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Items: 1 to 20 of 39

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function
Julia M. Adams, Sanket V. Rege, Angela T. Liu, Ninh V. Vu, Sharda Raina, Douglas Y. Kirsher, Amy L. Nguyen, Reema Harish, Balazs Szoke, Dino P. Leone, Eva Czirr, Steven Braithwaite, Meghan Kerrisk Campbell
Sci Adv. 2023 Nov 17; 9(46): eadf8764. Published online 2023 Nov 17. doi: 10.1126/sciadv.adf8764
PMCID:
PMC10656077
AbstractArticlePDF–2.5M
3.
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany
Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527
PMCID:
PMC9603860
AbstractArticlePDF–3.4M
4.
Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi
Alex Hopke, Tian Lin, Allison K. Scherer, Ashley E. Shay, Kyle D. Timmer, Brittany Wilson-Mifsud, Michael K. Mansour, Charles N. Serhan, Daniel Irimia, Bryan P. Hurley
iScience. 2022 Oct 21; 25(10): 105226. Published online 2022 Sep 28. doi: 10.1016/j.isci.2022.105226
PMCID:
PMC9576560
AbstractArticlePDF–2.7M
5.
Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation
Tomoaki Koga, Fumiyuki Sasaki, Kazuko Saeki, Soken Tsuchiya, Toshiaki Okuno, Mai Ohba, Takako Ichiki, Satoshi Iwamoto, Hirotsugu Uzawa, Keiko Kitajima, Chikara Meno, Eri Nakamura, Norihiro Tada, Yoshinori Fukui, Junichi Kikuta, Masaru Ishii, Yukihiko Sugimoto, Mitsuyoshi Nakao, Takehiko Yokomizo
Cell Mol Immunol. 2021 Jun; 18(6): 1437–1449. Published online 2020 Oct 9. doi: 10.1038/s41423-020-00559-7
PMCID:
PMC8167169
AbstractArticlePDF–3.8M
6.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
7.
Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease
John R. Montford, Colin Bauer, Evgenia Dobrinskikh, Katharina Hopp, Moshe Levi, Mary Weiser-Evans, Raphael Nemenoff, Seth B. Furgeson
Am J Physiol Renal Physiol. 2019 Apr 1; 316(4): F732–F742. Published online 2019 Jan 16. doi: 10.1152/ajprenal.00262.2018
PMCID:
PMC6483031
AbstractArticle
8.
An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness
Dhiren F. Patel, Teresa Peiró, Amelia Shoemark, Samia Akthar, Simone A. Walker, Aleksander M. Grabiec, Patricia L. Jackson, Tracy Hussell, Amit Gaggar, Xin Xu, Jennifer L. Trevor, Jindong Li, Chad Steele, Gael Tavernier, J. Edwin Blalock, Robert M. Niven, Lisa G. Gregory, Angela Simpson, Clare M. Lloyd, Robert J. Snelgrove
Sci Transl Med. Author manuscript; available in PMC 2019 Jan 22.
Published in final edited form as: Sci Transl Med. 2018 Aug 22; 10(455): eaaq0693. doi: 10.1126/scitranslmed.aaq0693
PMCID:
PMC6342449
AbstractArticlePDF–2.0M
9.
LTA4H regulates cell cycle and skin carcinogenesis
Naomi Oi, Hiroyuki Yamamoto, Alyssa Langfald, Ruihua Bai, Mee-Hyun Lee, Ann M. Bode, Zigang Dong
Carcinogenesis. 2017 Jul; 38(7): 728–737. Published online 2017 May 31. doi: 10.1093/carcin/bgx049
PMCID:
PMC6248358
AbstractArticlePDF–8.0M
10.
Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors
Shin Numao, Franziska Hasler, Claire Laguerre, Honnappa Srinivas, Nathalie Wack, Petra Jäger, Andres Schmid, Arnaud Osmont, Patrik Röthlisberger, Jeremy Houguenade, Christian Bergsdorf, Janet Dawson, Nathalie Carte, Andreas Hofmann, Christian Markert, Liz Hardaker, Andreas Billich, Romain M. Wolf, Carlos A. Penno, Birgit Bollbuck, Wolfgang Miltz, Till A. Röhn
Sci Rep. 2017; 7: 13591. Published online 2017 Oct 19. doi: 10.1038/s41598-017-13490-1
PMCID:
PMC5648829
AbstractArticlePDF–1.9M
11.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
12.
