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Select item 104905151.

Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons

Nannan Gao, Zhipeng Liu, Hongsheng Wang, Chen Shen, Zhaoqi Dong, Wanpeng Cui, Wen-Cheng Xiong, Lin Mei

J Neurosci. 2023 Sep 6; 43(36): 6249–6267. doi: 10.1523/JNEUROSCI.0247-23.2023

PMCID:: PMC10490515

Abstract Article PDF–8.5M

Select item 103326262.

Effects of heterozygous deletion of autism-related gene Cullin-3 in mice

Qiang-qiang Xia, Angela K. Walker, Chenghui Song, Jing Wang, Anju Singh, James A. Mobley, Zhong X. Xuan, Jeffrey D. Singer, Craig M. Powell

PLoS One. 2023; 18(7): e0283299. Published online 2023 Jul 10. doi: 10.1371/journal.pone.0283299

PMCID:: PMC10332626

Abstract Article PDF–3.3M

Select item 98736273.

Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits

Maximiliano Rapanelli, Wei Wang, Edward Hurley, Maria Laura Feltri, Christopher Pittenger, Luciana Romina Frick, Zhen Yan

Transl Psychiatry. 2023; 13: 22. Published online 2023 Jan 24. doi: 10.1038/s41398-023-02306-8

PMCID:: PMC9873627

Abstract Article PDF–3.0M

Select item 96029354.

Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney

Yujiro Maeoka, Ryan J. Cornelius, Mohammed Zubaerul Ferdaus, Avika Sharma, Luan T. Nguyen, James A. McCormick

Am J Physiol Renal Physiol. 2022 Nov 1; 323(5): F564–F576. Published online 2022 Aug 26. doi: 10.1152/ajprenal.00153.2022

PMCID:: PMC9602935

Abstract Article

Select item 95351725.

CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein

Min Dong, Min Qian, Zhengyi Ruan

J Immunother Cancer. 2022; 10(10): e005270. Published online 2022 Oct 5. doi: 10.1136/jitc-2022-005270

Correction in:: J Immunother Cancer. 2023; 11(12): e005270corr1.

PMCID:: PMC9535172

Abstract Article PDF–10M

Select item 92062986.

Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells

Jian Shen, Youqi Li, Menghao Li, Zhiming Li, Huantang Deng, Xiongwei Xie, Jinguang Liu

Biomed Eng Online. 2022; 21: 39. Published online 2022 Jun 17. doi: 10.1186/s12938-022-01002-w

PMCID:: PMC9206298

Abstract Article PDF–6.8M

Select item 90458507.

Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension

Jing Wu, Shi Fang, Ko-Ting Lu, Gaurav Kumar, John J Reho, Daniel T Brozoski, Adokole J Otanwa, Chunyan Hu, Anand R Nair, Kelsey K Wackman, Larry N Agbor, Justin L Grobe, Curt D Sigmund

Function (Oxf) 2022; 3(3): zqac017. Published online 2022 Apr 8. doi: 10.1093/function/zqac017

PMCID:: PMC9045850

Abstract Article PDF–4.6M

Select item 89750568.

Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice

Yujiro Maeoka, Mohammed Z. Ferdaus, Ryan J. Cornelius, Avika Sharma, Xiao-Tong Su, Lauren N. Miller, Joshua A. Robertson, Susan B. Gurley, Chao-Ling Yang, David H. Ellison, James A. McCormick

J Am Soc Nephrol. 2022 Mar; 33(3): 584–600. Published online 2022 Mar. doi: 10.1681/ASN.2021081099

PMCID:: PMC8975056

Abstract Article

Select item 88329739.

Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization

Cheng Chen, Lijie Gu, David J. Matye, Yung-Dai Clayton, Mohammad Nazmul Hasan, Yifeng Wang, Jacob E. Friedman, Tiangang Li

Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2111737119. Published online 2022 Feb 3. doi: 10.1073/pnas.2111737119

PMCID:: PMC8832973

Abstract Article PDF–2.2M

Select item 854953610.

STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development

Tohru Matsuki, Akio Iio, Masashi Ueda, Yumi Tsuneura, Brian W. Howell, Atsuo Nakayama

J Neurosci. 2021 Oct 27; 41(43): 8887–8903. doi: 10.1523/JNEUROSCI.0523-21.2021

PMCID:: PMC8549536

Abstract Article PDF–6.2M

Select item 844368311.

