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Select item 108766541.

VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma

Natalia Fernández-Parejo, L. Francisco Lorenzo-Martín, Juana M. García-Pedrero, Juan P. Rodrigo, Mercedes Dosil, Xosé R. Bustelo

Sci Rep. 2024; 14: 4060. Published online 2024 Feb 19. doi: 10.1038/s41598-024-54808-0

PMCID:: PMC10876654

Abstract Article PDF–17M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 98352963.

AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway

Bo Sun, Bai Ding, Yu Chen, Chuang Peng, Xu Chen

J Transl Med. 2023; 21: 18. Published online 2023 Jan 11. doi: 10.1186/s12967-023-03871-8

PMCID:: PMC9835296

Abstract Article PDF–23M

Select item 96815504.

The tRNA-Cys-GCA Derived tsRNAs Suppress Tumor Progression of Gliomas via Regulating VAV2

Jian Ren, Xiaoling Wu, Fei-Fei Shang, Yingqiang Qi, Zhurong Tang, Chunjie Wen, Weiguo Cao, Quan Cheng, Lihong Tan, Huan Chen, Hong-Hao Zhou, Hecun Zou

Dis Markers. 2022; 2022: 8708312. Published online 2022 Nov 15. doi: 10.1155/2022/8708312

PMCID:: PMC9681550

Abstract Article PDF–3.1M

Select item 93383135.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 92792856.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 84058167.

VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance

Weiling Liu, Chuanwang Miao, Shaosen Zhang, Yachen Liu, Xiangjie Niu, Yiyi Xi, Wenjia Guo, Jiahui Chu, Ai Lin, Hongjin Liu, Xinyu Yang, Xinjie Chen, Ce Zhong, Yuling Ma, Yuqian Wang, Shihao Zhu, Shuning Liu, Wen Tan, Dongxin Lin, Chen Wu

Signal Transduct Target Ther. 2021; 6: 322. Published online 2021 Aug 30. doi: 10.1038/s41392-021-00735-9

PMCID:: PMC8405816

Abstract Article PDF–5.9M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75237069.

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis

Katrin Tiemann, Carolina Garri, Sang Bok Lee, Paymaneh D. Malihi, Mincheol Park, Ruth M. Alvarez, Li Peng Yap, Parag Mallick, Jonathan E. Katz, Mitchell E. Gross, Kian Kani

Oncogene. Author manuscript; available in PMC 2020 Sep 29.

Published in final edited form as: Oncogene. 2019 Apr; 38(16): 3003–3018. Published online 2018 Dec 21. doi: 10.1038/s41388-018-0638-9

PMCID:: PMC7523706

Abstract Article PDF–2.3M

Select item 750883210.

VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

L. Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Mauricio Menacho-Márquez, Sonia Rodríguez-Fdez, Javier Robles-Valero, Sonia Zumalave, Salvatore Fabbiano, Gloria Pascual, Juana M. García-Pedrero, Antonio Abad, María C. García-Macías, Nazareno González, Pablo Lorenzano-Menna, Miguel A. Pavón, Rogelio González-Sarmiento, Carmen Segrelles, Jesús M. Paramio, José M. C. Tubío, Juan P. Rodrigo, Salvador A. Benitah, Myriam Cuadrado, Xosé R. Bustelo

Nat Commun. 2020; 11: 4788. Published online 2020 Sep 22. doi: 10.1038/s41467-020-18524-3

PMCID:: PMC7508832

Abstract Article PDF–5.8M

Select item 739233411.

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

Seung W. Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P. Zanini, Antony Harvey, Jon M. Huibregtse, Peter Mueller, Tanya T. Paull

PLoS Biol. 2020 Jul; 18(7): e3000606. Published online 2020 Jul 20. doi: 10.1371/journal.pbio.3000606

PMCID:: PMC7392334

Abstract Article PDF–2.7M

Select item 722681212.

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle

Cells. 2020 Apr; 9(4): 834. Published online 2020 Mar 30. doi: 10.3390/cells9040834

PMCID:: PMC7226812

Abstract Article PDF–2.3M

Select item 675758313.

Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis

Anthony W. Harrington, Ju Young Kim, Sung Ok Yoon

J Neurosci. 2002 Jan 1; 22(1): 156–166. doi: 10.1523/JNEUROSCI.22-01-00156.2002

PMCID:: PMC6757583

Abstract Article PDF–582K

Select item 659455114.

PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling

Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin

Cell Rep. Author manuscript; available in PMC 2019 Jun 26.

Published in final edited form as: Cell Rep. 2019 May 14; 27(7): 2157–2170.e8. doi: 10.1016/j.celrep.2019.04.060

PMCID:: PMC6594551

Abstract Article PDF–1.4M

Select item 655012715.

MicroRNA‐331‐3p inhibits epithelial‐mesenchymal transition by targeting ErbB2 and VAV2 through the Rac1/PAK1/β‐catenin axis in non‐small‐cell lung cancer

Xizhe Li, Jiali Zhu, Yuanqi Liu, Chaojun Duan, Ruimin Chang, Chunfang Zhang

Cancer Sci. 2019 Jun; 110(6): 1883–1896. Published online 2019 Apr 29. doi: 10.1111/cas.14014

PMCID:: PMC6550127

Abstract Article PDF–3.3M

Select item 603950116.

CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia

Qing-Yun Wu, Yuan-Yuan Zhu, Yang Liu, Fang Wei, Yu-Xue Tong, Jiang Cao, Ping Zhou, Ming-Shan Niu, Zhen-Yu Li, Ling-Yu Zeng, Feng Li, Kai-Lin Xu

Cell Death Dis. 2018 Jul; 9(7): 774. Published online 2018 Jul 10. doi: 10.1038/s41419-018-0812-6

PMCID:: PMC6039501

Abstract Article PDF–2.7M

Select item 603641817.

Ubiquitin E3 Ligase MARCH7 promotes proliferation and invasion of cervical cancer cells through VAV2-RAC1-CDC42 pathway

Jianguo Hu, Ying Meng, Jianhua Zeng, Biao Zeng, Xingwei Jiang

Oncol Lett. 2018 Aug; 16(2): 2312–2318. Published online 2018 Jun 5. doi: 10.3892/ol.2018.8908

PMCID:: PMC6036418

Abstract Article PDF–1.5M

Select item 582692618.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 577027719.

Targeting AR Variant-coactivator Interactions to Exploit Prostate Cancer Vulnerabilities

Fiorella Magani, Stephanie O. Peacock, Meghan A. Rice, Maria J. Martinez, Ann M. Greene, Pablo S. Magani, Rolando Lyles, Jonathan R. Weitz, Kerry L. Burnstein

Mol Cancer Res. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Mol Cancer Res. 2017 Nov; 15(11): 1469–1480. Published online 2017 Aug 15. doi: 10.1158/1541-7786.MCR-17-0280

PMCID:: PMC5770277

Abstract Article PDF–577K

Select item 567858120.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

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