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment
Joanna M. Poczobutt, Teresa T. Nguyen, Dwight Hanson, Howard Li, Trisha R. Sippel, Mary C. M. Weiser-Evans, Miguel Gijon, Robert C. Murphy, Raphael A. Nemenoff
J Immunol. 2016 Jan 15; 196(2): 891–901. Published online 2015 Dec 11. doi: 10.4049/jimmunol.1501648
PMCID:
PMC4705594
AbstractArticlePDF–1.3M
13.
Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection
Samia Akthar, Dhiren F. Patel, Rebecca C. Beale, Teresa Peiró, Xin Xu, Amit Gaggar, Patricia L. Jackson, J. Edwin Blalock, Clare M. Lloyd, Robert J. Snelgrove
Nat Commun. 2015; 6: 8423. Published online 2015 Sep 24. doi: 10.1038/ncomms9423
PMCID:
PMC4595997
AbstractArticlePDF–713K
14.
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells
Paulina A. Latos, Angela Goncalves, David Oxley, Hisham Mohammed, Ernest Turro, Myriam Hemberger
Nat Commun. 2015; 6: 7776. Published online 2015 Jul 24. doi: 10.1038/ncomms8776
PMCID:
PMC4525203
AbstractArticlePDF–1.9M
15.
An Aberrant Leukotriene A4 Hydrolase–Proline-Glycine-Proline Pathway in the Pathogenesis of Chronic Obstructive Pulmonary Disease
J. Michael Wells, Philip J. O’Reilly, Tomasz Szul, Daniel I. Sullivan, Guy Handley, Chris Garrett, Carmel M. McNicholas, Mojtaba Abdul Roda, Bruce E. Miller, Ruth Tal-Singer, Amit Gaggar, Stephen I. Rennard, Patricia L. Jackson, J. Edwin Blalock
Am J Respir Crit Care Med. 2014 Jul 1; 190(1): 51–61. Published online 2014 Jul 1. doi: 10.1164/rccm.201401-0145OC
PMCID:
PMC4226028
AbstractArticlePDF–1.0M
16.
Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema
Mikell Paige, Kan Wang, Marie Burdick, Sunhye Park, Josiah Cha, Erin Jeffrey, Nicholas Sherman, Y. Michael Shim
J Immunol. Author manuscript; available in PMC 2015 Jun 1.
Published in final edited form as: J Immunol. 2014 Jun 1; 192(11): 5059–5068. Published online 2014 Apr 25. doi: 10.4049/jimmunol.1400452
PMCID:
PMC4083682
AbstractArticlePDF–3.2M
17.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
18.
Joint Tissues Amplify Inflammation and Alter Their Invasive Behavior via Leukotriene B4 in Experimental Inflammatory Arthritis
Mei Chen, Bing K. Lam, Andrew D. Luster, Simona Zarini, Robert C. Murphy, Angela M. Bair, Roy J. Soberman, David M. Lee
J Immunol. Author manuscript; available in PMC 2013 Jun 23.
Published in final edited form as: J Immunol. 2010 Nov 1; 185(9): 5503–5511. Published online 2010 Sep 27. doi: 10.4049/jimmunol.1001258
PMCID:
PMC3690310
AbstractArticlePDF–2.1M
19.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
20.
Leukotriene B4 driven neutrophil recruitment to the skin is essential for allergic skin inflammation
Michiko K. Oyoshi, Rui He, Yitang Li, Subhanjan Mondal, Juhan Yoon, Roshi Afshar, Mei Chen, David M. Lee, Hongbo R. Luo, Andrew D. Luster, John S. Cho, Lloyd S. Miller, Allison Larson, George F. Murphy, Raif S. Geha
Immunity. Author manuscript; available in PMC 2013 Oct 19.
Published in final edited form as: Immunity. 2012 Oct 19; 37(4): 747–758. Published online 2012 Oct 11. doi: 10.1016/j.immuni.2012.06.018
PMCID:
PMC3478399
AbstractArticlePDF–1.3M

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