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Items: 1 to 20 of 180

1.
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang, Yuelong Yan, Ling Xia, Rakesh Bam, Zhifen Yang, Hyemin Lee, Takao Iwawaki, Boyi Gan, Albert C. Koong
Nat Commun. 2024; 15: 4114. Published online 2024 May 15. doi: 10.1038/s41467-024-48330-0
PMCID:
PMC11096184
AbstractArticlePDF–3.7M
2.
TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2
Nabil Ahmed, Christian Preisinger, Thomas Wilhelm, Michael Huber
Cells. 2024 May; 13(9): 747. Published online 2024 Apr 25. doi: 10.3390/cells13090747
PMCID:
PMC11082977
AbstractArticlePDF–3.0M
3.
Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish
Byungseok Jin, Tokiro Ishikawa, Mai Taniguchi, Satoshi Ninagawa, Tetsuya Okada, Shigehide Kagaya, Kazutoshi Mori
Cell Struct Funct. 2020; 45(1): 23–31. Published online 2019 Dec 26. doi: 10.1247/csf.19032
PMCID:
PMC10749220
AbstractArticlePDF–821K
4.
IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A
Magdalena Gebert, Sylwia Bartoszewska, Lukasz Opalinski, James F. Collawn, Rafał Bartoszewski
Cell Commun Signal. 2023; 21: 322. Published online 2023 Nov 9. doi: 10.1186/s12964-023-01349-0
PMCID:
PMC10634081
AbstractArticlePDF–8.1M
5.
Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid
Margaud Iovino, Megan Colonval, Chloé Wilkin, Laurent L’homme, Cédric Lassence, Manon Campas, Olivier Peulen, Pascal de Tullio, Jacques Piette, Sylvie Legrand-Poels
Front Immunol. 2023; 14: 1204126. Published online 2023 Aug 30. doi: 10.3389/fimmu.2023.1204126
PMCID:
PMC10498766
AbstractArticlePDF–3.8M
6.
The unfolded protein response components IRE1α and XBP1 promote human coronavirus infection
Jessica M. Oda, Andreas B. den Hartigh, Shoen M. Jackson, Ana R. Tronco, Susan L. Fink
mBio. 2023 Jul-Aug; 14(4): e00540-23. Published online 2023 Jun 12. doi: 10.1128/mbio.00540-23
PMCID:
PMC10470493
AbstractArticlePDF–832K
7.
IRE1a-Induced FilaminA Phosphorylation Enhances Migration of Mesenchymal Stem Cells Derived from Multiple Myeloma Patients
Francesco Da Ros, Kinga Kowal, Carla Vicinanza, Elisabetta Lombardi, Francesco Agostini, Rosanna Ciancia, Maurizio Rupolo, Cristina Durante, Mariagrazia Michieli, Mario Mazzucato
Cells. 2023 Aug; 12(15): 1935. Published online 2023 Jul 26. doi: 10.3390/cells12151935
PMCID:
PMC10417526
AbstractArticlePDF–1.9M
8.
Deubiquitylase OTUD3 Mediates Endoplasmic Reticulum Stress through Regulating Fortilin Stability to Restrain Dopaminergic Neurons Apoptosis
Ling Chen, Xuejie Huan, Fengju Jia, Zhen Zhang, Mingxia Bi, Lin Fu, Xixun Du, Xi Chen, Chunling Yan, Qian Jiao, Hong Jiang
Antioxidants (Basel) 2023 Apr; 12(4): 809. Published online 2023 Mar 26. doi: 10.3390/antiox12040809
PMCID:
PMC10135230
AbstractArticlePDF–3.4M
9.
Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice
Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori
Mol Biol Cell. 2023 Mar 1; 34(3): ar20. Published online 2023 Feb 21. doi: 10.1091/mbc.E22-07-0292
PMCID:
PMC10011727
AbstractArticlePDF–11M
10.
Enhanced IRE1α Phosphorylation/Oligomerization-Triggered XBP1 Splicing Contributes to Parkin-Mediated Prevention of SH-SY5Y Cell Death under Nitrosative Stress
Tsung-Lang Chiu, Hsin-Yi Huang, Hui-Fen Chang, Hsin-Rong Wu, Mei-Jen Wang
Int J Mol Sci. 2023 Feb; 24(3): 2017. Published online 2023 Jan 19. doi: 10.3390/ijms24032017
PMCID:
PMC9917145
AbstractArticlePDF–2.7M
11.
