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Select item 102359351.

Germline C1GALT1C1 mutation causes a multisystem chaperonopathy

Florian Erger, Rajindra P. Aryal, Björn Reusch, Yasuyuki Matsumoto, Robert Meyer, Junwei Zeng, Cordula Knopp, Maxence Noel, Lukas Muerner, Andrea Wenzel, Stefan Kohl, Nikolai Tschernoster, Gunter Rappl, Isabelle Rouvet, Jutta Schröder-Braunstein, Felix S. Seibert, Holger Thiele, Martin G. Häusler, Lutz T. Weber, Maike Büttner-Herold, Miriam Elbracht, Sandra F. Cummings, Janine Altmüller, Sandra Habbig, Richard D. Cummings, Bodo B. Beck

Proc Natl Acad Sci U S A. 2023 May 30; 120(22): e2211087120. Published online 2023 May 22. doi: 10.1073/pnas.2211087120

PMCID:: PMC10235935

Abstract Article PDF–4.2M

Select item 92316232.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 91197363.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 85496064.

Cosmc transfection decreases malignant behavior of Tn⁺ cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure

Ruisong Ding, Xingyou Hu, Wen Hu, Zhenzhen Du, Panpan Huang, Mengyang Wang, Jiaoyue Sheng, Yanchao Ma, Ailing Wang, Xiying Luan, Menghua Dong, Qizhi Cao, Yanfen Zou, Tao Hu

Aging (Albany NY) 2021 Oct 15; 13(19): 23393–23406. Published online 2021 Oct 13. doi: 10.18632/aging.203633

PMCID:: PMC8549606

Abstract Article PDF–1.7M

Select item 82360785.

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs

Katherine M. Almasy, Jonathan P. Davies, Lars Plate

Mol Cell Proteomics. 2021; 20: 100120. Published online 2021 Jun 27. doi: 10.1016/j.mcpro.2021.100120

PMCID:: PMC8236078

Abstract Article PDF–4.6M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73889927.

Cosmc基因突变与儿童过敏性紫癜易感性的相关性分析

谢秋玲, 莫茜, 刘少玲, 朱明昂, 陶悦, 张小秦, 王剑, 金金燕樑

Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jul 15; 18(7): 625–629. Chinese. doi: 10.7499/j.issn.1008-8830.2016.07.011

PMCID:: PMC7388992

Abstract Article PDF–1.5M

Select item 69333708.

Cosmc overexpression enhances malignancies in human colon cancer

Tianbo Gao, Tan Du, Xin Hu, Xichen Dong, Lina Li, Yakun Wang, Jian Liu, Lijie Liu, Tao Gu, Tao Wen

J Cell Mol Med. 2020 Jan; 24(1): 362–370. Published online 2019 Oct 21. doi: 10.1111/jcmm.14740

PMCID:: PMC6933370

Abstract Article PDF–1.0M

Select item 66009159.

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen Dendoncker, Steven Timmermans, Jolien Vandewalle, Melanie Eggermont, Joanna Lempiäinen, Evelien Van Hamme, Sylviane Dewaele, Sofie Vandevyver, Marlies Ballegeer, Jolien Souffriau, Lise Van Wyngene, Kelly Van Looveren, Tineke Vanderhaeghen, Rudi Beyaert, Karolien De Bosscher, Jorma J. Palvimo, Marc Van Montagu, Claude Libert

Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26): 12942–12951. Published online 2019 Jun 10. doi: 10.1073/pnas.1821565116

Correction in:: Proc Natl Acad Sci U S A. 2019 Jul 30; 116(31): 15745.

PMCID:: PMC6600915

Abstract Article PDF–1.7M

Select item 609720810.

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

Xiaodong Sun, Tongzhong Ju, Richard D. Cummings

BMC Cancer. 2018; 18: 827. Published online 2018 Aug 16. doi: 10.1186/s12885-018-4708-8

PMCID:: PMC6097208

Abstract Article PDF–7.5M

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549336912.

Biochemical characterization of functional domains of the chaperone Cosmc

Melinda S. Hanes, Kelley W. Moremen, Richard D. Cummings

PLoS One. 2017; 12(6): e0180242. Published online 2017 Jun 30. doi: 10.1371/journal.pone.0180242

PMCID:: PMC5493369

Abstract Article PDF–12M

Select item 532840513.

