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Select item 111937611.

Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma

Shanshan Deng, Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang, Guofei Cui, Andrew Yonemura, Honor Paine, Yi Zhou, Yi Zhang, Maria Maddalena Simile, Francesco Urigo, Matthias Evert, Diego F. Calvisi, Benjamin L. Green, Xin Chen

Cell Death Dis. 2024 Jun; 15(6): 441. Published online 2024 Jun 22. doi: 10.1038/s41419-024-06839-8

PMCID:: PMC11193761

Abstract Article PDF–4.4M

Select item 110961762.

Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis

Zhenlei Zhang, Yufan Wu, Jinrong Fu, Xiujie Yu, Yang Su, Shikai Jia, Huili Cheng, Yan Shen, Xianghui He, Kai Ren, Xiangqian Zheng, Haixia Guan, Feng Rao, Li Zhao

Nat Commun. 2024; 15: 4108. Published online 2024 May 15. doi: 10.1038/s41467-024-48173-9

Correction in:: Nat Commun. 2024; 15: 4936.

PMCID:: PMC11096176

Abstract Article PDF–5.7M

Select item 109332673.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 105658764.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 100291955.

TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration

Michael Karl Melzer, Silvia Schirge, Johann Gout, Frank Arnold, Dharini Srinivasan, Ingo Burtscher, Chantal Allgöwer, Medhanie Mulaw, Friedemann Zengerling, Cagatay Günes, Heiko Lickert, Vincent M. Christoffels, Stefan Liebau, Martin Wagner, Thomas Seufferlein, Christian Bolenz, Anne M. Moon, Lukas Perkhofer, Alexander Kleger

BMC Biol. 2023; 21: 55. Published online 2023 Mar 20. doi: 10.1186/s12915-023-01553-x

PMCID:: PMC10029195

Abstract Article PDF–4.1M

Select item 100103346.

Suppressed Cellular Senescence Mediated by T-box3 in Aged Gastric Epithelial Cells may Contribute to Aging-related Carcinogenesis

Akio Takeuchi, Naoki Asano, Akira Imatani, Masashi Saito, Xiaoyi Jin, Masahiro Saito, Takeshi Kanno, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune

Cancer Res Commun. 2022 Aug; 2(8): 772–783. Published online 2022 Aug 8. doi: 10.1158/2767-9764.CRC-22-0084

PMCID:: PMC10010334

Abstract Article PDF–12M

Select item 96683107.

Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset

Xiang Shi, Yanrong Zhuang, Zhenhua Chen, Mingrui Xu, Junqi Kuang, Xue-Lian Sun, Lisen Gao, Xia Kuang, Huairen Zhang, Wei Li, Samuel Zheng Hao Wong, Chuanyu Liu, Longqi Liu, Danhua Jiang, Duanqing Pei, Yi Lin, Qing-Feng Wu

Sci Adv. 2022 Nov; 8(46): eabq2987. Published online 2022 Nov 16. doi: 10.1126/sciadv.abq2987

PMCID:: PMC9668310

Abstract Article PDF–22M

Select item 93464718.

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2‐mediated degradation

Mi Chen, Shreyas Lingadahalli, Nitin Narwade, Kate Man Kei Lei, Shanshan Liu, Zuxianglan Zhao, Yimin Zheng, Qian Lu, Alexander Hin Ning Tang, Terence Chuen Wai Poon, Edwin Cheung

EMBO Rep. 2022 Aug; 23(8): e53468. Published online 2022 Jul 4. doi: 10.15252/embr.202153468

PMCID:: PMC9346471

Abstract Article PDF–5.2M

Select item 92816009.

TBX3 regulates the transcription of VEGFA to promote osteoblasts proliferation and microvascular regeneration

Lichuang Wu, Chenxian Su, Chuanhua Yang, Jinxing Liu, Yiheng Ye

PeerJ. 2022; 10: e13722. Published online 2022 Jul 11. doi: 10.7717/peerj.13722

PMCID:: PMC9281600

Abstract Article PDF–11M

Select item 904055610.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 860245111.

