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Items: 1 to 20 of 84

1.
Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX
Miquel Canyelles-Niño, Àngels González-Lafont, José M. Lluch
Int J Mol Sci. 2023 Apr; 24(7): 6064. Published online 2023 Mar 23. doi: 10.3390/ijms24076064
PMCID:
PMC10094721
AbstractArticlePDF–20M
2.
Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder
Michelle Tran, Rachel L. Signorelli, Adriana Yamaguchi, Eefie Chen, Michael Holinstat, Anthony T. Iavarone, Adam R. Offenbacher, Theodore Holman
Arch Biochem Biophys. Author manuscript; available in PMC 2023 Jan 31.
Published in final edited form as: Arch Biochem Biophys. 2023 Jan 1; 733: 109472. Published online 2022 Nov 25. doi: 10.1016/j.abb.2022.109472
PMCID:
PMC9888433
AbstractArticlePDF–1.3M
3.
ALOX12: A Novel Insight in Bevacizumab Response, Immunotherapy Effect, and Prognosis of Colorectal Cancer
Siyuan Weng, Zaoqu Liu, Hui Xu, Xiaoyong Ge, Yuqing Ren, Qin Dang, Long Liu, Jian Zhang, Peng Luo, Jianzhuang Ren, Xinwei Han
Front Immunol. 2022; 13: 910582. Published online 2022 Jun 27. doi: 10.3389/fimmu.2022.910582
PMCID:
PMC9271859
AbstractArticlePDF–26M
4.
EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation
Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing
Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6
PMCID:
PMC8748958
AbstractArticlePDF–3.0M
5.
Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase
Annalisa Contursi, Simone Schiavone, Melania Dovizio, Christine Hinz, Rosa Fullone, Stefania Tacconelli, Victoria J. Tyrrell, Rosalia Grande, Paola Lanuti, Marco Marchisio, Mirco Zucchelli, Patrizia Ballerini, Angel Lanas, Valerie B. O'Donnell, Paola Patrignani
J Lipid Res. 2021; 62: 100109. Published online 2021 Aug 21. doi: 10.1016/j.jlr.2021.100109
PMCID:
PMC8456051
AbstractArticlePDF–3.1M
6.
Regulation of Tissue Inflammation by 12-Lipoxygenases
Abhishek Kulkarni, Jerry L. Nadler, Raghavendra G. Mirmira, Isabel Casimiro
Biomolecules. 2021 May; 11(5): 717. Published online 2021 May 11. doi: 10.3390/biom11050717
PMCID:
PMC8150372
AbstractArticlePDF–1.9M
7.
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators
Cody Freedman, Adrianne Tran, Benjamin E. Tourdot, Chakrapani Kalyanaraman, Steve Perry, Michael Holinstat, Matthew P. Jacobson, Theodore R. Holman
Biochemistry. Author manuscript; available in PMC 2021 May 19.
Published in final edited form as: Biochemistry. 2020 May 19; 59(19): 1832–1844. Published online 2020 May 7. doi: 10.1021/acs.biochem.0c00233
PMCID:
PMC7729281
AbstractArticlePDF–829K
8.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
9.
Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-type 12-Lipoxygenase
Ansari Mukhtar Aleem, Wan-Chen Tsai, Jennyfer Tena, Gabriella Alvarez, Joshua Deschamps, Chakrapani Kalyanaraman, Matthew P. Jacobson, Theodore Holman
Biochemistry. Author manuscript; available in PMC 2020 Jun 4.
Published in final edited form as: Biochemistry. 2019 Feb 12; 58(6): 848–857. Published online 2019 Jan 4. doi: 10.1021/acs.biochem.8b01167
PMCID:
PMC7270147
AbstractArticlePDF–649K
10.
5S,15S-Dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1
Abigail R. Green, Cody Freedman, Jennyfer Tena, Benjamin E. Tourdot, Benjamin Liu, Michael Holinstat, Theodore R. Holman
Biochemistry. Author manuscript; available in PMC 2020 Jun 4.
Published in final edited form as: Biochemistry. 2018 Dec 4; 57(48): 6726–6734. Published online 2018 Nov 15. doi: 10.1021/acs.biochem.8b00889
PMCID:
PMC7270142
AbstractArticlePDF–761K
11.
Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer
Ehab H. Sarsour, Jyung Mean Son, Amanda L. Kalen, Wusheng Xiao, Juan Du, Matthew S. Alexander, Brianne R. O'Leary, Joseph J. Cullen, Prabhat C. Goswami
J Biol Chem. 2020 May 15; 295(20): 6946–6957. Published online 2020 Apr 7. doi: 10.1074/jbc.RA120.012798
PMCID:
PMC7242692
AbstractArticlePDF–2.9M
12.
