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Select item 111847531.

CRISPR/Cas9-mediated knock out of ITGB6 in human OSCC cells reduced migration and proliferation ability

Maximilian Geyer, Fabian Geyer, Ute Reuning, Sarah Klapproth, Klaus-Dietrich Wolff, Markus Nieberler

Head Face Med. 2024; 20: 37. Published online 2024 Jun 18. doi: 10.1186/s13005-024-00437-x

PMCID:: PMC11184753

Abstract Article PDF–3.9M

Select item 110288132.

Integrin alphavbeta6 promotes tumor tolerance in colorectal cancer

Shao-Bo Yang, Yun Du, Ben-Yan Wu, Shi-Ping Xu, Jun-Bao Wen, Min Zhu, Chang-Hao Cai, Ping-Chang Yang

Cancer Immunol Immunother. 2012 Mar; 61(3): 335–342. Published online 2011 Sep 13. doi: 10.1007/s00262-011-1108-1

PMCID:: PMC11028813

Abstract Article PDF–396K

Select item 106415243.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 98468904.

Receptor-binding domain of SARS-CoV-2 is a functional αv-integrin agonist

Emma G. Norris, Xuan Sabrina Pan, Denise C. Hocking

J Biol Chem. 2023 Mar; 299(3): 102922. Published online 2023 Jan 18. doi: 10.1016/j.jbc.2023.102922

PMCID:: PMC9846890

Abstract Article PDF–2.6M

Select item 90771405.

Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation

Bo You, Si Pan, Miao Gu, Kaiwen Zhang, Tian Xia, Siyu Zhang, Wenhui Chen, Haijing Xie, Yue Fan, Hui Yao, Tianyi Cheng, Panpan Zhang, Dong Liu, Yiwen You

J Extracell Vesicles. 2022 May; 11(5): e12221. Published online 2022 May 6. doi: 10.1002/jev2.12221

Correction in:: J Extracell Vesicles. 2022 Jun; 11(6): e12236.

PMCID:: PMC9077140

Abstract Article PDF–13M

Select item 82312666.

ITGB6-Knockout Suppresses Cholangiocarcinoma Cell Migration and Invasion with Declining PODXL2 Expression

Yurie Soejima, Miho Takeuchi, Nao Miyamoto, Motoji Sawabe, Toshio Fukusato

Int J Mol Sci. 2021 Jun; 22(12): 6303. Published online 2021 Jun 11. doi: 10.3390/ijms22126303

PMCID:: PMC8231266

Abstract Article PDF–7.4M

Select item 79339327.

Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium‐induced colitis in mice

Haiyan Chen, Liubo Chen, Xin Wang, Xiaoxu Ge, Lifeng Sun, Zhanhuai Wang, Xiaoming Xu, Yongmao Song, Jing Chen, Qun Deng, Haiting Xie, Ting Chen, Yan Chen, Kefeng Ding, Jingjing Wu, Jian Wang

J Cell Mol Med. 2021 Mar; 25(5): 2679–2690. Published online 2021 Jan 24. doi: 10.1111/jcmm.16297

PMCID:: PMC7933932

Abstract Article PDF–2.1M

Select item 74571478.

RNA Interference Characterization of Proteins Discovered by Proteomic Analysis of Pancreatic Cancer Reveals Function in Cell Growth and Survival

Candy N. Lee, Jenny L. Heidbrink, Katherine McKinnon, Victoria Bushman, Henrik Olsen, William FitzHugh, Aiqun Li, Karen Van Orden, Tao He, Steven M. Ruben, Paul A. Moore

Pancreas. Author manuscript; available in PMC 2020 Aug 31.

Published in final edited form as: Pancreas. 2012 Jan; 41(1): 84–94. doi: 10.1097/MPA.0b013e3182236385

PMCID:: PMC7457147

Abstract Article PDF–3.9M

Select item 74430359.

Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Cell Invasion through Integrin β6 Upregulation in Colorectal Cancer

Qi Sun, Yukui Shang, Fengkai Sun, Xiwen Dong, Jun Niu, Fanni Li

Oxid Med Cell Longev. 2020; 2020: 8032187. Published online 2020 Aug 13. doi: 10.1155/2020/8032187

PMCID:: PMC7443035

Abstract Article PDF–1.8M

Select item 704870810.

Integrin αvβ6 mediates epithelial-mesenchymal transition in human bronchial epithelial cells induced by lipopolysaccharides of Pseudomonas aeruginosa via TGF-β1-Smad2/3 signaling pathway

Weiming Liu, Tieying Sun, Yong Wang

Folia Microbiol (Praha) 2020; 65(2): 329–338. Published online 2019 Jun 26. doi: 10.1007/s12223-019-00728-w

PMCID:: PMC7048708

Abstract Article PDF–1.1M

Select item 685243411.