Identification of proximal SUMO-dependent interactors using SUMO-ID

Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland

Nat Commun. 2021; 12: 6671. Published online 2021 Nov 18. doi: 10.1038/s41467-021-26807-6

PMCID:: PMC8602451

Abstract Article PDF–11M

Select item 858088612.

Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells

Somdutta Mukherjee, Deborah L. French, Paul Gadue

Stem Cell Reports. 2021 Nov 9; 16(11): 2617–2627. Published online 2021 Oct 14. doi: 10.1016/j.stemcr.2021.09.004

PMCID:: PMC8580886

Abstract Article PDF–1.8M

Select item 833717813.

TBX3 及 TBX18 在人源诱导多能干细胞向窦房结样细胞富集分化中的作用

锋刘, 易冰方, 琪熊, 良琴罗, 锐周, 斌廖

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2019 Apr; 33(4): 497–506. Chinese. doi: 10.7507/1002-1892.201812009

PMCID:: PMC8337178

Abstract Article PDF–7.5M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 815322315.

Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.

Vincent W.W. van Eif, Stephanie Protze, Fernanda M. Bosada, Xuefei Yuan, Tanvi Sinha, Karel van Duijvenboden, Auriane C. Ernault, Rajiv A. Mohan, Vincent Wakker, Corrie de Gier-de Vries, Ingeborg B. Hooijkaas, Michael D. Wilson, Arie O. Verkerk, Jeroen Bakkers, Bastiaan J. Boukens, Brian L. Black, Ian C. Scott, Vincent M. Christoffels

Circ Res. Author manuscript; available in PMC 2021 Dec 4.

Published in final edited form as: Circ Res. 2020 Dec 4; 127(12): 1522–1535. Published online 2020 Oct 12. doi: 10.1161/CIRCRESAHA.120.317054

PMCID:: PMC8153223

Abstract Article PDF–2.5M

Select item 800904816.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 797455217.

A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells

Poornima Bhat-Nakshatri, Hongyu Gao, Liu Sheng, Patrick C. McGuire, Xiaoling Xuei, Jun Wan, Yunlong Liu, Sandra K. Althouse, Austyn Colter, George Sandusky, Anna Maria Storniolo, Harikrishna Nakshatri

Cell Rep Med. 2021 Mar 16; 2(3): 100219. Published online 2021 Mar 16. doi: 10.1016/j.xcrm.2021.100219

PMCID:: PMC7974552

Abstract Article PDF–6.7M

Select item 784472218.

T-box Transcription Factor Tbx3 Contributes to Human Hepatocellular Carcinoma Cell Migration and Invasion by Repressing E-Cadherin Expression

Xianguang Feng, Wenhuan Yao, Zengzhen Zhang, Fangshui Yuan, Li Liang, Jingqiang Zhou, Shuang Liu, Jiqing Song

Oncol Res. 2018; 26(6): 959–966. Published online 2018 Jul 5. doi: 10.3727/096504017X15145624664031

PMCID:: PMC7844722

Abstract Article PDF–6.6M

Select item 733977119.

Transcription box-3 protects human umbilical vein endothelial cells in a high-glucose environment through sirtuin 1/AKT signaling

Zhanjiang Yu, Wei Zhang, Xiankun Zhang, Donghui Xu, Na Wang

Mol Med Rep. 2020 Aug; 22(2): 1145–1154. Published online 2020 Jun 15. doi: 10.3892/mmr.2020.11237

PMCID:: PMC7339771

Abstract Article PDF–977K

Select item 731663220.

Differential DNA methylation patterns in human Schlemm’s canal endothelial cells with glaucoma

Jingwen Cai, Michelle D. Drewry, Kristin Perkumas, W. Michael Dismuke, Michael A. Hauser, W. Daniel Stamer, Yutao Liu

Mol Vis. 2020; 26: 483–493. Published online 2020 Jun 26.

PMCID:: PMC7316632

Abstract Article PDF–1.1M

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