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

Megha Amar, Akula Bala Pramod, Nam-Kyung Yu, Victor Munive Herrera, Lily R. Qiu, Patricia Moran-Losada, Pan Zhang, Cleber A. Trujillo, Jacob Ellegood, Jorge Urresti, Kevin Chau, Jolene Diedrich, Jiaye Chen, Jessica Gutierrez, Jonathan Sebat, Dhakshin Ramanathan, Jason P. Lerch, John R. Yates, III, Alysson R. Muotri, Lilia M. Iakoucheva

Mol Psychiatry. 2021; 26(7): 3586–3613. Published online 2021 Mar 16. doi: 10.1038/s41380-021-01052-x

PMCID:: PMC8443683

Abstract Article PDF–7.7M

Select item 842344512.

ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

Miaomiao Tian, Fengqi Hao, Xin Jin, Xue Sun, Ying Jiang, Yang Wang, Dan Li, Tianyi Chang, Yingying Zou, Pinghui Peng, Chaoyi Xia, Jia Liu, Yuanxi Li, Ping Wang, Yunpeng Feng, Min Wei

eLife. 2021; 10: e62394. Published online 2021 Sep 7. doi: 10.7554/eLife.62394

PMCID:: PMC8423445

Abstract Article PDF–1.2M

Select item 831323913.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 814422514.

Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development

Jasmin Morandell, Lena A. Schwarz, Bernadette Basilico, Saren Tasciyan, Georgi Dimchev, Armel Nicolas, Christoph Sommer, Caroline Kreuzinger, Christoph P. Dotter, Lisa S. Knaus, Zoe Dobler, Emanuele Cacci, Florian K. M. Schur, Johann G. Danzl, Gaia Novarino

Nat Commun. 2021; 12: 3058. Published online 2021 May 24. doi: 10.1038/s41467-021-23123-x

PMCID:: PMC8144225

Abstract Article PDF–8.9M

Select item 793877015.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 700739916.

CUL3 deficiency causes social deficits and anxiety-like behaviors by impairing excitation-inhibition balance via promoting Cap-dependent translation

Zhaoqi Dong, Wenbing Chen, Chao Chen, Hongsheng Wang, Wanpeng Cui, Zhibing Tan, Heath Robinson, Nannan Gao, Bin Luo, Lei Zhang, Kai Zhao, Wen-Cheng Xiong, Lin Mei

Neuron. Author manuscript; available in PMC 2021 Feb 5.

Published in final edited form as: Neuron. 2020 Feb 5; 105(3): 475–490.e6. Published online 2019 Nov 25. doi: 10.1016/j.neuron.2019.10.035

PMCID:: PMC7007399

Abstract Article PDF–3.4M

Select item 688574117.

Cul3‐Klhl18 ubiquitin ligase modulates rod transducin translocation during light‐dark adaptation

Taro Chaya, Ryotaro Tsutsumi, Leah Rie Varner, Yamato Maeda, Satoyo Yoshida, Takahisa Furukawa

EMBO J. 2019 Dec 2; 38(23): e101409. Published online 2019 Nov 7. doi: 10.15252/embj.2018101409

PMCID:: PMC6885741

Abstract Article PDF–5.2M

Select item 667558418.

Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension

Larry N. Agbor, Anand R. Nair, Jing Wu, Ko-Ting Lu, Deborah R. Davis, Henry L. Keen, Frederick W. Quelle, James A. McCormick, Jeffrey D. Singer, Curt D. Sigmund

JCI Insight. 2019 Jul 25; 4(14): e129793. Published online 2019 Jul 25. doi: 10.1172/jci.insight.129793

PMCID:: PMC6675584

Abstract Article PDF–6.7M

Select item 667204819.

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation

Shengyi Sun, Sherwin Kelekar, Steven A. Kliewer, David J. Mangelsdorf

Genes Dev. 2019 Aug 1; 33(15-16): 1083–1094. doi: 10.1101/gad.326868.119

PMCID:: PMC6672048

Abstract Article PDF–7.3M

Select item 649398920.

Severe Arterial Hypertension from Cullin 3 Mutations Is Caused by Both Renal and Vascular Effects

Waed Abdel Khalek, Chloé Rafael, Irmine Loisel-Ferreira, Ilektra Kouranti, Eric Clauser, Juliette Hadchouel, Xavier Jeunemaitre

J Am Soc Nephrol. 2019 May; 30(5): 811–823. Published online 2019 Apr 9. doi: 10.1681/ASN.2017121307

PMCID:: PMC6493989

Abstract Article

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