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Items: 1 to 20 of 166

1.
Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection
Mingli Gong, Cheng Peng, Chen Yang, Zhenhua Wang, Hongwu Qian, Xue Hu, Peng Zhou, Chao Shan, Qiang Ding
PLoS Pathog. 2024 Aug; 20(8): e1012444. Published online 2024 Aug 22. doi: 10.1371/journal.ppat.1012444
PMCID:
PMC11341029
AbstractArticlePDF–4.0M
2.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
3.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
4.
ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation
Mengshu Jia, Xiao Yue, Weixia Sun, Qianjun Zhou, Cheng Chang, Weihua Gong, Jian Feng, Xie Li, Ruonan Zhan, Kemin Mo, Lijuan Zhang, Yajie Qian, Yuying Sun, Aoxue Wang, Yejun Zou, Weicai Chen, Yan Li, Li Huang, Yi Yang, Yuzheng Zhao, Xiawei Cheng
Sci Adv. 2023 Jun 2; 9(22): eadg4993. Published online 2023 Jun 2. doi: 10.1126/sciadv.adg4993
PMCID:
PMC10413652
AbstractArticlePDF–2.8M
5.
PIK3C3/VPS34 keeps body fats healthy
Wenqiang Song, J. Luke Postoak, Lan Wu, Luc Van Kaer
Autophagy. 2023; 19(8): 2398–2400. Published online 2023 Jan 18. doi: 10.1080/15548627.2023.2166275
PMCID:
PMC10351436
AbstractArticlePDF–610K
6.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
7.
Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34
Robert J. Cain, Mariela Scortti, Héctor J. Monzó, José A. Vázquez-Boland
mBio. 2023 Jan-Feb; 14(1): e03221-22. Published online 2023 Jan 19. doi: 10.1128/mbio.03221-22
PMCID:
PMC9973280
AbstractArticlePDF–2.4M
8.
Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers
Shaoyang Zhang, Xiufeng Liu, Saleh Abdulmomen Ali Mohammed, Hui Li, Wanhua Cai, Wen Guan, Daiyun Liu, Yanli Wei, Dade Rong, Ying Fang, Farhan Haider, Haimei Lv, Ziwei Jin, Xiaomin Chen, Zhuomao Mo, Lujie Li, Shulan Yang, Haihe Wang
Autophagy. 2022; 18(8): 1822–1840. Published online 2021 Dec 6. doi: 10.1080/15548627.2021.2002108
PMCID:
PMC9450985
AbstractArticlePDF–9.9M
9.
GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer
Feifei Zhou, Yufeng Liu, Wenqian Ai, Yanan Wang, Mingxi Gan, Qingkun Jiang, Tianyu Han, Jian-Bin Wang
Cell Commun Signal. 2022; 20: 133. Published online 2022 Aug 30. doi: 10.1186/s12964-022-00936-x
PMCID:
PMC9426035
AbstractArticlePDF–3.0M
10.
The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis
Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi
Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y
PMCID:
PMC9343455
AbstractArticlePDF–3.7M
11.
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
Lidia Wrobel, Sandra M. Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J. Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W. Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M. Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W. Bürli, David C. Rubinsztein
Nat Commun. 2022; 13: 4146. Published online 2022 Jul 16. doi: 10.1038/s41467-022-31905-0
PMCID:
PMC9288506
AbstractArticlePDF–3.9M
12.
Global Proximity Interactome of the Human Macroautophagy Pathway
Yi Xin (Iris) Tu, Andrew M. Sydor, Etienne Coyaud, Estelle M. N. Laurent, Diana Dyer, Nora Mellouk, Jonathan St-Germain, Robert M. Vernon, Julie D. Forman-Kay, Taoyingnan Li, Rong Hua, Kexin Zhao, Neale D. Ridgway, Peter K. Kim, Brian Raught, John H. Brumell
Autophagy. 2022; 18(5): 1174–1186. Published online 2021 Sep 15. doi: 10.1080/15548627.2021.1965711
PMCID:
PMC9196747
AbstractArticlePDF–3.1M
13.
Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss
Xiaobo Wang, Min Gu, Yongjian Ju, Juying Zhou
J Radiat Res. 2022 May; 63(3): 331–341. Published online 2022 Mar 25. doi: 10.1093/jrr/rrac004
PMCID:
PMC9124615
AbstractArticlePDF–2.0M
14.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
15.
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang
J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009
PMCID:
PMC9058836
AbstractArticlePDF–2.9M
16.
CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression
Xuan Li, Kai-Bin Yang, Wei Chen, Jia Mai, Xiao-Qi Wu, Ting Sun, Rui-Yan Wu, Lin Jiao, Dan-Dan Li, Jiao Ji, Hai-Liang Zhang, Yan Yu, Yu-Hong Chen, Gong-Kan Feng, Rong Deng, Jun-Dong Li, Xiao-Feng Zhu
Autophagy. 2021; 17(12): 4323–4340. Published online 2021 May 12. doi: 10.1080/15548627.2021.1912270
PMCID:
PMC8726624
AbstractArticlePDF–26M
17.
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
Mila Basic, Alexandra Hertel, Justyna Bajdzienko, Florian Bonn, Mariana Tellechea, Alexandra Stolz, Andreas Kern, Christian Behl, Anja Bremm
J Biol Chem. 2021 Nov; 297(5): 101263. Published online 2021 Sep 30. doi: 10.1016/j.jbc.2021.101263
PMCID:
PMC8546420
AbstractArticlePDF–2.4M
18.
PDPK1 regulates autophagosome biogenesis by binding to PIK3C3
Boli Hu, Yina Zhang, Tingjuan Deng, Jinyan Gu, Juan Liu, Hui Yang, Yuting Xu, Yan Yan, Fan Yang, Heng Zhang, Yulan Jin, Jiyong Zhou
Autophagy. 2021; 17(9): 2166–2183. Published online 2020 Sep 10. doi: 10.1080/15548627.2020.1817279
PMCID:
PMC8496706
AbstractArticlePDF–10M
19.
STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I
Cefan Zhou, Xuehong Qian, Miao Hu, Rui Zhang, Nanxi Liu, Yuan Huang, Jing Yang, Juan Zhang, Hua Bai, Yuyan Yang, Yefu Wang, Declan Ali, Marek Michalak, Xing-Zhen Chen, Jingfeng Tang
Autophagy. 2020; 16(10): 1786–1806. Published online 2019 Nov 7. doi: 10.1080/15548627.2019.1687212
PMCID:
PMC8386619
AbstractArticlePDF–10M
20.
Binding of Avibirnavirus VP3 to the PIK3C3-PDPK1 complex inhibits autophagy by activating the AKT-MTOR pathway
Yina Zhang, Boli Hu, Yahui Li, Tingjuan Deng, Yuting Xu, Jing Lei, Jiyong Zhou
Autophagy. 2020; 16(9): 1697–1710. Published online 2019 Dec 29. doi: 10.1080/15548627.2019.1704118
PMCID:
PMC8386615
AbstractArticlePDF–3.6M

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