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

Claire S Reader, Sabari Vallath, Colin W Steele, Syed Haider, Adam Brentnall, Ami Desai, Kate M Moore, Nigel B Jamieson, David Chang, Peter Bailey, Aldo Scarpa, Rita Lawlor, Claude Chelala, Stephen M Keyse, Andrew Biankin, Jennifer P Morton, TR Jeffry Evans, Simon T Barry, Owen J Sansom, Hemant M Kocher, John F Marshall

J Pathol. 2019 Nov; 249(3): 332–342. Published online 2019 Jul 30. doi: 10.1002/path.5320

PMCID:: PMC6852434

Abstract Article PDF–4.8M

Select item 678143012.

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood–brain barrier

Kuniyuki Nakamura, Tomoko Ikeuchi, Kazuki Nara, Craig S. Rhodes, Peipei Zhang, Yuta Chiba, Saiko Kazuno, Yoshiki Miura, Tetsuro Ago, Eri Arikawa-Hirasawa, Yoh-suke Mukouyama, Yoshihiko Yamada

J Cell Biol. 2019 Oct 7; 218(10): 3506–3525. Published online 2019 Sep 20. doi: 10.1083/jcb.201807178

PMCID:: PMC6781430

Abstract Article PDF–5.3M

Select item 643551613.

Integrin αvβ6 plays a bi-directional regulation role between colon cancer cells and cancer-associated fibroblasts

Cheng Peng, Xueqing Zou, Wanying Xia, Huijie Gao, Zequn Li, Naiqing Liu, Zongquan Xu, Chao Gao, Zhaobin He, Weibo Niu, Ruliang Fang, Siddhartha Biswas, Michael Agrez, Xuting Zhi, Jun Niu

Biosci Rep. 2018 Dec 21; 38(6): BSR20180243. Prepublished online 2018 Oct 24. Published online 2018 Dec 7. doi: 10.1042/BSR20180243

PMCID:: PMC6435516

Abstract Article PDF–1.3M

Select item 638658814.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 616668215.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 608124016.

Exosomal α_vβ₆ Integrin Is Required for Monocyte M2 Polarization In Prostate Cancer

Huimin Lu, Nicholas Bowler, Larry A. Harshyne, D. Craig Hooper, Shiv Ram Krishn, Senem Kurtoglu, Carmine Fedele, Qin Liu, Hsin-Yao Tang, Andrew V. Kossenkov, William K. Kelly, Kerith Wang, Rhonda B. Kean, Paul H. Weinreb, Lei Yu, Anindita Dutta, Paolo Fortina, Adam Ertel, Maria Stanczak, Flemming Forsberg, Dmitry I. Gabrilovich, David W. Speicher, Dario C. Altieri, Lucia R. Languino

Matrix Biol. Author manuscript; available in PMC 2019 Sep 1.

Published in final edited form as: Matrix Biol. 2018 Sep; 70: 20–35. Published online 2018 Mar 9. doi: 10.1016/j.matbio.2018.03.009

PMCID:: PMC6081240

Abstract Article PDF–1.1M

Select item 560124717.

Pro‐migratory and TGF‐β‐activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8‐dependent GTPase switch

Jo Tod, Christopher J Hanley, Mark R Morgan, Marta Rucka, Toby Mellows, Maria‐Antoinette Lopez, Philip Kiely, Karwan A Moutasim, Steven J Frampton, Durgagauri Sabnis, David R Fine, Colin Johnson, John F Marshall, Giorgio Scita, Veronika Jenei, Gareth J Thomas

J Pathol. 2017 Sep; 243(1): 37–50. Published online 2017 Aug 7. doi: 10.1002/path.4923

PMCID:: PMC5601247

Abstract Article PDF–2.7M

Select item 558614718.

Force Interacts with Macromolecular Structure in Activation of TGF-β

Xianchi Dong, Bo Zhao, Roxana E. Iacob, Jianghai Zhu, Adem C. Koksal, Chafen Lu, John R. Engen, Timothy A. Springer

Nature. Author manuscript; available in PMC 2017 Sep 6.

Published in final edited form as: Nature. 2017 Feb 2; 542(7639): 55–59. Published online 2017 Jan 25. doi: 10.1038/nature21035

PMCID:: PMC5586147

Abstract Article PDF–6.0M

Select item 545752019.

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen, David I. Stuart

Nat Commun. 2017; 8: 15408. Published online 2017 May 23. doi: 10.1038/ncomms15408

PMCID:: PMC5457520

Abstract Article PDF–4.1M

Select item 538669820.

The clinical significance and underlying correlation of pStat-3 and integrin αvβ6 expression in gallbladder cancer

Liu Enyu, Wang Na, Zhao Chuanzong, Wang Ben, Wu Xiaojuan, Wang Yan, Li Zequn, Hong Jianguo, Wang Jiayong, Liang Benjia, Peng Cheng, Zhu Min, Zhang Zongli

Oncotarget. 2017 Mar 21; 8(12): 19467–19477. Published online 2017 Jan 2. doi: 10.18632/oncotarget.14444

PMCID:: PMC5386698

Abstract Article PDF–3.0M

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