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway

Krzysztof Kiryluk, Yifu Li, Zina Moldoveanu, Hitoshi Suzuki, Colin Reily, Ping Hou, Jingyuan Xie, Nikol Mladkova, Sindhuri Prakash, Clara Fischman, Samantha Shapiro, Robert A. LeDesma, Drew Bradbury, Iuliana Ionita-Laza, Frank Eitner, Thomas Rauen, Nicolas Maillard, Francois Berthoux, Jürgen Floege, Nan Chen, Hong Zhang, Francesco Scolari, Robert J. Wyatt, Bruce A. Julian, Ali G. Gharavi, Jan Novak

PLoS Genet. 2017 Feb; 13(2): e1006609. Published online 2017 Feb 10. doi: 10.1371/journal.pgen.1006609

PMCID:: PMC5328405

Abstract Article PDF–2.6M

Select item 530870114.

The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn

Chia-Wen Ho, Chi-Yu Lin, Yi-Wei Liaw, Hsiao-Ling Chiang, Yu-Tang Chin, Rui-Lan Huang, Hung-Cheng Lai, Yaw-Wen Hsu, Po-Jan Kuo, Chiao-En Chen, Hung-Yun Lin, Jacqueline Whang-Peng, Shin Nieh, Earl Fu, Leroy F. Liu, Jaulang Hwang

Oncotarget. 2016 Sep 20; 7(38): 61930–61944. Published online 2016 Aug 17. doi: 10.18632/oncotarget.11324

PMCID:: PMC5308701

Abstract Article PDF–6.1M

Select item 461721115.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 452102716.

Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation

Junwei Zeng, Rongjuan Mi, Yingchun Wang, Yujing Li, Li Lin, Bing Yao, Lina Song, Irma van Die, Arlene B. Chapman, Richard D. Cummings, Peng Jin, Tongzhong Ju

J Biol Chem. 2015 Jul 31; 290(31): 19018–19033. Published online 2015 Jun 10. doi: 10.1074/jbc.M115.654244

PMCID:: PMC4521027

Abstract Article PDF–2.9M

Select item 444700717.

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

Bianca T. Hofmann, Laura Schlüter, Philip Lange, Baris Mercanoglu, Florian Ewald, Aljonna Fölster, Aeint-Steffen Picksak, Sönke Harder, Alexander T. El Gammal, Katharina Grupp, Cenap Güngör, Astrid Drenckhan, Hartmut Schlüter, Christoph Wagener, Jakob R. Izbicki, Manfred Jücker, Maximilian Bockhorn, Gerrit Wolters-Eisfeld

Mol Cancer. 2015; 14: 109. Published online 2015 May 29. doi: 10.1186/s12943-015-0386-1

PMCID:: PMC4447007

Abstract Article PDF–2.6M

Select item 444007418.

Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29

Xiaofeng Yu, Zhenzhen Du, Xuhong Sun, Chuanqin Shi, Huaixiang Zhang, Tao Hu

Int J Clin Exp Pathol. 2015; 8(3): 2590–2602. Published online 2015 Mar 1.

PMCID:: PMC4440074

Abstract Article PDF–1.6M

Select item 431539619.

DNA Methylation in Cosmc Promoter Region and Aberrantly Glycosylated IgA1 Associated with Pediatric IgA Nephropathy

Qiang Sun, Jianqian Zhang, Nan Zhou, Xiaorong Liu, Ying Shen

PLoS One. 2015; 10(2): e0112305. Published online 2015 Feb 3. doi: 10.1371/journal.pone.0112305

PMCID:: PMC4315396

Abstract Article PDF–1.5M

Select item 400207320.

Identification of a Novel Protein Binding Motif within the T-synthase for the Molecular Chaperone Cosmc

Rajindra P. Aryal, Tongzhong Ju, Richard D. Cummings

J Biol Chem. 2014 Apr 25; 289(17): 11630–11641. Published online 2014 Mar 10. doi: 10.1074/jbc.M114.555870

PMCID:: PMC4002073

Abstract Article PDF–3.6M

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