Ebola Virus Activates IRE1α-Dependent XBP1u Splicing
Cornelius Rohde, Sebastian Pfeiffer, Sara Baumgart, Stephan Becker, Verena Krähling
Viruses. 2023 Jan; 15(1): 122. Published online 2022 Dec 30. doi: 10.3390/v15010122
PMCID:
PMC9863596
AbstractArticlePDF–2.9M
12.
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer
Michael J. P. Crowley, Bhavneet Bhinder, Geoffrey J. Markowitz, Mitchell Martin, Akanksha Verma, Tito A. Sandoval, Chang-Suk Chae, Shira Yomtoubian, Yang Hu, Sahil Chopra, Diamile A. Tavarez, Paolo Giovanelli, Dingcheng Gao, Timothy E. McGraw, Nasser K. Altorki, Olivier Elemento, Juan R. Cubillos-Ruiz, Vivek Mittal
Nat Commun. 2023; 14: 120. Published online 2023 Jan 9. doi: 10.1038/s41467-022-35584-9
PMCID:
PMC9829901
AbstractArticlePDF–2.8M
13.
Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates
Donghwi Bae, Rachel Elizabeth Jones, Katherine M. Piscopo, Mitali Tyagi, Jason D. Shepherd, Julie Hollien
Mol Biol Cell. 2022 Nov 1; 33(13): ar125. Published online 2022 Nov 1. doi: 10.1091/mbc.E22-07-0281
PMCID:
PMC9634971
AbstractArticlePDF–5.3M
14.
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells
Long C. Nguyen, David M. Renner, Diane Silva, Dongbo Yang, Nicholas A. Parenti, Kaeri M. Medina, Vlad Nicolaescu, Haley Gula, Nir Drayman, Andrea Valdespino, Adil Mohamed, Christopher Dann, Kristin Wannemo, Lydia Robinson-Mailman, Alan Gonzalez, Letícia Stock, Mengrui Cao, Zeyu Qiao, Raymond E. Moellering, Savas Tay, Glenn Randall, Michael F. Beers, Marsha Rich Rosner, Scott A. Oakes, Susan R. Weiss
mBio. 2022 Sep-Oct; 13(5): e02415-22. Published online 2022 Sep 20. doi: 10.1128/mbio.02415-22
PMCID:
PMC9600248
AbstractArticlePDF–3.8M
15.
Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation
Shuai Yang, Hua Jiang, Weixiang Bian, Wenyan Xu, Yifan Guo, Sha Song, Jiadong Zheng, Xiaoyu Kuang, Chenxi Wu, Xiang Ding, Xiaowei Guo, Lei Xue, Zijing Yu, Yongdeng Zhang, Hyung Don Ryoo, Xu Li, Xianjue Ma
Proc Natl Acad Sci U S A. 2022 Oct 18; 119(42): e2202133119. Published online 2022 Oct 10. doi: 10.1073/pnas.2202133119
PMCID:
PMC9586321
AbstractArticlePDF–4.4M
16.
Human cDC1s display constitutive activation of the UPR sensor IRE1
Paulina García‐González, Dominique Fernández, Diane Gutiérrez, Mauro Parra‐Cordero, Fabiola Osorio
Eur J Immunol. 2022 Jul; 52(7): 1069–1076. Published online 2022 Apr 22. doi: 10.1002/eji.202149774
PMCID:
PMC9541385
AbstractArticlePDF–1.2M
17.
Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas
Rossella Benedetti, Andrea Arena, Maria Anele Romeo, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Pankaj Trivedi, Mara Cirone
Int J Mol Sci. 2022 Aug; 23(16): 9113. Published online 2022 Aug 14. doi: 10.3390/ijms23169113
PMCID:
PMC9409055
AbstractArticlePDF–2.4M
18.
Aqueous Extract of Descuraniae Semen Attenuates Lipopolysaccharide-Induced Inflammation and Apoptosis by Regulating the Proteasomal Degradation and IRE1α-Dependent Unfolded Protein Response in A549 Cells
Po-Chun Hsieh, Chung-Kan Peng, Guan-Ting Liu, Chan-Yen Kuo, I-Shiang Tzeng, Ming-Chieh Wang, Chou-Chin Lan, Kun-Lun Huang
Front Immunol. 2022; 13: 916102. Published online 2022 Jun 24. doi: 10.3389/fimmu.2022.916102
PMCID:
PMC9265213
AbstractArticlePDF–10M
19.
Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
Vladislav Belyy, Iratxe Zuazo-Gaztelu, Andrew Alamban, Avi Ashkenazi, Peter Walter
eLife. 2022; 11: e74342. Published online 2022 Jun 22. doi: 10.7554/eLife.74342
PMCID:
PMC9217129
AbstractArticlePDF–4.7M
20.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M

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