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma
Lily Oguh-Olayinka, Vijay Agarwal, Dulani Ranatunge, Anne Campbell, Stefan Laufer, Lynn Cawkwell, Michael J. Lind
Pathol Oncol Res. 2020; 26(2): 985–995. Published online 2019 Apr 2. doi: 10.1007/s12253-019-00652-x
PMCID:
PMC7242492
AbstractArticlePDF–1.7M
13.
Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis
Jee Yeon Kim, Bong-Geun Choi, Jaroslav Jelinek, Dae Hyun Kim, Seo Hyun Lee, Kwangjo Cho, Seo Hee Rha, Young Ho Lee, Hyo Sun Jin, Dae-Kyoung Choi, Geun-Eun Kim, Sun U. Kwon, Junha Hwang, Jae Kwan Cha, Sukhoon Lee, Jean-Pierre J. Issa, Jei Kim
Clin Epigenetics. 2020; 12: 66. Published online 2020 May 12. doi: 10.1186/s13148-020-00846-0
PMCID:
PMC7218560
AbstractArticlePDF–2.1M
14.
The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer
Qi Zhang, Guifang Yan, Juan Lei, Yu Chen, Ting Wang, Juan Gong, Yong Zhou, Huakan Zhao, Hao Chen, Yu Zhou, Lei Wu, Jiangang Zhang, Xiao Zhang, Jingchun Wang, Yongsheng Li
Mol Med. 2020; 26: 39. Published online 2020 May 6. doi: 10.1186/s10020-020-00174-2
PMCID:
PMC7201572
AbstractArticlePDF–1.7M
15.
12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2γ knockout
Xinping Liu, Harold F. Sims, Christopher M. Jenkins, Shaoping Guan, Beverly G. Dilthey, Richard W. Gross
J Biol Chem. 2020 Apr 17; 295(16): 5307–5320. Published online 2020 Mar 11. doi: 10.1074/jbc.RA119.012296
PMCID:
PMC7170522
AbstractArticlePDF–3.1M
16.
12-lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat
Luiz Osório Leiria, Chih-Hao Wang, Matthew D. Lynes, Kunyan Yang, Farnaz Shamsi, Mari Sato, Satoru Sugimoto, Emily Y. Chen, Valerie Bussberg, Niven R. Narain, Brian E. Sansbury, Justin Darcy, Tian Lian Huang, Sean D. Kodani, Masaji Sakaguchi, Andréa L. Rocha, Tim J. Schulz, Alexander Bartelt, Gökhan S. Hotamisligil, Michael F. Hirshman, Klaus van Leyen, Laurie J. Goodyear, Matthias Blüher, Aaron M. Cypess, Michael A. Kiebish, Matthew Spite, Yu-Hua Tseng
Cell Metab. Author manuscript; available in PMC 2020 Oct 1.
Published in final edited form as: Cell Metab. 2019 Oct 1; 30(4): 768–783.e7. Published online 2019 Jul 25. doi: 10.1016/j.cmet.2019.07.001
PMCID:
PMC6774888
AbstractArticlePDF–3.0M
17.
ALOX12 is required for p53-mediated tumor suppression through a distinct ferroptosis pathway
Bo Chu, Ning Kon, Delin Chen, Tongyuan Li, Tong Liu, Le Jiang, Shujuan Song, Omid Tavana, Wei Gu
Nat Cell Biol. Author manuscript; available in PMC 2019 Oct 8.
Published in final edited form as: Nat Cell Biol. 2019 May; 21(5): 579–591. Published online 2019 Apr 8. doi: 10.1038/s41556-019-0305-6
PMCID:
PMC6624840
AbstractArticlePDF–2.1M
18.
Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
Nikhlesh K. Singh, Gadiparthi N. Rao
Prog Lipid Res. Author manuscript; available in PMC 2020 Jan 1.
Published in final edited form as: Prog Lipid Res. 2019 Jan; 73: 28–45. Published online 2018 Nov 22. doi: 10.1016/j.plipres.2018.11.001
PMCID:
PMC6338518
AbstractArticlePDF–1.1M
19.
Molecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase
Niharika Samala, Sarah A. Tersey, Naga Chalasani, Ryan M. Anderson, Raghavendra G. Mirmira
J Diabetes Complications. Author manuscript; available in PMC 2018 Nov 1.
Published in final edited form as: J Diabetes Complications. 2017 Nov; 31(11): 1630–1637. Published online 2017 Jul 31. doi: 10.1016/j.jdiacomp.2017.07.014
PMCID:
PMC5643240
AbstractArticlePDF–501K
20.
12-HETrE, a 12-LOX oxylipin of DGLA, inhibits thrombosis via Gαs signaling in platelets
Jennifer Yeung, Benjamin E. Tourdot, Reheman Adili, Abigail R. Green, Cody J. Freedman, Pilar Fernandez-Perez, Johnny Yu, Theodore R. Holman, Michael Holinstat
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2017 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Oct; 36(10): 2068–2077. Published online 2016 Jul 28. doi: 10.1161/ATVBAHA.116.308050
PMCID:
PMC5488693
AbstractArticlePDF–1.0M

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