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Select item 108300861.

Sirtuin3 promotes the degradation of hepatic Z alpha-1 antitrypsin through lipophagy

Brittney Poole, Regina Oshins, Zhiguang Huo, Alek Aranyos, Jesse West, Sergio Duarte, Virginia C. Clark, Thiago Beduschi, Ali Zarrinpar, Mark Brantly, Nazli Khodayari

Hepatol Commun. 2024 Feb; 8(2): e0370. Published online 2024 Jan 29. doi: 10.1097/HC9.0000000000000370

Correction in:: Hepatol Commun. 2024 Jun; 8(6): e0439.

PMCID:: PMC10830086

Abstract Article PDF–1.4M

Select item 104920242.

Increased expression or activation of TRPML1 reduces hepatic storage of toxic Z alpha-1 antitrypsin

Nunzia Pastore, Francesco Annunziata, Rita Colonna, Veronica Maffia, Teresa Giuliano, Bruno Maria Custode, Bernadette Lombardi, Elena Polishchuk, Vincenzo Cacace, Lucia De Stefano, Edoardo Nusco, Nicolina Cristina Sorrentino, Pasquale Piccolo, Nicola Brunetti-Pierri

Mol Ther. 2023 Sep 6; 31(9): 2651–2661. Published online 2023 Jul 1. doi: 10.1016/j.ymthe.2023.06.018

PMCID:: PMC10492024

Abstract Article PDF–4.0M

Select item 103078523.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 94991714.

Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways

Sri Harsha Meghadri, Beatriz Martinez-Delgado, Lena Ostermann, Gema Gomez-Mariano, Sara Perez-Luz, Srinu Tumpara, Sabine Wrenger, David S. DeLuca, Ulrich A. Maus, Tobias Welte, Sabina Janciauskiene

Int J Mol Sci. 2022 Sep; 23(18): 10425. Published online 2022 Sep 9. doi: 10.3390/ijms231810425

PMCID:: PMC9499171

Abstract Article PDF–1.8M

Select item 90694735.

Placental HTRA1 cleaves α₁-antitrypsin to generate a NET-inhibitory peptide

Robert A. Campbell, Heather D. Campbell, J. Samuel Bircher, Claudia Valeria de Araujo, Frederik Denorme, Jacob L. Crandell, John L. Rustad, Josh Monts, Mark J. Cody, Yasuhiro Kosaka, Christian C. Yost

Blood. 2021 Sep 16; 138(11): 977–988. Prepublished online 2021 Jun 30. doi: 10.1182/blood.2020009021

PMCID:: PMC9069473

Abstract Article

Select item 78613546.

Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury

Kyle Stearns, Monica Goldklang, Rui Xiao, Tina Zelonina, Keith Blomenkamp, Jeffery Teckman, Jeanine M. D’Armiento

PLoS One. 2021; 16(2): e0246040. Published online 2021 Feb 4. doi: 10.1371/journal.pone.0246040

PMCID:: PMC7861354

Abstract Article PDF–1.0M

Select item 65224767.

A combined in silico and in vitro study on mouse Serpina1a antitrypsin-deficiency mutants

Reto Eggenschwiler, Atanas Patronov, Jan Hegermann, Mariane Fráguas-Eggenschwiler, Guangming Wu, Leon Cortnumme, Matthias Ochs, Iris Antes, Tobias Cantz

Sci Rep. 2019; 9: 7486. Published online 2019 May 16. doi: 10.1038/s41598-019-44043-3

PMCID:: PMC6522476

Abstract Article PDF–1.9M

Select item 53882188.

Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy

Lijie Feng, Jin Zhang, Na Zhu, Qian Ding, Xiaojie Zhang, Jishuang Yu, Weimin Qiang, Zhetao Zhang, Yuyang Ma, Dake Huang, Yujun Shen, Shengyun Fang, Yifan Yu, Haiping Wang, Yuxian Shen

Autophagy. 2017; 13(4): 686–702. Published online 2017 Jan 25. doi: 10.1080/15548627.2017.1280207

PMCID:: PMC5388218

Abstract Article PDF–1.7M

Select item 53812269.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 522315910.

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression

Alexandra Naba, Karl R. Clauser, D. R. Mani, Steven A. Carr, Richard O. Hynes

Sci Rep. 2017; 7: 40495. Published online 2017 Jan 10. doi: 10.1038/srep40495

PMCID:: PMC5223159

Abstract Article PDF–2.3M

Select item 510711811.

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation

Andrea Di Francesco, Clara Di Germanio, Amaresh C. Panda, Phu Huynh, Robert Peaden, Ignacio Navas-Enamorado, Paul Bastian, Elin Lehrmann, Alberto Diaz-Ruiz, David Ross, David Siegel, Jennifer L. Martindale, Michel Bernier, Myriam Gorospe, Kotb Abdelmohsen, Rafael de Cabo

Free Radic Biol Med. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Free Radic Biol Med. 2016 Oct; 99: 225–233. Published online 2016 Aug 8. doi: 10.1016/j.freeradbiomed.2016.08.005

PMCID:: PMC5107118

Abstract Article PDF–787K

Select item 488375812.

Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus

Ahmed S. Elshikha, Yuanqing Lu, Mong-Jen Chen, Mohammad Akbar, Leilani Zeumer, Andrea Ritter, Hanaa Elghamry, Mahmoud A. Mahdi, Laurence Morel, Sihong Song

PLoS One. 2016; 11(5): e0156583. Published online 2016 May 27. doi: 10.1371/journal.pone.0156583

PMCID:: PMC4883758

Abstract Article PDF–3.8M

Select item 454881413.

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α₁-antitrypsin while allowing its antiproteinase activity

Adriana Ordóñez, Juan Pérez, Lu Tan, Jennifer A. Dickens, Neda Motamedi-Shad, James A. Irving, Imran Haq, Ugo Ekeowa, Stefan J. Marciniak, Elena Miranda, David A. Lomas

FASEB J. 2015 Jun; 29(6): 2667–2678. Published online 2015 Mar 10. doi: 10.1096/fj.14-267351

PMCID:: PMC4548814

Abstract Article

Select item 454666714.

FBG1 Is the Final Arbitrator of A1AT-Z Degradation

John H. Wen, Hsiang Wen, Katherine N. Gibson-Corley, Kevin A. Glenn

PLoS One. 2015; 10(8): e0135591. Published online 2015 Aug 21. doi: 10.1371/journal.pone.0135591

PMCID:: PMC4546667

Abstract Article PDF–1.9M

Select item 402997815.

Rapid Renal Alpha-1 Antitrypsin Gene Induction in Experimental and Clinical Acute Kidney Injury

Richard A. Zager, Ali C. M. Johnson, Kirsten B. Frostad

PLoS One. 2014; 9(5): e98380. Published online 2014 May 21. doi: 10.1371/journal.pone.0098380

PMCID:: PMC4029978

Abstract Article PDF–1.9M

Select item 399057216.

Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium

Angelia D. Lockett, Mary Beth Brown, Nieves Santos-Falcon, Natalia I. Rush, Houssam Oueini, Amber J. Oberle, Esther Bolanis, Miryam A. Fragoso, Daniela N. Petrusca, Karina A. Serban, Kelly S. Schweitzer, Robert G. Presson Jr., Michael Campos, Irina Petrache

PLoS One. 2014; 9(4): e93979. Published online 2014 Apr 17. doi: 10.1371/journal.pone.0093979