douglas Engel

Genes Dev. 2018 Dec 1; 32(23-24): 1537–1549. doi: 10.1101/gad.318436.118

PMCID:: PMC6295165

Abstract Article PDF–3.5M

Select item 628834416.

Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range Phenotype

Roxana M. Tarnita, Adrian R. Wilkie, James A. DeCaprio

J Virol. 2019 Jan 1; 93(1): e01330-18. Prepublished online 2018 Oct 17. Published online 2018 Dec 10. doi: 10.1128/JVI.01330-18

PMCID:: PMC6288344

Abstract Article PDF–1.8M

Select item 616668217.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 570387818.

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Ramesh Kumar, Román González-Prieto, Zhenyu Xiao, Matty Verlaan-de Vries, Alfred C. O. Vertegaal

Nat Commun. 2017; 8: 1809. Published online 2017 Nov 27. doi: 10.1038/s41467-017-01900-x

PMCID:: PMC5703878

Abstract Article PDF–3.7M

Select item 553161119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522520.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

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